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Items: 37


New class of precision antimicrobials redefines role of Clostridium difficile S-layer in virulence and viability.

Kirk JA, Gebhart D, Buckley AM, Lok S, Scholl D, Douce GR, Govoni GR, Fagan RP.

Sci Transl Med. 2017 Sep 6;9(406). pii: eaah6813. doi: 10.1126/scitranslmed.aah6813.


The National Ebola Training and Education Center: Preparing the United States for Ebola and Other Special Pathogens.

Kratochvil CJ, Evans L, Ribner BS, Lowe JJ, Harvey MC, Hunt RC, Tumpey AJ, Fagan RP, Schwedhelm MM, Bell S, Maher J, Kraft CS, Cagliuso NV Sr, Vanairsdale S, Vasa A, Smith PW.

Health Secur. 2017 May/Jun;15(3):253-260. doi: 10.1089/hs.2017.0005.


Investigation of the First Seven Reported Cases of Candida auris, a Globally Emerging Invasive, Multidrug-Resistant Fungus-United States, May 2013-August 2016.

Vallabhaneni S, Kallen A, Tsay S, Chow N, Welsh R, Kerins J, Kemble SK, Pacilli M, Black SR, Landon E, Ridgway J, Palmore TN, Zelzany A, Adams EH, Quinn M, Chaturvedi S, Greenko J, Fernandez R, Southwick K, Furuya EY, Calfee DP, Hamula C, Patel G, Barrett P, Lafaro P, Berkow EL, Moulton-Meissner H, Noble-Wang J, Fagan RP, Jackson BR, Lockhart SR, Litvintseva AP, Chiller TM.

Am J Transplant. 2017 Jan;17(1):296-299. doi: 10.1111/ajt.14121.


Investigation of the First Seven Reported Cases of Candida auris, a Globally Emerging Invasive, Multidrug-Resistant Fungus - United States, May 2013-August 2016.

Vallabhaneni S, Kallen A, Tsay S, Chow N, Welsh R, Kerins J, Kemble SK, Pacilli M, Black SR, Landon E, Ridgway J, Palmore TN, Zelzany A, Adams EH, Quinn M, Chaturvedi S, Greenko J, Fernandez R, Southwick K, Furuya EY, Calfee DP, Hamula C, Patel G, Barrett P; MSD, Lafaro P, Berkow EL, Moulton-Meissner H, Noble-Wang J, Fagan RP, Jackson BR, Lockhart SR, Litvintseva AP, Chiller TM.

MMWR Morb Mortal Wkly Rep. 2016 Nov 11;65(44):1234-1237. doi: 10.15585/mmwr.mm6544e1.


Heat shock increases conjugation efficiency in Clostridium difficile.

Kirk JA, Fagan RP.

Anaerobe. 2016 Dec;42:1-5. doi: 10.1016/j.anaerobe.2016.06.009. Epub 2016 Jul 1.


Characterization of the spore surface and exosporium proteins of Clostridium sporogenes; implications for Clostridium botulinum group I strains.

Janganan TK, Mullin N, Tzokov SB, Stringer S, Fagan RP, Hobbs JK, Moir A, Bullough PA.

Food Microbiol. 2016 Oct;59:205-12. doi: 10.1016/ Epub 2016 Jun 6.


Characteristics of the Clostridium difficile cell envelope and its importance in therapeutics.

Kirk JA, Banerji O, Fagan RP.

Microb Biotechnol. 2017 Jan;10(1):76-90. doi: 10.1111/1751-7915.12372. Epub 2016 Jun 17. Review.


Lighting Up Clostridium Difficile: Reporting Gene Expression Using Fluorescent Lov Domains.

Buckley AM, Jukes C, Candlish D, Irvine JJ, Spencer J, Fagan RP, Roe AJ, Christie JM, Fairweather NF, Douce GR.

Sci Rep. 2016 Mar 21;6:23463. doi: 10.1038/srep23463.


Surgical site infection risk factors and risk stratification.

Florschutz AV, Fagan RP, Matar WY, Sawyer RG, Berrios-Torres SI.

J Am Acad Orthop Surg. 2015 Apr;23 Suppl:S8-S11. doi: 10.5435/JAAOS-D-14-00447.


High-throughput analysis of gene essentiality and sporulation in Clostridium difficile.

Dembek M, Barquist L, Boinett CJ, Cain AK, Mayho M, Lawley TD, Fairweather NF, Fagan RP.

