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Items: 1 to 50 of 119

1.

Characterization of the Major Purine and Pyrimidine Adducts Formed after Incubations of 1-Chloro-3-buten-2-one with Single-/Double-Stranded DNA and Human Cells.

Liu LY, Zheng J, Kong C, An J, Yu YX, Zhang XY, Elfarra AA.

Chem Res Toxicol. 2017 Feb 20;30(2):552-563. doi: 10.1021/acs.chemrestox.6b00282. Epub 2016 Dec 15.

PMID:
27977153
2.

Potential roles of myeloperoxidase and hypochlorous acid in metabolism and toxicity of alkene hydrocarbons and drug molecules containing olefinic moieties.

Zhang XY, Elfarra AA.

Expert Opin Drug Metab Toxicol. 2017 May;13(5):513-524. doi: 10.1080/17425255.2017.1271413. Epub 2016 Dec 16. Review.

PMID:
27936967
3.

Identification of a Fused-Ring 2'-Deoxyadenosine Adduct Formed in Human Cells Incubated with 1-Chloro-3-buten-2-one, a Potential Reactive Metabolite of 1,3-Butadiene.

Zeng FM, Liu LY, Zheng J, Kong C, An J, Yu YX, Zhang XY, Elfarra AA.

Chem Res Toxicol. 2016 Jun 20;29(6):1041-50. doi: 10.1021/acs.chemrestox.6b00095. Epub 2016 May 17.

PMID:
27161607
4.

Novel adducts from the reaction of 1-chloro-3-buten-2-one with 2'-deoxyguanosine. Structural characterization and potential as tools to investigate 1,3-butadiene carcinogenicity.

Zheng J, Li Y, Yu YX, An J, Zhang XY, Elfarra AA.

Chem Biol Interact. 2015 Jan 25;226:40-8. doi: 10.1016/j.cbi.2014.12.003. Epub 2014 Dec 10.

PMID:
25500269
5.

Formation of fused-ring 2'-deoxycytidine adducts from 1-chloro-3-buten-2-one, an in vitro 1,3-butadiene metabolite, under in vitro physiological conditions.

Sun L, Pelah A, Zhang DP, Zhong YF, An J, Yu YX, Zhang XY, Elfarra AA.

Chem Res Toxicol. 2013 Oct 21;26(10):1545-53. doi: 10.1021/tx4002435. Epub 2013 Sep 25.

6.

Cytotoxicity, genotoxicity, and mutagenicity of 1-chloro-2-hydroxy-3-butene and 1-chloro-3-buten-2-one, two alternative metabolites of 1,3-butadiene.

Liu XJ, Zeng FM, An J, Yu YX, Zhang XY, Elfarra AA.

Toxicol Appl Pharmacol. 2013 Aug 15;271(1):13-9. doi: 10.1016/j.taap.2013.04.019. Epub 2013 May 2.

7.

Mutagenicity of the cysteine S-conjugate sulfoxides of trichloroethylene and tetrachloroethylene in the Ames test.

Irving RM, Elfarra AA.

Toxicology. 2013 Apr 5;306:157-61. doi: 10.1016/j.tox.2013.02.003. Epub 2013 Feb 13.

8.

Characterization of the chemical reactivity and nephrotoxicity of N-acetyl-S-(1,2-dichlorovinyl)-L-cysteine sulfoxide, a potential reactive metabolite of trichloroethylene.

Irving RM, Pinkerton ME, Elfarra AA.

Toxicol Appl Pharmacol. 2013 Feb 15;267(1):1-10. doi: 10.1016/j.taap.2012.12.002. Epub 2012 Dec 16.

9.
10.

Role of reactive metabolites in the circulation in extrahepatic toxicity.

Irving RM, Elfarra AA.

Expert Opin Drug Metab Toxicol. 2012 Sep;8(9):1157-72. doi: 10.1517/17425255.2012.695347. Epub 2012 Jun 11. Review.

12.

The biochemical and toxicological significance of hypermethionemia: new insights and clinical relevance.

Dever JT, Elfarra AA.

Expert Opin Drug Metab Toxicol. 2010 Nov;6(11):1333-46. doi: 10.1517/17425255.2010.522177. Epub 2010 Sep 28. Review.

13.

Isoform distinct time-, dose-, and castration-dependent alterations in flavin-containing monooxygenase expression in mouse liver after 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment.

Novick RM, Vezina CM, Elfarra AA.

Biochem Pharmacol. 2010 May 1;79(9):1345-51. doi: 10.1016/j.bcp.2009.12.020. Epub 2009 Dec 28.

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Differential localization of flavin-containing monooxygenase (FMO) isoforms 1, 3, and 4 in rat liver and kidney and evidence for expression of FMO4 in mouse, rat, and human liver and kidney microsomes.

