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Gastrointestinal bleeding risk of selective serotonin reuptake inhibitors by level of kidney function: a population-based cohort study.

Iwagami M, Tomlinson LA, Mansfield KE, Douglas IJ, Smeeth L, Nitsch D.

Br J Clin Pharmacol. 2018 Jun 4. doi: 10.1111/bcp.13660. [Epub ahead of print]


Long-term effects of bariatric surgery on acute kidney injury: a propensity-matched cohort in the UK Clinical Practice Research Datalink.

Koppe U, Nitsch D, Mansfield KE, Mathur R, Bhaskaran K, Batterham RL, Smeeth L, Douglas IJ.

BMJ Open. 2018 May 16;8(5):e020371. doi: 10.1136/bmjopen-2017-020371.


Liberal Versus Restrictive Intravenous Fluid Therapy for Early Septic Shock: Rationale for a Randomized Trial.

Self WH, Semler MW, Bellomo R, Brown SM, deBoisblanc BP, Exline MC, Ginde AA, Grissom CK, Janz DR, Jones AE, Liu KD, Macdonald SPJ, Miller CD, Park PK, Reineck LA, Rice TW, Steingrub JS, Talmor D, Yealy DM, Douglas IS, Shapiro NI; CLOVERS Protocol Committee and NHLBI Prevention and Early Treatment of Acute Lung Injury (PETAL) Network Investigators.

Ann Emerg Med. 2018 May 9. pii: S0196-0644(18)30315-9. doi: 10.1016/j.annemergmed.2018.03.039. [Epub ahead of print]


Myocardial Infarction and Ischaemic Stroke Following Exacerbations of Chronic Obstructive Pulmonary Disease.

Rothnie KJ, Connell O, Müllerová H, Smeeth L, Pearce N, Douglas I, Quint JK.

Ann Am Thorac Soc. 2018 May 3. doi: 10.1513/AnnalsATS.201710-815OC. [Epub ahead of print]


Real-world effects of medications for chronic obstructive pulmonary disease: protocol for a UK population-based non-interventional cohort study with validation against randomised trial results.

Wing K, Williamson E, Carpenter JR, Wise L, Schneeweiss S, Smeeth L, Quint JK, Douglas I.

BMJ Open. 2018 Mar 25;8(3):e019475. doi: 10.1136/bmjopen-2017-019475.


Trimethoprim use for urinary tract infection and risk of adverse outcomes in older patients: cohort study.

Crellin E, Mansfield KE, Leyrat C, Nitsch D, Douglas IJ, Root A, Williamson E, Smeeth L, Tomlinson LA.

BMJ. 2018 Feb 9;360:k341. doi: 10.1136/bmj.k341.


Acute kidney injury and infections in patients taking antihypertensive drugs: a self-controlled case series analysis.

Mansfield KE, Douglas IJ, Nitsch D, Thomas SL, Smeeth L, Tomlinson LA.

Clin Epidemiol. 2018 Jan 30;10:187-202. doi: 10.2147/CLEP.S146757. eCollection 2018.


Cardiovascular Outcomes after a Respiratory Tract Infection among Adults with Non-Cystic Fibrosis Bronchiectasis: A General Population-based Study.

Navaratnam V, Root AA, Douglas I, Smeeth L, Hubbard RB, Quint JK.

Ann Am Thorac Soc. 2018 Mar;15(3):315-321. doi: 10.1513/AnnalsATS.201706-488OC.


Validation of asthma recording in electronic health records: a systematic review.

Nissen F, Quint JK, Wilkinson S, Mullerova H, Smeeth L, Douglas IJ.

Clin Epidemiol. 2017 Dec 1;9:643-656. doi: 10.2147/CLEP.S143718. eCollection 2017. Review.


Erythropoietin-Producing Hepatoma Receptor Tyrosine Kinase A2 Modulation Associates with Protective Effect of Prone Position in Ventilator-induced Lung Injury.

Park BH, Shin MH, Douglas IS, Chung KS, Song JH, Kim SY, Kim EY, Jung JY, Kang YA, Chang J, Kim YS, Park MS.

Am J Respir Cell Mol Biol. 2018 Apr;58(4):519-529. doi: 10.1165/rcmb.2017-0143OC.


Lansoprazole use and tuberculosis incidence in the United Kingdom Clinical Practice Research Datalink: A population based cohort.

Yates TA, Tomlinson LA, Bhaskaran K, Langan S, Thomas S, Smeeth L, Douglas IJ.

PLoS Med. 2017 Nov 21;14(11):e1002457. doi: 10.1371/journal.pmed.1002457. eCollection 2017 Nov.


