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Items: 27


Stress-Triggered Phase Separation Is an Adaptive, Evolutionarily Tuned Response.

Riback JA, Katanski CD, Kear-Scott JL, Pilipenko EV, Rojek AE, Sosnick TR, Drummond DA.

Cell. 2017 Mar 9;168(6):1028-1040.e19. doi: 10.1016/j.cell.2017.02.027.


Heat Shock Factor 1: From Fire Chief to Crowd-Control Specialist.

Triandafillou CG, Drummond DA.

Mol Cell. 2016 Jul 7;63(1):1-2. doi: 10.1016/j.molcel.2016.06.026.


Reversible, Specific, Active Aggregates of Endogenous Proteins Assemble upon Heat Stress.

Wallace EW, Kear-Scott JL, Pilipenko EV, Schwartz MH, Laskowski PR, Rojek AE, Katanski CD, Riback JA, Dion MF, Franks AM, Airoldi EM, Pan T, Budnik BA, Drummond DA.

Cell. 2015 Sep 10;162(6):1286-98. doi: 10.1016/j.cell.2015.08.041.


Dying mRNA Tells a Story of Its Life.

Wallace EW, Drummond DA.

Cell. 2015 Jun 4;161(6):1246-8. doi: 10.1016/j.cell.2015.05.043.


Estimating a structured covariance matrix from multi-lab measurements in high-throughput biology.

Franks AM, Csárdi G, Drummond DA, Airoldi EM.

J Am Stat Assoc. 2015 Mar 1;110(509):27-44.


Accounting for experimental noise reveals that mRNA levels, amplified by post-transcriptional processes, largely determine steady-state protein levels in yeast.

Csárdi G, Franks A, Choi DS, Airoldi EM, Drummond DA.

PLoS Genet. 2015 May 7;11(5):e1005206. doi: 10.1371/journal.pgen.1005206. eCollection 2015 May.


Correction: A nutrient-driven tRNA modification alters translational fidelity and genome-wide protein coding across an animal genus.

Zaborske JM, Bauer DuMont VL, Wallace EW, Pan T, Aquadro CF, Drummond DA.

PLoS Biol. 2015 Apr 29;13(4):e1002150. doi: 10.1371/journal.pbio.1002150. eCollection 2015 Apr.


A nutrient-driven tRNA modification alters translational fidelity and genome-wide protein coding across an animal genus.

Zaborske JM, DuMont VL, Wallace EW, Pan T, Aquadro CF, Drummond DA.

PLoS Biol. 2014 Dec 9;12(12):e1002015. doi: 10.1371/journal.pbio.1002015. eCollection 2014 Dec. Erratum in: PLoS Biol. 2015 Apr;13(4):e1002150.


Quantifying condition-dependent intracellular protein levels enables high-precision fitness estimates.

Geiler-Samerotte KA, Hashimoto T, Dion MF, Budnik BA, Airoldi EM, Drummond DA.

PLoS One. 2013 Sep 25;8(9):e75320. doi: 10.1371/journal.pone.0075320. eCollection 2013. Erratum in: PLoS One. 2013;8(10). doi:10.1371/annotation/9f5465d9-e9fa-4a80-84ca-9c9a3f6e82c7.


Estimating selection on synonymous codon usage from noisy experimental data.

Wallace EW, Airoldi EM, Drummond DA.

Mol Biol Evol. 2013 Jun;30(6):1438-53. doi: 10.1093/molbev/mst051. Epub 2013 Mar 14.


How infidelity creates a sticky situation.

Drummond DA.

Mol Cell. 2012 Dec 14;48(5):663-4. doi: 10.1016/j.molcel.2012.11.024.


Good codons, bad transcript: large reductions in gene expression and fitness arising from synonymous mutations in a key enzyme.

Agashe D, Martinez-Gomez NC, Drummond DA, Marx CJ.

Mol Biol Evol. 2013 Mar;30(3):549-60. doi: 10.1093/molbev/mss273. Epub 2012 Dec 4.


Misfolded proteins impose a dosage-dependent fitness cost and trigger a cytosolic unfolded protein response in yeast.

Geiler-Samerotte KA, Dion MF, Budnik BA, Wang SM, Hartl DL, Drummond DA.

Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):680-5. doi: 10.1073/pnas.1017570108. Epub 2010 Dec 27.


Signatures of protein biophysics in coding sequence evolution.

Wilke CO, Drummond DA.

Curr Opin Struct Biol. 2010 Jun;20(3):385-9. doi: 10.1016/ Epub 2010 Apr 13. Review.


Protein evolution: innovative chaps.

Drummond DA.

Curr Biol. 2009 Sep 15;19(17):R740-2. doi: 10.1016/j.cub.2009.07.039.


The evolutionary consequences of erroneous protein synthesis.

Drummond DA, Wilke CO.

Nat Rev Genet. 2009 Oct;10(10):715-24. doi: 10.1038/nrg2662. Review.


Mistranslation-induced protein misfolding as a dominant constraint on coding-sequence evolution.

Drummond DA, Wilke CO.

Cell. 2008 Jul 25;134(2):341-52. doi: 10.1016/j.cell.2008.05.042.


Contact density affects protein evolutionary rate from bacteria to animals.

Zhou T, Drummond DA, Wilke CO.

J Mol Evol. 2008 Apr;66(4):395-404. doi: 10.1007/s00239-008-9094-4. Epub 2008 Apr 1.


A diverse family of thermostable cytochrome P450s created by recombination of stabilizing fragments.

Li Y, Drummond DA, Sawayama AM, Snow CD, Bloom JD, Arnold FH.

Nat Biotechnol. 2007 Sep;25(9):1051-6. Epub 2007 Aug 26. Erratum in: Nat Biotechnol. 2007 Dec;25(12):1488.


Structural determinants of the rate of protein evolution in yeast.

Bloom JD, Drummond DA, Arnold FH, Wilke CO.

Mol Biol Evol. 2006 Sep;23(9):1751-61. Epub 2006 Jun 16.


Population genetics of translational robustness.

Wilke CO, Drummond DA.

Genetics. 2006 May;173(1):473-81. Epub 2006 Feb 19.


A single determinant dominates the rate of yeast protein evolution.

Drummond DA, Raval A, Wilke CO.

Mol Biol Evol. 2006 Feb;23(2):327-37. Epub 2005 Oct 19.


Why highly expressed proteins evolve slowly.

Drummond DA, Bloom JD, Adami C, Wilke CO, Arnold FH.

Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14338-43. Epub 2005 Sep 21.


Predicting the tolerance of proteins to random amino acid substitution.

Wilke CO, Bloom JD, Drummond DA, Raval A.

Biophys J. 2005 Dec;89(6):3714-20. Epub 2005 Sep 8.


Why high-error-rate random mutagenesis libraries are enriched in functional and improved proteins.

Drummond DA, Iverson BL, Georgiou G, Arnold FH.

J Mol Biol. 2005 Jul 22;350(4):806-16.


On the conservative nature of intragenic recombination.

Drummond DA, Silberg JJ, Meyer MM, Wilke CO, Arnold FH.

Proc Natl Acad Sci U S A. 2005 Apr 12;102(15):5380-5. Epub 2005 Apr 4.


Thermodynamic prediction of protein neutrality.

Bloom JD, Silberg JJ, Wilke CO, Drummond DA, Adami C, Arnold FH.

Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):606-11. Epub 2005 Jan 11.

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