Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 60

1.

Mutation and Suppressor Analysis of the Essential Lipopolysaccharide Transport Protein LptA Reveals Strategies To Overcome Severe Outer Membrane Permeability Defects in Escherichia coli.

Falchi FA, Maccagni EA, Puccio S, Peano C, De Castro C, Palmigiano A, Garozzo D, Martorana AM, Polissi A, Dehò G, Sperandeo P.

J Bacteriol. 2017 Dec 20;200(2). pii: e00487-17. doi: 10.1128/JB.00487-17. Print 2018 Jan 15.

PMID:
29109183
2.

Crassiflorone derivatives that inhibit Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH) and Trypanosoma cruzi trypanothione reductase (TcTR) and display trypanocidal activity.

Uliassi E, Fiorani G, Krauth-Siegel RL, Bergamini C, Fato R, Bianchini G, Carlos Menéndez J, Molina MT, López-Montero E, Falchi F, Cavalli A, Gul S, Kuzikov M, Ellinger B, Witt G, Moraes CB, Freitas-Junior LH, Borsari C, Costi MP, Bolognesi ML.

Eur J Med Chem. 2017 Dec 1;141:138-148. doi: 10.1016/j.ejmech.2017.10.005. Epub 2017 Oct 3.

PMID:
29031061
3.

Synthetic Lethality Triggered by Combining Olaparib with BRCA2-Rad51 Disruptors.

Falchi F, Giacomini E, Masini T, Boutard N, Di Ianni L, Manerba M, Farabegoli F, Rossini L, Robertson J, Minucci S, Pallavicini I, Di Stefano G, Roberti M, Pellicciari R, Cavalli A.

ACS Chem Biol. 2017 Oct 20;12(10):2491-2497. doi: 10.1021/acschembio.7b00707. Epub 2017 Sep 1.

PMID:
28841282
4.

Development of a multisite model for Ni(II) ion in solution from thermodynamic and kinetic data.

Masetti M, Musiani F, Bernetti M, Falchi F, Cavalli A, Ciurli S, Recanatini M.

J Comput Chem. 2017 Jun 5;38(21):1834-1843. doi: 10.1002/jcc.24827. Epub 2017 May 30.

PMID:
28558120
5.

Chalcone-based carbamates for Alzheimer's disease treatment.

Rampa A, Montanari S, Pruccoli L, Bartolini M, Falchi F, Feoli A, Cavalli A, Belluti F, Gobbi S, Tarozzi A, Bisi A.

Future Med Chem. 2017 May;9(8):749-764. doi: 10.4155/fmc-2017-0029. Epub 2017 May 12.

PMID:
28498775
6.

Protein Tunnels: The Case of Urease Accessory Proteins.

Musiani F, Gioia D, Masetti M, Falchi F, Cavalli A, Recanatini M, Ciurli S.

J Chem Theory Comput. 2017 May 9;13(5):2322-2331. doi: 10.1021/acs.jctc.7b00042. Epub 2017 Apr 12.

PMID:
28379694
7.

Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases.

Tassini S, Sun L, Lanko K, Crespan E, Langron E, Falchi F, Kissova M, Armijos-Rivera JI, Delang L, Mirabelli C, Neyts J, Pieroni M, Cavalli A, Costantino G, Maga G, Vergani P, Leyssen P, Radi M.

J Med Chem. 2017 Feb 23;60(4):1400-1416. doi: 10.1021/acs.jmedchem.6b01521. Epub 2017 Feb 10.

PMID:
28122178
8.

Synthesis of natural urolithin M6, a galloflavin mimetic, as a potential inhibitor of lactate dehydrogenase A.

Rupiani S, Guidotti L, Manerba M, Di Ianni L, Giacomini E, Falchi F, Di Stefano G, Roberti M, Recanatini M.

Org Biomol Chem. 2016 Nov 22;14(46):10981-10987. doi: 10.1039/c6ob01977c.

PMID:
27827510
9.

Kernel-Based, Partial Least Squares Quantitative Structure-Retention Relationship Model for UPLC Retention Time Prediction: A Useful Tool for Metabolite Identification.