MBio. 2015 Feb 24;6(2):e02383. doi: 10.1128/mBio.02383-14.


Clostridium difficile surface proteins are anchored to the cell wall using CWB2 motifs that recognise the anionic polymer PSII.

Willing SE, Candela T, Shaw HA, Seager Z, Mesnage S, Fagan RP, Fairweather NF.

Mol Microbiol. 2015 May;96(3):596-608. doi: 10.1111/mmi.12958. Epub 2015 Mar 6.


Botulism mortality in the USA, 1975-2009.

Jackson KA, Mahon BE, Copeland J, Fagan RP.

Botulinum J. 2015;3(1):6-17. doi: 10.1504/TBJ.2015.078132. Epub 2016 Aug 4.


Functional genomics reveals that Clostridium difficile Spo0A coordinates sporulation, virulence and metabolism.

Pettit LJ, Browne HP, Yu L, Smits WK, Fagan RP, Barquist L, Martin MJ, Goulding D, Duncan SH, Flint HJ, Dougan G, Choudhary JS, Lawley TD.

BMC Genomics. 2014 Feb 25;15:160. doi: 10.1186/1471-2164-15-160.


Biogenesis and functions of bacterial S-layers.

Fagan RP, Fairweather NF.

Nat Rev Microbiol. 2014 Mar;12(3):211-22. doi: 10.1038/nrmicro3213. Epub 2014 Feb 10. Review.


Incidence trends in pathogen-specific central line-associated bloodstream infections in US intensive care units, 1990-2010.

Fagan RP, Edwards JR, Park BJ, Fridkin SK, Magill SS.

Infect Control Hosp Epidemiol. 2013 Sep;34(9):893-9. doi: 10.1086/671724. Epub 2013 Jul 16.


Snap denaturation reveals dimerization by AraC-like protein Rns.

Mahon V, Fagan RP, Smith SG.

Biochimie. 2012 Sep;94(9):2058-61. doi: 10.1016/j.biochi.2012.05.014. Epub 2012 May 22.


The Clostridium difficile spo0A gene is a persistence and transmission factor.

Deakin LJ, Clare S, Fagan RP, Dawson LF, Pickard DJ, West MR, Wren BW, Fairweather NF, Dougan G, Lawley TD.

Infect Immun. 2012 Aug;80(8):2704-11. doi: 10.1128/IAI.00147-12. Epub 2012 May 21.


Asymmetric type F botulism with cranial nerve demyelination.

Filozov A, Kattan JA, Jitendranath L, Smith CG, Lúquez C, Phan QN, Fagan RP.

Emerg Infect Dis. 2012 Jan;18(1):102-4. doi: 10.3201/eid1801.110471.


Initial recovery and rebound of type f intestinal colonization botulism after administration of investigational heptavalent botulinum antitoxin.

Fagan RP, Neil KP, Sasich R, Luquez C, Asaad H, Maslanka S, Khalil W.

Clin Infect Dis. 2011 Nov;53(9):e125-8. doi: 10.1093/cid/cir550. Epub 2011 Sep 6.


Novel inhibitors of surface layer processing in Clostridium difficile.

Tam Dang TH, Fagan RP, Fairweather NF, Tate EW.

Bioorg Med Chem. 2012 Jan 15;20(2):614-21. doi: 10.1016/j.bmc.2011.06.042. Epub 2011 Jun 21.


Multistate outbreak of Listeria monocytogenes associated with Mexican-style cheese made from pasteurized milk among pregnant, Hispanic women.

Jackson KA, Biggerstaff M, Tobin-D'Angelo M, Sweat D, Klos R, Nosari J, Garrison O, Boothe E, Saathoff-Huber L, Hainstock L, Fagan RP.

J Food Prot. 2011 Jun;74(6):949-53. doi: 10.4315/0362-028X.JFP-10-536.


Clostridium difficile has two parallel and essential Sec secretion systems.

Fagan RP, Fairweather NF.

J Biol Chem. 2011 Aug 5;286(31):27483-93. doi: 10.1074/jbc.M111.263889. Epub 2011 Jun 9.


The Clostridium difficile cell wall protein CwpV is antigenically variable between strains, but exhibits conserved aggregation-promoting function.

Reynolds CB, Emerson JE, de la Riva L, Fagan RP, Fairweather NF.

PLoS Pathog. 2011 Apr;7(4):e1002024. doi: 10.1371/journal.ppat.1002024. Epub 2011 Apr 21.


