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Unmasking the skiptic task of TDP-43.

Rouaux C, Gonzalez De Aguilar JL, Dupuis L.

EMBO J. 2018 May 16. pii: e99645. doi: 10.15252/embj.201899645. [Epub ahead of print] No abstract available.


Comparison of the Incorporation of DHA in Circulatory and Neural Tissue When Provided as Triacylglycerol (TAG), Monoacylglycerol (MAG) or Phospholipids (PL) Provides New Insight into Fatty Acid Bioavailability.

Destaillats F, Oliveira M, Bastic Schmid V, Masserey-Elmelegy I, Giuffrida F, Thakkar SK, Dupuis L, Gosoniu ML, Cruz-Hernandez C.

Nutrients. 2018 May 15;10(5). pii: E620. doi: 10.3390/nu10050620.


Paradox of amyotrophic lateral sclerosis and energy metabolism.

Ahmed RM, Dupuis L, Kiernan MC.

J Neurol Neurosurg Psychiatry. 2018 May 7. pii: jnnp-2018-318428. doi: 10.1136/jnnp-2018-318428. [Epub ahead of print] No abstract available.


Pharmacologic interventions for fatigue in cancer and transplantation: a meta-analysis.

Tomlinson D, Robinson PD, Oberoi S, Cataudella D, Culos-Reed N, Davis H, Duong N, Gibson F, Götte M, Hinds P, Nijhof SL, van der Torre P, Cabral S, Dupuis LL, Sung L.

Curr Oncol. 2018 Apr;25(2):e152-e167. doi: 10.3747/co.25.3883. Epub 2018 Apr 30. Review.


Safety of Dexamethasone for Nausea and Vomiting Prophylaxis in Children Receiving Hematopoietic Stem Cell Transplantation.

Sing EPC, Schechter T, Ali M, Sung L, Dupuis LL.

J Pediatr Hematol Oncol. 2018 Apr 26. doi: 10.1097/MPH.0000000000001186. [Epub ahead of print]


Validation of the Proxy Version of Symptom Screening in Pediatrics Tool in Children Receiving Cancer Treatments.

Hyslop S, Dupuis LL, Baggott C, Dix D, Gibson P, Kuczynski S, Johnston DL, Orsey A, Portwine C, Price V, Spiegler B, Tomlinson D, Vanan M, Tomlinson GA, Sung L.

J Pain Symptom Manage. 2018 Apr 6. pii: S0885-3924(18)30185-4. doi: 10.1016/j.jpainsymman.2018.03.025. [Epub ahead of print]


Describing symptoms using the Symptom Screening in Pediatrics Tool in hospitalized children with cancer and hematopoietic stem cell transplant recipients.

Johnston DL, Hyslop S, Tomlinson D, Baggott C, Gibson P, Orsey A, Dix D, Price V, Vanan M, Portwine C, Kuczynski S, Spiegler B, Tomlinson GA, Dupuis LL, Sung L.

Cancer Med. 2018 May;7(5):1750-1755. doi: 10.1002/cam4.1433. Epub 2018 Mar 23.


Chemotherapy-Colchicine Interaction in a Child with Familial Mediterranean Fever and Hodgkin Lymphoma.

Langenberg-Ververgaert KPS, Laxer RM, Punnett AS, Dupuis LL, Finkelstein Y, Abla O.

Mediterr J Hematol Infect Dis. 2018 Mar 1;10(1):e2018019. doi: 10.4084/MJHID.2018.019. eCollection 2018.


Association of Serum Retinol-Binding Protein 4 Concentration With Risk for and Prognosis of Amyotrophic Lateral Sclerosis.

Rosenbohm A, Nagel G, Peter RS, Brehme T, Koenig W, Dupuis L, Rothenbacher D, Ludolph AC; ALS Registry Study Group.

JAMA Neurol. 2018 Feb 26. doi: 10.1001/jamaneurol.2017.5129. [Epub ahead of print]


Physical activity reduces fatigue in patients with cancer and hematopoietic stem cell transplant recipients: A systematic review and meta-analysis of randomized trials.

