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Items: 1 to 50 of 200

1.

A potential method to improve the in vitro cytotoxicity of half-sandwich Os(ii) complexes against A2780 cells.

Štarha P, Trávníček Z, Herchel R, Jewula P, Dvořák Z.

Dalton Trans. 2018 Apr 24;47(16):5714-5724. doi: 10.1039/c8dt00193f.

PMID:
29632937
2.
3.

Methylindoles and methoxyindoles are agonists and antagonists of human aryl hydrocarbon receptor AhR.

Stepankova M, Bartonkova I, Jiskrova E, Vrzal R, Mani S, Kortagere S, Dvorak Z.

Mol Pharmacol. 2018 Apr 6. pii: mol.118.112151. doi: 10.1124/mol.118.112151. [Epub ahead of print]

4.

In vitro profiling of toxic effects of prominent environmental lower-chlorinated PCB congeners linked with endocrine disruption and tumor promotion.

Pěnčíková K, Svržková L, Strapáčová S, Neča J, Bartoňková I, Dvořák Z, Hýžďalová M, Pivnička J, Pálková L, Lehmler HJ, Li X, Vondráček J, Machala M.

Environ Pollut. 2018 Jun;237:473-486. doi: 10.1016/j.envpol.2018.02.067. Epub 2018 Mar 15.

PMID:
29518658
5.

Effects of human interleukins in the transgenic gene reporter cell lines IZ-VDRE and IZ-CYP24 designed to assess the transcriptional activity of vitamin D receptor.

Bartonkova I, Kallay E, Dvorak Z.

PLoS One. 2018 Feb 28;13(2):e0193655. doi: 10.1371/journal.pone.0193655. eCollection 2018.

6.

[Pedicled Flaps for Reconstruction of Head and Neck Region].

Pink R, Dvořák Z, Heinz P, Michl P, Tvrdý P, Azar B.

Klin Onkol. 2017 Winter;31(1):59-65. doi: 10.14735/amko201859. Czech.

PMID:
29488780
7.

Half-Sandwich Ru(II) and Os(II) Bathophenanthroline Complexes Containing a Releasable Dichloroacetato Ligand.

Štarha P, Trávníček Z, Vančo J, Dvořák Z.

Molecules. 2018 Feb 14;23(2). pii: E420. doi: 10.3390/molecules23020420.

8.

In vitro analysis of itraconazole cis-diastereoisomers inhibition of nine cytochrome P450 enzymes: stereoselective inhibition of CYP3A.

Krasulova K, Dvorak Z, Anzenbacher P.

Xenobiotica. 2018 Jan 22:1-7. doi: 10.1080/00498254.2018.1425510. [Epub ahead of print]

PMID:
29320899
9.

Copper(II) complexes based on tripodal pyrazolyl amines: Synthesis, structure, magnetic properties and anticancer activity.

Massoud SS, Louka FR, Ducharme GT, Fischer RC, Mautner FA, Vančo J, Herchel R, Dvořák Z, Trávníček Z.

J Inorg Biochem. 2018 Mar;180:39-46. doi: 10.1016/j.jinorgbio.2017.11.023. Epub 2017 Dec 5.

PMID:
29232637
10.

Essential oils of culinary herbs and spices display agonist and antagonist activities at human aryl hydrocarbon receptor AhR.

Bartoňková I, Dvořák Z.

Food Chem Toxicol. 2018 Jan;111:374-384. doi: 10.1016/j.fct.2017.11.049. Epub 2017 Nov 27.

PMID:
29191726
11.

Profiling of anthocyanidins against transcriptional activities of steroid and nuclear receptors.

Pastorková B, Illés P, Dvořák Z.

Drug Chem Toxicol. 2017 Oct 26:1-7. doi: 10.1080/01480545.2017.1380659. [Epub ahead of print]

PMID:
29072505
12.

Profiling of bisphenol S towards nuclear receptors activities in human reporter cell lines.

Zenata O, Dvorak Z, Vrzal R.

Toxicol Lett. 2017 Nov 5;281:10-19. doi: 10.1016/j.toxlet.2017.09.006. Epub 2017 Sep 12.

PMID:
28916285
13.

Involvement of aryl hydrocarbon receptor (AhR) in polyphenol inhibition of benzo[a]pyrene-induced oxidative stress and neoplastic transformation.

Dvorak Z.

Food Chem Toxicol. 2017 Sep;107(Pt A):523-525. doi: 10.1016/j.fct.2017.07.001. Epub 2017 Jul 1. No abstract available.

PMID:
28676325
14.

Molecular, cellular and pharmacological effects of platinum(II) diiodido complexes containing 9-deazahypoxanthine derivatives: A group of broad-spectrum anticancer active agents.

