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Metastasis inside-out: dissemination of cancer cell clusters with inverted polarity.

Ewald AJ.

EMBO J. 2018 Mar 9. pii: e99144. doi: 10.15252/embj.201899144. [Epub ahead of print] No abstract available.


TRPV1 is a physiological regulator of μ-opioid receptors.

Scherer PC, Zaccor NW, Neumann NM, Vasavda C, Barrow R, Ewald AJ, Rao F, Sumner CJ, Snyder SH.

Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):13561-13566. doi: 10.1073/pnas.1717005114. Epub 2017 Dec 4.


mTORC1 loss impairs epidermal adhesion via TGF-β/Rho kinase activation.

Asrani K, Sood A, Torres A, Georgess D, Phatak P, Kaur H, Dubin A, Talbot CC Jr, Elhelu L, Ewald AJ, Xiao B, Worley P, Lotan TL.

J Clin Invest. 2017 Nov 1;127(11):4001-4017. doi: 10.1172/JCI92893. Epub 2017 Sep 25.


A First-in-Class TWIST1 Inhibitor with Activity in Oncogene-Driven Lung Cancer.

Yochum ZA, Cades J, Mazzacurati L, Neumann NM, Khetarpal SK, Chatterjee S, Wang H, Attar MA, Huang EH, Chatley SN, Nugent K, Somasundaram A, Engh JA, Ewald AJ, Cho YJ, Rudin CM, Tran PT, Burns TF.

Mol Cancer Res. 2017 Dec;15(12):1764-1776. doi: 10.1158/1541-7786.MCR-17-0298. Epub 2017 Aug 29.


Mosaic loss of non-muscle myosin IIA and IIB is sufficient to induce mammary epithelial proliferation.

Nguyen-Ngoc KV, Silvestri VL, Georgess D, Fairchild AN, Ewald AJ.

J Cell Sci. 2017 Oct 1;130(19):3213-3221. doi: 10.1242/jcs.208546. Epub 2017 Aug 18.


HMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell niche.

Xian L, Georgess D, Huso T, Cope L, Belton A, Chang YT, Kuang W, Gu Q, Zhang X, Senger S, Fasano A, Huso DL, Ewald AJ, Resar LMS.

Nat Commun. 2017 Apr 28;8:15008. doi: 10.1038/ncomms15008.


Pulling cells out of tumours.

Ewald AJ.

Nat Cell Biol. 2017 Mar 1;19(3):147-149. doi: 10.1038/ncb3484.


3D cell biology - the expanding frontier.

Ewald AJ.

J Cell Sci. 2017 Jan 1;130(1):1. doi: 10.1242/jcs.200543. No abstract available.


HOXA5 determines cell fate transition and impedes tumor initiation and progression in breast cancer through regulation of E-cadherin and CD24.

Teo WW, Merino VF, Cho S, Korangath P, Liang X, Wu RC, Neumann NM, Ewald AJ, Sukumar S.

Oncogene. 2016 Oct 20;35(42):5539-5551. doi: 10.1038/onc.2016.95. Epub 2016 May 9.


GBM heterogeneity as a function of variable epidermal growth factor receptor variant III activity.

Lindberg OR, McKinney A, Engler JR, Koshkakaryan G, Gong H, Robinson AE, Ewald AJ, Huillard E, David James C, Molinaro AM, Shieh JT, Phillips JJ.

Oncotarget. 2016 Nov 29;7(48):79101-79116. doi: 10.18632/oncotarget.12600.


Twist1-positive epithelial cells retain adhesive and proliferative capacity throughout dissemination.

Shamir ER, Coutinho K, Georgess D, Auer M, Ewald AJ.

Biol Open. 2016 Sep 15;5(9):1216-28. doi: 10.1242/bio.019703.


A collective route to metastasis: Seeding by tumor cell clusters.

Cheung KJ, Ewald AJ.

