Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 188

1.

IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold.

Dixon MJ, Gray A, Schenning M, Agacan M, Tempel W, Tong Y, Nedyalkova L, Park HW, Leslie NR, van Aalten DM, Downes CP, Batty IH.

J Biol Chem. 2012 Jun 29;287(27):22483-96. doi: 10.1074/jbc.M112.352773. Epub 2012 Apr 5.

2.

A screen for novel phosphoinositide 3-kinase effector proteins.

Dixon MJ, Gray A, Boisvert FM, Agacan M, Morrice NA, Gourlay R, Leslie NR, Downes CP, Batty IH.

Mol Cell Proteomics. 2011 Apr;10(4):M110.003178. doi: 10.1074/mcp.M110.003178. Epub 2011 Jan 24.

3.

Ubiquitination of PTEN (phosphatase and tensin homolog) inhibits phosphatase activity and is enhanced by membrane targeting and hyperosmotic stress.

Maccario H, Perera NM, Gray A, Downes CP, Leslie NR.

J Biol Chem. 2010 Apr 23;285(17):12620-8. doi: 10.1074/jbc.M109.072280. Epub 2010 Feb 22.

4.

Suppression of cellular proliferation and invasion by the concerted lipid and protein phosphatase activities of PTEN.

Davidson L, Maccario H, Perera NM, Yang X, Spinelli L, Tibarewal P, Glancy B, Gray A, Weijer CJ, Downes CP, Leslie NR.

Oncogene. 2010 Feb 4;29(5):687-97. doi: 10.1038/onc.2009.384. Epub 2009 Nov 16.

5.

Indirect mechanisms of carcinogenesis via downregulation of PTEN function.

Leslie NR, Spinelli L, Tibarewal P, Zilidis G, Weerasinghe N, Lim JC, Maccario H, Downes CP.

Adv Enzyme Regul. 2010;50(1):112-8. doi: 10.1016/j.advenzreg.2009.10.015. Epub 2009 Nov 4. Review. No abstract available.

PMID:
19895830
6.

MyosinV controls PTEN function and neuronal cell size.

van Diepen MT, Parsons M, Downes CP, Leslie NR, Hindges R, Eickholt BJ.

Nat Cell Biol. 2009 Oct;11(10):1191-6. doi: 10.1038/ncb1961. Epub 2009 Sep 20. Erratum in: Nat Cell Biol. 2009 Nov;11(11):1387.

7.

Characterization of a selective inhibitor of inositol hexakisphosphate kinases: use in defining biological roles and metabolic relationships of inositol pyrophosphates.

Padmanabhan U, Dollins DE, Fridy PC, York JD, Downes CP.

J Biol Chem. 2009 Apr 17;284(16):10571-82. doi: 10.1074/jbc.M900752200. Epub 2009 Feb 10.

8.

Understanding PTEN regulation: PIP2, polarity and protein stability.

Leslie NR, Batty IH, Maccario H, Davidson L, Downes CP.

Oncogene. 2008 Sep 18;27(41):5464-76. doi: 10.1038/onc.2008.243. Review.

PMID:
18794881
9.

Binding of influenza A virus NS1 protein to the inter-SH2 domain of p85 suggests a novel mechanism for phosphoinositide 3-kinase activation.

Hale BG, Batty IH, Downes CP, Randall RE.

J Biol Chem. 2008 Jan 18;283(3):1372-80. Epub 2007 Nov 20.

10.
11.

Loss of PTEN selectively desensitizes upstream IGF1 and insulin signaling.

Lackey J, Barnett J, Davidson L, Batty IH, Leslie NR, Downes CP.

Oncogene. 2007 Nov 1;26(50):7132-42. Epub 2007 May 7.

12.

PTEN is destabilized by phosphorylation on Thr366.

Maccario H, Perera NM, Davidson L, Downes CP, Leslie NR.

Biochem J. 2007 Aug 1;405(3):439-44.

13.

Metabolic switching of PI3K-dependent lipid signals.

Downes CP, Leslie NR, Batty IH, van der Kaay J.

Biochem Soc Trans. 2007 Apr;35(Pt 2):188-92.

PMID:
17371235
14.

Differential redox regulation within the PTP superfamily.

