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Items: 1 to 50 of 81

1.

KEAP1 and Done? Targeting the NRF2 Pathway with Sulforaphane.

Dinkova-Kostova AT, Fahey JW, Kostov RV, Kensler TW.

Trends Food Sci Technol. 2017 Nov;69(Pt B):257-269. doi: 10.1016/j.tifs.2017.02.002. Epub 2017 Feb 16.

PMID:
29242678
2.

Sulforaphane from Broccoli Reduces Symptoms of Autism: A Follow-up Case Series from a Randomized Double-blind Study.

Lynch R, Diggins EL, Connors SL, Zimmerman AW, Singh K, Liu H, Talalay P, Fahey JW.

Glob Adv Health Med. 2017 Oct 26;6:2164957X17735826. doi: 10.1177/2164957X17735826. eCollection 2017.

3.

Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes.

Axelsson AS, Tubbs E, Mecham B, Chacko S, Nenonen HA, Tang Y, Fahey JW, Derry JMJ, Wollheim CB, Wierup N, Haymond MW, Friend SH, Mulder H, Rosengren AH.

Sci Transl Med. 2017 Jun 14;9(394). pii: eaah4477. doi: 10.1126/scitranslmed.aah4477.

PMID:
28615356
4.

Sulforaphane for the chemoprevention of bladder cancer: molecular mechanism targeted approach.

Leone A, Diorio G, Sexton W, Schell M, Alexandrow M, Fahey JW, Kumar NB.

Oncotarget. 2017 May 23;8(21):35412-35424. doi: 10.18632/oncotarget.16015. Review.

5.

Correction: Lack of Effect of Oral Sulforaphane Administration on Nrf2 Expression in COPD: A Randomized, Double-Blind, Placebo Controlled Trial.

Wise RA, Holbrook JT, Criner G, Sethi S, Rayapudi S, Sudini KR, Sugar EA, Burke A, Thimmulappa R, Singh A, Talalay P, Fahey JW, Berenson CS, Jacobs MR, Biswal S; Broccoli Sprout Extract Trial Research Group.

PLoS One. 2017 Mar 28;12(3):e0175077. doi: 10.1371/journal.pone.0175077. eCollection 2017.

6.

Stabilized sulforaphane for clinical use: Phytochemical delivery efficiency.

Fahey JW, Wade KL, Wehage SL, Holtzclaw WD, Liu H, Talalay P, Fuchs E, Stephenson KK.

Mol Nutr Food Res. 2017 Apr;61(4). doi: 10.1002/mnfr.201600766. Epub 2017 Feb 8.

PMID:
27935214
7.

Lack of Effect of Oral Sulforaphane Administration on Nrf2 Expression in COPD: A Randomized, Double-Blind, Placebo Controlled Trial.

Wise RA, Holbrook JT, Criner G, Sethi S, Rayapudi S, Sudini KR, Sugar EA, Burke A, Thimmulappa R, Singh A, Talalay P, Fahey JW, Berenson CS, Jacobs MR, Biswal S; Broccoli Sprout Extract Trial Research Group.

PLoS One. 2016 Nov 10;11(11):e0163716. doi: 10.1371/journal.pone.0163716. eCollection 2016. Erratum in: PLoS One. 2017 Mar 28;12 (3):e0175077.

8.

Leaf Protein and Mineral Concentrations across the "Miracle Tree" Genus Moringa.

Olson ME, Sankaran RP, Fahey JW, Grusak MA, Odee D, Nouman W.

PLoS One. 2016 Jul 26;11(7):e0159782. doi: 10.1371/journal.pone.0159782. eCollection 2016.

9.

Prevention of Carcinogen-Induced Oral Cancer by Sulforaphane.

Bauman JE, Zang Y, Sen M, Li C, Wang L, Egner PA, Fahey JW, Normolle DP, Grandis JR, Kensler TW, Johnson DE.

Cancer Prev Res (Phila). 2016 Jul;9(7):547-57. doi: 10.1158/1940-6207.CAPR-15-0290. Epub 2016 Jun 23.

10.

Loss of Nrf2 abrogates the protective effect of Keap1 downregulation in a preclinical model of cutaneous squamous cell carcinoma.

Knatko EV, Higgins M, Fahey JW, Dinkova-Kostova AT.

Sci Rep. 2016 May 24;6:25804. doi: 10.1038/srep25804.

11.

Biomarker-Guided Strategy for Treatment of Autism Spectrum Disorder (ASD).

Liu H, Talalay P, Fahey JW.

CNS Neurol Disord Drug Targets. 2016;15(5):602-13. Review.

PMID:
27071792
12.

An inflammation-independent contraction mechanophenotype of airway smooth muscle in asthma.

