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Metabolic Regulation by Nuclear Receptors.

Liu S, Downes M, Evans RM.

In: Nakao K, Minato N, Uemoto S, editors. Innovative Medicine: Basic Research and Development [Internet]. Tokyo: Springer; 2015.


Prognostic pathologic factors in radical cystectomy after neoadjuvant chemotherapy.

Brimo F, Downes MR, Jamaspishvili T, Berman D, Barkan GA, Athanazio D, Abro S, Visram K, Yilmaz A, Solanki S, Hahn E, Siemens R, Kassouf W, Trpkov K.

Histopathology. 2018 May 18. doi: 10.1111/his.13654. [Epub ahead of print]


Vitamin D Switches BAF Complexes to Protect β Cells.

Wei Z, Yoshihara E, He N, Hah N, Fan W, Pinto AFM, Huddy T, Wang Y, Ross B, Estepa G, Dai Y, Ding N, Sherman MH, Fang S, Zhao X, Liddle C, Atkins AR, Yu RT, Downes M, Evans RM.

Cell. 2018 May 17;173(5):1135-1149.e15. doi: 10.1016/j.cell.2018.04.013. Epub 2018 May 10.


PD-L1 Immunohistochemistry Assay Concordance in Urothelial Carcinoma of the Bladder and Hypopharyngeal Squamous Cell Carcinoma.

Hodgson A, Slodkowska E, Jungbluth A, Liu SK, Vesprini D, Enepekides D, Higgins K, Katabi N, Xu B, Downes MR.

Am J Surg Pathol. 2018 May 10. doi: 10.1097/PAS.0000000000001084. [Epub ahead of print]


Multilevel Regression and Poststratification: A Modelling Approach to Estimating Population Quantities From Highly Selected Survey Samples.

Downes M, Gurrin LC, English DR, Pirkis J, Currier D, Spittal MJ, Carlin JB.

Am J Epidemiol. 2018 Apr 9. doi: 10.1093/aje/kwy070. [Epub ahead of print]


ERRγ Preserves Brown Fat Innate Thermogenic Activity.

Ahmadian M, Liu S, Reilly SM, Hah N, Fan W, Yoshihara E, Jha P, De Magalhaes Filho CD, Jacinto S, Gomez AV, Dai Y, Yu RT, Liddle C, Atkins AR, Auwerx J, Saltiel AR, Downes M, Evans RM.

Cell Rep. 2018 Mar 13;22(11):2849-2859. doi: 10.1016/j.celrep.2018.02.061.


ERRγ Promotes Angiogenesis, Mitochondrial Biogenesis, and Oxidative Remodeling in PGC1α/β-Deficient Muscle.

Fan W, He N, Lin CS, Wei Z, Hah N, Waizenegger W, He MX, Liddle C, Yu RT, Atkins AR, Downes M, Evans RM.

Cell Rep. 2018 Mar 6;22(10):2521-2529. doi: 10.1016/j.celrep.2018.02.047.


Visual attention control differences in 12-month-old preterm infants.

Downes M, Kelly D, Day K, Marlow N, de Haan M.

Infant Behav Dev. 2018 Feb;50:180-188. doi: 10.1016/j.infbeh.2018.01.002. Epub 2018 Feb 3.


Overnight auto-adjusting continuous airway pressure + standard care compared with standard care alone in the prevention of morbidity in sickle cell disease phase II (POMS2b): study protocol for a randomised controlled trial.

Howard J, Slee AE, Skene S, Inusa B, Kawadler J, Downes M, Gavlak J, Koelbel M, Stotesbury H, Chorozoglou M, Tebbs S, Chakravorty S, Awogbade M, Rees DC, Gupta A, Murphy PB, Hart N, Sahota S, Nwosu C, Gwam M, Saunders D, Muthurangu V, Barber N, Ako E, Thein SL, Marshall M, Reading IC, Cheng MYE, Kirkham FJ, Liossi C.

Trials. 2018 Jan 22;19(1):55. doi: 10.1186/s13063-017-2419-0.


Use of clinical vignette questionnaires to investigate the variation in management of keratoconjunctivitis sicca and acute glaucoma in dogs.

White CN, Downes MJ, Jones G, Wigfall C, Dean RS, Brennan ML.

Vet Rec. 2018 Jan 6;182(1):21. doi: 10.1136/vr.104390. Epub 2017 Dec 23.


Reprogramming pancreatic stellate cells via p53 activation: A putative target for pancreatic cancer therapy.

Saison-Ridinger M, DelGiorno KE, Zhang T, Kraus A, French R, Jaquish D, Tsui C, Erikson G, Spike BT, Shokhirev MN, Liddle C, Yu RT, Downes M, Evans RM, Saghatelian A, Lowy AM, Wahl GM.

