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Pharmacokinetics and Toxicology of the Neuroprotective e,e,e-Methanofullerene(60)-63-tris Malonic Acid [C3] in Mice and Primates.

Hardt JI, Perlmutter JS, Smith CJ, Quick KL, Wei L, Chakraborty SK, Dugan LL.

Eur J Drug Metab Pharmacokinet. 2018 Mar 8. doi: 10.1007/s13318-018-0464-z. [Epub ahead of print]


Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.

Tkavc R, Matrosova VY, Grichenko OE, Gostinčar C, Volpe RP, Klimenkova P, Gaidamakova EK, Zhou CE, Stewart BJ, Lyman MG, Malfatti SA, Rubinfeld B, Courtot M, Singh J, Dalgard CL, Hamilton T, Frey KG, Gunde-Cimerman N, Dugan L, Daly MJ.

Front Microbiol. 2018 Jan 8;8:2528. doi: 10.3389/fmicb.2017.02528. eCollection 2017.


Rhodotorula taiwanensis MD1149 produces hypoacetylated PEFA compounds with increased surface activity compared to Rhodotorula babjevae MD1169.

Lyman M, Rubinfeld B, Leif R, Mulcahy H, Dugan L, Souza B.

PLoS One. 2018 Jan 2;13(1):e0190373. doi: 10.1371/journal.pone.0190373. eCollection 2018.


When Enough Is Enough: Decision Criteria for Moving a Known Drug into Clinical Testing for a New Indication in the Absence of Preclinical Efficacy Data.

Pulley JM, Jerome RN, Zaleski NM, Shirey-Rice JK, Pruijssers AJ, Lavieri RR, Chettiar SN, Naylor HM, Aronoff DM, Edwards DA, Niswender CM, Dugan LL, Crofford LJ, Bernard GR, Holroyd KJ.

Assay Drug Dev Technol. 2017 Dec;15(8):354-361. doi: 10.1089/adt.2017.821. Epub 2017 Dec 1.


Development of a Positron Emission Tomography Radiotracer for Imaging Elevated Levels of Superoxide in Neuroinflammation.

Hou C, Hsieh CJ, Li S, Lee H, Graham TJ, Xu K, Weng CC, Doot RK, Chu W, Chakraborty SK, Dugan LL, Mintun MA, Mach RH.

ACS Chem Neurosci. 2018 Mar 21;9(3):578-586. doi: 10.1021/acschemneuro.7b00385. Epub 2017 Dec 3.


Androgen receptor expression on circulating tumor cells in metastatic breast cancer.

Fujii T, Reuben JM, Huo L, Espinosa Fernandez JR, Gong Y, Krupa R, Suraneni MV, Graf RP, Lee J, Greene S, Rodriguez A, Dugan L, Louw J, Lim B, Barcenas CH, Marx AN, Tripathy D, Wang Y, Landers M, Dittamore R, Ueno NT.

PLoS One. 2017 Sep 28;12(9):e0185231. doi: 10.1371/journal.pone.0185231. eCollection 2017.


Phenotypic Heterogeneity of Circulating Tumor Cells Informs Clinical Decisions between AR Signaling Inhibitors and Taxanes in Metastatic Prostate Cancer.

Scher HI, Graf RP, Schreiber NA, McLaughlin B, Jendrisak A, Wang Y, Lee J, Greene S, Krupa R, Lu D, Bamford P, Louw JE, Dugan L, Vargas HA, Fleisher M, Landers M, Heller G, Dittamore R.

Cancer Res. 2017 Oct 15;77(20):5687-5698. doi: 10.1158/0008-5472.CAN-17-1353. Epub 2017 Aug 17.


A comprehensive multi-omics approach uncovers adaptations for growth and survival of Pseudomonas aeruginosa on n-alkanes.

Grady SL, Malfatti SA, Gunasekera TS, Dalley BK, Lyman MG, Striebich RC, Mayhew MB, Zhou CL, Ruiz ON, Dugan LC.

BMC Genomics. 2017 Apr 28;18(1):334. doi: 10.1186/s12864-017-3708-4.


Cellular Expression of PD-L1 in the Peripheral Blood of Lung Cancer Patients is Associated with Worse Survival.

Boffa DJ, Graf RP, Salazar MC, Hoag J, Lu D, Krupa R, Louw J, Dugan L, Wang Y, Landers M, Suraneni M, Greene SB, Magaña M, Makani S, Bazhenova L, Dittamore RV, Nieva J.

Cancer Epidemiol Biomarkers Prev. 2017 Jul;26(7):1139-1145. doi: 10.1158/1055-9965.EPI-17-0120. Epub 2017 Apr 26.