An outbreak of 2009 pandemic influenza A (H1N1) virus infection in an elementary school in Pennsylvania.

Marchbanks TL, Bhattarai A, Fagan RP, Ostroff S, Sodha SV, Moll ME, Lee BY, Chang CC, Ennis B, Britz P, Fiore A, Nguyen M, Palekar R, Archer WR, Gift TL, Leap R, Nygren BL, Cauchemez S, Angulo FJ, Swerdlow D; Pennsylvania Working Group.

Clin Infect Dis. 2011 Jan 1;52 Suppl 1:S154-60. doi: 10.1093/cid/ciq058.


Endemic foodborne botulism among Alaska Native persons--Alaska, 1947-2007.

Fagan RP, McLaughlin JB, Castrodale LJ, Gessner BD, Jenkerson SA, Funk EA, Hennessy TW, Middaugh JP, Butler JC.

Clin Infect Dis. 2011 Mar 1;52(5):585-92. doi: 10.1093/cid/ciq240.


Role of social networks in shaping disease transmission during a community outbreak of 2009 H1N1 pandemic influenza.

Cauchemez S, Bhattarai A, Marchbanks TL, Fagan RP, Ostroff S, Ferguson NM, Swerdlow D; Pennsylvania H1N1 working group.

Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2825-30. doi: 10.1073/pnas.1008895108. Epub 2011 Jan 31.


A proposed nomenclature for cell wall proteins of Clostridium difficile.

Fagan RP, Janoir C, Collignon A, Mastrantonio P, Poxton IR, Fairweather NF.

J Med Microbiol. 2011 Aug;60(Pt 8):1225-8. doi: 10.1099/jmm.0.028472-0. Epub 2011 Jan 20.


Household effects of school closure during pandemic (H1N1) 2009, Pennsylvania, USA.

Gift TL, Palekar RS, Sodha SV, Kent CK, Fagan RP, Archer WR, Edelson PJ, Marchbanks T, Bhattarai A, Swerdlow D, Ostroff S, Meltzer MI; Pennsylvania H1N1 Working Group.

Emerg Infect Dis. 2010 Aug;16(8):1315-7. doi: 10.3201/eid1608.091827.


Source of botulinum antitoxin products needs clarifying.

Fagan RP, Kim HJ.

Pediatr Ann. 2010 May;39(5):261-2. No abstract available.


Chemical probes of surface layer biogenesis in Clostridium difficile.

Dang TH, de la Riva L, Fagan RP, Storck EM, Heal WP, Janoir C, Fairweather NF, Tate EW.

ACS Chem Biol. 2010 Mar 19;5(3):279-85. doi: 10.1021/cb9002859.


A novel genetic switch controls phase variable expression of CwpV, a Clostridium difficile cell wall protein.

Emerson JE, Reynolds CB, Fagan RP, Shaw HA, Goulding D, Fairweather NF.

Mol Microbiol. 2009 Nov;74(3):541-56. doi: 10.1111/j.1365-2958.2009.06812.x. Epub 2009 Jul 28.


Persistence of botulinum toxin in patients' serum: Alaska, 1959-2007.

Fagan RP, McLaughlin JB, Middaugh JP.

J Infect Dis. 2009 Apr 1;199(7):1029-31. doi: 10.1086/597310.


Structural insights into the molecular organization of the S-layer from Clostridium difficile.

Fagan RP, Albesa-Jové D, Qazi O, Svergun DI, Brown KA, Fairweather NF.

Mol Microbiol. 2009 Mar;71(5):1308-22. doi: 10.1111/j.1365-2958.2009.06603.x. Epub 2009 Jan 29.


Controlled, household-randomized, open-label trial of the effect of treatment of Helicobacter pylori infection on iron deficiency among children in rural Alaska: results at 40 months.

Fagan RP, Dunaway CE, Bruden DL, Parkinson AJ, Gessner BD.

J Infect Dis. 2009 Mar 1;199(5):652-60. doi: 10.1086/596659.


A molecular Swiss army knife: OmpA structure, function and expression.

Smith SG, Mahon V, Lambert MA, Fagan RP.

FEMS Microbiol Lett. 2007 Aug;273(1):1-11. Epub 2007 Jun 6. Review.


The Hek outer membrane protein of Escherichia coli is an auto-aggregating adhesin and invasin.

Fagan RP, Smith SG.

FEMS Microbiol Lett. 2007 Apr;269(2):248-55. Epub 2007 Jan 15.

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