Oberoi S, Robinson PD, Cataudella D, Culos-Reed SN, Davis H, Duong N, Gibson F, Götte M, Hinds P, Nijhof SL, Tomlinson D, van der Torre P, Cabral S, Dupuis LL, Sung L.

Crit Rev Oncol Hematol. 2018 Feb;122:52-59. doi: 10.1016/j.critrevonc.2017.12.011. Epub 2017 Dec 16. Review.


Periodic reanalysis of whole-genome sequencing data enhances the diagnostic advantage over standard clinical genetic testing.

Costain G, Jobling R, Walker S, Reuter MS, Snell M, Bowdin S, Cohn RD, Dupuis L, Hewson S, Mercimek-Andrews S, Shuman C, Sondheimer N, Weksberg R, Yoon G, Meyn MS, Stavropoulos DJ, Scherer SW, Mendoza-Londono R, Marshall CR.

Eur J Hum Genet. 2018 May;26(5):740-744. doi: 10.1038/s41431-018-0114-6. Epub 2018 Feb 16.


Hypothalamic Alterations in Neurodegenerative Diseases and Their Relation to Abnormal Energy Metabolism.

Vercruysse P, Vieau D, Blum D, Petersén Å, Dupuis L.

Front Mol Neurosci. 2018 Jan 19;11:2. doi: 10.3389/fnmol.2018.00002. eCollection 2018. Review.


Functional Dysregulation of CDC42 Causes Diverse Developmental Phenotypes.

Martinelli S, Krumbach OHF, Pantaleoni F, Coppola S, Amin E, Pannone L, Nouri K, Farina L, Dvorsky R, Lepri F, Buchholzer M, Konopatzki R, Walsh L, Payne K, Pierpont ME, Vergano SS, Langley KG, Larsen D, Farwell KD, Tang S, Mroske C, Gallotta I, Di Schiavi E, Della Monica M, Lugli L, Rossi C, Seri M, Cocchi G, Henderson L, Baskin B, Alders M, Mendoza-Londono R, Dupuis L, Nickerson DA, Chong JX; University of Washington Center for Mendelian Genomics, Meeks N, Brown K, Causey T, Cho MT, Demuth S, Digilio MC, Gelb BD, Bamshad MJ, Zenker M, Ahmadian MR, Hennekam RC, Tartaglia M, Mirzaa GM.

Am J Hum Genet. 2018 Jan 17. pii: S0002-9297(17)30504-9. doi: 10.1016/j.ajhg.2017.12.015. [Epub ahead of print]


Response to 'Aprepitant and fosaprepitant decrease the effectiveness of hormonal contraceptives'.

Patel P, Leeder JS, Piquette-Miller M, Dupuis LL.

Br J Clin Pharmacol. 2018 Mar;84(3):604. doi: 10.1111/bcp.13487. Epub 2018 Jan 6. No abstract available.


Could Conservative Iron Chelation Lead to Neuroprotection in Amyotrophic Lateral Sclerosis?

Moreau C, Danel V, Devedjian JC, Grolez G, Timmerman K, Laloux C, Petrault M, Gouel F, Jonneaux A, Dutheil M, Lachaud C, Lopes R, Kuchcinski G, Auger F, Kyheng M, Duhamel A, Pérez T, Pradat PF, Blasco H, Veyrat-Durebex C, Corcia P, Oeckl P, Otto M, Dupuis L, Garçon G, Defebvre L, Cabantchik ZI, Duce J, Bordet R, Devos D.

Antioxid Redox Signal. 2018 Feb 8. doi: 10.1089/ars.2017.7493. [Epub ahead of print]


Validation of the Symptom Screening in Pediatrics Tool in Children Receiving Cancer Treatments.

Dupuis LL, Johnston DL, Baggott C, Hyslop S, Tomlinson D, Gibson P, Orsey A, Dix D, Price V, Vanan M, Portwine C, Kuczynski S, Spiegler B, Tomlinson GA, Sung L.

J Natl Cancer Inst. 2017 Dec 20. doi: 10.1093/jnci/djx250. [Epub ahead of print]


Severe rhizomelic shortening in a child with a complex duplication/deletion rearrangement of chromosome X.

Deshwar AR, Dupuis L, Bergmann C, Stavropoulos J, Mendoza-Londono R.