Falchi F, Bertozzi SM, Ottonello G, Ruda GF, Colombano G, Fiorelli C, Martucci C, Bertorelli R, Scarpelli R, Cavalli A, Bandiera T, Armirotti A.

Anal Chem. 2016 Oct 4;88(19):9510-9517. Epub 2016 Sep 14.

10.

The Lack of the Essential LptC Protein in the Trans-Envelope Lipopolysaccharide Transport Machine Is Circumvented by Suppressor Mutations in LptF, an Inner Membrane Component of the Escherichia coli Transporter.

Benedet M, Falchi FA, Puccio S, Di Benedetto C, Peano C, Polissi A, Dehò G.

PLoS One. 2016 Aug 16;11(8):e0161354. doi: 10.1371/journal.pone.0161354. eCollection 2016.

11.

The new world atlas of artificial night sky brightness.

Falchi F, Cinzano P, Duriscoe D, Kyba CC, Elvidge CD, Baugh K, Portnov BA, Rybnikova NA, Furgoni R.

Sci Adv. 2016 Jun 10;2(6):e1600377. doi: 10.1126/sciadv.1600377. eCollection 2016 Jun.

12.

Resources of dark skies in German climatic health resorts.

Gabriel KM, Kuechly HU, Falchi F, Wosniok W, Hölker F.

Int J Biometeorol. 2017 Jan;61(1):11-22. doi: 10.1007/s00484-016-1187-y. Epub 2016 May 19.

PMID:
27192999
13.

Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin-Based Derivatives.

Montanari S, Bartolini M, Neviani P, Belluti F, Gobbi S, Pruccoli L, Tarozzi A, Falchi F, Andrisano V, Miszta P, Cavalli A, Filipek S, Bisi A, Rampa A.

ChemMedChem. 2016 Jun 20;11(12):1296-308. doi: 10.1002/cmdc.201500392. Epub 2015 Oct 28.

PMID:
26507467
14.

Corrigendum: Worldwide variations in artificial skyglow.

Kyba CC, Tong KP, Bennie J, Birriel I, Birriel JJ, Cool A, Danielsen A, Davies TW, den Outer PN, Edwards W, Ehlert R, Falchi F, Fischer J, Giacomelli A, Giubbilini F, Haaima M, Hesse C, Heygster G, Hölker F, Inger R, Jensen LJ, Kuechly HU, Kuehn J, Langill P, Lolkema DE, Nagy M, Nievas M, Ochi N, Popow E, Posch T, Puschnig J, Ruhtz T, Schmidt W, Schwarz R, Schwope A, Spoelstra H, Tekatch A, Trueblood M, Walker CE, Weber M, Welch DL, Zamorano J, Gaston KJ.

Sci Rep. 2015 Aug 5;5:12180. doi: 10.1038/srep12180. No abstract available.

15.

2-Phenoxy-1,4-naphthoquinones: From a Multitarget Antitrypanosomal to a Potential Antitumor Profile.

Prati F, Bergamini C, Molina MT, Falchi F, Cavalli A, Kaiser M, Brun R, Fato R, Bolognesi ML.

J Med Chem. 2015 Aug 27;58(16):6422-34. doi: 10.1021/acs.jmedchem.5b00748. Epub 2015 Aug 11.

PMID:
26237241
16.

Identification of N-acylhydrazone derivatives as novel lactate dehydrogenase A inhibitors.

Rupiani S, Buonfiglio R, Manerba M, Di Ianni L, Vettraino M, Giacomini E, Masetti M, Falchi F, Di Stefano G, Roberti M, Recanatini M.

Eur J Med Chem. 2015 Aug 28;101:63-70. doi: 10.1016/j.ejmech.2015.06.028. Epub 2015 Jun 18.

PMID:
26114812
17.

From AChE to BACE1 inhibitors: The role of the amine on the indanone scaffold.

Rampa A, Mancini F, De Simone A, Falchi F, Belluti F, Di Martino RM, Gobbi S, Andrisano V, Tarozzi A, Bartolini M, Cavalli A, Bisi A.

