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Items: 1 to 50 of 174

1.

Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors.

Culina S, Lalanne AI, Afonso G, Cerosaletti K, Pinto S, Sebastiani G, Kuranda K, Nigi L, Eugster A, Østerbye T, Maugein A, McLaren JE, Ladell K, Larger E, Beressi JP, Lissina A, Appay V, Davidson HW, Buus S, Price DA, Kuhn M, Bonifacio E, Battaglia M, Caillat-Zucman S, Dotta F, Scharfmann R, Kyewski B, Mallone R; ImMaDiab Study Group.

Sci Immunol. 2018 Feb 2;3(20). pii: eaao4013. doi: 10.1126/sciimmunol.aao4013.

PMID:
29429978
2.

Circulating microRNA (miRNA) Expression Profiling in Plasma of Patients with Gestational Diabetes Mellitus Reveals Upregulation of miRNA miR-330-3p.

Sebastiani G, Guarino E, Grieco GE, Formichi C, Delli Poggi C, Ceccarelli E, Dotta F.

Front Endocrinol (Lausanne). 2017 Dec 12;8:345. doi: 10.3389/fendo.2017.00345. eCollection 2017.

3.

Efficacy and Safety of Once-Weekly Semaglutide Versus Exenatide ER in Subjects With Type 2 Diabetes (SUSTAIN 3): A 56-Week, Open-Label, Randomized Clinical Trial.

Ahmann AJ, Capehorn M, Charpentier G, Dotta F, Henkel E, Lingvay I, Holst AG, Annett MP, Aroda VR.

Diabetes Care. 2018 Feb;41(2):258-266. doi: 10.2337/dc17-0417. Epub 2017 Dec 15.

PMID:
29246950
4.

Effects on the incidence of cardiovascular events of the addition of pioglitazone versus sulfonylureas in patients with type 2 diabetes inadequately controlled with metformin (TOSCA.IT): a randomised, multicentre trial.

Vaccaro O, Masulli M, Nicolucci A, Bonora E, Del Prato S, Maggioni AP, Rivellese AA, Squatrito S, Giorda CB, Sesti G, Mocarelli P, Lucisano G, Sacco M, Signorini S, Cappellini F, Perriello G, Babini AC, Lapolla A, Gregori G, Giordano C, Corsi L, Buzzetti R, Clemente G, Di Cianni G, Iannarelli R, Cordera R, La Macchia O, Zamboni C, Scaranna C, Boemi M, Iovine C, Lauro D, Leotta S, Dall'Aglio E, Cannarsa E, Tonutti L, Pugliese G, Bossi AC, Anichini R, Dotta F, Di Benedetto A, Citro G, Antenucci D, Ricci L, Giorgino F, Santini C, Gnasso A, De Cosmo S, Zavaroni D, Vedovato M, Consoli A, Calabrese M, di Bartolo P, Fornengo P, Riccardi G; Thiazolidinediones Or Sulfonylureas Cardiovascular Accidents Intervention Trial (TOSCA.IT) study group; Italian Diabetes Society.

Lancet Diabetes Endocrinol. 2017 Nov;5(11):887-897. doi: 10.1016/S2213-8587(17)30317-0. Epub 2017 Sep 13.

PMID:
28917544
5.

Regulatory T-cells from pancreatic lymphnodes of patients with type-1 diabetes express increased levels of microRNA miR-125a-5p that limits CCR2 expression.

Sebastiani G, Ventriglia G, Stabilini A, Socci C, Morsiani C, Laurenzi A, Nigi L, Formichi C, Mfarrej B, Petrelli A, Fousteri G, Brusko TM, Dotta F, Battaglia M.

Sci Rep. 2017 Jul 31;7(1):6897. doi: 10.1038/s41598-017-07172-1.

6.

Dapagliflozin modulates glucagon secretion in an SGLT2-independent manner in murine alpha cells.

Solini A, Sebastiani G, Nigi L, Santini E, Rossi C, Dotta F.

Diabetes Metab. 2017 Dec;43(6):512-520. doi: 10.1016/j.diabet.2017.04.002. Epub 2017 May 9.

PMID:
28499695
7.

Circulating microRNAs and diabetes mellitus: a novel tool for disease prediction, diagnosis, and staging?

Sebastiani G, Nigi L, Grieco GE, Mancarella F, Ventriglia G, Dotta F.

J Endocrinol Invest. 2017 Jun;40(6):591-610. doi: 10.1007/s40618-017-0611-4. Epub 2017 Feb 17. Review.

PMID:
28213644
8.