Am J Med Genet A. 2018 Feb;176(2):450-454. doi: 10.1002/ajmg.a.38570. Epub 2017 Dec 22.


Acupressure bands do not improve chemotherapy-induced nausea control in pediatric patients receiving highly emetogenic chemotherapy: A single-blinded, randomized controlled trial.

Dupuis LL, Kelly KM, Krischer JP, Langevin AM, Tamura RN, Xu P, Chen L, Kolb EA, Ullrich NJ, Sahler OJZ, Hendershot E, Stratton A, Sung L, McLean TW.

Cancer. 2018 Mar 15;124(6):1188-1196. doi: 10.1002/cncr.31198. Epub 2017 Dec 19.


GSTA1 diplotypes affect busulfan clearance and toxicity in children undergoing allogeneic hematopoietic stem cell transplantation: a multicenter study.

Ansari M, Curtis PH, Uppugunduri CRS, Rezgui MA, Nava T, Mlakar V, Lesne L, Théoret Y, Chalandon Y, Dupuis LL, Schechter T, Bartelink IH, Boelens JJ, Bredius R, Dalle JH, Azarnoush S, Sedlacek P, Lewis V, Champagne M, Peters C, Bittencourt H, Krajinovic M.

Oncotarget. 2017 Aug 27;8(53):90852-90867. doi: 10.18632/oncotarget.20310. eCollection 2017 Oct 31.


Mind and body practices for fatigue reduction in patients with cancer and hematopoietic stem cell transplant recipients: A systematic review and meta-analysis.

Duong N, Davis H, Robinson PD, Oberoi S, Cataudella D, Culos-Reed SN, Gibson F, Götte M, Hinds P, Nijhof SL, Tomlinson D, van der Torre P, Ladas E, Cabral S, Dupuis LL, Sung L.

Crit Rev Oncol Hematol. 2017 Dec;120:210-216. doi: 10.1016/j.critrevonc.2017.11.011. Epub 2017 Nov 20. Review.


Life course body mass index and risk and prognosis of amyotrophic lateral sclerosis: results from the ALS registry Swabia.

Peter RS, Rosenbohm A, Dupuis L, Brehme T, Kassubek J, Rothenbacher D, Nagel G, Ludolph AC.

Eur J Epidemiol. 2017 Oct;32(10):901-908. doi: 10.1007/s10654-017-0318-z. Epub 2017 Oct 3.


Reversible induction of TDP-43 granules in cortical neurons after traumatic injury.

Wiesner D, Tar L, Linkus B, Chandrasekar A, Olde Heuvel F, Dupuis L, Tsao W, Wong PC, Ludolph A, Roselli F.

Exp Neurol. 2018 Jan;299(Pt A):15-25. doi: 10.1016/j.expneurol.2017.09.011. Epub 2017 Sep 21.


Degeneration of serotonin neurons triggers spasticity in amyotrophic lateral sclerosis.

El Oussini H, Scekic-Zahirovic J, Vercruysse P, Marques C, Dirrig-Grosch S, Dieterlé S, Picchiarelli G, Sinniger J, Rouaux C, Dupuis L.

Ann Neurol. 2017 Sep;82(3):444-456. doi: 10.1002/ana.25030.


Olanzapine for prevention of chemotherapy-induced nausea and vomiting in children and adolescents: a multi-center, feasibility study.

Flank J, Schechter T, Gibson P, Johnston DL, Orsey AD, Portwine C, Sung L, Dupuis LL.

Support Care Cancer. 2018 Feb;26(2):549-555. doi: 10.1007/s00520-017-3864-8. Epub 2017 Aug 30.


Proteomic Alterations Associated with Biomechanical Dysfunction are Early Processes in the Emilin1 Deficient Mouse Model of Aortic Valve Disease.

Angel PM, Narmoneva DA, Sewell-Loftin MK, Munjal C, Dupuis L, Landis BJ, Jegga A, Kern CB, Merryman WD, Baldwin HS, Bressan GM, Hinton RB.

Ann Biomed Eng. 2017 Nov;45(11):2548-2562. doi: 10.1007/s10439-017-1899-0. Epub 2017 Aug 15.