Novick RM, Mitzey AM, Brownfield MS, Elfarra AA.

J Pharmacol Exp Ther. 2009 Jun;329(3):1148-55. doi: 10.1124/jpet.109.152058. Epub 2009 Mar 23.

19.

Gender differences in methionine accumulation and metabolism in freshly isolated mouse hepatocytes: potential roles in toxicity.

Dever JT, Elfarra AA.

Toxicol Appl Pharmacol. 2009 May 1;236(3):358-65. doi: 10.1016/j.taap.2009.02.009. Epub 2009 Feb 21.

20.

Reduction of L-methionine selenoxide to seleno-L-methionine by endogenous thiols, ascorbic acid, or methimazole.

Krause RJ, Elfarra AA.

Biochem Pharmacol. 2009 Jan 1;77(1):134-40. doi: 10.1016/j.bcp.2008.09.022. Epub 2008 Sep 27.

21.

Purification and characterization of flavin-containing monooxygenase isoform 3 from rat kidney microsomes.

Novick RM, Elfarra AA.

Drug Metab Dispos. 2008 Dec;36(12):2468-74. doi: 10.1124/dmd.108.021436. Epub 2008 Sep 5.

22.

L-methionine-dl-sulfoxide metabolism and toxicity in freshly isolated mouse hepatocytes: gender differences and inhibition with aminooxyacetic acid.

Dever JT, Elfarra AA.

Drug Metab Dispos. 2008 Nov;36(11):2252-60. doi: 10.1124/dmd.108.023390. Epub 2008 Aug 7.

24.

L-methionine toxicity in freshly isolated mouse hepatocytes is gender-dependent and mediated in part by transamination.

Dever JT, Elfarra AA.

J Pharmacol Exp Ther. 2008 Sep;326(3):809-17. doi: 10.1124/jpet.108.141044. Epub 2008 Jun 13.

26.

Human glutathione transferases catalyzing the bioactivation of anticancer thiopurine prodrugs.

Eklund BI, Gunnarsdottir S, Elfarra AA, Mannervik B.

Biochem Pharmacol. 2007 Jun 1;73(11):1829-41. Epub 2007 Feb 12.

PMID:
17433263
28.

Oxidative metabolism of seleno-L-methionine to L-methionine selenoxide by flavin-containing monooxygenases.

Krause RJ, Glocke SC, Sicuri AR, Ripp SL, Elfarra AA.

Chem Res Toxicol. 2006 Dec;19(12):1643-9.

30.

Mass spectral analyses of hemoglobin adducts formed after in vitro exposure of erythrocytes to hydroxymethylvinyl ketone.

Barshteyn N, Krause RJ, Elfarra AA.

Chem Biol Interact. 2007 Mar 20;166(1-3):176-81. Epub 2006 May 1.

PMID:
16735035
32.

Protection of rats against 3-butene-1,2-diol-induced hepatotoxicity and hypoglycemia by N-acetyl-l-cysteine.

Sprague CL, Elfarra AA.

Toxicol Appl Pharmacol. 2005 Sep 15;207(3):266-74.

PMID:
16129119
34.
36.

Species and tissue differences in the toxicity of 3-butene-1,2-diol in male Sprague-Dawley rats and B6C3F1 mice.

Sprague CL, Phillips LA, Young KM, Elfarra AA.

Toxicol Sci. 2004 Jul;80(1):3-13. Epub 2004 May 5.

PMID:
15129020
40.

Detection of carboxylic acids and inhibition of hippuric acid formation in rats treated with 3-butene-1,2-diol, a major metabolite of 1,3-butadiene.

Sprague CL, Elfarra AA.

Drug Metab Dispos. 2003 Aug;31(8):986-92. Erratum in: Drug Metab Dispos. 2003 Sep 31(9):1198.

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47.

Renal toxicity of perchloroethylene and S-(1,2,2-trichlorovinyl)glutathione in rats and mice: sex- and species-dependent differences.

Lash LH, Qian W, Putt DA, Hueni SE, Elfarra AA, Sicuri AR, Parker JC.

Toxicol Appl Pharmacol. 2002 Mar 15;179(3):163-71.

PMID:
11906246
48.

Reactive metabolites of 1,3-butadiene: DNA and hemoglobin adduct formation and potential roles in carcinogenicity.

Elfarra AA, Moll TS, Krause RJ, Kemper RA, Selzer RR.

Adv Exp Med Biol. 2001;500:93-103. Review. No abstract available.

PMID:
11765021
50.

Advances in the mass spectrometry of hemoglobin adducts: global analysis of the covalent binding of butadiene monoxide.

Moll TS, Harms AC, Elfarra AA.

Chem Biol Interact. 2001 Jun 1;135-136:667-74.

PMID:
11397420

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