Ross SH, Lindsay Y, Safrany ST, Lorenzo O, Villa F, Toth R, Clague MJ, Downes CP, Leslie NR.

Cell Signal. 2007 Jul;19(7):1521-30. Epub 2007 Feb 6.

PMID:
17346927
15.

Stimulation of PI 3-kinase signaling via inhibition of the tumor suppressor phosphatase, PTEN.

Downes CP, Ross S, Maccario H, Perera N, Davidson L, Leslie NR.

Adv Enzyme Regul. 2007;47:184-94. Epub 2006 Dec 30. Review. No abstract available.

PMID:
17343901
16.

PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration.

Leslie NR, Yang X, Downes CP, Weijer CJ.

Curr Biol. 2007 Jan 23;17(2):115-25.

17.

Substrate specificity and acute regulation of the tumour suppressor phosphatase, PTEN.

Downes CP, Perera N, Ross S, Leslie NR.

Biochem Soc Symp. 2007;(74):69-80. Review.

PMID:
17233581
18.

Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression.

Lindsay Y, McCoull D, Davidson L, Leslie NR, Fairservice A, Gray A, Lucocq J, Downes CP.

J Cell Sci. 2006 Dec 15;119(Pt 24):5160-8.

19.

A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic beta-cells.

Ning K, Miller LC, Laidlaw HA, Burgess LA, Perera NM, Downes CP, Leslie NR, Ashford ML.

EMBO J. 2006 Jun 7;25(11):2377-87. Epub 2006 May 4.

20.

Regulation of insulin receptor substrate 1 pleckstrin homology domain by protein kinase C: role of serine 24 phosphorylation.

Nawaratne R, Gray A, Jørgensen CH, Downes CP, Siddle K, Sethi JK.

Mol Endocrinol. 2006 Aug;20(8):1838-52. Epub 2006 Mar 30.

21.

The regulation of cell migration by PTEN.

Leslie NR, Yang X, Downes CP, Weijer CJ.

Biochem Soc Trans. 2005 Dec;33(Pt 6):1507-8. Review.

PMID:
16246156
22.

The regulation of membrane to cytosol partitioning of signalling proteins by phosphoinositides and their soluble headgroups.

Downes CP, Gray A, Fairservice A, Safrany ST, Batty IH, Fleming I.

Biochem Soc Trans. 2005 Dec;33(Pt 6):1303-7.

PMID:
16246104
23.

Probing phosphoinositide functions in signaling and membrane trafficking.

Downes CP, Gray A, Lucocq JM.

Trends Cell Biol. 2005 May;15(5):259-68. Review.

PMID:
15866030
24.

Redox regulation of phosphatase function.

Leslie NR, Lindsay Y, Ross SH, Downes CP.

Biochem Soc Trans. 2004 Dec;32(Pt 6):1018-20.

PMID:
15506952
25.

Small molecule antagonists of the sigma-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo.

Spruce BA, Campbell LA, McTavish N, Cooper MA, Appleyard MV, O'Neill M, Howie J, Samson J, Watt S, Murray K, McLean D, Leslie NR, Safrany ST, Ferguson MJ, Peters JA, Prescott AR, Box G, Hayes A, Nutley B, Raynaud F, Downes CP, Lambert JJ, Thompson AM, Eccles S.

Cancer Res. 2004 Jul 15;64(14):4875-86.

26.

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins.

Harrington LS, Findlay GM, Gray A, Tolkacheva T, Wigfield S, Rebholz H, Barnett J, Leslie NR, Cheng S, Shepherd PR, Gout I, Downes CP, Lamb RF.

J Cell Biol. 2004 Jul 19;166(2):213-23. Epub 2004 Jul 12.

27.
28.

PTEN function: how normal cells control it and tumour cells lose it.

Leslie NR, Downes CP.

Biochem J. 2004 Aug 15;382(Pt 1):1-11. Review.

29.

Acute regulation of the tumour suppressor phosphatase, PTEN, by anionic lipids and reactive oxygen species.

Downes CP, Walker S, McConnachie G, Lindsay Y, Batty IH, Leslie NR.

Biochem Soc Trans. 2004 Apr;32(Pt 2):338-42. Review.

PMID:
15046604
31.