Antiemetics: American Society of Clinical Oncology Clinical Practice Guideline Update.

Hesketh PJ, Kris MG, Basch E, Bohlke K, Barbour SY, Clark-Snow RA, Danso MA, Dennis K, Dupuis LL, Dusetzina SB, Eng C, Feyer PC, Jordan K, Noonan K, Sparacio D, Somerfield MR, Lyman GH.

J Clin Oncol. 2017 Oct 1;35(28):3240-3261. doi: 10.1200/JCO.2017.74.4789. Epub 2017 Jul 31. Review.


Adipokines, C-reactive protein and Amyotrophic Lateral Sclerosis - results from a population- based ALS registry in Germany.

Nagel G, Peter RS, Rosenbohm A, Koenig W, Dupuis L, Rothenbacher D, Ludolph AC.

Sci Rep. 2017 Jun 29;7(1):4374. doi: 10.1038/s41598-017-04706-5.


Hypothalamic atrophy is related to body mass index and age at onset in amyotrophic lateral sclerosis.

Gorges M, Vercruysse P, Müller HP, Huppertz HJ, Rosenbohm A, Nagel G, Weydt P, Petersén Å, Ludolph AC, Kassubek J, Dupuis L.

J Neurol Neurosurg Psychiatry. 2017 Dec;88(12):1033-1041. doi: 10.1136/jnnp-2017-315795. Epub 2017 Jun 8.


The burden of chemotherapy-induced nausea and vomiting in children receiving hematopoietic stem cell transplantation conditioning: a prospective study.

Flank J, Sparavalo J, Vol H, Hagen L, Stuhler R, Chong D, Courtney S, Doyle JJ, Gassas A, Schechter T, Dupuis LL.

Bone Marrow Transplant. 2017 Sep;52(9):1294-1299. doi: 10.1038/bmt.2017.112. Epub 2017 Jun 5.


The genetic landscape of familial congenital hydrocephalus.

Shaheen R, Sebai MA, Patel N, Ewida N, Kurdi W, Altweijri I, Sogaty S, Almardawi E, Seidahmed MZ, Alnemri A, Madirevula S, Ibrahim N, Abdulwahab F, Hashem M, Al-Sheddi T, Alomar R, Alobeid E, Sallout B, AlBaqawi B, AlAali W, Ajaji N, Lesmana H, Hopkin RJ, Dupuis L, Mendoza-Londono R, Al Rukban H, Yoon G, Faqeih E, Alkuraya FS.

Ann Neurol. 2017 Jun;81(6):890-897. doi: 10.1002/ana.24964.


A Dual Palladium and Copper Hydride Catalyzed Approach for Alkyl-Aryl Cross-Coupling of Aryl Halides and Olefins.

Friis SD, Pirnot MT, Dupuis LN, Buchwald SL.

Angew Chem Int Ed Engl. 2017 Jun 12;56(25):7242-7246. doi: 10.1002/anie.201703400. Epub 2017 May 16.


Nausea and vomiting in children and adolescents receiving intrathecal methotrexate: A prospective, observational study.

Flank J, Nadeem K, Moledina S, Khanna M, Schindera C, Punnett A, Dupuis LL.

Pediatr Blood Cancer. 2017 Oct;64(10). doi: 10.1002/pbc.26603. Epub 2017 May 13.


Self-report of symptoms in children with cancer younger than 8 years of age: a systematic review.

Tomlinson D, Tigelaar L, Hyslop S, Lazor T, Dupuis LL, Griener K, Oliveria J, Sung L.

Support Care Cancer. 2017 Aug;25(8):2663-2670. doi: 10.1007/s00520-017-3740-6. Epub 2017 May 12. Review.


CHARGE and Kabuki Syndromes: Gene-Specific DNA Methylation Signatures Identify Epigenetic Mechanisms Linking These Clinically Overlapping Conditions.

Butcher DT, Cytrynbaum C, Turinsky AL, Siu MT, Inbar-Feigenberg M, Mendoza-Londono R, Chitayat D, Walker S, Machado J, Caluseriu O, Dupuis L, Grafodatskaya D, Reardon W, Gilbert-Dussardier B, Verloes A, Bilan F, Milunsky JM, Basran R, Papsin B, Stockley TL, Scherer SW, Choufani S, Brudno M, Weksberg R.