Bioorg Med Chem Lett. 2015 Jul 15;25(14):2804-8. doi: 10.1016/j.bmcl.2015.05.002. Epub 2015 May 9.

PMID:
26003339
18.

Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors.

Tintori C, La Sala G, Vignaroli G, Botta L, Fallacara AL, Falchi F, Radi M, Zamperini C, Dreassi E, Dello Iacono L, Orioli D, Biamonti G, Garbelli M, Lossani A, Gasparrini F, Tuccinardi T, Laurenzana I, Angelucci A, Maga G, Schenone S, Brullo C, Musumeci F, Desogus A, Crespan E, Botta M.

J Med Chem. 2015 Jun 11;58(11):4590-609. doi: 10.1021/acs.jmedchem.5b00140. Epub 2015 May 20.

PMID:
25923950
19.

Worldwide variations in artificial skyglow.

Kyba CC, Tong KP, Bennie J, Birriel I, Birriel JJ, Cool A, Danielsen A, Davies TW, Outer PN, Edwards W, Ehlert R, Falchi F, Fischer J, Giacomelli A, Giubbilini F, Haaima M, Hesse C, Heygster G, Hölker F, Inger R, Jensen LJ, Kuechly HU, Kuehn J, Langill P, Lolkema DE, Nagy M, Nievas M, Ochi N, Popow E, Posch T, Puschnig J, Ruhtz T, Schmidt W, Schwarz R, Schwope A, Spoelstra H, Tekatch A, Trueblood M, Walker CE, Weber M, Welch DL, Zamorano J, Gaston KJ.

Sci Rep. 2015 Feb 12;5:8409. doi: 10.1038/srep08409. Erratum in: Sci Rep. 2015;5:12180.

20.

Novel antiproliferative chimeric compounds with marked histone deacetylase inhibitory activity.

Giacomini E, Nebbioso A, Ciotta A, Ianni C, Falchi F, Roberti M, Tolomeo M, Grimaudo S, Cristina AD, Pipitone RM, Altucci L, Recanatini M.

ACS Med Chem Lett. 2014 Jul 8;5(9):973-8. doi: 10.1021/ml5000959. eCollection 2014 Sep 11.

21.

Dissecting Escherichia coli outer membrane biogenesis using differential proteomics.

Martorana AM, Motta S, Di Silvestre D, Falchi F, Dehò G, Mauri P, Sperandeo P, Polissi A.

PLoS One. 2014 Jun 26;9(6):e100941. doi: 10.1371/journal.pone.0100941. eCollection 2014.

22.

Protein dynamics of the HIF-2α PAS-B domain upon heterodimerization and ligand binding.

Masetti M, Falchi F, Recanatini M.

PLoS One. 2014 Apr 15;9(4):e94986. doi: 10.1371/journal.pone.0094986. eCollection 2014.

23.

Structure-based design of small-molecule protein-protein interaction modulators: the story so far.

Falchi F, Caporuscio F, Recanatini M.

Future Med Chem. 2014 Mar;6(3):343-57. doi: 10.4155/fmc.13.204. Review.

PMID:
24575969
24.

Collecting and assessing human lactate dehydrogenase-A conformations for structure-based virtual screening.

Buonfiglio R, Ferraro M, Falchi F, Cavalli A, Masetti M, Recanatini M.

J Chem Inf Model. 2013 Nov 25;53(11):2792-7. doi: 10.1021/ci400543y. Epub 2013 Nov 13.

PMID:
24138094
25.

Identification of Hck inhibitors as hits for the development of antileukemia and anti-HIV agents.

Tintori C, Laurenzana I, La Rocca F, Falchi F, Carraro F, Ruiz A, Esté JA, Kissova M, Crespan E, Maga G, Biava M, Brullo C, Schenone S, Botta M.

ChemMedChem. 2013 Aug;8(8):1353-60. doi: 10.1002/cmdc.201300204. Epub 2013 Jun 28.

PMID:
23813855
26.

Citizen science provides valuable data for monitoring global night sky luminance.

Kyba CC, Wagner JM, Kuechly HU, Walker CE, Elvidge CD, Falchi F, Ruhtz T, Fischer J, Hölker F.