An SS, Mitzner W, Tang WY, Ahn K, Yoon AR, Huang J, Kilic O, Yong HM, Fahey JW, Kumar S, Biswal S, Holgate ST, Panettieri RA Jr, Solway J, Liggett SB.

J Allergy Clin Immunol. 2016 Jul;138(1):294-297.e4. doi: 10.1016/j.jaci.2015.12.1315. Epub 2016 Feb 28. No abstract available.

13.

Sulforaphane Bioavailability from Glucoraphanin-Rich Broccoli: Control by Active Endogenous Myrosinase.

Fahey JW, Holtzclaw WD, Wehage SL, Wade KL, Stephenson KK, Talalay P.

PLoS One. 2015 Nov 2;10(11):e0140963. doi: 10.1371/journal.pone.0140963. eCollection 2015.

14.

Sulforaphane improves the bronchoprotective response in asthmatics through Nrf2-mediated gene pathways.

Brown RH, Reynolds C, Brooker A, Talalay P, Fahey JW.

Respir Res. 2015 Sep 15;16:106. doi: 10.1186/s12931-015-0253-z.

15.

Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans.

Knatko EV, Ibbotson SH, Zhang Y, Higgins M, Fahey JW, Talalay P, Dawe RS, Ferguson J, Huang JT, Clarke R, Zheng S, Saito A, Kalra S, Benedict AL, Honda T, Proby CM, Dinkova-Kostova AT.

Cancer Prev Res (Phila). 2015 Jun;8(6):475-86. doi: 10.1158/1940-6207.CAPR-14-0362. Epub 2015 Mar 24.

16.

Dietary amelioration of Helicobacter infection.

Fahey JW, Stephenson KK, Wallace AJ.

Nutr Res. 2015 Jun;35(6):461-73. doi: 10.1016/j.nutres.2015.03.001. Epub 2015 Mar 6. Review.

17.

Sulforaphane treatment of autism spectrum disorder (ASD).

Singh K, Connors SL, Macklin EA, Smith KD, Fahey JW, Talalay P, Zimmerman AW.

Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15550-5. doi: 10.1073/pnas.1416940111. Epub 2014 Oct 13.

18.

Purification of active myrosinase from plants by aqueous two-phase counter-current chromatography.

Wade KL, Ito Y, Ramarathnam A, Holtzclaw WD, Fahey JW.

Phytochem Anal. 2015 Jan-Feb;26(1):47-53. doi: 10.1002/pca.2535. Epub 2014 Aug 7.

19.

Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China.

Egner PA, Chen JG, Zarth AT, Ng DK, Wang JB, Kensler KH, Jacobson LP, Muñoz A, Johnson JL, Groopman JD, Fahey JW, Talalay P, Zhu J, Chen TY, Qian GS, Carmella SG, Hecht SS, Kensler TW.

Cancer Prev Res (Phila). 2014 Aug;7(8):813-823. doi: 10.1158/1940-6207.CAPR-14-0103. Epub 2014 Jun 9.

20.

Structure-activity analysis of flavonoids: direct and indirect antioxidant, and antiinflammatory potencies and toxicities.

Tsuji PA, Stephenson KK, Wade KL, Liu H, Fahey JW.

Nutr Cancer. 2013;65(7):1014-25. doi: 10.1080/01635581.2013.809127. Epub 2013 Oct 2.

PMID:
24087992
21.

Urease from Helicobacter pylori is inactivated by sulforaphane and other isothiocyanates.

Fahey JW, Stephenson KK, Wade KL, Talalay P.

Biochem Biophys Res Commun. 2013 May 24;435(1):1-7. doi: 10.1016/j.bbrc.2013.03.126. Epub 2013 Apr 11.

22.

Health span extension through green chemoprevention.

Fahey JW, Kensler TW.

Virtual Mentor. 2013 Apr 1;15(4):311-8. doi: 10.1001/virtualmentor.2013.15.4.stas1-1304. No abstract available.

23.

Keap1-nrf2 signaling: a target for cancer prevention by sulforaphane.

Kensler TW, Egner PA, Agyeman AS, Visvanathan K, Groopman JD, Chen JG, Chen TY, Fahey JW, Talalay P.

Top Curr Chem. 2013;329:163-77. doi: 10.1007/128_2012_339. Review.

24.

Black cohosh: coming full circle?

Johnson TL, Fahey JW.

J Ethnopharmacol. 2012 Jun 14;141(3):775-9. doi: 10.1016/j.jep.2012.03.050. Epub 2012 Apr 6. Review.

PMID:
22504147
25.

Protection of humans by plant glucosinolates: efficiency of conversion of glucosinolates to isothiocyanates by the gastrointestinal microflora.

