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Items: 1 to 50 of 281

1.

The past, present, and the promise of the future of nuclear medicine and biology.

Eckelman WC, Windhorst AD, O'Hara C.

Nucl Med Biol. 2017 Dec;55:47-48. doi: 10.1016/j.nucmedbio.2017.10.002. Epub 2017 Oct 12. No abstract available.

PMID:
29117904
2.

Commentary.

Eckelman WC.

Nucl Med Biol. 2017 Jan;44:1-3. doi: 10.1016/j.nucmedbio.2016.08.019. Epub 2016 Sep 3. No abstract available.

PMID:
27721107
3.

Myocardial Blood Flow and Innervation Measures from a Single Scan: An Appealing Concept but a Challenging Paradigm.

Dilsizian V, Eckelman WC.

J Nucl Med. 2015 Nov;56(11):1645-6. doi: 10.2967/jnumed.115.164251. Epub 2015 Aug 27. No abstract available.

4.

Chemistry and biology of radiotracers that target changes in sympathetic and parasympathetic nervous systems in heart disease.

Eckelman WC, Dilsizian V.

J Nucl Med. 2015 Jun;56 Suppl 4:7S-10S. doi: 10.2967/jnumed.114.142802.

5.

Choosing a single target as a biomarker or therapeutic using radioactive probes.

Eckelman WC, Mankoff DA.

Nucl Med Biol. 2015 May;42(5):421-425. doi: 10.1016/j.nucmedbio.2015.01.005. Epub 2015 Jan 28. Review. No abstract available.

PMID:
25684651
6.

Rational development of radiopharmaceuticals for HIV-1.

Lau CY, Maldarelli F, Eckelman WC, Neumann RD.

Nucl Med Biol. 2014 Apr;41(4):299-308. doi: 10.1016/j.nucmedbio.2014.01.005. Epub 2014 Jan 17. Review.

7.

Perspective, the one most responsive to change.

Eckelman WC, Lau CY, Neumann RD.

Nucl Med Biol. 2014 Apr;41(4):297-8. doi: 10.1016/j.nucmedbio.2013.10.002. Epub 2013 Oct 11. No abstract available.

PMID:
24268902
8.

Preface for "The quantification with FDG as seen by a physician" by Galli et al.

Eckelman WC.

Nucl Med Biol. 2013 Aug;40(6):719. doi: 10.1016/j.nucmedbio.2013.06.011. No abstract available.

PMID:
23915798
9.

Progress using Tc-99m radiopharmaceuticals for measuring high capacity sites and low density sites.

Eckelman WC, Jones AG, Duatti A, Reba RC.

Drug Discov Today. 2013 Oct;18(19-20):984-91. doi: 10.1016/j.drudis.2013.06.008. Epub 2013 Jun 24. Review.

PMID:
23806975
10.

99mTc-labeled small-molecule inhibitors of prostate-specific membrane antigen for molecular imaging of prostate cancer.

Hillier SM, Maresca KP, Lu G, Merkin RD, Marquis JC, Zimmerman CN, Eckelman WC, Joyal JL, Babich JW.

J Nucl Med. 2013 Aug;54(8):1369-76. doi: 10.2967/jnumed.112.116624. Epub 2013 Jun 3.

11.

Synthesis and SAR of ⁹⁹mTc/Re-labeled small molecule prostate specific membrane antigen inhibitors with novel polar chelates.

Lu G, Maresca KP, Hillier SM, Zimmerman CN, Eckelman WC, Joyal JL, Babich JW.

Bioorg Med Chem Lett. 2013 Mar 1;23(5):1557-63. doi: 10.1016/j.bmcl.2012.09.014. Epub 2012 Sep 13.

PMID:
23333070
12.

First-in-man evaluation of 2 high-affinity PSMA-avid small molecules for imaging prostate cancer.

Barrett JA, Coleman RE, Goldsmith SJ, Vallabhajosula S, Petry NA, Cho S, Armor T, Stubbs JB, Maresca KP, Stabin MG, Joyal JL, Eckelman WC, Babich JW.

J Nucl Med. 2013 Mar;54(3):380-7. doi: 10.2967/jnumed.112.111203. Epub 2013 Jan 9.

13.

Synthesis and SAR of novel Re/99mTc-labeled benzenesulfonamide carbonic anhydrase IX inhibitors for molecular imaging of tumor hypoxia.