Investigating the assumptions of the self-controlled case series method.

Whitaker HJ, Ghebremichael-Weldeselassie Y, Douglas IJ, Smeeth L, Farrington CP.

Stat Med. 2018 Feb 20;37(4):643-658. doi: 10.1002/sim.7536. Epub 2017 Nov 2.


Exacerbation risk and characterisation of the UK's asthma population from infants to old age.

Bloom CI, Nissen F, Douglas IJ, Smeeth L, Cullinan P, Quint JK.

Thorax. 2018 Apr;73(4):313-320. doi: 10.1136/thoraxjnl-2017-210650. Epub 2017 Oct 26.


Development and validation of immune dysfunction score to predict 28-day mortality of sepsis patients.

Fang WF, Douglas IS, Chen YM, Lin CY, Kao HC, Fang YT, Huang CH, Chang YT, Huang KT, Wang YH, Wang CC, Lin MC.

PLoS One. 2017 Oct 26;12(10):e0187088. doi: 10.1371/journal.pone.0187088. eCollection 2017.


Reporting to Improve Reproducibility and Facilitate Validity Assessment for Healthcare Database Studies V1.0.

Wang SV, Schneeweiss S, Berger ML, Brown J, de Vries F, Douglas I, Gagne JJ, Gini R, Klungel O, Mullins CD, Nguyen MD, Rassen JA, Smeeth L, Sturkenboom M; joint ISPE‐ISPOR Special Task Force on Real World Evidence in Health Care Decision Making.

Value Health. 2017 Sep;20(8):1009-1022. doi: 10.1016/j.jval.2017.08.3018. Epub 2017 Sep 15. Erratum in: Value Health. 2018 Feb;21(2):248.


Trends for prevalence and incidence of resistant hypertension: population based cohort study in the UK 1995-2015.

Sinnott SJ, Smeeth L, Williamson E, Douglas IJ.

BMJ. 2017 Sep 22;358:j3984. doi: 10.1136/bmj.j3984.


Re: Biomedical Informatics Approaches to Identifying Drug-Drug Interactions: Application to Insulin Secretagogues.

Root A, Douglas I, Evans S.

Epidemiology. 2018 Jan;29(1):e8. doi: 10.1097/EDE.0000000000000760. No abstract available.


Reporting to Improve Reproducibility and Facilitate Validity Assessment for Healthcare Database Studies V1.0.

Wang SV, Schneeweiss S, Berger ML, Brown J, de Vries F, Douglas I, Gagne JJ, Gini R, Klungel O, Mullins CD, Nguyen MD, Rassen JA, Smeeth L, Sturkenboom M; joint ISPE-ISPOR Special Task Force on Real World Evidence in Health Care Decision Making.

Pharmacoepidemiol Drug Saf. 2017 Sep;26(9):1018-1032. doi: 10.1002/pds.4295. Erratum in: Pharmacoepidemiol Drug Saf. 2017 Dec;26(12 ):1570.


Quantification of the risk of liver injury associated with flucloxacillin: a UK population-based cohort study.

Wing K, Bhaskaran K, Pealing L, Root A, Smeeth L, van Staa TP, Klungel OH, Reynolds RF, Douglas I.

J Antimicrob Chemother. 2017 Sep 1;72(9):2636-2646. doi: 10.1093/jac/dkx183.


The impact of tailored intervention services on charges and mortality for adult super-utilizers.

Durfee J, Johnson T, Batal H, Long J, Rinehart D, Everhart R, Oronce CI, Douglas I, Moore K, Atherly A.

Healthc (Amst). 2017 Aug 25. pii: S2213-0764(17)30057-X. doi: 10.1016/j.hjdsi.2017.08.004. [Epub ahead of print]


Validation of asthma recording in the Clinical Practice Research Datalink (CPRD).

Nissen F, Morales DR, Mullerova H, Smeeth L, Douglas IJ, Quint JK.

BMJ Open. 2017 Aug 11;7(8):e017474. doi: 10.1136/bmjopen-2017-017474.


All-trans retinoic acid attenuates bleomycin-induced pulmonary fibrosis via downregulating EphA2-EphrinA1 signaling.

Leem AY, Shin MH, Douglas IS, Song JH, Chung KS, Kim EY, Jung JY, Kang YA, Chang J, Kim YS, Park MS.

Biochem Biophys Res Commun. 2017 Sep 23;491(3):721-726. doi: 10.1016/j.bbrc.2017.07.122. Epub 2017 Jul 22.