Fahey JW, Wehage SL, Holtzclaw WD, Kensler TW, Egner PA, Shapiro TA, Talalay P.

Cancer Prev Res (Phila). 2012 Apr;5(4):603-11. doi: 10.1158/1940-6207.CAPR-11-0538. Epub 2012 Feb 7.

26.

Notes from the field: "green" chemoprevention as frugal medicine.

Fahey JW, Talalay P, Kensler TW.

Cancer Prev Res (Phila). 2012 Feb;5(2):179-88. doi: 10.1158/1940-6207.CAPR-11-0572. Review.

27.

Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China.

Kensler TW, Ng D, Carmella SG, Chen M, Jacobson LP, Muñoz A, Egner PA, Chen JG, Qian GS, Chen TY, Fahey JW, Talalay P, Groopman JD, Yuan JM, Hecht SS.

Carcinogenesis. 2012 Jan;33(1):101-7. doi: 10.1093/carcin/bgr229. Epub 2011 Nov 1. Erratum in: Carcinogenesis. 2012 Mar;33(3):722.

28.

Bioavailability of Sulforaphane from two broccoli sprout beverages: results of a short-term, cross-over clinical trial in Qidong, China.

Egner PA, Chen JG, Wang JB, Wu Y, Sun Y, Lu JH, Zhu J, Zhang YH, Chen YS, Friesen MD, Jacobson LP, Muñoz A, Ng D, Qian GS, Zhu YR, Chen TY, Botting NP, Zhang Q, Fahey JW, Talalay P, Groopman JD, Kensler TW.

Cancer Prev Res (Phila). 2011 Mar;4(3):384-95. doi: 10.1158/1940-6207.CAPR-10-0296.

29.

Broccoli ( Brassica oleracea var. italica) sprouts and extracts rich in glucosinolates and isothiocyanates affect cholesterol metabolism and genes involved in lipid homeostasis in hamsters.

Rodríguez-Cantú LN, Gutiérrez-Uribe JA, Arriola-Vucovich J, Díaz-De La Garza RI, Fahey JW, Serna-Saldivar SO.

J Agric Food Chem. 2011 Feb 23;59(4):1095-103. doi: 10.1021/jf103513w. Epub 2011 Jan 21.

PMID:
21254774
30.

Stimulation of phagocytosis by sulforaphane.

Suganuma H, Fahey JW, Bryan KE, Healy ZR, Talalay P.

Biochem Biophys Res Commun. 2011 Feb 4;405(1):146-51. doi: 10.1016/j.bbrc.2011.01.025. Epub 2011 Jan 8.

31.

Allyl isothiocyanate-rich mustard seed powder inhibits bladder cancer growth and muscle invasion.

Bhattacharya A, Li Y, Wade KL, Paonessa JD, Fahey JW, Zhang Y.

Carcinogenesis. 2010 Dec;31(12):2105-10. doi: 10.1093/carcin/bgq202. Epub 2010 Oct 1.

32.

Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice.

Dinkova-Kostova AT, Fahey JW, Benedict AL, Jenkins SN, Ye L, Wehage SL, Talalay P.

Photochem Photobiol Sci. 2010 Apr;9(4):597-600. doi: 10.1039/b9pp00130a.

33.

Adoption of Moringa oleifera to combat under-nutrition viewed through the lens of the "Diffusion of innovations" theory.

Thurber MD, Fahey JW.

Ecol Food Nutr. 2009 May-Jun;48(3):212-25. doi: 10.1080/03670240902794598.

34.

Cultivar effect on Moringa oleifera glucosinolate content and taste: a pilot study.

Doerr B, Wade KL, Stephenson KK, Reed SB, Fahey JW.

Ecol Food Nutr. 2009 May-Jun;48(3):199-211. doi: 10.1080/03670240902794630.

PMID:
21883061
35.

Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans.

Yanaka A, Fahey JW, Fukumoto A, Nakayama M, Inoue S, Zhang S, Tauchi M, Suzuki H, Hyodo I, Yamamoto M.

Cancer Prev Res (Phila). 2009 Apr;2(4):353-60. doi: 10.1158/1940-6207.CAPR-08-0192.

36.

Induction of chemoprotective phase 2 enzymes by ginseng and its components.

Lee LS, Stephenson KK, Fahey JW, Parsons TL, Lietman PS, Andrade AS, Lei X, Yun H, Soon GH, Shen P, Danishefsky S, Flexner C.

Planta Med. 2009 Aug;75(10):1129-33. doi: 10.1055/s-0029-1185508. Epub 2009 Mar 26.

PMID:
19326326
37.

Precise determination of the erythema response of human skin to ultraviolet radiation and quantification of effects of protectors.

Healy ZR, Dinkova-Kostova AT, Wehage SL, Thompson RE, Fahey JW, Talalay P.