Vančo J, Trávníček Z, Křikavová R, Gáliková J, Dvořák Z, Chalupová M.

J Photochem Photobiol B. 2017 Aug;173:423-433. doi: 10.1016/j.jphotobiol.2017.06.017. Epub 2017 Jun 19.

PMID:
28662469
15.

Activated thyroid hormone receptor modulates dioxin-inducible aryl hydrocarbon receptor-mediated CYP1A1 induction in human hepatocytes but not in human hepatocarcinoma HepG2 cells.

Vrzal R, Vrzalova A, Grycova A, Dvorak Z.

Toxicol Lett. 2017 Jun 5;275:77-82. doi: 10.1016/j.toxlet.2017.05.001. Epub 2017 May 3.

PMID:
28478156
16.

Itraconazole cis-diastereoisomers activate aryl hydrocarbon receptor AhR and pregnane X receptor PXR and induce CYP1A1 in human cell lines and human hepatocytes.

Stepankova M, Pastorkova B, Bachleda P, Dvorak Z.

Toxicology. 2017 May 15;383:40-49. doi: 10.1016/j.tox.2017.04.002. Epub 2017 Apr 5.

PMID:
28390928
17.

Janus-faced Acrolein prevents allergy but accelerates tumor growth by promoting immunoregulatory Foxp3+ cells: Mouse model for passive respiratory exposure.

Roth-Walter F, Bergmayr C, Meitz S, Buchleitner S, Stremnitzer C, Fazekas J, Moskovskich A, Müller MA, Roth GA, Manzano-Szalai K, Dvorak Z, Neunkirchner A, Jensen-Jarolim E.

Sci Rep. 2017 Mar 23;7:45067. doi: 10.1038/srep45067.

18.

Hydroxystilbenes and methoxystilbenes activate human aryl hydrocarbon receptor and induce CYP1A genes in human hepatoma cells and human hepatocytes.

Pastorková B, Vrzalová A, Bachleda P, Dvořák Z.

Food Chem Toxicol. 2017 May;103:122-132. doi: 10.1016/j.fct.2017.03.008. Epub 2017 Mar 6.

PMID:
28279696
19.

In vitro modulatory effects of functionalized pyrimidines and piperidine derivatives on Aryl hydrocarbon receptor (AhR) and glucocorticoid receptor (GR) activities.

Yar M, Shahzadi L, Farooq A, Jalil Imran S, Cerón-Carrasco JP, den-Haan H, Kumar S, Peña-García J, Pérez-Sánchez H, Grycova A, Dvorak Z, Vrzal R.

Bioorg Chem. 2017 Apr;71:285-293. doi: 10.1016/j.bioorg.2017.02.013. Epub 2017 Feb 21.

PMID:
28267985
20.

Lipomodelling - advanced technique for the correction of Congenital hypoplastic breast malformations and deformities.

Streit L, Dražan L, Novák P, Schneiderová M, Dvořák Z, Teplá K, Veselý J.

Acta Chir Plast. Winter 2016;58(2):70-76.

PMID:
28079392
22.

In Vitro Antitumor Active Gold(I) Triphenylphosphane Complexes Containing 7-Azaindoles.

Štarha P, Trávníček Z, Drahoš B, Dvořák Z.

Int J Mol Sci. 2016 Dec 11;17(12). pii: E2084.

23.

Platinum(II) Iodido Complexes of 7-Azaindoles with Significant Antiproliferative Effects: An Old Story Revisited with Unexpected Outcomes.

Štarha P, Vančo J, Trávníček Z, Hošek J, Klusáková J, Dvořák Z.

PLoS One. 2016 Dec 1;11(12):e0165062. doi: 10.1371/journal.pone.0165062. eCollection 2016.

24.

Design and characterization of highly in vitro antitumor active ternary copper(II) complexes containing 2'-hydroxychalcone ligands.

Křikavová R, Vančo J, Trávníček Z, Hutyra J, Dvořák Z.

J Inorg Biochem. 2016 Oct;163:8-17. doi: 10.1016/j.jinorgbio.2016.07.005. Epub 2016 Jul 9.

PMID:
27423037
25.

Optical isomers of dihydropyridine calcium channel blockers display enantiospecific effects on the expression and enzyme activities of human xenobiotics-metabolizing cytochromes P450.

Štěpánková M, Krasulová K, Dořičáková A, Kurka O, Anzenbacher P, Dvořák Z.

Toxicol Lett. 2016 Nov 16;262:173-186. doi: 10.1016/j.toxlet.2016.10.005. Epub 2016 Oct 11.

PMID:
27732883
26.