Reversal of Diabetes in NOD Mice by Clinical-Grade Proinsulin and IL-10-Secreting Lactococcus lactis in Combination With Low-Dose Anti-CD3 Depends on the Induction of Foxp3-Positive T Cells.

Takiishi T, Cook DP, Korf H, Sebastiani G, Mancarella F, Cunha JP, Wasserfall C, Casares N, Lasarte JJ, Steidler L, Rottiers P, Dotta F, Gysemans C, Mathieu C.

Diabetes. 2017 Feb;66(2):448-459. doi: 10.2337/db15-1625. Epub 2016 Nov 8.

9.

MicroRNA expression profiles of human iPSCs differentiation into insulin-producing cells.

Sebastiani G, Valentini M, Grieco GE, Ventriglia G, Nigi L, Mancarella F, Pellegrini S, Martino G, Sordi V, Piemonti L, Dotta F.

Acta Diabetol. 2017 Mar;54(3):265-281. doi: 10.1007/s00592-016-0955-9. Epub 2016 Dec 30.

PMID:
28039581
10.

MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic β-Cells.

Grieco FA, Sebastiani G, Juan-Mateu J, Villate O, Marroqui L, Ladrière L, Tugay K, Regazzi R, Bugliani M, Marchetti P, Dotta F, Eizirik DL.

Diabetes. 2017 Jan;66(1):100-112. doi: 10.2337/db16-0592. Epub 2016 Oct 13.

11.

Relative sensitivity of immunohistochemistry, multiple reaction monitoring mass spectrometry, in situ hybridization and PCR to detect Coxsackievirus B1 in A549 cells.

Laiho JE, Oikarinen M, Richardson SJ, Frisk G, Nyalwidhe J, Burch TC, Morris MA, Oikarinen S, Pugliese A, Dotta F, Campbell-Thompson M, Nadler J, Morgan NG, Hyöty H; JDRF nPOD-Virus Group.

J Clin Virol. 2016 Apr;77:21-8. doi: 10.1016/j.jcv.2016.01.015. Epub 2016 Feb 2.

12.

Erectile dysfunction and diabetes: Association with the impairment of lipid metabolism and oxidative stress.

Belba A, Cortelazzo A, Andrea G, Durante J, Nigi L, Dotta F, Timperio AM, Zolla L, Leoncini R, Guerranti R, Ponchietti R.

Clin Biochem. 2016 Jan;49(1-2):70-8. doi: 10.1016/j.clinbiochem.2015.10.004. Epub 2015 Oct 21.

PMID:
26500005
13.

Towards an Earlier and Timely Diagnosis of Type 1 Diabetes: Is it Time to Change Criteria to Define Disease Onset?

Battaglia M, Nigi L, Dotta F.

Curr Diab Rep. 2015 Dec;15(12):115. doi: 10.1007/s11892-015-0690-6. Review.

PMID:
26468153
14.

MicroRNAs: Novel Players in the Dialogue between Pancreatic Islets and Immune System in Autoimmune Diabetes.

Ventriglia G, Nigi L, Sebastiani G, Dotta F.

Biomed Res Int. 2015;2015:749734. doi: 10.1155/2015/749734. Epub 2015 Aug 3. Review.

15.

Long-term changes in cardiovascular risk markers during administration of exenatide twice daily or glimepiride: results from the European exenatide study.

Simó R, Guerci B, Schernthaner G, Gallwitz B, Rosas-Guzmàn J, Dotta F, Festa A, Zhou M, Kiljański J.

Cardiovasc Diabetol. 2015 Sep 4;14:116. doi: 10.1186/s12933-015-0279-z.

16.

Mast cells infiltrate pancreatic islets in human type 1 diabetes.

Martino L, Masini M, Bugliani M, Marselli L, Suleiman M, Boggi U, Nogueira TC, Filipponi F, Occhipinti M, Campani D, Dotta F, Syed F, Eizirik DL, Marchetti P, De Tata V.

Diabetologia. 2015 Nov;58(11):2554-62. doi: 10.1007/s00125-015-3734-1. Epub 2015 Aug 15.

PMID:
26276263
17.

Treatment escalation options for patients with type 2 diabetes after failure of exenatide twice daily or glimepiride added to metformin: results from the prospective European Exenatide (EUREXA) study.

Schernthaner G, Rosas-Guzmán J, Dotta F, Guerci B, Simó R, Festa A, Kiljański J, Zhou M, Gallwitz B.

Diabetes Obes Metab. 2015 Jul;17(7):689-98. doi: 10.1111/dom.12471. Epub 2015 May 8.