Transcriptomic Analyses Elucidate Adaptive Differences of Closely Related Strains of Pseudomonas aeruginosa in Fuel.

Gunasekera TS, Bowen LL, Zhou CE, Howard-Byerly SC, Foley WS, Striebich RC, Dugan LC, Ruiz ON.

Appl Environ Microbiol. 2017 May 1;83(10). pii: e03249-16. doi: 10.1128/AEM.03249-16. Print 2017 May 15.


Nuclear-specific AR-V7 Protein Localization is Necessary to Guide Treatment Selection in Metastatic Castration-resistant Prostate Cancer.

Scher HI, Graf RP, Schreiber NA, McLaughlin B, Lu D, Louw J, Danila DC, Dugan L, Johnson A, Heller G, Fleisher M, Dittamore R.

Eur Urol. 2017 Jun;71(6):874-882. doi: 10.1016/j.eururo.2016.11.024. Epub 2016 Dec 12.


Transcriptomic analysis of the highly efficient oil-degrading bacterium Acinetobacter venetianus RAG-1 reveals genes important in dodecane uptake and utilization.

Kothari A, Charrier M, Wu YW, Malfatti S, Zhou CE, Singer SW, Dugan L, Mukhopadhyay A.

FEMS Microbiol Lett. 2016 Oct;363(20). pii: fnw224. Epub 2016 Sep 22.


Programmed death-ligand 1 (PD-L1) characterization of circulating tumor cells (CTCs) in muscle invasive and metastatic bladder cancer patients.

Anantharaman A, Friedlander T, Lu D, Krupa R, Premasekharan G, Hough J, Edwards M, Paz R, Lindquist K, Graf R, Jendrisak A, Louw J, Dugan L, Baird S, Wang Y, Dittamore R, Paris PL.

BMC Cancer. 2016 Sep 22;16(1):744.


Carboxyfullerene neuroprotection postinjury in Parkinsonian nonhuman primates.

Dugan LL, Tian L, Quick KL, Hardt JI, Karimi M, Brown C, Loftin S, Flores H, Moerlein SM, Polich J, Tabbal SD, Mink JW, Perlmutter JS.

Ann Neurol. 2014 Sep;76(3):393-402. doi: 10.1002/ana.24220. Epub 2014 Jul 22.


Development of a PET radiotracer for non-invasive imaging of the reactive oxygen species, superoxide, in vivo.

Chu W, Chepetan A, Zhou D, Shoghi KI, Xu J, Dugan LL, Gropler RJ, Mintun MA, Mach RH.

Org Biomol Chem. 2014 Jul 7;12(25):4421-31. doi: 10.1039/c3ob42379d.


AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function.

Dugan LL, You YH, Ali SS, Diamond-Stanic M, Miyamoto S, DeCleves AE, Andreyev A, Quach T, Ly S, Shekhtman G, Nguyen W, Chepetan A, Le TP, Wang L, Xu M, Paik KP, Fogo A, Viollet B, Murphy A, Brosius F, Naviaux RK, Sharma K.

J Clin Invest. 2013 Nov;123(11):4888-99. doi: 10.1172/JCI66218. Epub 2013 Oct 25.


Incidence and cost of nurse workplace violence perpetrated by hospital patients or patient visitors.

Speroni KG, Fitch T, Dawson E, Dugan L, Atherton M.

J Emerg Nurs. 2014 May;40(3):218-28; quiz 295. doi: 10.1016/j.jen.2013.05.014. Epub 2013 Sep 17.


nNOS(+) striatal neurons, a subpopulation spared in Huntington's Disease, possess functional NMDA receptors but fail to generate mitochondrial ROS in response to an excitotoxic challenge.

Canzoniero LM, Granzotto A, Turetsky DM, Choi DW, Dugan LL, Sensi SL.

Front Physiol. 2013 May 16;4:112. doi: 10.3389/fphys.2013.00112. eCollection 2013.


Antipurinergic therapy corrects the autism-like features in the poly(IC) mouse model.

Naviaux RK, Zolkipli Z, Wang L, Nakayama T, Naviaux JC, Le TP, Schuchbauer MA, Rogac M, Tang Q, Dugan LL, Powell SB.

PLoS One. 2013;8(3):e57380. doi: 10.1371/journal.pone.0057380. Epub 2013 Mar 13.


Detection of Bacillus anthracis from spores and cells by loop-mediated isothermal amplification without sample preparation.

Dugan L, Bearinger J, Hinckley A, Strout C, Souza B.

J Microbiol Methods. 2012 Sep;90(3):280-4. doi: 10.1016/j.mimet.2012.05.022. Epub 2012 Jun 5.