Assessment of the aryl hydrocarbon receptor-mediated activities of polycyclic aromatic hydrocarbons in a human cell-based reporter gene assay.

Vondráček J, Pěnčíková K, Neča J, Ciganek M, Grycová A, Dvořák Z, Machala M.

Environ Pollut. 2017 Jan;220(Pt A):307-316. doi: 10.1016/j.envpol.2016.09.064. Epub 2016 Sep 29.

PMID:
27692884
27.

Transplant drugs affect the expression of phase II and antioxidant enzymes in human carcinoma cells HepG2 but not in primary cultures of human hepatocytes: In vitro comparative study.

Vrzal R, Illes P, Dvorak Z.

Pharmacol Rep. 2016 Oct;68(5):1008-14. doi: 10.1016/j.pharep.2016.06.001. Epub 2016 Jul 17.

PMID:
27428762
29.

Platinum(II) carboxylato complexes containing 7-azaindoles as N-donor carrier ligands showed cytotoxicity against cancer cell lines.

Štarha P, Trávníček Z, Pazderová L, Dvořák Z.

J Inorg Biochem. 2016 Sep;162:109-116. doi: 10.1016/j.jinorgbio.2016.06.018. Epub 2016 Jun 16.

PMID:
27350081
30.

Profiling of Vitamin D Metabolic Intermediates toward VDR Using Novel Stable Gene Reporter Cell Lines IZ-VDRE and IZ-CYP24.

Bartonkova I, Grycova A, Dvorak Z.

Chem Res Toxicol. 2016 Jul 18;29(7):1211-22. doi: 10.1021/acs.chemrestox.6b00170. Epub 2016 Jul 1.

PMID:
27327272
31.
32.

Mixed-ligand copper(II) complexes activate aryl hydrocarbon receptor AhR and induce CYP1A genes expression in human hepatocytes and human cell lines.

Kubešová K, Dořičáková A, Trávníček Z, Dvořák Z.

Toxicol Lett. 2016 Jul 25;255:24-35. doi: 10.1016/j.toxlet.2016.05.014. Epub 2016 May 12.

PMID:
27180721
33.

Structural changes in amber due to uranium mineralization.

Havelcová M, Machovič V, Mizera J, Sýkorová I, René M, Borecká L, Lapčák L, Bičáková O, Janeček O, Dvořák Z.

J Environ Radioact. 2016 Jul;158-159:89-101. doi: 10.1016/j.jenvrad.2016.04.004. Epub 2016 Apr 13.

PMID:
27085038
34.

Pivotal role of the aryl hydrocarbon receptor in modulations caused by benzo[a]pyrene and ketoconazole in the estrogenic responses induced by 17β-estradiol in male goldfish.

Dvorak Z.

Environ Sci Pollut Res Int. 2016 May;23(9):9247-8. doi: 10.1007/s11356-016-6387-9. Epub 2016 Mar 8. No abstract available.

PMID:
26951223
35.

Acetylation of lysine 109 modulates pregnane X receptor DNA binding and transcriptional activity.

Pasquel D, Doricakova A, Li H, Kortagere S, Krasowski MD, Biswas A, Walton WG, Redinbo MR, Dvorak Z, Mani S.

Biochim Biophys Acta. 2016 Sep;1859(9):1155-1169. doi: 10.1016/j.bbagrm.2016.01.006. Epub 2016 Feb 23.

36.

TWISTED DISTAL LATERAL ARM FLAP FOR IMMEDIATE RECONSTRUCTION OF THUMB AVULSION INJURY.

Hyza P, Streit L, Dvorak Z, Lombardo GA, Mrazek T, Vesely J.

Acta Chir Plast. 2015;57(1-2):13-6.

PMID:
26650108
37.

VASOSPASM OF THE FLAP PEDICLE--MAGNESIUM SULPHATE RELIEVES VASOSPASM OF AXIAL FLAP PEDICLE IN PORCINE MODEL.

Hyza P, Streit L, Gopfert ED, Dvorak Z, Stupka I, Schwarz D, Kubek T, Lombardo GA.

Acta Chir Plast. 2015;57(1-2):4-8.

PMID:
26650106
38.

Opportunities and challenges in using human hepatocytes in cytochromes P450 induction assays.

Dvorak Z.

Expert Opin Drug Metab Toxicol. 2016;12(2):169-74. doi: 10.1517/17425255.2016.1125881. Epub 2016 Jan 8. Review.

PMID:
26612411
39.

Reconstruction of a Nose Bitten and Eaten by a Dog: A Ten-Year Follow-up of a Bitten-Off Nose Replantation Performed on an Eleven-Year-Old Boy.