PMID:
25846577
18.

Human induced pluripotent stem cells differentiate into insulin-producing cells able to engraft in vivo.

Pellegrini S, Ungaro F, Mercalli A, Melzi R, Sebastiani G, Dotta F, Broccoli V, Piemonti L, Sordi V.

Acta Diabetol. 2015 Dec;52(6):1025-35. doi: 10.1007/s00592-015-0726-z. Epub 2015 Mar 4.

PMID:
25733399
19.

The social burden of hypoglycemia in the elderly.

Nicolucci A, Pintaudi B, Rossi MC, Messina R, Dotta F, Frontoni S, Caputo S, Lauro R.

Acta Diabetol. 2015 Aug;52(4):677-85. doi: 10.1007/s00592-015-0717-0. Epub 2015 Feb 8.

PMID:
25663036
20.

Tyrosine phosphatase-related islet antigen 2(256-760) autoantibodies, the only marker of islet autoimmunity that increases by increasing the degree of BMI in obese subjects with type 2 diabetes.

Buzzetti R, Spoletini M, Zampetti S, Campagna G, Marandola L, Panimolle F, Dotta F, Tiberti C; NIRAD Study Group (NIRAD 8).

Diabetes Care. 2015 Mar;38(3):513-20. doi: 10.2337/dc14-1638. Epub 2015 Jan 7.

PMID:
25567348
21.

MicroRNA-124a is hyperexpressed in type 2 diabetic human pancreatic islets and negatively regulates insulin secretion.

Sebastiani G, Po A, Miele E, Ventriglia G, Ceccarelli E, Bugliani M, Marselli L, Marchetti P, Gulino A, Ferretti E, Dotta F.

Acta Diabetol. 2015 Jun;52(3):523-30. doi: 10.1007/s00592-014-0675-y. Epub 2014 Nov 19.

PMID:
25408296
22.

Circulating miRNA95 and miRNA190 are sensitive markers for the differential diagnosis of thyroid nodules in a Caucasian population.

Cantara S, Pilli T, Sebastiani G, Cevenini G, Busonero G, Cardinale S, Dotta F, Pacini F.

J Clin Endocrinol Metab. 2014 Nov;99(11):4190-8. doi: 10.1210/jc.2014-1923. Epub 2014 Jul 24.

PMID:
25057879
23.

Oral delivery of glutamic acid decarboxylase (GAD)-65 and IL10 by Lactococcus lactis reverses diabetes in recent-onset NOD mice.

Robert S, Gysemans C, Takiishi T, Korf H, Spagnuolo I, Sebastiani G, Van Huynegem K, Steidler L, Caluwaerts S, Demetter P, Wasserfall CH, Atkinson MA, Dotta F, Rottiers P, Van Belle TL, Mathieu C.

Diabetes. 2014 Aug;63(8):2876-87. doi: 10.2337/db13-1236. Epub 2014 Mar 27.

24.

Dietary supplementation with high doses of regular vitamin D3 safely reduces diabetes incidence in NOD mice when given early and long term.

Takiishi T, Ding L, Baeke F, Spagnuolo I, Sebastiani G, Laureys J, Verstuyf A, Carmeliet G, Dotta F, Van Belle TL, Gysemans CA, Mathieu C.

Diabetes. 2014 Jun;63(6):2026-36. doi: 10.2337/db13-1559. Epub 2014 Feb 18.

25.

Enteroviral infections and development of type 1 diabetes: The Brothers Karamazov within the CVBs.

Dotta F, Sebastiani G.

Diabetes. 2014 Feb;63(2):384-6. doi: 10.2337/db13-1441. No abstract available.

26.

Long-standing type 1 diabetes: patients with adult-onset develop celiac-specific immunoreactivity more frequently than patients with childhood-onset diabetes, in a disease duration-dependent manner.

Tiberti C, Panimolle F, Bonamico M, Filardi T, Pallotta L, Nenna R, Pontone S, Dotta F, Pugliese G, Lenzi A, Balducci S, Morano S.

Acta Diabetol. 2014 Aug;51(4):675-8. doi: 10.1007/s00592-013-0536-0. Epub 2014 Jan 23.

PMID:
24452477
27.

IL-17A increases the expression of proinflammatory chemokines in human pancreatic islets.

Grieco FA, Moore F, Vigneron F, Santin I, Villate O, Marselli L, Rondas D, Korf H, Overbergh L, Dotta F, Marchetti P, Mathieu C, Eizirik DL.