Lu G, Hillier SM, Maresca KP, Zimmerman CN, Eckelman WC, Joyal JL, Babich JW.

J Med Chem. 2013 Jan 24;56(2):510-20. doi: 10.1021/jm3015348. Epub 2013 Jan 8.

PMID:
23234246
14.

The synthesis and in vivo pharmacokinetics of fluorinated arachidonic acid: implications for imaging neuroinflammation.

Pichika R, Taha AY, Gao F, Kotta K, Cheon Y, Chang L, Kiesewetter D, Rapoport SI, Eckelman WC.

J Nucl Med. 2012 Sep;53(9):1383-91. doi: 10.2967/jnumed.112.105734. Epub 2012 Jul 31.

15.

Essential parameters to consider for the characterization of optical imaging probes.

Leung K, Chopra A, Shan L, Eckelman WC, Menkens AE.

Nanomedicine (Lond). 2012 Jul;7(7):1101-7. doi: 10.2217/nnm.12.79.

16.

A receptor-targeted fluorescent radiopharmaceutical for multireporter sentinel lymph node imaging.

Emerson DK, Limmer KK, Hall DJ, Han SH, Eckelman WC, Kane CJ, Wallace AM, Vera DR.

Radiology. 2012 Oct;265(1):186-93. Epub 2012 Jul 2.

17.

Targeted molecular imaging: target significance and probe validation.

Eckelman WC.

JACC Cardiovasc Imaging. 2012 Jun;5(6):616-8. doi: 10.1016/j.jcmg.2012.02.013. No abstract available.

18.

A name change for the Society: perspectives.

Eckelman WC, Maurer AH, Sajdak RA, Basso DA.

J Nucl Med. 2011 Dec;52(12):22N-5N. No abstract available.

19.

Molecular Imaging and Contrast Agent Database (MICAD): evolution and progress.

Chopra A, Shan L, Eckelman WC, Leung K, Latterner M, Bryant SH, Menkens A.

Mol Imaging Biol. 2012 Feb;14(1):4-13. doi: 10.1007/s11307-011-0521-3. Review.

20.

Important parameters to consider for the characterization of PET and SPECT imaging probes.

Chopra A, Shan L, Eckelman WC, Leung K, Menkens AE.

Nucl Med Biol. 2011 Nov;38(8):1079-84. doi: 10.1016/j.nucmedbio.2011.05.011. Epub 2011 Aug 19. No abstract available.

PMID:
21855359
21.

Imaging of the muscarinic acetylcholine neuroreceptor in rats with the M2 selective agonist [18F]FP-TZTP.

Ravasi L, Tokugawa J, Nakayama T, Seidel J, Sokoloff L, Eckelman WC, Kiesewetter DO.

Nucl Med Biol. 2012 Jan;39(1):45-55. doi: 10.1016/j.nucmedbio.2011.06.003. Epub 2011 Aug 9.

22.

123I-MIP-1072, a small-molecule inhibitor of prostate-specific membrane antigen, is effective at monitoring tumor response to taxane therapy.

Hillier SM, Kern AM, Maresca KP, Marquis JC, Eckelman WC, Joyal JL, Babich JW.

J Nucl Med. 2011 Jul;52(7):1087-93. doi: 10.2967/jnumed.110.086751. Epub 2011 Jun 16.

23.

[(76) Br]BMK-152, a nonpeptide analogue, with high affinity and low nonspecific binding for the corticotropin-releasing factor type 1 receptor.

Jagoda EM, Lang L, McCullough K, Contoreggi C, Kim BM, Ma Y, Rice KC, Szajek LP, Eckelman WC, Kiesewetter DO.

Synapse. 2011 Sep;65(9):910-8. doi: 10.1002/syn.20919. Epub 2011 Apr 11.

24.

Fast 18F labeling of a near-infrared fluorophore enables positron emission tomography and optical imaging of sentinel lymph nodes.

Ting R, Aguilera TA, Crisp JL, Hall DJ, Eckelman WC, Vera DR, Tsien RY.

Bioconjug Chem. 2010 Oct 20;21(10):1811-9. doi: 10.1021/bc1001328.

25.

Novel polar single amino acid chelates for technetium-99m tricarbonyl-based radiopharmaceuticals with enhanced renal clearance: application to octreotide.

Maresca KP, Marquis JC, Hillier SM, Lu G, Femia FJ, Zimmerman CN, Eckelman WC, Joyal JL, Babich JW.