Stupka I, Dvorak Z, Vesely J, Novak P, Perrotta RE, Lombardo GA.

Ann Plast Surg. 2015 Dec;75(6):585-7. doi: 10.1097/SAP.0000000000000643.

PMID:
26418804
40.

Optical Isomers of Atorvastatin, Rosuvastatin and Fluvastatin Enantiospecifically Activate Pregnane X Receptor PXR and Induce CYP2A6, CYP2B6 and CYP3A4 in Human Hepatocytes.

Korhonova M, Doricakova A, Dvorak Z.

PLoS One. 2015 Sep 14;10(9):e0137720. doi: 10.1371/journal.pone.0137720. eCollection 2015.

41.

Impurities contained in antifungal drug ketoconazole are potent activators of human aryl hydrocarbon receptor.

Grycová A, Dořičáková A, Dvořák Z.

Toxicol Lett. 2015 Dec 3;239(2):67-72. doi: 10.1016/j.toxlet.2015.09.004. Epub 2015 Sep 9.

PMID:
26363502
42.

Enantiospecific effects of chiral drugs on cytochrome P450 inhibition in vitro.

Krasulova K, Siller M, Holas O, Dvorak Z, Anzenbacher P.

Xenobiotica. 2016;46(4):315-24. doi: 10.3109/00498254.2015.1076086. Epub 2015 Aug 24.

PMID:
26338061
43.

Highly and Broad-Spectrum In Vitro Antitumor Active cis-Dichloridoplatinum(II) Complexes with 7-Azaindoles.

Štarha P, Dvořák Z, Trávníček Z.

PLoS One. 2015 Aug 26;10(8):e0136338. doi: 10.1371/journal.pone.0136338. eCollection 2015.

44.

Development and Characterization of a Human Reporter Cell Line for the Assessment of Thyroid Receptor Transcriptional Activity: A Case of Organotin Endocrine Disruptors.

Illés P, Brtko J, Dvořák Z.

J Agric Food Chem. 2015 Aug 12;63(31):7074-83. doi: 10.1021/acs.jafc.5b01519. Epub 2015 Aug 3.

PMID:
26208032
45.

Environmental pollutants parathion, paraquat and bisphenol A show distinct effects towards nuclear receptors-mediated induction of xenobiotics-metabolizing cytochromes P450 in human hepatocytes.

Vrzal R, Zenata O, Doricakova A, Dvorak Z.

Toxicol Lett. 2015 Oct 1;238(1):43-53. doi: 10.1016/j.toxlet.2015.07.008. Epub 2015 Jul 18. Erratum in: Toxicol Lett. 2015 Nov 19;239(1):65.

PMID:
26196221
46.

The effects of drugs with immunosuppressive or immunomodulatory activities on xenobiotics-metabolizing enzymes expression in primary human hepatocytes.

Vrzal R, Zenata O, Bachleda P, Dvorak Z.

Toxicol In Vitro. 2015 Aug;29(5):1088-99. doi: 10.1016/j.tiv.2015.04.013. Epub 2015 Apr 28.

PMID:
25929522
47.

Agonistic effect of selected isoflavones on arylhydrocarbon receptor in a novel AZ-AhR transgenic gene reporter human cell line.

Bialesova L, Novotna A, Macejova D, Brtko J, Dvorak Z.

Gen Physiol Biophys. 2015 Jul;34(3):331-4. doi: 10.4149/gpb_2015008. Epub 2015 Apr 30.

PMID:
25926549
48.

Potentiating effect of UVA irradiation on anticancer activity of Carboplatin derivatives involving 7-azaindoles.

Štarha P, Trávníček Z, Dvořák Z, Radošová-Muchová T, Prachařová J, Vančo J, Kašpárková J.

PLoS One. 2015 Apr 15;10(4):e0123595. doi: 10.1371/journal.pone.0123595. eCollection 2015.

49.

The aryl hydrocarbon receptor-dependent disruption of contact inhibition in rat liver WB-F344 epithelial cells is linked with induction of survivin, but not with inhibition of apoptosis.

Svobodová J, Kabátková M, Šmerdová L, Brenerová P, Dvořák Z, Machala M, Vondráček J.

Toxicology. 2015 Jul 3;333:37-44. doi: 10.1016/j.tox.2015.04.001. Epub 2015 Apr 2.

PMID:
25843524
50.

Novel stably transfected human reporter cell line AIZ-AR as a tool for an assessment of human androgen receptor transcriptional activity.

Bartonkova I, Novotna A, Dvorak Z.

PLoS One. 2015 Mar 26;10(3):e0121316. doi: 10.1371/journal.pone.0121316. eCollection 2015.

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