David Cockburn OAM MScOptom DSc (Honoris Causa) FACO 25 August 1923-26 September 2016: A tribute to David Cockburn, a consummate clinician and educator.

Gutteridge IF, Douglas IS, Anjou MD.

Clin Exp Optom. 2017 Jul;100(4):399-401. doi: 10.1111/cxo.12572. No abstract available.


Propensity score analysis with partially observed covariates: How should multiple imputation be used?

Leyrat C, Seaman SR, White IR, Douglas I, Smeeth L, Kim J, Resche-Rigon M, Carpenter JR, Williamson EJ.

Stat Methods Med Res. 2017 Jan 1:962280217713032. doi: 10.1177/0962280217713032. [Epub ahead of print]


Validation of asthma recording in electronic health records: protocol for a systematic review.

Nissen F, Quint JK, Wilkinson S, Mullerova H, Smeeth L, Douglas IJ.

BMJ Open. 2017 May 29;7(5):e014694. doi: 10.1136/bmjopen-2016-014694. Review.


Evidence-based Utilization of Noninvasive Ventilation and Patient Outcomes.

Mehta AB, Douglas IS, Walkey AJ.

Ann Am Thorac Soc. 2017 Nov;14(11):1667-1673. doi: 10.1513/AnnalsATS.201703-208OC.


The Experience of Patients with Alcohol Misuse after Surviving a Critical Illness. A Qualitative Study.

Clark BJ, Jones J, Reed KD, Hodapp R, Douglas IS, Van Pelt D, Burnham EL, Moss M.

Ann Am Thorac Soc. 2017 Jul;14(7):1154-1161. doi: 10.1513/AnnalsATS.201611-854OC.


Innate Immune Function and Organ Failure Recovery in Adults With Sepsis.

Maddux AB, Hiller TD, Overdier KH, Pyle LL, Douglas IS.

J Intensive Care Med. 2017 Jan 1:885066617701903. doi: 10.1177/0885066617701903. [Epub ahead of print]


The history of risk: a review.

Stahel PF, Douglas IS, VanderHeiden TF, Weckbach S.

World J Emerg Surg. 2017 Mar 14;12:15. doi: 10.1186/s13017-017-0125-6. eCollection 2017. Review.


Pulmonary infections in critical/intensive care - rapid diagnosis and optimizing antimicrobial usage.

Douglas IS.

Curr Opin Pulm Med. 2017 May;23(3):198-203. doi: 10.1097/MCP.0000000000000366. Review.


Population trends in the 10-year incidence and prevalence of diabetic retinopathy in the UK: a cohort study in the Clinical Practice Research Datalink 2004-2014.

Mathur R, Bhaskaran K, Edwards E, Lee H, Chaturvedi N, Smeeth L, Douglas I.

BMJ Open. 2017 Feb 28;7(2):e014444. doi: 10.1136/bmjopen-2016-014444.


Pharmacoepidemiology for nephrologists: do proton pump inhibitors cause chronic kidney disease?

Tomlinson LA, Fogarty DG, Douglas I, Nitsch D.

Nephrol Dial Transplant. 2017 Apr 1;32(suppl_2):ii40-ii46. doi: 10.1093/ndt/gfw349. Review.


Respiratory Health in Migrant Populations: A Crisis Overlooked.

Holguin F, Moughrabieh MA, Ojeda V, Patel SR, Peyrani P, Pinedo M, Celedón JC, Douglas IS, Upson DJ, Roman J.

Ann Am Thorac Soc. 2017 Feb;14(2):153-159. doi: 10.1513/AnnalsATS.201608-592PS. Review.


Reply: Hospital Noninvasive Ventilation for Acute Exacerbations of Chronic Obstructive Pulmonary Disease: Another Look at the Same Coin.

Mehta AB, Douglas IS, Walkey AJ.

Ann Am Thorac Soc. 2016 Dec;13(12):2279-2280. No abstract available.


Comparative effectiveness of fourth-line anti-hypertensive agents in resistant hypertension: A systematic review and meta-analysis.

Sinnott SJ, Tomlinson LA, Root AA, Mathur R, Mansfield KE, Smeeth L, Douglas IJ.

Eur J Prev Cardiol. 2017 Feb;24(3):228-238. doi: 10.1177/2047487316675194. Epub 2016 Nov 19. Review.


Ex vivo rabbit and human corneas as models for bacterial and fungal keratitis.

Pinnock A, Shivshetty N, Roy S, Rimmer S, Douglas I, MacNeil S, Garg P.

Graefes Arch Clin Exp Ophthalmol. 2017 Feb;255(2):333-342. doi: 10.1007/s00417-016-3546-0. Epub 2016 Nov 14.