Science. 2016 Apr 8;352(6282):167-9. doi: 10.1126/science.aaf6546. Review.


Mammary epithelial tubes elongate through MAPK-dependent coordination of cell migration.

Huebner RJ, Neumann NM, Ewald AJ.

Development. 2016 Mar 15;143(6):983-93. doi: 10.1242/dev.127944. Epub 2016 Feb 2.


Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters.

Cheung KJ, Padmanaban V, Silvestri V, Schipper K, Cohen JD, Fairchild AN, Gorin MA, Verdone JE, Pienta KJ, Bader JS, Ewald AJ.

Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E854-63. doi: 10.1073/pnas.1508541113. Epub 2016 Feb 1.


Cell-cell communication enhances the capacity of cell ensembles to sense shallow gradients during morphogenesis.

Ellison D, Mugler A, Brennan MD, Lee SH, Huebner RJ, Shamir ER, Woo LA, Kim J, Amar P, Nemenman I, Ewald AJ, Levchenko A.

Proc Natl Acad Sci U S A. 2016 Feb 9;113(6):E679-88. doi: 10.1073/pnas.1516503113. Epub 2016 Jan 20.


An Arresting Story about Basement Membrane Invasion.

Ewald AJ.

Dev Cell. 2015 Oct 26;35(2):143-4. doi: 10.1016/j.devcel.2015.10.009.


p114RhoGEF governs cell motility and lumen formation during tubulogenesis through a ROCK-myosin-II pathway.

Kim M, M Shewan A, Ewald AJ, Werb Z, Mostov KE.

J Cell Sci. 2015 Dec 1;128(23):4317-27. doi: 10.1242/jcs.172361. Epub 2015 Oct 19.


Adhesion in mammary development: novel roles for E-cadherin in individual and collective cell migration.

Shamir ER, Ewald AJ.

Curr Top Dev Biol. 2015;112:353-82. doi: 10.1016/bs.ctdb.2014.12.001. Epub 2015 Feb 11. Review.


Systemic delivery of microencapsulated 3-bromopyruvate for the therapy of pancreatic cancer.

Chapiro J, Sur S, Savic LJ, Ganapathy-Kanniappan S, Reyes J, Duran R, Thiruganasambandam SC, Moats CR, Lin M, Luo W, Tran PT, Herman JM, Semenza GL, Ewald AJ, Vogelstein B, Geschwind JF.

Clin Cancer Res. 2014 Dec 15;20(24):6406-17. doi: 10.1158/1078-0432.CCR-14-1271. Epub 2014 Oct 17.


A molecular switch for the orientation of epithelial cell polarization.

Bryant DM, Roignot J, Datta A, Overeem AW, Kim M, Yu W, Peng X, Eastburn DJ, Ewald AJ, Werb Z, Mostov KE.

Dev Cell. 2014 Oct 27;31(2):171-87. doi: 10.1016/j.devcel.2014.08.027. Epub 2014 Oct 9.


3D culture assays of murine mammary branching morphogenesis and epithelial invasion.

Nguyen-Ngoc KV, Shamir ER, Huebner RJ, Beck JN, Cheung KJ, Ewald AJ.

Methods Mol Biol. 2015;1189:135-62. doi: 10.1007/978-1-4939-1164-6_10.


Three-dimensional organotypic culture: experimental models of mammalian biology and disease.

Shamir ER, Ewald AJ.

Nat Rev Mol Cell Biol. 2014 Oct;15(10):647-64. doi: 10.1038/nrm3873. Epub 2014 Sep 17. Review.


Illuminating breast cancer invasion: diverse roles for cell-cell interactions.

Cheung KJ, Ewald AJ.

Curr Opin Cell Biol. 2014 Oct;30:99-111. doi: 10.1016/ Epub 2014 Aug 17. Review.


Cancer: Sugar-coated cell signalling.

Ewald AJ, Egeblad M.

Nature. 2014 Jul 17;511(7509):298-9. doi: 10.1038/nature13506. Epub 2014 Jun 25. No abstract available.