Sci Rep. 2013;3:1835. doi: 10.1038/srep01835.

27.

A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model: from in silico screening to cyclodextrin formulation.

Radi M, Evensen L, Dreassi E, Zamperini C, Caporicci M, Falchi F, Musumeci F, Schenone S, Lorens JB, Botta M.

Bioorg Med Chem Lett. 2012 Sep 1;22(17):5579-83. doi: 10.1016/j.bmcl.2012.07.014. Epub 2012 Jul 13.

PMID:
22853993
28.

Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: towards the next generation HIV-1 inhibitors.

Radi M, Falchi F, Garbelli A, Samuele A, Bernardo V, Paolucci S, Baldanti F, Schenone S, Manetti F, Maga G, Botta M.

Bioorg Med Chem Lett. 2012 Mar 1;22(5):2094-8. doi: 10.1016/j.bmcl.2011.12.135. Epub 2012 Jan 8.

PMID:
22300661
29.

N-[2-Methyl-5-(triazol-1-yl)phenyl]pyrimidin-2-amine as a scaffold for the synthesis of inhibitors of Bcr-Abl.

Arioli F, Borrelli S, Colombo F, Falchi F, Filippi I, Crespan E, Naldini A, Scalia G, Silvani A, Maga G, Carraro F, Botta M, Passarella D.

ChemMedChem. 2011 Nov 4;6(11):2009-18. doi: 10.1002/cmdc.201100304. Epub 2011 Aug 30.

PMID:
21990039
30.

Computational techniques are valuable tools for the discovery of protein-protein interaction inhibitors: the 14-3-3σ case.

Corradi V, Mancini M, Santucci MA, Carlomagno T, Sanfelice D, Mori M, Vignaroli G, Falchi F, Manetti F, Radi M, Botta M.

Bioorg Med Chem Lett. 2011 Nov 15;21(22):6867-71. doi: 10.1016/j.bmcl.2011.09.011. Epub 2011 Sep 10.

PMID:
21962576
31.

Limiting the impact of light pollution on human health, environment and stellar visibility.

Falchi F, Cinzano P, Elvidge CD, Keith DM, Haim A.

J Environ Manage. 2011 Oct;92(10):2714-22. doi: 10.1016/j.jenvman.2011.06.029. Epub 2011 Jul 13.

PMID:
21745709
32.

Toward the discovery of novel anti-HIV drugs. Second-generation inhibitors of the cellular ATPase DDX3 with improved anti-HIV activity: synthesis, structure-activity relationship analysis, cytotoxicity studies, and target validation.

Maga G, Falchi F, Radi M, Botta L, Casaluce G, Bernardini M, Irannejad H, Manetti F, Garbelli A, Samuele A, Zanoli S, Esté JA, Gonzalez E, Zucca E, Paolucci S, Baldanti F, De Rijck J, Debyser Z, Botta M.

ChemMedChem. 2011 Aug 1;6(8):1371-89. doi: 10.1002/cmdc.201100166. Epub 2011 Jun 22.

PMID:
21698775
33.

Fyn kinase in brain diseases and cancer: the search for inhibitors.

Schenone S, Brullo C, Musumeci F, Biava M, Falchi F, Botta M.

Curr Med Chem. 2011;18(19):2921-42. Review.

PMID:
21651487
34.

Targeting the human DEAD-box polypeptide 3 (DDX3) RNA helicase as a novel strategy to inhibit viral replication.

Garbelli A, Radi M, Falchi F, Beermann S, Zanoli S, Manetti F, Dietrich U, Botta M, Maga G.

Curr Med Chem. 2011;18(20):3015-27. Review.

PMID:
21651478
35.

Design and synthesis of thiadiazoles and thiazoles targeting the Bcr-Abl T315I mutant: from docking false positives to ATP-noncompetitive inhibitors.

Radi M, Crespan E, Falchi F, Bernardo V, Zanoli S, Manetti F, Schenone S, Maga G, Botta M.

ChemMedChem. 2010 Aug 2;5(8):1226-31. doi: 10.1002/cmdc.201000066. No abstract available.