Diabetologia. 2014 Mar;57(3):502-11. doi: 10.1007/s00125-013-3135-2. Epub 2013 Dec 19.

PMID:
24352375
28.

Photodynamic topical antimicrobial therapy for infected foot ulcers in patients with diabetes: a randomized, double-blind, placebo-controlled study--the D.A.N.T.E (Diabetic ulcer Antimicrobial New Topical treatment Evaluation) study.

Mannucci E, Genovese S, Monami M, Navalesi G, Dotta F, Anichini R, Romagnoli F, Gensini G.

Acta Diabetol. 2014;51(3):435-40. doi: 10.1007/s00592-013-0533-3. Epub 2013 Dec 19.

PMID:
24352342
29.

Beyond glycemic control in diabetes mellitus: effects of incretin-based therapies on bone metabolism.

Ceccarelli E, Guarino EG, Merlotti D, Patti A, Gennari L, Nuti R, Dotta F.

Front Endocrinol (Lausanne). 2013 Jun 18;4:73. doi: 10.3389/fendo.2013.00073. eCollection 2013.

30.

The case for virus-induced type 1 diabetes.

Spagnuolo I, Patti A, Sebastiani G, Nigi L, Dotta F.

Curr Opin Endocrinol Diabetes Obes. 2013 Aug;20(4):292-8. doi: 10.1097/MED.0b013e328362a7d7. Review.

PMID:
23743646
31.

Endocrine actions of osteocalcin.

Patti A, Gennari L, Merlotti D, Dotta F, Nuti R.

Int J Endocrinol. 2013;2013:846480. doi: 10.1155/2013/846480. Epub 2013 Apr 30.

32.

Incretin hormones and beta-cell mass expansion: what we know and what is missing?

Tortosa F, Dotta F.

Arch Physiol Biochem. 2013 Oct;119(4):161-9. doi: 10.3109/13813455.2013.795175. Epub 2013 May 23. Review.

PMID:
23697580
33.

Viral infections and diabetes.

Galleri L, Sebastiani G, Vendrame F, Grieco FA, Spagnuolo I, Dotta F.

Adv Exp Med Biol. 2012;771:252-71. Review.

PMID:
23393684
34.

Reduction of circulating neutrophils precedes and accompanies type 1 diabetes.

Valle A, Giamporcaro GM, Scavini M, Stabilini A, Grogan P, Bianconi E, Sebastiani G, Masini M, Maugeri N, Porretti L, Bonfanti R, Meschi F, De Pellegrin M, Lesma A, Rossini S, Piemonti L, Marchetti P, Dotta F, Bosi E, Battaglia M.

Diabetes. 2013 Jun;62(6):2072-7. doi: 10.2337/db12-1345. Epub 2013 Jan 24.

35.

A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets.

Marchetti P, Lupi R, Bugliani M, Kirkpatrick CL, Sebastiani G, Grieco FA, Del Guerra S, D'Aleo V, Piro S, Marselli L, Boggi U, Filipponi F, Tinti L, Salvini L, Wollheim CB, Purrello F, Dotta F.

Diabetologia. 2012 Dec;55(12):3262-72. doi: 10.1007/s00125-012-2716-9. Epub 2012 Sep 11.

PMID:
22965295
36.

Exenatide twice daily versus glimepiride for prevention of glycaemic deterioration in patients with type 2 diabetes with metformin failure (EUREXA): an open-label, randomised controlled trial.

Gallwitz B, Guzman J, Dotta F, Guerci B, Simó R, Basson BR, Festa A, Kiljański J, Sapin H, Trautmann M, Schernthaner G.

Lancet. 2012 Jun 16;379(9833):2270-8. doi: 10.1016/S0140-6736(12)60479-6. Epub 2012 Jun 9.

PMID:
22683137
37.

Reversal of autoimmune diabetes by restoration of antigen-specific tolerance using genetically modified Lactococcus lactis in mice.

Takiishi T, Korf H, Van Belle TL, Robert S, Grieco FA, Caluwaerts S, Galleri L, Spagnuolo I, Steidler L, Van Huynegem K, Demetter P, Wasserfall C, Atkinson MA, Dotta F, Rottiers P, Gysemans C, Mathieu C.

J Clin Invest. 2012 May;122(5):1717-25. doi: 10.1172/JCI60530. Epub 2012 Apr 9.

38.

Circulating sclerostin levels and bone turnover in type 1 and type 2 diabetes.

Gennari L, Merlotti D, Valenti R, Ceccarelli E, Ruvio M, Pietrini MG, Capodarca C, Franci MB, Campagna MS, Calabrò A, Cataldo D, Stolakis K, Dotta F, Nuti R.