Bioconjug Chem. 2010 Jun 16;21(6):1032-42. doi: 10.1021/bc900517x.

PMID:
20402463
26.

Genetic variation in cholinergic muscarinic-2 receptor gene modulates M2 receptor binding in vivo and accounts for reduced binding in bipolar disorder.

Cannon DM, Klaver JK, Gandhi SK, Solorio G, Peck SA, Erickson K, Akula N, Savitz J, Eckelman WC, Furey ML, Sahakian BJ, McMahon FJ, Drevets WC.

Mol Psychiatry. 2011 Apr;16(4):407-18. doi: 10.1038/mp.2010.24. Epub 2010 Mar 30.

27.

Preclinical evaluation of novel glutamate-urea-lysine analogues that target prostate-specific membrane antigen as molecular imaging pharmaceuticals for prostate cancer.

Hillier SM, Maresca KP, Femia FJ, Marquis JC, Foss CA, Nguyen N, Zimmerman CN, Barrett JA, Eckelman WC, Pomper MG, Joyal JL, Babich JW.

Cancer Res. 2009 Sep 1;69(17):6932-40. doi: 10.1158/0008-5472.CAN-09-1682. Epub 2009 Aug 25.

28.

Comprehensive radiolabeling, stability, and tissue distribution studies of technetium-99m single amino acid chelates (SAAC).

Maresca KP, Hillier SM, Femia FJ, Zimmerman CN, Levadala MK, Banerjee SR, Hicks J, Sundararajan C, Valliant J, Zubieta J, Eckelman WC, Joyal JL, Babich JW.

Bioconjug Chem. 2009 Aug 19;20(8):1625-33. doi: 10.1021/bc900192b. Epub 2009 Jul 2.

PMID:
19572702
29.

Unparalleled contribution of technetium-99m to medicine over 5 decades.

Eckelman WC.

JACC Cardiovasc Imaging. 2009 Mar;2(3):364-8. doi: 10.1016/j.jcmg.2008.12.013. Review. No abstract available.

30.

Specific to nonspecific binding in radiopharmaceutical studies: it's not so simple as it seems!

Eckelman WC, Kilbourn MR, Mathis CA.

Nucl Med Biol. 2009 Apr;36(3):235-7. doi: 10.1016/j.nucmedbio.2008.12.002. No abstract available.

PMID:
19324268
31.

Imaging incorporation of circulating docosahexaenoic acid into the human brain using positron emission tomography.

Umhau JC, Zhou W, Carson RE, Rapoport SI, Polozova A, Demar J, Hussein N, Bhattacharjee AK, Ma K, Esposito G, Majchrzak S, Herscovitch P, Eckelman WC, Kurdziel KA, Salem N Jr.

J Lipid Res. 2009 Jul;50(7):1259-68. doi: 10.1194/jlr.M800530-JLR200. Epub 2008 Dec 26.

32.

A series of halogenated heterodimeric inhibitors of prostate specific membrane antigen (PSMA) as radiolabeled probes for targeting prostate cancer.

Maresca KP, Hillier SM, Femia FJ, Keith D, Barone C, Joyal JL, Zimmerman CN, Kozikowski AP, Barrett JA, Eckelman WC, Babich JW.

J Med Chem. 2009 Jan 22;52(2):347-57. doi: 10.1021/jm800994j.

PMID:
19111054
33.

Imaging neuroinflammation in Alzheimer's disease with radiolabeled arachidonic acid and PET.

Esposito G, Giovacchini G, Liow JS, Bhattacharjee AK, Greenstein D, Schapiro M, Hallett M, Herscovitch P, Eckelman WC, Carson RE, Rapoport SI.

J Nucl Med. 2008 Sep;49(9):1414-21. doi: 10.2967/jnumed.107.049619. Epub 2008 Aug 14.

34.

Targeted imaging: an important biomarker for understanding disease progression in the era of personalized medicine.

Eckelman WC, Reba RC, Kelloff GJ.

Drug Discov Today. 2008 Sep;13(17-18):748-59. doi: 10.1016/j.drudis.2008.05.009. Epub 2008 Jul 24. Review.

PMID:
18617011
35.

True radiotracers: are we approaching theoretical specific activity with Tc-99m and I-123?

Eckelman WC, Bonardi M, Volkert WA.

Nucl Med Biol. 2008 Jul;35(5):523-7. doi: 10.1016/j.nucmedbio.2008.03.005. Review. No abstract available.

PMID:
18589295
36.