Hypoxia-adaptation involves mitochondrial metabolic depression and decreased ROS leakage.

Ali SS, Hsiao M, Zhao HW, Dugan LL, Haddad GG, Zhou D.

PLoS One. 2012;7(5):e36801. doi: 10.1371/journal.pone.0036801. Epub 2012 May 4.


An in vitro ischemic penumbral mimic perfusate increases NADPH oxidase-mediated superoxide production in cultured hippocampal neurons.

Pamenter ME, Ali SS, Tang Q, Finley JC, Gu XQ, Dugan LL, Haddad GG.

Brain Res. 2012 May 3;1452:165-72. doi: 10.1016/j.brainres.2012.03.004. Epub 2012 Mar 9.


Dynamic optical imaging of metabolic and NADPH oxidase-derived superoxide in live mouse brain using fluorescence lifetime unmixing.

Hall DJ, Han SH, Chepetan A, Inui EG, Rogers M, Dugan LL.

J Cereb Blood Flow Metab. 2012 Jan;32(1):23-32. doi: 10.1038/jcbfm.2011.119. Epub 2011 Aug 17. Erratum in: J Cereb Blood Flow Metab. 2012 Feb;32(2):400.


Comparative effectiveness of standard endotracheal tubes vs. endotracheal tubes with continuous subglottic suctioning on ventilator-associated pneumonia rates.

Speroni KG, Lucas J, Dugan L, O'Meara-Lett M, Putman M, Daniel M, Atherton M.

Nurs Econ. 2011 Jan-Feb;29(1):15-20, 37.


Development and initial results of a low cost, disposable, point-of-care testing device for pathogen detection.

Bearinger JP, Dugan LC, Baker BR, Hall SB, Ebert K, Mioulet V, Madi M, King DP.

IEEE Trans Biomed Eng. 2011 Mar;58(3):805-8. doi: 10.1109/TBME.2010.2089054.


Initial evidence linking synaptic superoxide production with poor short-term memory in aged mice.

Ali SS, Young JW, Wallace CK, Gresack J, Jeste DV, Geyer MA, Dugan LL, Risbrough VB.

Brain Res. 2011 Jan 12;1368:65-70. doi: 10.1016/j.brainres.2010.11.009. Epub 2010 Nov 11.


Metabolic depression and increased reactive oxygen species production by isolated mitochondria at moderately lower temperatures.

Ali SS, Marcondes MC, Bajova H, Dugan LL, Conti B.

J Biol Chem. 2010 Oct 15;285(42):32522-8. doi: 10.1074/jbc.M110.155432. Epub 2010 Aug 17.


A 2-tier study of direct care providers assessing the effectiveness of the red rule education project and precipitating factors surrounding red rule violations.

O'Neil S, Speroni KG, Dugan L, Daniel MG.

Qual Manag Health Care. 2010 Jul-Sep;19(3):259-64. doi: 10.1097/QMH.0b013e3181eaa1b4.


Neuronal death during combined intermittent hypoxia/hypercapnia is due to mitochondrial dysfunction.

Douglas RM, Ryu J, Kanaan A, Del Carmen Rivero M, Dugan LL, Haddad GG, Ali SS.

Am J Physiol Cell Physiol. 2010 Jun;298(6):C1594-602. doi: 10.1152/ajpcell.00298.2009. Epub 2010 Mar 31.


A comparison of the quality of blood specimens drawn in the field by EMS versus specimens obtained in the emergency department.

Harrison G, Speroni KG, Dugan L, Daniel MG.

J Emerg Nurs. 2010 Jan;36(1):16-20. doi: 10.1016/j.jen.2008.11.001. Epub 2009 Feb 13.


IL-6 mediated degeneration of forebrain GABAergic interneurons and cognitive impairment in aged mice through activation of neuronal NADPH oxidase.

Dugan LL, Ali SS, Shekhtman G, Roberts AJ, Lucero J, Quick KL, Behrens MM.

PLoS One. 2009;4(5):e5518. doi: 10.1371/journal.pone.0005518. Epub 2009 May 13.


Porphyrin-based photocatalytic nanolithography: a new fabrication tool for protein arrays.

Bearinger JP, Stone G, Dugan LC, El Dasher B, Stockton C, Conway JW, Kuenzler T, Hubbell JA.

Mol Cell Proteomics. 2009 Aug;8(8):1823-31. doi: 10.1074/mcp.M800585-MCP200. Epub 2009 Apr 29.


Chemical tethering of motile bacteria to silicon surfaces.

Bearinger J, Dugan L, Wu L, Hill H, Christian A, Hubbell J.