Am J Hum Genet. 2017 May 4;100(5):773-788. doi: 10.1016/j.ajhg.2017.04.004.


Aprepitant and fosaprepitant drug interactions: a systematic review.

Patel P, Leeder JS, Piquette-Miller M, Dupuis LL.

Br J Clin Pharmacol. 2017 Oct;83(10):2148-2162. doi: 10.1111/bcp.13322. Epub 2017 Jun 10.


Guideline for the Management of Fever and Neutropenia in Children With Cancer and Hematopoietic Stem-Cell Transplantation Recipients: 2017 Update.

Lehrnbecher T, Robinson P, Fisher B, Alexander S, Ammann RA, Beauchemin M, Carlesse F, Groll AH, Haeusler GM, Santolaya M, Steinbach WJ, Castagnola E, Davis BL, Dupuis LL, Gaur AH, Tissing WJE, Zaoutis T, Phillips R, Sung L.

J Clin Oncol. 2017 Jun 20;35(18):2082-2094. doi: 10.1200/JCO.2016.71.7017. Epub 2017 May 1. Review.


Guideline for the prevention of acute chemotherapy-induced nausea and vomiting in pediatric cancer patients: A focused update.

Patel P, Robinson PD, Thackray J, Flank J, Holdsworth MT, Gibson P, Orsey A, Portwine C, Freedman J, Madden JR, Phillips R, Sung L, Dupuis LL.

Pediatr Blood Cancer. 2017 Oct;64(10). doi: 10.1002/pbc.26542. Epub 2017 Apr 28. Review.


In ovo vaccination using Eimeria profilin and Clostridium perfringens NetB proteins in Montanide IMS adjuvant increases protective immunity against experimentally-induced necrotic enteritis.

Lillehoj HS, Jang SI, Panebra A, Lillehoj EP, Dupuis L, Ben Arous J, Lee SK, Oh ST.

Asian-Australas J Anim Sci. 2017 Oct;30(10):1478-1485. doi: 10.5713/ajas.17.0053. Epub 2017 Mar 21.


Motor neuron intrinsic and extrinsic mechanisms contribute to the pathogenesis of FUS-associated amyotrophic lateral sclerosis.

Scekic-Zahirovic J, Oussini HE, Mersmann S, Drenner K, Wagner M, Sun Y, Allmeroth K, Dieterlé S, Sinniger J, Dirrig-Grosch S, René F, Dormann D, Haass C, Ludolph AC, Lagier-Tourenne C, Storkebaum E, Dupuis L.

Acta Neuropathol. 2017 Jun;133(6):887-906. doi: 10.1007/s00401-017-1687-9. Epub 2017 Feb 28.


Debunking Occam's razor: Diagnosing multiple genetic diseases in families by whole-exome sequencing.

Balci TB, Hartley T, Xi Y, Dyment DA, Beaulieu CL, Bernier FP, Dupuis L, Horvath GA, Mendoza-Londono R, Prasad C, Richer J, Yang XR, Armour CM, Bareke E, Fernandez BA, McMillan HJ, Lamont RE, Majewski J, Parboosingh JS, Prasad AN, Rupar CA, Schwartzentruber J, Smith AC, Tétreault M; FORGE Canada Consortium; Care4Rare Canada Consortium, Innes AM, Boycott KM.

Clin Genet. 2017 Sep;92(3):281-289. doi: 10.1111/cge.12987. Epub 2017 Mar 13.


Mutations in EXTL3 Cause Neuro-immuno-skeletal Dysplasia Syndrome.

Oud MM, Tuijnenburg P, Hempel M, van Vlies N, Ren Z, Ferdinandusse S, Jansen MH, Santer R, Johannsen J, Bacchelli C, Alders M, Li R, Davies R, Dupuis L, Cale CM, Wanders RJA, Pals ST, Ocaka L, James C, Müller I, Lehmberg K, Strom T, Engels H, Williams HJ, Beales P, Roepman R, Dias P, Brunner HG, Cobben JM, Hall C, Hartley T, Le Quesne Stabej P, Mendoza-Londono R, Davies EG, de Sousa SB, Lessel D, Arts HH, Kuijpers TW.