PLoS One. 2017 Dec 6;12(12):e0189051. doi: 10.1371/journal.pone.0189051. eCollection 2017.


Erratum: Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity.

Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner C, Anstee QM, Karin M.

Nature. 2017 Dec 21;552(7685):430. doi: 10.1038/nature25028. Epub 2017 Nov 22.


Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice.

Hartmann P, Hochrath K, Horvath A, Chen P, Seebauer CT, Llorente C, Wang L, Alnouti Y, Fouts DE, Stärkel P, Loomba R, Coulter S, Liddle C, Yu RT, Ling L, Rossi SJ, DePaoli AM, Downes M, Evans RM, Brenner DA, Schnabl B.

Hepatology. 2017 Nov 21. doi: 10.1002/hep.29676. [Epub ahead of print]


Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity.

Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner C, Anstee QM, Karin M.

Nature. 2017 Nov 16;551(7680):340-345. doi: 10.1038/nature24302. Epub 2017 Nov 8. Erratum in: Nature. 2017 Nov 22;:.


Prevalence and risk factors for autism spectrum disorder in epilepsy: a systematic review and meta-analysis.

Strasser L, Downes M, Kung J, Cross JH, De Haan M.

Dev Med Child Neurol. 2018 Jan;60(1):19-29. doi: 10.1111/dmcn.13598. Epub 2017 Nov 9. Review.


Circadian clock cryptochrome proteins regulate autoimmunity.

Cao Q, Zhao X, Bai J, Gery S, Sun H, Lin DC, Chen Q, Chen Z, Mack L, Yang H, Deng R, Shi X, Chong LW, Cho H, Xie J, Li QZ, Müschen M, Atkins AR, Liddle C, Yu RT, Alkan S, Said JW, Zheng Y, Downes M, Evans RM, Koeffler HP.

Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):12548-12553. doi: 10.1073/pnas.1619119114. Epub 2017 Nov 6.


Metabolic control of regulatory T cell (Treg) survival and function by Lkb1.

He N, Fan W, Henriquez B, Yu RT, Atkins AR, Liddle C, Zheng Y, Downes M, Evans RM.

Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):12542-12547. doi: 10.1073/pnas.1715363114. Epub 2017 Nov 6.


Altered Neurophysiological Processing of Auditory Attention in Preschool Children With Sickle Cell Disease.

Downes M, Kirkham FJ, Telfer PT, de Haan M.

J Pediatr Psychol. 2017 Sep 18. doi: 10.1093/jpepsy/jsx115. [Epub ahead of print]


NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection.

Wang J, He N, Zhang N, Quan D, Zhang S, Zhang C, Yu RT, Atkins AR, Zhu R, Yang C, Cui Y, Liddle C, Downes M, Xiao H, Zheng Y, Auwerx J, Evans RM, Leng Q.

Nat Commun. 2017 Oct 16;8(1):959. doi: 10.1038/s41467-017-00931-8.


Toward Biological Subtyping of Papillary Renal Cell Carcinoma With Clinical Implications Through Histologic, Immunohistochemical, and Molecular Analysis.

Saleeb RM, Brimo F, Farag M, Rompré-Brodeur A, Rotondo F, Beharry V, Wala S, Plant P, Downes MR, Pace K, Evans A, Bjarnason G, Bartlett JMS, Yousef GM.

Am J Surg Pathol. 2017 Dec;41(12):1618-1629. doi: 10.1097/PAS.0000000000000962.


Understanding the context for pet cat and dog feeding and exercising behaviour among pet owners in Ireland: a qualitative study.

Downes MJ, Devitt C, Downes MT, More SJ.

Ir Vet J. 2017 Sep 20;70:29. doi: 10.1186/s13620-017-0107-8. eCollection 2017.


The cost-effectiveness of oral health interventions: A systematic review of cost-utility analyses.

Hettiarachchi RM, Kularatna S, Downes MJ, Byrnes J, Kroon J, Lalloo R, Johnson NW, Scuffham PA.

Community Dent Oral Epidemiol. 2018 Apr;46(2):118-124. doi: 10.1111/cdoe.12336. Epub 2017 Sep 19.


Tumour front inflammation and necrosis are independent prognostic predictors in high-grade urothelial carcinoma of the bladder.

Hodgson A, Xu B, Satkunasivam R, Downes MR.

J Clin Pathol. 2018 Feb;71(2):154-160. doi: 10.1136/jclinpath-2017-204562. Epub 2017 Aug 2.


Prostate carcinoma with amphicrine features: further refining the spectrum of neuroendocrine differentiation in tumours of primary prostatic origin?

Prendeville S, Al-Bozom I, Compérat E, Sweet J, Evans AJ, Ben-Gashir M, Mete O, van der Kwast TH, Downes MR.

Histopathology. 2017 Dec;71(6):926-933. doi: 10.1111/his.13330. Epub 2017 Oct 6.


Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity.

Kriebs A, Jordan SD, Soto E, Henriksson E, Sandate CR, Vaughan ME, Chan AB, Duglan D, Papp SJ, Huber AL, Afetian ME, Yu RT, Zhao X, Downes M, Evans RM, Lamia KA.

Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):8776-8781. doi: 10.1073/pnas.1704955114. Epub 2017 Jul 27.


Efficacy of nutritional interventions to lower circulating ceramides in young adults: FRUVEDomic pilot study.

Mathews AT, Famodu OA, Olfert MD, Murray PJ, Cuff CF, Downes MT, Haughey NJ, Colby SE, Chantler PD, Olfert IM, McFadden JW.

Physiol Rep. 2017 Jul;5(13). pii: e13329. doi: 10.14814/phy2.13329.


CRY1/2 Selectively Repress PPARδ and Limit Exercise Capacity.

Jordan SD, Kriebs A, Vaughan M, Duglan D, Fan W, Henriksson E, Huber AL, Papp SJ, Nguyen M, Afetian M, Downes M, Yu RT, Kralli A, Evans RM, Lamia KA.

Cell Metab. 2017 Jul 5;26(1):243-255.e6. doi: 10.1016/j.cmet.2017.06.002.


Inhibition of IKKɛ and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 Diabetes.

Oral EA, Reilly SM, Gomez AV, Meral R, Butz L, Ajluni N, Chenevert TL, Korytnaya E, Neidert AH, Hench R, Rus D, Horowitz JF, Poirier B, Zhao P, Lehmann K, Jain M, Yu R, Liddle C, Ahmadian M, Downes M, Evans RM, Saltiel AR.

Cell Metab. 2017 Jul 5;26(1):157-170.e7. doi: 10.1016/j.cmet.2017.06.006.


Telephone consultations for general practice: a systematic review.

Downes MJ, Mervin MC, Byrnes JM, Scuffham PA.

Syst Rev. 2017 Jul 3;6(1):128. doi: 10.1186/s13643-017-0529-0. Review.


FGF1 - a new weapon to control type 2 diabetes mellitus.

Gasser E, Moutos CP, Downes M, Evans RM.

Nat Rev Endocrinol. 2017 Oct;13(10):599-609. doi: 10.1038/nrendo.2017.78. Epub 2017 Jun 30. Review.


Use of Angiotensin System Inhibitors Is Associated with Immune Activation and Longer Survival in Nonmetastatic Pancreatic Ductal Adenocarcinoma.

Liu H, Naxerova K, Pinter M, Incio J, Lee H, Shigeta K, Ho WW, Crain JA, Jacobson A, Michelakos T, Dias-Santos D, Zanconato A, Hong TS, Clark JW, Murphy JE, Ryan DP, Deshpande V, Lillemoe KD, Fernandez-Del Castillo C, Downes M, Evans RM, Michaelson J, Ferrone CR, Boucher Y, Jain RK.

Clin Cancer Res. 2017 Oct 1;23(19):5959-5969. doi: 10.1158/1078-0432.CCR-17-0256. Epub 2017 Jun 9.


Task utility and norms for the Preschool Executive Task Assessment (PETA).

Downes M, Berg C, Kirkham FJ, Kischkel L, McMurray I, de Haan M.

Child Neuropsychol. 2017 May 31:1-15. doi: 10.1080/09297049.2017.1333092. [Epub ahead of print]


PPARδ Promotes Running Endurance by Preserving Glucose.

Fan W, Waizenegger W, Lin CS, Sorrentino V, He MX, Wall CE, Li H, Liddle C, Yu RT, Atkins AR, Auwerx J, Downes M, Evans RM.

Cell Metab. 2017 May 2;25(5):1186-1193.e4. doi: 10.1016/j.cmet.2017.04.006.


Intestinal PPARδ protects against diet-induced obesity, insulin resistance and dyslipidemia.

Doktorova M, Zwarts I, Zutphen TV, Dijk THV, Bloks VW, Harkema L, Bruin A, Downes M, Evans RM, Verkade HJ, Jonker JW.

Sci Rep. 2017 Apr 12;7(1):846. doi: 10.1038/s41598-017-00889-z.


Re-engineering the Pancreas Tumor Microenvironment: A "Regenerative Program" Hacked.

Evan GI, Hah N, Littlewood TD, Sodir NM, Campos T, Downes M, Evans RM.

Clin Cancer Res. 2017 Apr 1;23(7):1647-1655. doi: 10.1158/1078-0432.CCR-16-3275. Review.


p53 immunohistochemistry in high-grade urothelial carcinoma of the bladder is prognostically significant.

Hodgson A, Xu B, Downes MR.

Histopathology. 2017 Aug;71(2):296-304. doi: 10.1111/his.13225. Epub 2017 May 22.