Cellular foundations of mammary tubulogenesis.

Huebner RJ, Ewald AJ.

Semin Cell Dev Biol. 2014 Jul;31:124-31. doi: 10.1016/j.semcdb.2014.04.019. Epub 2014 Apr 18. Review.


Invasive leader cells: metastatic oncotarget.

Cheung KJ, Ewald AJ.

Oncotarget. 2014 Mar 30;5(6):1390-1. No abstract available.


Twist1-induced dissemination preserves epithelial identity and requires E-cadherin.

Shamir ER, Pappalardo E, Jorgens DM, Coutinho K, Tsai WT, Aziz K, Auer M, Tran PT, Bader JS, Ewald AJ.

J Cell Biol. 2014 Mar 3;204(5):839-56. doi: 10.1083/jcb.201306088.


A temporal requirement for Hippo signaling in mammary gland differentiation, growth, and tumorigenesis.

Chen Q, Zhang N, Gray RS, Li H, Ewald AJ, Zahnow CA, Pan D.

Genes Dev. 2014 Mar 1;28(5):432-7. doi: 10.1101/gad.233676.113.


Collective invasion in breast cancer requires a conserved basal epithelial program.

Cheung KJ, Gabrielson E, Werb Z, Ewald AJ.

Cell. 2013 Dec 19;155(7):1639-51. doi: 10.1016/j.cell.2013.11.029. Epub 2013 Dec 12.


The independent roles of mechanical, structural and adhesion characteristics of 3D hydrogels on the regulation of cancer invasion and dissemination.

Beck JN, Singh A, Rothenberg AR, Elisseeff JH, Ewald AJ.

Biomaterials. 2013 Dec;34(37):9486-95. doi: 10.1016/j.biomaterials.2013.08.077. Epub 2013 Sep 14.


Mammary ductal elongation and myoepithelial migration are regulated by the composition of the extracellular matrix.

Nguyen-Ngoc KV, Ewald AJ.

J Microsc. 2013 Sep;251(3):212-23. doi: 10.1111/jmi.12017. Epub 2013 Feb 22.


Isolation of mouse mammary organoids for long-term time-lapse imaging.

Ewald AJ.

Cold Spring Harb Protoc. 2013 Feb 1;2013(2):130-3. doi: 10.1101/pdb.prot072892.


Practical considerations for long-term time-lapse imaging of epithelial morphogenesis in three-dimensional organotypic cultures.

Ewald AJ.

Cold Spring Harb Protoc. 2013 Feb 1;2013(2):100-17. doi: 10.1101/pdb.top072884.


ECM microenvironment regulates collective migration and local dissemination in normal and malignant mammary epithelium.

Nguyen-Ngoc KV, Cheung KJ, Brenot A, Shamir ER, Gray RS, Hines WC, Yaswen P, Werb Z, Ewald AJ.

Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):E2595-604. Epub 2012 Aug 23.


Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance.

Nakasone ES, Askautrud HA, Kees T, Park JH, Plaks V, Ewald AJ, Fein M, Rasch MG, Tan YX, Qiu J, Park J, Sinha P, Bissell MJ, Frengen E, Werb Z, Egeblad M.

Cancer Cell. 2012 Apr 17;21(4):488-503. doi: 10.1016/j.ccr.2012.02.017.


Mammary collective cell migration involves transient loss of epithelial features and individual cell migration within the epithelium.

Ewald AJ, Huebner RJ, Palsdottir H, Lee JK, Perez MJ, Jorgens DM, Tauscher AN, Cheung KJ, Werb Z, Auer M.

J Cell Sci. 2012 Jun 1;125(Pt 11):2638-54. doi: 10.1242/jcs.096875. Epub 2012 Feb 17.


Dynamic, long-term in vivo imaging of tumor-stroma interactions in mouse models of breast cancer using spinning-disk confocal microscopy.