Am J Hum Genet. 2017 Feb 2;100(2):281-296. doi: 10.1016/j.ajhg.2017.01.013. Epub 2017 Jan 26.


The importance of evidence-based supportive care practice guidelines in childhood cancer-a plea for their development and implementation.

Loeffen EA, Kremer LC, Mulder RL, Font-Gonzalez A, Dupuis LL, Sung L, Robinson PD, van de Wetering MD, Tissing WJ.

Support Care Cancer. 2017 Apr;25(4):1121-1125. doi: 10.1007/s00520-016-3501-y. Epub 2016 Dec 8.


Long-term reduction in food allergy susceptibility in mice by combining breastfeeding-induced tolerance and TGF-β-enriched formula after weaning.

Rekima A, Macchiaverni P, Turfkruyer M, Holvoet S, Dupuis L, Baiz N, Annesi-Maesano I, Mercenier A, Nutten S, Verhasselt V.

Clin Exp Allergy. 2017 Apr;47(4):565-576. doi: 10.1111/cea.12864. Epub 2017 Jan 26.


ALS-causing mutations differentially affect PGC-1α expression and function in the brain vs. peripheral tissues.

Bayer H, Lang K, Buck E, Higelin J, Barteczko L, Pasquarelli N, Sprissler J, Lucas T, Holzmann K, Demestre M, Lindenberg KS, Danzer KM, Boeckers T, Ludolph AC, Dupuis L, Weydt P, Witting A.

Neurobiol Dis. 2017 Jan;97(Pt A):36-45. doi: 10.1016/j.nbd.2016.11.001. Epub 2016 Nov 3.


Mechano-chemical Interactions in Cardiac Sarcomere Contraction: A Computational Modeling Study.

Dupuis LJ, Lumens J, Arts T, Delhaas T.

PLoS Comput Biol. 2016 Oct 7;12(10):e1005126. doi: 10.1371/journal.pcbi.1005126. eCollection 2016 Oct.


Body fat distribution in Parkinson's disease: An MRI-based body fat quantification study.

Bernhardt D, Müller HP, Ludolph AC, Dupuis L, Kassubek J.

Parkinsonism Relat Disord. 2016 Dec;33:84-89. doi: 10.1016/j.parkreldis.2016.09.016. Epub 2016 Sep 16.


2016 MASCC and ESMO guideline update for the prevention of chemotherapy- and radiotherapy-induced nausea and vomiting and of nausea and vomiting in advanced cancer patients.

Roila F, Molassiotis A, Herrstedt J, Aapro M, Gralla RJ, Bruera E, Clark-Snow RA, Dupuis LL, Einhorn LH, Feyer P, Hesketh PJ, Jordan K, Olver I, Rapoport BL, Roscoe J, Ruhlmann CH, Walsh D, Warr D, van der Wetering M; participants of the MASCC/ESMO Consensus Conference Copenhagen 2015.

Ann Oncol. 2016 Sep;27(suppl 5):v119-v133. No abstract available.


2016 updated MASCC/ESMO consensus recommendations: Prevention of acute chemotherapy-induced nausea and vomiting in children.

Dupuis LL, Sung L, Molassiotis A, Orsey AD, Tissing W, van de Wetering M.

Support Care Cancer. 2017 Jan;25(1):323-331. Epub 2016 Aug 26.


2016 updated MASCC/ESMO consensus recommendations: Anticipatory nausea and vomiting in children and adults receiving chemotherapy.

Dupuis LL, Roscoe JA, Olver I, Aapro M, Molassiotis A.

Support Care Cancer. 2017 Jan;25(1):317-321. Epub 2016 Aug 10.


Development of myotendinous-like junctions that anchor cardiac valves requires fibromodulin and lumican.

Dupuis LE, Doucette L, Rice AK, Lancaster AE, Berger MG, Chakravarti S, Kern CB.

Dev Dyn. 2016 Oct;245(10):1029-42. doi: 10.1002/dvdy.24435. Epub 2016 Aug 25.

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