Oral Fluoroquinolone Use and Retinal Detachment.

Douglas IJ, Root A, Krishnan B.

JAMA Ophthalmol. 2016 Dec 1;134(12):1448. doi: 10.1001/jamaophthalmol.2016.3477. No abstract available.


Association of Early Do-Not-Resuscitate Orders with Unplanned Readmissions among Patients Hospitalized for Pneumonia.

Mehta AB, Cooke CR, Douglas IS, Lindenauer PK, Wiener RS, Walkey AJ.

Ann Am Thorac Soc. 2017 Jan;14(1):103-109. doi: 10.1513/AnnalsATS.201608-617OC.


Self controlled case series methods: an alternative to standard epidemiological study designs.

Petersen I, Douglas I, Whitaker H.

BMJ. 2016 Sep 12;354:i4515. doi: 10.1136/bmj.i4515. Review. No abstract available.


Optimising case detection within UK electronic health records: use of multiple linked databases for detecting liver injury.

Wing K, Bhaskaran K, Smeeth L, van Staa TP, Klungel OH, Reynolds RF, Douglas I.

BMJ Open. 2016 Sep 2;6(9):e012102. doi: 10.1136/bmjopen-2016-012102.


Inhibition of EphA2/EphrinA1 signal attenuates lipopolysaccharide-induced lung injury.

Hong JY, Shin MH, Douglas IS, Chung KS, Kim EY, Jung JY, Kang YA, Kim SK, Chang J, Kim YS, Park MS.

Clin Sci (Lond). 2016 Nov 1;130(21):1993-2003. Epub 2016 Aug 22.


In Vitro Modeling of RSV Infection and Cytopathogenesis in Well-Differentiated Human Primary Airway Epithelial Cells (WD-PAECs).

Broadbent L, Villenave R, Guo-Parke H, Douglas I, Shields MD, Power UF.

Methods Mol Biol. 2016;1442:119-39. doi: 10.1007/978-1-4939-3687-8_9.


Phosphodiesterase Type 5 Inhibitors and Risk of Malignant Melanoma: Matched Cohort Study Using Primary Care Data from the UK Clinical Practice Research Datalink.

Matthews A, Langan SM, Douglas IJ, Smeeth L, Bhaskaran K.

PLoS Med. 2016 Jun 14;13(6):e1002037. doi: 10.1371/journal.pmed.1002037. eCollection 2016 Jun.


Latest trends in ADHD drug prescribing patterns in children in the UK: prevalence, incidence and persistence.

Beau-Lejdstrom R, Douglas I, Evans SJ, Smeeth L.

BMJ Open. 2016 Jun 13;6(6):e010508. doi: 10.1136/bmjopen-2015-010508.


Evaluation of the risk of cardiovascular events with clarithromycin using both propensity score and self-controlled study designs.

Root AA, Wong AY, Ghebremichael-Weldeselassie Y, Smeeth L, Bhaskaran K, Evans SJ, Brauer R, Wong IC, Navaratnam V, Douglas I.

Br J Clin Pharmacol. 2016 Aug;82(2):512-21. doi: 10.1111/bcp.12983. Epub 2016 Jun 8.


Association between oral fluoroquinolones and seizures: A self-controlled case series study.

Chui CS, Chan EW, Wong AY, Root A, Douglas IJ, Wong IC.

Neurology. 2016 May 3;86(18):1708-15. doi: 10.1212/WNL.0000000000002633. Epub 2016 Apr 6.


Case-only designs for studying the association of antidepressants and hip or femur fracture.

de Groot MC, Candore G, Uddin MJ, Souverein PC, Ali MS, Belitser SV, Huerta C, Groenwold RH, Alvarez Y, Slattery J, Korevaar J, Hoes AW, Roes KC, de Boer A, Douglas IJ, Schlienger RG, Reynolds R, Klungel OH, Gardarsdottir H.

Pharmacoepidemiol Drug Saf. 2016 Mar;25 Suppl 1:103-13. doi: 10.1002/pds.3850.


Risk of acute liver injury associated with use of antibiotics. Comparative cohort and nested case-control studies using two primary care databases in Europe.

Brauer R, Douglas I, Garcia Rodriguez LA, Downey G, Huerta C, de Abajo F, Bate A, Feudjo Tepie M, de Groot MC, Schlienger R, Reynolds R, Smeeth L, Klungel O, Ruigómez A.

Pharmacoepidemiol Drug Saf. 2016 Mar;25 Suppl 1:29-38. doi: 10.1002/pds.3861.


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