Comparative proteomics of primitive hematopoietic cell populations reveals differences in expression of proteins regulating motility.

Evans CA, Tonge R, Blinco D, Pierce A, Shaw J, Lu Y, Hamzah HG, Gray A, Downes CP, Gaskell SJ, Spooncer E, Whetton AD.

Blood. 2004 May 15;103(10):3751-9. Epub 2004 Feb 5.

32.

The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif.

Walker SM, Leslie NR, Perera NM, Batty IH, Downes CP.

Biochem J. 2004 Apr 15;379(Pt 2):301-7.

33.

Advances in procedures for the detection and localization of inositol phospholipid signals in cells, tissues, and enzyme assays.

Downes CP, Gray A, Watt SA, Lucocq JM.

Methods Enzymol. 2003;366:64-84. No abstract available.

PMID:
14674240
34.
35.

PTEN M-CBR3, a versatile and selective regulator of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5). Evidence for Ins(1,3,4,5,6)P5 as a proliferative signal.

Orchiston EA, Bennett D, Leslie NR, Clarke RG, Winward L, Downes CP, Safrany ST.

J Biol Chem. 2004 Jan 9;279(2):1116-22. Epub 2003 Oct 15.

36.

Redox regulation of PI 3-kinase signalling via inactivation of PTEN.

Leslie NR, Bennett D, Lindsay YE, Stewart H, Gray A, Downes CP.

EMBO J. 2003 Oct 15;22(20):5501-10.

37.

Interleukin-3-mediated cell survival signals include phosphatidylinositol 3-kinase-dependent translocation of the glucose transporter GLUT1 to the cell surface.

Bentley J, Itchayanan D, Barnes K, McIntosh E, Tang X, Downes CP, Holman GD, Whetton AD, Owen-Lynch PJ, Baldwin SA.

J Biol Chem. 2003 Oct 10;278(41):39337-48. Epub 2003 Jul 16.

38.
39.
40.

A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation.

Clayton E, Bardi G, Bell SE, Chantry D, Downes CP, Gray A, Humphries LA, Rawlings D, Reynolds H, Vigorito E, Turner M.

J Exp Med. 2002 Sep 16;196(6):753-63.

41.
42.

dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1.

Radimerski T, Montagne J, Rintelen F, Stocker H, van der Kaay J, Downes CP, Hafen E, Thomas G.

Nat Cell Biol. 2002 Mar;4(3):251-5.

43.

PTEN: The down side of PI 3-kinase signalling.

Leslie NR, Downes CP.

Cell Signal. 2002 Apr;14(4):285-95. Review.

PMID:
11858936
44.

Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo.

Kimber WA, Trinkle-Mulcahy L, Cheung PC, Deak M, Marsden LJ, Kieloch A, Watt S, Javier RT, Gray A, Downes CP, Lucocq JM, Alessi DR.

Biochem J. 2002 Feb 1;361(Pt 3):525-36.

45.

TPIP: a novel phosphoinositide 3-phosphatase.

Walker SM, Downes CP, Leslie NR.

Biochem J. 2001 Dec 1;360(Pt 2):277-83.

46.

Antagonism of PI 3-kinase-dependent signalling pathways by the tumour suppressor protein, PTEN.

Downes CP, Bennett D, McConnachie G, Leslie NR, Pass I, MacPhee C, Patel L, Gray A.

Biochem Soc Trans. 2001 Nov;29(Pt 6):846-51. Review.

PMID:
11709086
48.

Regulation of clathrin-coated vesicle formation.

Hill E, Olusanya O, van der Kaay J, Downes CP, Andrews PD, Swedlow JR, Smythe E.

Biochem Soc Trans. 2001 Aug;29(Pt 4):375-7. Review.

PMID:
11497992
49.

Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions.

Leslie NR, Bennett D, Gray A, Pass I, Hoang-Xuan K, Downes CP.

Biochem J. 2001 Jul 15;357(Pt 2):427-35.

50.

Tumor suppressor and anti-inflammatory actions of PPARgamma agonists are mediated via upregulation of PTEN.

Patel L, Pass I, Coxon P, Downes CP, Smith SA, Macphee CH.

Curr Biol. 2001 May 15;11(10):764-8.

Supplemental Content

Loading ...
Support Center