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Items: 18


New class of precision antimicrobials redefines role of Clostridium difficile S-layer in virulence and viability.

Kirk JA, Gebhart D, Buckley AM, Lok S, Scholl D, Douce GR, Govoni GR, Fagan RP.

Sci Transl Med. 2017 Sep 6;9(406). pii: eaah6813. doi: 10.1126/scitranslmed.aah6813.


Efficacy of species-specific protein antibiotics in a murine model of acute Pseudomonas aeruginosa lung infection.

McCaughey LC, Ritchie ND, Douce GR, Evans TJ, Walker D.

Sci Rep. 2016 Jul 22;6:30201. doi: 10.1038/srep30201.


Lighting Up Clostridium Difficile: Reporting Gene Expression Using Fluorescent Lov Domains.

Buckley AM, Jukes C, Candlish D, Irvine JJ, Spencer J, Fagan RP, Roe AJ, Christie JM, Fairweather NF, Douce GR.

Sci Rep. 2016 Mar 21;6:23463. doi: 10.1038/srep23463.


Bacteriophage Combinations Significantly Reduce Clostridium difficile Growth In Vitro and Proliferation In Vivo.

Nale JY, Spencer J, Hargreaves KR, Buckley AM, Trzepiński P, Douce GR, Clokie MR.

Antimicrob Agents Chemother. 2015 Dec 7;60(2):968-81. doi: 10.1128/AAC.01774-15. Print 2016 Feb.


LOV-based reporters for fluorescence imaging.

Buckley AM, Petersen J, Roe AJ, Douce GR, Christie JM.

Curr Opin Chem Biol. 2015 Aug;27:39-45. doi: 10.1016/j.cbpa.2015.05.011. Epub 2015 Jun 15. Review.


The post-translational modification of the Clostridium difficile flagellin affects motility, cell surface properties and virulence.

Faulds-Pain A, Twine SM, Vinogradov E, Strong PC, Dell A, Buckley AM, Douce GR, Valiente E, Logan SM, Wren BW.

Mol Microbiol. 2014 Oct;94(2):272-89. doi: 10.1111/mmi.12755. Epub 2014 Sep 15.


The HtrA-like protease CD3284 modulates virulence of Clostridium difficile.

Bakker D, Buckley AM, de Jong A, van Winden VJ, Verhoeks JP, Kuipers OP, Douce GR, Kuijper EJ, Smits WK, Corver J.

Infect Immun. 2014 Oct;82(10):4222-32. doi: 10.1128/IAI.02336-14. Epub 2014 Jul 21.


The metabolic enzyme AdhE controls the virulence of Escherichia coli O157:H7.

Beckham KS, Connolly JP, Ritchie JM, Wang D, Gawthorne JA, Tahoun A, Gally DL, Burgess K, Burchmore RJ, Smith BO, Beatson SA, Byron O, Wolfe AJ, Douce GR, Roe AJ.

Mol Microbiol. 2014 Jul;93(1):199-211. doi: 10.1111/mmi.12651. Epub 2014 Jun 9.


Vaccination against Clostridium difficile using toxin fragments: Observations and analysis in animal models.

Spencer J, Leuzzi R, Buckley A, Irvine J, Candlish D, Scarselli M, Douce GR.

Gut Microbes. 2014 Mar-Apr;5(2):225-32. doi: 10.4161/gmic.27712. Epub 2014 Jan 22.


Protective efficacy induced by recombinant Clostridium difficile toxin fragments.

Leuzzi R, Spencer J, Buckley A, Brettoni C, Martinelli M, Tulli L, Marchi S, Luzzi E, Irvine J, Candlish D, Veggi D, Pansegrau W, Fiaschi L, Savino S, Swennen E, Cakici O, Oviedo-Orta E, Giraldi M, Baudner B, D'Urzo N, Maione D, Soriani M, Rappuoli R, Pizza M, Douce GR, Scarselli M.

Infect Immun. 2013 Aug;81(8):2851-60. doi: 10.1128/IAI.01341-12. Epub 2013 May 28.


Susceptibility of hamsters to Clostridium difficile isolates of differing toxinotype.

Buckley AM, Spencer J, Maclellan LM, Candlish D, Irvine JJ, Douce GR.

PLoS One. 2013 May 21;8(5):e64121. doi: 10.1371/journal.pone.0064121. Print 2013.


The anti-sigma factor TcdC modulates hypervirulence in an epidemic BI/NAP1/027 clinical isolate of Clostridium difficile.

Carter GP, Douce GR, Govind R, Howarth PM, Mackin KE, Spencer J, Buckley AM, Antunes A, Kotsanas D, Jenkin GA, Dupuy B, Rood JI, Lyras D.

PLoS Pathog. 2011 Oct;7(10):e1002317. doi: 10.1371/journal.ppat.1002317. Epub 2011 Oct 13.


Infection of hamsters with the UK Clostridium difficile ribotype 027 outbreak strain R20291.

Buckley AM, Spencer J, Candlish D, Irvine JJ, Douce GR.

J Med Microbiol. 2011 Aug;60(Pt 8):1174-80. doi: 10.1099/jmm.0.028514-0. Epub 2011 Feb 17.


Distinctive profiles of infection and pathology in hamsters infected with Clostridium difficile strains 630 and B1.

Goulding D, Thompson H, Emerson J, Fairweather NF, Dougan G, Douce GR.

Infect Immun. 2009 Dec;77(12):5478-85. doi: 10.1128/IAI.00551-09. Epub 2009 Sep 14.


Construction and immunological characterization of a novel nontoxic protective pneumolysin mutant for use in future pneumococcal vaccines.

Kirkham LA, Kerr AR, Douce GR, Paterson GK, Dilts DA, Liu DF, Mitchell TJ.

Infect Immun. 2006 Jan;74(1):586-93.


Biological and genetic characterization of TnphoA mutants of Salmonella typhimurium TML in the context of gastroenteritis.

Lodge J, Douce GR, Amin II, Bolton AJ, Martin GD, Chatfield S, Dougan G, Brown NL, Stephen J.

Infect Immun. 1995 Mar;63(3):762-9.


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