Biotechniques. 2009 Mar;46(3):209-16. doi: 10.2144/000113073.


Phototocatalytic lithography of poly(propylene sulfide) block copolymers: toward high-throughput nanolithography for biomolecular arraying applications.

Bearinger JP, Stone G, Hiddessen AL, Dugan LC, Wu L, Hailey P, Conway JW, Kuenzler T, Feller L, Cerritelli S, Hubbell JA.

Langmuir. 2009 Jan 20;25(2):1238-44. doi: 10.1021/la802727s.


Interleukin-6 mediates the increase in NADPH-oxidase in the ketamine model of schizophrenia.

Behrens MM, Ali SS, Dugan LL.

J Neurosci. 2008 Dec 17;28(51):13957-66. doi: 10.1523/JNEUROSCI.4457-08.2008.


SOD activity of carboxyfullerenes predicts their neuroprotective efficacy: a structure-activity study.

Ali SS, Hardt JI, Dugan LL.

Nanomedicine. 2008 Dec;4(4):283-94. doi: 10.1016/j.nano.2008.05.003. Epub 2008 Jul 24.


Porphyrin-based photocatalytic lithography.

Bearinger JP, Stone G, Christian AT, Dugan L, Hiddessen AL, Wu KJ, Wu L, Hamilton J, Stockton C, Hubbell JA.

Langmuir. 2008 May 6;24(9):5179-84. doi: 10.1021/la703992r. Epub 2008 Apr 2.


Prolonged alpha-tocopherol deficiency decreases oxidative stress and unmasks alpha-tocopherol-dependent regulation of mitochondrial function in the brain.

Cuddihy SL, Ali SS, Musiek ES, Lucero J, Kopp SJ, Morrow JD, Dugan LL.

J Biol Chem. 2008 Mar 14;283(11):6915-24. doi: 10.1074/jbc.M702572200. Epub 2008 Jan 7.


Ketamine-induced loss of phenotype of fast-spiking interneurons is mediated by NADPH-oxidase.

Behrens MM, Ali SS, Dao DN, Lucero J, Shekhtman G, Quick KL, Dugan LL.

Science. 2007 Dec 7;318(5856):1645-7.


Gender differences in free radical homeostasis during aging: shorter-lived female C57BL6 mice have increased oxidative stress.

Ali SS, Xiong C, Lucero J, Behrens MM, Dugan LL, Quick KL.

Aging Cell. 2006 Dec;5(6):565-74.


A carboxyfullerene SOD mimetic improves cognition and extends the lifespan of mice.

Quick KL, Ali SS, Arch R, Xiong C, Wozniak D, Dugan LL.

Neurobiol Aging. 2008 Jan;29(1):117-28. Epub 2006 Oct 31.


Perihematomal mitochondrial dysfunction after intracerebral hemorrhage.

Kim-Han JS, Kopp SJ, Dugan LL, Diringer MN.

Stroke. 2006 Oct;37(10):2457-62. Epub 2006 Sep 7. Erratum in: Stroke. 2006 Dec;37(12):3057.


Factors affecting hemolysis rates in blood samples drawn from newly placed IV sites in the emergency department.

Dugan L, Leech L, Speroni KG, Corriher J.

J Emerg Nurs. 2005 Aug;31(4):338-45.


Mitochondrial uncoupling proteins in the central nervous system.

Kim-Han JS, Dugan LL.

Antioxid Redox Signal. 2005 Sep-Oct;7(9-10):1173-81. Review.


Reactive oxygen species and aging: evolving questions.

Dugan LL, Quick KL.

Sci Aging Knowledge Environ. 2005 Jun 29;2005(26):pe20. Review.


Polymerase chain reaction-based suppression of repetitive sequences in whole chromosome painting probes for FISH.

Dugan LC, Pattee MS, Williams J, Eklund M, Sorensen K, Bedford JS, Christian AT.

Chromosome Res. 2005;13(1):27-32.


Long-term vitamin E deficiency in mice decreases superoxide radical production in brain.

Cuddihy SL, Musiek ES, Morrow JD, Dugan LL.

Ann N Y Acad Sci. 2004 Dec;1031:428-31.


A biologically effective fullerene (C60) derivative with superoxide dismutase mimetic properties.

Ali SS, Hardt JI, Quick KL, Kim-Han JS, Erlanger BF, Huang TT, Epstein CJ, Dugan LL.

Free Radic Biol Med. 2004 Oct 15;37(8):1191-202.


Astrocyte mitochondria in in vitro models of ischemia.

Dugan LL, Kim-Han JS.

J Bioenerg Biomembr. 2004 Aug;36(4):317-21. Review.


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