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Items: 19


Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients.

Schonhoft JD, Monteiro C, Plate L, Eisele YS, Kelly JM, Boland D, Parker CG, Cravatt BF, Teruya S, Helmke S, Maurer M, Berk J, Sekijima Y, Novais M, Coelho T, Powers ET, Kelly JW.

Sci Transl Med. 2017 Sep 13;9(407). pii: eaam7621. doi: 10.1126/scitranslmed.aam7621.


Conversion of Synthetic Aβ to In Vivo Active Seeds and Amyloid Plaque Formation in a Hippocampal Slice Culture Model.

Novotny R, Langer F, Mahler J, Skodras A, Vlachos A, Wegenast-Braun BM, Kaeser SA, Neher JJ, Eisele YS, Pietrowski MJ, Nilsson KP, Deller T, Staufenbiel M, Heimrich B, Jucker M.

J Neurosci. 2016 May 4;36(18):5084-93. doi: 10.1523/JNEUROSCI.0258-16.2016.


Propagation of Aß pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies.

Eisele YS, Duyckaerts C.

Acta Neuropathol. 2016 Jan;131(1):5-25. doi: 10.1007/s00401-015-1516-y. Epub 2015 Dec 29. Review.


Persistence of Aβ seeds in APP null mouse brain.

Ye L, Fritschi SK, Schelle J, Obermüller U, Degenhardt K, Kaeser SA, Eisele YS, Walker LC, Baumann F, Staufenbiel M, Jucker M.

Nat Neurosci. 2015 Nov;18(11):1559-61. doi: 10.1038/nn.4117. Epub 2015 Sep 9.


Targeting protein aggregation for the treatment of degenerative diseases.

Eisele YS, Monteiro C, Fearns C, Encalada SE, Wiseman RL, Powers ET, Kelly JW.

Nat Rev Drug Discov. 2015 Nov;14(11):759-80. doi: 10.1038/nrd4593. Epub 2015 Sep 4. Review.


A fluorogenic aryl fluorosulfate for intraorganellar transthyretin imaging in living cells and in Caenorhabditis elegans.

Baranczak A, Liu Y, Connelly S, Du WG, Greiner ER, Genereux JC, Wiseman RL, Eisele YS, Bradbury NC, Dong J, Noodleman L, Sharpless KB, Wilson IA, Encalada SE, Kelly JW.

J Am Chem Soc. 2015 Jun 17;137(23):7404-14. doi: 10.1021/jacs.5b03042. Epub 2015 Jun 8.


Endogenous murine Aβ increases amyloid deposition in APP23 but not in APPPS1 transgenic mice.

Mahler J, Morales-Corraliza J, Stolz J, Skodras A, Radde R, Duma CC, Eisele YS, Mazzella MJ, Wong H, Klunk WE, Nilsson KPR, Staufenbiel M, Mathews PM, Jucker M, Wegenast-Braun BM.

Neurobiol Aging. 2015 Jul;36(7):2241-2247. doi: 10.1016/j.neurobiolaging.2015.03.011. Epub 2015 Mar 25.


Progression of Seed-Induced Aβ Deposition within the Limbic Connectome.

Ye L, Hamaguchi T, Fritschi SK, Eisele YS, Obermüller U, Jucker M, Walker LC.

Brain Pathol. 2015 Nov;25(6):743-52. doi: 10.1111/bpa.12252. Epub 2015 Mar 24.


Formaldehyde-fixed brain tissue from spontaneously ill α-synuclein transgenic mice induces fatal α-synucleinopathy in transgenic hosts.

Schweighauser M, Bacioglu M, Fritschi SK, Shimshek DR, Kahle PJ, Eisele YS, Jucker M.

Acta Neuropathol. 2015 Jan;129(1):157-9. doi: 10.1007/s00401-014-1360-5. Epub 2014 Nov 4. No abstract available.


Multiple factors contribute to the peripheral induction of cerebral β-amyloidosis.

Eisele YS, Fritschi SK, Hamaguchi T, Obermüller U, Füger P, Skodras A, Schäfer C, Odenthal J, Heikenwalder M, Staufenbiel M, Jucker M.

J Neurosci. 2014 Jul 30;34(31):10264-73. doi: 10.1523/JNEUROSCI.1608-14.2014.


Blood platelets in the progression of Alzheimer's disease.

Gowert NS, Donner L, Chatterjee M, Eisele YS, Towhid ST, Münzer P, Walker B, Ogorek I, Borst O, Grandoch M, Schaller M, Fischer JW, Gawaz M, Weggen S, Lang F, Jucker M, Elvers M.

PLoS One. 2014 Feb 28;9(2):e90523. doi: 10.1371/journal.pone.0090523. eCollection 2014.


Seeded strain-like transmission of β-amyloid morphotypes in APP transgenic mice.

Heilbronner G, Eisele YS, Langer F, Kaeser SA, Novotny R, Nagarathinam A, Aslund A, Hammarström P, Nilsson KP, Jucker M.

EMBO Rep. 2013 Nov;14(11):1017-22. doi: 10.1038/embor.2013.137. Epub 2013 Sep 3.


From soluble aβ to progressive aβ aggregation: could prion-like templated misfolding play a role?

Eisele YS.

Brain Pathol. 2013 May;23(3):333-41. doi: 10.1111/bpa.12049. Review.


The presence of Aβ seeds, and not age per se, is critical to the initiation of Aβ deposition in the brain.

Hamaguchi T, Eisele YS, Varvel NH, Lamb BT, Walker LC, Jucker M.

Acta Neuropathol. 2012 Jan;123(1):31-7. doi: 10.1007/s00401-011-0912-1. Epub 2011 Nov 20.


Soluble Aβ seeds are potent inducers of cerebral β-amyloid deposition.

Langer F, Eisele YS, Fritschi SK, Staufenbiel M, Walker LC, Jucker M.

J Neurosci. 2011 Oct 12;31(41):14488-95. doi: 10.1523/JNEUROSCI.3088-11.2011.


Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis.

Eisele YS, Obermüller U, Heilbronner G, Baumann F, Kaeser SA, Wolburg H, Walker LC, Staufenbiel M, Heikenwalder M, Jucker M.

Science. 2010 Nov 12;330(6006):980-2. doi: 10.1126/science.1194516. Epub 2010 Oct 21.


Induction of cerebral beta-amyloidosis: intracerebral versus systemic Abeta inoculation.

Eisele YS, Bolmont T, Heikenwalder M, Langer F, Jacobson LH, Yan ZX, Roth K, Aguzzi A, Staufenbiel M, Walker LC, Jucker M.

Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12926-31. doi: 10.1073/pnas.0903200106. Epub 2009 Jul 21.


E22Q-mutant Abeta peptide (AbetaDutch) increases vascular but reduces parenchymal Abeta deposition.

Herzig MC, Eisele YS, Staufenbiel M, Jucker M.

Am J Pathol. 2009 Mar;174(3):722-6. doi: 10.2353/ajpath.2009.080790. Epub 2009 Feb 13.


Gleevec increases levels of the amyloid precursor protein intracellular domain and of the amyloid-beta degrading enzyme neprilysin.

Eisele YS, Baumann M, Klebl B, Nordhammer C, Jucker M, Kilger E.

Mol Biol Cell. 2007 Sep;18(9):3591-600. Epub 2007 Jul 11.

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