J Clin Endocrinol Metab. 2012 May;97(5):1737-44. doi: 10.1210/jc.2011-2958. Epub 2012 Mar 7.

PMID:
22399511
39.

Combination therapy with metformin plus vildagliptin in type 2 diabetes mellitus.

Guarino E, Nigi L, Patti A, Fondelli C, Dotta F.

Expert Opin Pharmacother. 2012 Jun;13(9):1377-84. doi: 10.1517/14656566.2012.667078. Epub 2012 Mar 7. Review.

PMID:
22397507
40.

Immunology in the clinic review series; focus on type 1 diabetes and viruses: how viral infections modulate beta cell function.

Grieco FA, Sebastiani G, Spagnuolo I, Patti A, Dotta F.

Clin Exp Immunol. 2012 Apr;168(1):24-9. doi: 10.1111/j.1365-2249.2011.04556.x. Review.

41.

In vitro effects of mycophenolic acid on survival, function, and gene expression of pancreatic beta-cells.

Gallo R, Natale M, Vendrame F, Boggi U, Filipponi F, Marchetti P, Laghi Pasini F, Dotta F.

Acta Diabetol. 2012 Dec;49 Suppl 1:S123-31. doi: 10.1007/s00592-011-0368-8. Epub 2012 Jan 17.

PMID:
22249339
42.

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients.

Coppieters KT, Dotta F, Amirian N, Campbell PD, Kay TW, Atkinson MA, Roep BO, von Herrath MG.

J Exp Med. 2012 Jan 16;209(1):51-60. doi: 10.1084/jem.20111187. Epub 2012 Jan 2.

43.

Increased expression of microRNA miR-326 in type 1 diabetic patients with ongoing islet autoimmunity.

Sebastiani G, Grieco FA, Spagnuolo I, Galleri L, Cataldo D, Dotta F.

Diabetes Metab Res Rev. 2011 Nov;27(8):862-6. doi: 10.1002/dmrr.1262.

PMID:
22069274
44.

Delta-cell-specific expression of hedgehog pathway Ptch1 receptor in murine and human endocrine pancreas.

Grieco FA, Moretti M, Sebastiani G, Galleri L, Spagnuolo I, Scafetta G, Gulino A, De Smaele E, Maroder M, Dotta F.

Diabetes Metab Res Rev. 2011 Nov;27(8):755-60. doi: 10.1002/dmrr.1247.

PMID:
22069255
45.

Detection of four diabetes specific autoantibodies in a single radioimmunoassay: an innovative high-throughput approach for autoimmune diabetes screening.

Tiberti C, Yu L, Lucantoni F, Panimolle F, Spagnuolo I, Lenzi A, Eisenbarth GS, Dotta F.

Clin Exp Immunol. 2011 Dec;166(3):317-24. doi: 10.1111/j.1365-2249.2011.04479.x.

46.

In type 1 diabetes immunocompetent cells are defective in IL-16 secretion.

Vendrame F, Cataldo D, Ciarlo L, Umland O, Misasi R, Dotta F.

Scand J Immunol. 2012 Jan;75(1):127-8. doi: 10.1111/j.1365-3083.2011.02630.x. No abstract available.

47.

Histopathology and ex vivo insulin secretion of pancreatic islets in gestational diabetes: A case report.

Tancredi M, Marselli L, Lencioni C, Masini M, Bugliani M, Suleiman M, Masiello P, Boggi U, Filipponi F, Dotta F, Marchetti P, Di Cianni G.

Islets. 2011 Sep-Oct;3(5):231-3. Epub 2011 Sep 1.

PMID:
21765242
48.

Measuring adrenal autoantibody response: interlaboratory concordance in the first international serum exchange for the determination of 21-hydroxylase autoantibodies.

Falorni A, Chen S, Zanchetta R, Yu L, Tiberti C, Bacosi ML, Furmaniak J, Bini V, Dotta F, Eisenbarth GS, Smith BR, Betterle C.

Clin Immunol. 2011 Sep;140(3):291-9. doi: 10.1016/j.clim.2011.04.012. Epub 2011 Apr 28.

PMID:
21570358
49.

MicroRNAs as new tools for exploring type 1 diabetes: relevance for immunomodulation and transplantation therapy.

Sebastiani G, Vendrame F, Dotta F.

Transplant Proc. 2011 Jan-Feb;43(1):330-2. doi: 10.1016/j.transproceed.2010.09.104.

PMID:
21335216
50.

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