Ewald AJ, Werb Z, Egeblad M.

Cold Spring Harb Protoc. 2011 Feb 1;2011(2):pdb.top97. doi: 10.1101/pdb.top97. No abstract available.


Monitoring of vital signs for long-term survival of mice under anesthesia.

Ewald AJ, Werb Z, Egeblad M.

Cold Spring Harb Protoc. 2011 Feb 1;2011(2):pdb.prot5563. doi: 10.1101/pdb.prot5563. No abstract available.


Preparation of mice for long-term intravital imaging of the mammary gland.

Ewald AJ, Werb Z, Egeblad M.

Cold Spring Harb Protoc. 2011 Feb 1;2011(2):pdb.prot5562. doi: 10.1101/pdb.prot5562. No abstract available.


Cellular mechanisms regulating epithelial morphogenesis and cancer invasion.

Gray RS, Cheung KJ, Ewald AJ.

Curr Opin Cell Biol. 2010 Oct;22(5):640-50. doi: 10.1016/ Epub 2010 Sep 9. Review.


The relationship between terminal functionalization and molecular weight of a gene delivery polymer and transfection efficacy in mammary epithelial 2-D cultures and 3-D organotypic cultures.

Bhise NS, Gray RS, Sunshine JC, Htet S, Ewald AJ, Green JJ.

Biomaterials. 2010 Nov;31(31):8088-96. doi: 10.1016/j.biomaterials.2010.07.023. Epub 2010 Jul 31.


Morphogenesis of epithelial tubes: Insights into tube formation, elongation, and elaboration.

Andrew DJ, Ewald AJ.

Dev Biol. 2010 May 1;341(1):34-55. doi: 10.1016/j.ydbio.2009.09.024. Epub 2009 Sep 22. Review.


Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy.

Egeblad M, Ewald AJ, Askautrud HA, Truitt ML, Welm BE, Bainbridge E, Peeters G, Krummel MF, Werb Z.

Dis Model Mech. 2008 Sep-Oct;1(2-3):155-67; discussion 165. doi: 10.1242/dmm.000596. Epub 2008 Sep 18.


Vertebrate gastrulation: separation is sticky and tense.

Ewald AJ, Wallingford JB.

Curr Biol. 2008 Jul 22;18(14):R615-7. doi: 10.1016/j.cub.2008.06.016.


Genetic mosaic analysis reveals FGF receptor 2 function in terminal end buds during mammary gland branching morphogenesis.

Lu P, Ewald AJ, Martin GR, Werb Z.

Dev Biol. 2008 Sep 1;321(1):77-87. doi: 10.1016/j.ydbio.2008.06.005. Epub 2008 Jun 13.


Collective epithelial migration and cell rearrangements drive mammary branching morphogenesis.

Ewald AJ, Brenot A, Duong M, Chan BS, Werb Z.

Dev Cell. 2008 Apr;14(4):570-81. doi: 10.1016/j.devcel.2008.03.003.


Cell-polarity dynamics controls the mechanism of lumen formation in epithelial morphogenesis.

Martín-Belmonte F, Yu W, Rodríguez-Fraticelli AE, Ewald AJ, Werb Z, Alonso MA, Mostov K.

Curr Biol. 2008 Apr 8;18(7):507-13. doi: 10.1016/j.cub.2008.02.076. Erratum in: Curr Biol. 2008 Jul 8;18(13):1016. Curr Biol. 2008 Apr 22;18(8):630. Ewald, Andrew [corrected to Ewald, Andrew J].


A model of intussusceptive angiogenesis.

Levin M, Ewald AJ, McMahon M, Werb Z, Mostov K.

Novartis Found Symp. 2007;283:37-42; discussion 42-5, 238-41.


Meningitis in the athlete.

Ewald AJ, McKeag DB.

Curr Sports Med Rep. 2008 Feb;7(1):22-7. doi: 10.1097/01.CSMR.0000308668.22688.0d. Review.


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