PMID:
20509136
36.

Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data.

Dreassi E, Zizzari AT, Falchi F, Schenone S, Santucci A, Maga G, Botta M.

Eur J Med Chem. 2009 Sep;44(9):3712-7. doi: 10.1016/j.ejmech.2009.03.039. Epub 2009 Apr 8.

PMID:
19410338
37.

3D QSAR models built on structure-based alignments of Abl tyrosine kinase inhibitors.

Falchi F, Manetti F, Carraro F, Naldini A, Maga G, Crespan E, Schenone S, Bruno O, Brullo C, Botta M.

ChemMedChem. 2009 Jun;4(6):976-87. doi: 10.1002/cmdc.200800441.

PMID:
19326384
38.

Pharmacophore modeling and molecular docking led to the discovery of inhibitors of human immunodeficiency virus-1 replication targeting the human cellular aspartic acid-glutamic acid-alanine-aspartic acid box polypeptide 3.

Maga G, Falchi F, Garbelli A, Belfiore A, Witvrouw M, Manetti F, Botta M.

J Med Chem. 2008 Nov 13;51(21):6635-8. doi: 10.1021/jm8008844. Epub 2008 Oct 4.

PMID:
18834110
39.

N-(thiazol-2-yl)-2-thiophene carboxamide derivatives as Abl inhibitors identified by a pharmacophore-based database screening of commercially available compounds.

Manetti F, Falchi F, Crespan E, Schenone S, Maga G, Botta M.

Bioorg Med Chem Lett. 2008 Aug 1;18(15):4328-31. doi: 10.1016/j.bmcl.2008.06.082. Epub 2008 Jun 28.

PMID:
18621522
40.

Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents.

Radi M, Crespan E, Botta G, Falchi F, Maga G, Manetti F, Corradi V, Mancini M, Santucci MA, Schenone S, Botta M.

Bioorg Med Chem Lett. 2008 Feb 1;18(3):1207-11. Epub 2007 Dec 4.

PMID:
18078752
41.

Morphological study of cellular distribution of T3 and T4 (PAP-method) in peripheral and bone marrow granulated and lymphoid cells of normal and leukemic subjects.

Notario A, Petrucci E, Pricca D, Torriani A, Zocchi MT, Falchi F.

Haematologica. 1983 Jul-Aug;68(4):495-502. No abstract available.

PMID:
6414900
42.

[Rheumatic disease: study of the septic foci in the oral cavity].

Preda GE, Falchi F, Zanasi G.

Riv Ital Stomatol. 1981;50(12):995-1003. Italian. No abstract available.

PMID:
6960421
43.

[The association of diazepam and dipramid (Valtrax-Valeas) in coronary insufficiency].

Falchi F.

Minerva Med. 1970 Oct 13;61(82):4551-8. Italian. No abstract available.

PMID:
4394446
44.

Chronology of the mitotic cycle of acute leukemia cells.

Rondanelli EG, Magliulo E, Pilla G, Falchi F, Barigazzi GM.

Acta Haematol. 1969;42(2):76-85. No abstract available.

PMID:
4187961
45.
46.

[The erythroblast in benzolic erythremia. Electron microscopic studies].

Osculati F, Falchi F, Carosi G, Gerna G.

Haematologica. 1967;52(7):563-78. Italian. No abstract available.

PMID:
4971835
47.

[Tolazamide and hepatic damage].

Ferrero E, Marioni G, Antognetti R, Falchi F.

Minerva Med. 1965 Oct 24;56(85):3609-13. Italian. No abstract available.

PMID:
5841666
48.

[Behavior of some erythrocyte metabolic indices in patients with malignant neoplasms].

NICOLINI E, FALCHI F.

Arch Med Interna. 1962 Jul-Sep;14:204-8. Italian. No abstract available.

PMID:
13938440
49.

[Behavior of some enzyme systems and some lymphocyte metabolic indices during antibody formation].

NICOLINI E, FALCHI F.

Arch Med Interna. 1962 Jul-Sep;14:141-8. Italian. No abstract available.

PMID:
13938439
50.

Supplemental Content

Loading ...
Support Center