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Items: 13

1.

BRD4 profiling identifies critical Chronic Lymphocytic Leukemia oncogenic circuits and reveals sensitivity to PLX51107, a novel structurally distinct BET inhibitor.

Ozer HG, El-Gamal D, Powell B, Hing ZA, Blachly JS, Harrington B, Mitchell S, Grieselhuber NR, Williams K, Lai TH, Alinari L, Baiocchi RA, Brinton L, Baskin E, Cannon M, Beaver L, Goettl VM, Lucas DM, Woyach JA, Sampath D, Lehman AM, Yu L, Zhang J, Ma Y, Zhang Y, Spevak W, Shi S, Severson P, Shellooe R, Carias H, Tsang G, Dong K, Ewing T, Marimuthu A, Tantoy C, Walters J, Sanftner L, Rezaei H, Nespi M, Matusow B, Habets G, Ibrahim P, Zhang C, Mathé EA, Bollag G, Byrd JC, Lapalombella R.

Cancer Discov. 2018 Jan 31. pii: CD-17-0902. doi: 10.1158/2159-8290.CD-17-0902. [Epub ahead of print]

PMID:
29386193
2.

Targeting BTK through microRNA in chronic lymphocytic leukemia.

Bottoni A, Rizzotto L, Lai TH, Liu C, Smith LL, Mantel R, Reiff S, El-Gamal D, Larkin K, Johnson AJ, Lapalombella R, Lehman A, Plunkett W, Byrd JC, Blachly JS, Woyach JA, Sampath D.

Blood. 2016 Dec 29;128(26):3101-3112. doi: 10.1182/blood-2016-07-727750. Epub 2016 Oct 17.

3.

Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies.

Hing ZA, Fung HY, Ranganathan P, Mitchell S, El-Gamal D, Woyach JA, Williams K, Goettl VM, Smith J, Yu X, Meng X, Sun Q, Cagatay T, Lehman AM, Lucas DM, Baloglu E, Shacham S, Kauffman MG, Byrd JC, Chook YM, Garzon R, Lapalombella R.

Leukemia. 2016 Dec;30(12):2364-2372. doi: 10.1038/leu.2016.136. Epub 2016 May 20.

4.

The authors reply.

El-Gamal D, Frank S, Hallström S, Marsche G.

Kidney Int. 2015 Apr;87(4):861-2. doi: 10.1038/ki.2015.42. No abstract available.

PMID:
25826551
5.

PKC-β as a therapeutic target in CLL: PKC inhibitor AEB071 demonstrates preclinical activity in CLL.

El-Gamal D, Williams K, LaFollette TD, Cannon M, Blachly JS, Zhong Y, Woyach JA, Williams E, Awan FT, Jones J, Andritsos L, Maddocks K, Wu CH, Chen CS, Lehman A, Zhang X, Lapalombella R, Byrd JC.

Blood. 2014 Aug 28;124(9):1481-91. doi: 10.1182/blood-2014-05-574830. Epub 2014 Jul 7.

6.

The urea decomposition product cyanate promotes endothelial dysfunction.

El-Gamal D, Rao SP, Holzer M, Hallström S, Haybaeck J, Gauster M, Wadsack C, Kozina A, Frank S, Schicho R, Schuligoi R, Heinemann A, Marsche G.

Kidney Int. 2014 Nov;86(5):923-31. doi: 10.1038/ki.2014.218. Epub 2014 Jun 18.

7.

Selinexor suppresses downstream effectors of B-cell activation, proliferation and migration in chronic lymphocytic leukemia cells.

Zhong Y, El-Gamal D, Dubovsky JA, Beckwith KA, Harrington BK, Williams KE, Goettl VM, Jha S, Mo X, Jones JA, Flynn JM, Maddocks KJ, Andritsos LA, McCauley D, Shacham S, Kauffman M, Byrd JC, Lapalombella R.

Leukemia. 2014 May;28(5):1158-63. doi: 10.1038/leu.2014.9. Epub 2014 Jan 13. No abstract available.

8.

Effects of phytate on thyroid gland of rats intoxicated with cadmium.

Mohamed TM, Salama AF, El Nimr TM, El Gamal DM.

Toxicol Ind Health. 2015 Dec;31(12):1258-68. doi: 10.1177/0748233713485887. Epub 2013 Jun 24.

PMID:
23796758
9.

The myeloperoxidase product hypochlorous acid generates irreversible high-density lipoprotein receptor inhibitors.

Binder V, Ljubojevic S, Haybaeck J, Holzer M, El-Gamal D, Schicho R, Pieske B, Heinemann A, Marsche G.

Arterioscler Thromb Vasc Biol. 2013 May;33(5):1020-7. doi: 10.1161/ATVBAHA.113.301235. Epub 2013 Mar 14.

10.

Psoriasis alters HDL composition and cholesterol efflux capacity.

Holzer M, Wolf P, Curcic S, Birner-Gruenberger R, Weger W, Inzinger M, El-Gamal D, Wadsack C, Heinemann A, Marsche G.

J Lipid Res. 2012 Aug;53(8):1618-24. doi: 10.1194/jlr.M027367. Epub 2012 May 30.

11.

Myeloperoxidase-derived chlorinating species induce protein carbamylation through decomposition of thiocyanate and urea: novel pathways generating dysfunctional high-density lipoprotein.

Holzer M, Zangger K, El-Gamal D, Binder V, Curcic S, Konya V, Schuligoi R, Heinemann A, Marsche G.

Antioxid Redox Signal. 2012 Oct 15;17(8):1043-52. doi: 10.1089/ars.2011.4403. Epub 2012 May 8.

12.

Cyanate is a novel inducer of endothelial icam-1 expression.

El-Gamal D, Holzer M, Gauster M, Schicho R, Binder V, Konya V, Wadsack C, Schuligoi R, Heinemann A, Marsche G.

Antioxid Redox Signal. 2012 Jan 15;16(2):129-37. doi: 10.1089/ars.2011.4090. Epub 2011 Oct 14.

13.

Uremia alters HDL composition and function.

Holzer M, Birner-Gruenberger R, Stojakovic T, El-Gamal D, Binder V, Wadsack C, Heinemann A, Marsche G.

J Am Soc Nephrol. 2011 Sep;22(9):1631-41. doi: 10.1681/ASN.2010111144. Epub 2011 Jul 29.

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