Structural basis for specific ligation of the peroxisome proliferator-activated receptor δ.

Wu CC, Baiga TJ, Downes M, La Clair JJ, Atkins AR, Richard SB, Fan W, Stockley-Noel TA, Bowman ME, Noel JP, Evans RM.

Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):E2563-E2570. doi: 10.1073/pnas.1621513114. Epub 2017 Mar 20.


Farnesoid X Receptor an Emerging Target to Combat Obesity.

De Magalhaes Filho CD, Downes M, Evans RM.

Dig Dis. 2017;35(3):185-190. doi: 10.1159/000450909. Epub 2017 Mar 1. Review.


The Australian longitudinal study on male health sampling design and survey weighting: implications for analysis and interpretation of clustered data.

Spittal MJ, Carlin JB, Currier D, Downes M, English DR, Gordon I, Pirkis J, Gurrin L.

BMC Public Health. 2016 Oct 31;16(Suppl 3):1062. doi: 10.1186/s12889-016-3699-0.


Event-related potential measures of executive functioning from preschool to adolescence.

Downes M, Bathelt J, De Haan M.

Dev Med Child Neurol. 2017 Jun;59(6):581-590. doi: 10.1111/dmcn.13395. Epub 2017 Feb 6. Review.


Validation of an iPad activity to measure preschool children's food and physical activity knowledge and preferences.

Wiseman N, Harris N, Downes M.

Int J Behav Nutr Phys Act. 2017 Feb 1;14(1):11. doi: 10.1186/s12966-017-0469-z.


Impact of an emergency short stay unit on emergency department performance of poisoned patients.

Downes MA, Balshaw JK, Muscat TM, Ritchie N, Isbister GK.

Am J Emerg Med. 2017 May;35(5):764-768. doi: 10.1016/j.ajem.2017.01.027. Epub 2017 Jan 26.


Stromal cues regulate the pancreatic cancer epigenome and metabolome.

Sherman MH, Yu RT, Tseng TW, Sousa CM, Liu S, Truitt ML, He N, Ding N, Liddle C, Atkins AR, Leblanc M, Collisson EA, Asara JM, Kimmelman AC, Downes M, Evans RM.

Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1129-1134. doi: 10.1073/pnas.1620164114. Epub 2017 Jan 17.


Gastroesophageal Mucosal Injury after Cholecystectomy: An Indication for Surveillance?

Shah Gilani SN, Bass GA, Kharytaniuk N, Downes MR, Caffrey EF, Tobbia I, Walsh TN.

J Am Coll Surg. 2017 Mar;224(3):319-326. doi: 10.1016/j.jamcollsurg.2016.12.003. Epub 2016 Dec 18.


Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis.

Chung HK, Ryu D, Kim KS, Chang JY, Kim YK, Yi HS, Kang SG, Choi MJ, Lee SE, Jung SB, Ryu MJ, Kim SJ, Kweon GR, Kim H, Hwang JH, Lee CH, Lee SJ, Wall CE, Downes M, Evans RM, Auwerx J, Shong M.

J Cell Biol. 2017 Jan 2;216(1):149-165. doi: 10.1083/jcb.201607110. Epub 2016 Dec 16.


Development of a critical appraisal tool to assess the quality of cross-sectional studies (AXIS).

Downes MJ, Brennan ML, Williams HC, Dean RS.

BMJ Open. 2016 Dec 8;6(12):e011458. doi: 10.1136/bmjopen-2016-011458.


Evaluation of ERG and PTEN protein expression in cribriform architecture prostate carcinomas.

Downes MR, Satturwar S, Trudel D, van der Kwast TH.

Pathol Res Pract. 2017 Jan;213(1):34-38. doi: 10.1016/j.prp.2016.10.007. Epub 2016 Oct 26.


Parent reported sleep problems in preschool children with sickle cell anemia and controls in East London.

Downes M, de Haan M, Kirkham FJ, Telfer PT.

Pediatr Blood Cancer. 2017 Jun;64(6). doi: 10.1002/pbc.26337. Epub 2016 Nov 15.


Determination of the Association Between T2-weighted MRI and Gleason Sub-pattern: A Proof of Principle Study.

Downes MR, Gibson E, Sykes J, Haider M, van der Kwast TH, Ward A.

Acad Radiol. 2016 Nov;23(11):1412-1421. doi: 10.1016/j.acra.2016.07.013. Epub 2016 Sep 14.


Analysis of papillary urothelial carcinomas of the bladder with grade heterogeneity: supportive evidence for an early role of CDKN2A deletions in the FGFR3 pathway.

Downes MR, Weening B, van Rhijn BW, Have CL, Treurniet KM, van der Kwast TH.

Histopathology. 2017 Jan;70(2):281-289. doi: 10.1111/his.13063. Epub 2016 Oct 28.


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