Synthesis and evaluation of a series of 99mTc(CO)3+ lisinopril complexes for in vivo imaging of angiotensin-converting enzyme expression.

Femia FJ, Maresca KP, Hillier SM, Zimmerman CN, Joyal JL, Barrett JA, Aras O, Dilsizian V, Eckelman WC, Babich JW.

J Nucl Med. 2008 Jun;49(6):970-7. doi: 10.2967/jnumed.107.049064. Epub 2008 May 15.

37.

Comparison of the pharmacokinetics of different analogs of 11C-labeled TZTP for imaging muscarinic M2 receptors with PET.

Reid AE, Ding YS, Eckelman WC, Logan J, Alexoff D, Shea C, Xu Y, Fowler JS.

Nucl Med Biol. 2008 Apr;35(3):287-98. doi: 10.1016/j.nucmedbio.2008.01.001.

38.

Further discussions on choosing the number of animals for an experiment.

Eckelman WC.

Nucl Med Biol. 2008 Jan;35(1):1-2. No abstract available.

PMID:
18158936
39.
40.

Synthesis and validation of fatty acid analogs radiolabeled by nonisotopic substitution.

Eckelman WC, Babich JW.

J Nucl Cardiol. 2007 May-Jun;14(3 Suppl):S100-9. Review. No abstract available.

PMID:
17556177
41.

An automated one-step one-pot [(18)F]FCWAY synthesis: development and minimization of chemical impurities.

Vuong BK, Kiesewetter DO, Lang L, Ma Y, Eckelman WC, Channing MA.

Nucl Med Biol. 2007 May;34(4):433-8.

42.

The role and regulation of cardiac angiotensin-converting enzyme for noninvasive molecular imaging in heart failure.

Aras O, Messina SA, Shirani J, Eckelman WC, Dilsizian V.

Curr Cardiol Rep. 2007 Apr;9(2):150-8. Review.

PMID:
17430683
43.

Biomedical imaging research opportunities workshop IV: a white paper.

Hendee WR, Banovac F, Carson PL, DeFronzo RA, Eckelman WC, Fullerton GD, Larson SM, McLennan G, Welch MJ.

Med Phys. 2007 Feb;34(2):673-9.

44.

Novel imaging strategies for predicting remodeling and evolution of heart failure: targeting the Renin-Angiotensin system.

Shirani J, Narula J, Eckelman WC, Dilsizian V.

Heart Fail Clin. 2006 Apr;2(2):231-47. Review. No abstract available.

PMID:
17386892
45.

Justifying the number of animals for each experiment.

Eckelman WC, Kilbourn MR, Joyal JL, Labiris R, Valliant JF.

Nucl Med Biol. 2007 Apr;34(3):229-32. No abstract available.

PMID:
17383571
46.

The influence of tumor oxygenation on hypoxia imaging in murine squamous cell carcinoma using [64Cu]Cu-ATSM or [18F]Fluoromisonidazole positron emission tomography.

Matsumoto K, Szajek L, Krishna MC, Cook JA, Seidel J, Grimes K, Carson J, Sowers AL, English S, Green MV, Bacharach SL, Eckelman WC, Mitchell JB.

Int J Oncol. 2007 Apr;30(4):873-81.

PMID:
17332926
47.

Evaluation of [18F]fluoroxanomeline {5-{4-[(6-[18F]fluorohexyl)oxy]-1,2,5-thiadiazol-3-yl}-1-methyl-1,2,3,6-tetrahydropyridine} in muscarinic knockout mice.

Kiesewetter DO, Jagoda EM, Shimoji K, Ma Y, Eckelman WC.

Nucl Med Biol. 2007 Feb;34(2):141-52. Epub 2007 Jan 17.

PMID:
17307122
48.

Early imaging in heart failure: exploring novel molecular targets.

Shirani J, Narula J, Eckelman WC, Narula N, Dilsizian V.

J Nucl Cardiol. 2007 Jan;14(1):100-10. Review. No abstract available.

PMID:
17276312
49.
50.

Postmeeting summary on the round table discussion at the Seventh International Symposium on Technetium in Chemistry and Nuclear Medicine held in Bressanone, Italy on Sept 6-9, 2006.

Eckelman WC, Erba PA, Schwaiger M, Wagner HN Jr, Alberto R, Mazzi U.

Nucl Med Biol. 2007 Jan;34(1):1-4. No abstract available.

PMID:
17210456

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