Photodermatol Photoimmunol Photomed. 2009 Feb;25(1):45-50. doi: 10.1111/j.1600-0781.2009.00404.x.

38.

Rapid body weight gain increases the risk of UV radiation-induced skin carcinogenesis in SKH-1 hairless mice.

Dinkova-Kostova AT, Fahey JW, Jenkins SN, Wehage SL, Talalay P.

Nutr Res. 2008 Aug;28(8):539-43. doi: 10.1016/j.nutres.2008.05.009.

39.

Diet as a factor in unexpectedly low prevalence of Helicobacter pylori infection.

Farag TH, Fahey JW, Khalfan SS, Tielsch JM.

Trans R Soc Trop Med Hyg. 2008 Nov;102(11):1164-5. doi: 10.1016/j.trstmh.2008.08.019. Epub 2008 Sep 18. No abstract available.

PMID:
18804252
40.

Inhibition of urinary bladder carcinogenesis by broccoli sprouts.

Munday R, Mhawech-Fauceglia P, Munday CM, Paonessa JD, Tang L, Munday JS, Lister C, Wilson P, Fahey JW, Davis W, Zhang Y.

Cancer Res. 2008 Mar 1;68(5):1593-600. doi: 10.1158/0008-5472.CAN-07-5009. Epub 2008 Feb 29.

41.

A dicyanotriterpenoid induces cytoprotective enzymes and reduces multiplicity of skin tumors in UV-irradiated mice.

Dinkova-Kostova AT, Jenkins SN, Wehage SL, Huso DL, Benedict AL, Stephenson KK, Fahey JW, Liu H, Liby KT, Honda T, Gribble GW, Sporn MB, Talalay P.

Biochem Biophys Res Commun. 2008 Mar 21;367(4):859-65. doi: 10.1016/j.bbrc.2008.01.026. Epub 2008 Jan 17.

PMID:
18206646
42.

Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation.

Talalay P, Fahey JW, Healy ZR, Wehage SL, Benedict AL, Min C, Dinkova-Kostova AT.

Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17500-5. Epub 2007 Oct 23.

43.

Improved hydrophilic interaction chromatography method for the identification and quantification of glucosinolates.

Wade KL, Garrard IJ, Fahey JW.

J Chromatogr A. 2007 Jun 22;1154(1-2):469-72. Epub 2007 Apr 20.

44.

Induction of the phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extracts.

Dinkova-Kostova AT, Fahey JW, Wade KL, Jenkins SN, Shapiro TA, Fuchs EJ, Kerns ML, Talalay P.

Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):847-51.

45.

Role of dietary supplements/nutraceuticals in chemoprevention through induction of cytoprotective enzymes.

Fahey JW, Kensler TW.

Chem Res Toxicol. 2007 Apr;20(4):572-6. Epub 2007 Mar 16. No abstract available.

46.

Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast.

Cornblatt BS, Ye L, Dinkova-Kostova AT, Erb M, Fahey JW, Singh NK, Chen MS, Stierer T, Garrett-Mayer E, Argani P, Davidson NE, Talalay P, Kensler TW, Visvanathan K.

Carcinogenesis. 2007 Jul;28(7):1485-90. Epub 2007 Mar 7.

PMID:
17347138
47.

Induction of GST and NQO1 in cultured bladder cells and in the urinary bladders of rats by an extract of broccoli (Brassica oleracea italica) sprouts.

Zhang Y, Munday R, Jobson HE, Munday CM, Lister C, Wilson P, Fahey JW, Mhawech-Fauceglia P.

J Agric Food Chem. 2006 Dec 13;54(25):9370-6.

PMID:
17147420
48.

Safety, tolerance, and metabolism of broccoli sprout glucosinolates and isothiocyanates: a clinical phase I study.

Shapiro TA, Fahey JW, Dinkova-Kostova AT, Holtzclaw WD, Stephenson KK, Wade KL, Ye L, Talalay P.

Nutr Cancer. 2006;55(1):53-62.

PMID:
16965241
49.

Evaluation of isothiocyanates as potent inducers of carcinogen-detoxifying enzymes in the urinary bladder: critical nature of in vivo bioassay.

Munday R, Zhang Y, Fahey JW, Jobson HE, Munday CM, Li J, Stephenson KK.

Nutr Cancer. 2006;54(2):223-31.

PMID:
16898867
50.

Potent activation of mitochondria-mediated apoptosis and arrest in S and M phases of cancer cells by a broccoli sprout extract.

Tang L, Zhang Y, Jobson HE, Li J, Stephenson KK, Wade KL, Fahey JW.

Mol Cancer Ther. 2006 Apr;5(4):935-44.

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