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Cancer immunotherapy in patients with brain metastases.

Caponnetto S, Draghi A, Borch TH, Nuti M, Cortesi E, Svane IM, Donia M.

Cancer Immunol Immunother. 2018 Mar 8. doi: 10.1007/s00262-018-2146-8. [Epub ahead of print] Review.


Peptide-MHC Class I Tetramers Can Fail To Detect Relevant Functional T Cell Clonotypes and Underestimate Antigen-Reactive T Cell Populations.

Rius C, Attaf M, Tungatt K, Bianchi V, Legut M, Bovay A, Donia M, Thor Straten P, Peakman M, Svane IM, Ott S, Connor T, Szomolay B, Dolton G, Sewell AK.

J Immunol. 2018 Feb 26. pii: ji1700242. doi: 10.4049/jimmunol.1700242. [Epub ahead of print]


Frequent adaptive immune responses against arginase-1.

Martinenaite E, Mortensen REJ, Hansen M, Orebo Holmström M, Munir Ahmad S, Grønne Dahlager Jørgensen N, Met Ö, Donia M, Svane IM, Andersen MH.

Oncoimmunology. 2017 Dec 26;7(3):e1404215. doi: 10.1080/2162402X.2017.1404215. eCollection 2018.


Elevated Serum α-Synuclein Autoantibodies in Patients with Parkinson's Disease Relative to Alzheimer's Disease and Controls.

Shalash A, Salama M, Makar M, Roushdy T, Elrassas HH, Mohamed W, El-Balkimy M, Abou Donia M.

Front Neurol. 2017 Dec 22;8:720. doi: 10.3389/fneur.2017.00720. eCollection 2017.


The inhibitory checkpoint, PD-L2, is a target for effector T cells: Novel possibilities for immune therapy.

Ahmad SM, Martinenaite E, Holmström M, Jørgensen MA, Met Ö, Nastasi C, Klausen U, Donia M, Pedersen LM, Munksgaard L, Ødum N, Woetmann A, Svane IM, Andersen MH.

Oncoimmunology. 2017 Nov 1;7(2):e1390641. doi: 10.1080/2162402X.2017.1390641. eCollection 2018.


T-cell Responses in the Microenvironment of Primary Renal Cell Carcinoma-Implications for Adoptive Cell Therapy.

Andersen R, Westergaard MCW, Kjeldsen JW, Müller A, Pedersen NW, Hadrup SR, Met Ö, Seliger B, Kromann-Andersen B, Hasselager T, Donia M, Svane IM.

Cancer Immunol Res. 2018 Feb;6(2):222-235. doi: 10.1158/2326-6066.CIR-17-0467. Epub 2018 Jan 4.


Mutational and putative neoantigen load predict clinical benefit of adoptive T cell therapy in melanoma.

Lauss M, Donia M, Harbst K, Andersen R, Mitra S, Rosengren F, Salim M, Vallon-Christersson J, Törngren T, Kvist A, Ringnér M, Svane IM, Jönsson G.

Nat Commun. 2017 Nov 23;8(1):1738. doi: 10.1038/s41467-017-01460-0.


Amyotrophic lateral sclerosis-A case report and mechanistic review of the association with toluene and other volatile organic compounds.

Ratner MH, Jabre JF, Ewing WM, Abou-Donia M, Oliver LC.

Am J Ind Med. 2018 Mar;61(3):251-260. doi: 10.1002/ajim.22791. Epub 2017 Nov 10.


Neural autoantibodies in patients with neurological symptoms and histories of chemical/mold exposures.

Abou-Donia MB, Lieberman A, Curtis L.

Toxicol Ind Health. 2018 Jan;34(1):44-53. doi: 10.1177/0748233717733852. Epub 2017 Oct 25.


Clinical responses to adoptive T-cell transfer can be modeled in an autologous immune-humanized mouse model.

Jespersen H, Lindberg MF, Donia M, Söderberg EMV, Andersen R, Keller U, Ny L, Svane IM, Nilsson LM, Nilsson JA.

Nat Commun. 2017 Sep 27;8(1):707. doi: 10.1038/s41467-017-00786-z.


A Panel of Autoantibodies Against Neural Proteins as Peripheral Biomarker for Pesticide-Induced Neurotoxicity.

El Rahman HAA, Salama M, Gad El-Hak SA, El-Harouny MA, ElKafrawy P, Abou-Donia MB.

Neurotox Res. 2018 Feb;33(2):316-336. doi: 10.1007/s12640-017-9793-y. Epub 2017 Sep 5.


Lactobacillus reuteri induces gut intraepithelial CD4+CD8αα+ T cells.

Cervantes-Barragan L, Chai JN, Tianero MD, Di Luccia B, Ahern PP, Merriman J, Cortez VS, Caparon MG, Donia MS, Gilfillan S, Cella M, Gordon JI, Hsieh CS, Colonna M.

Science. 2017 Aug 25;357(6353):806-810. doi: 10.1126/science.aah5825. Epub 2017 Aug 3.


PD-1+ Polyfunctional T Cells Dominate the Periphery after Tumor-Infiltrating Lymphocyte Therapy for Cancer.

Donia M, Kjeldsen JW, Andersen R, Westergaard MCW, Bianchi V, Legut M, Attaf M, Szomolay B, Ott S, Dolton G, Lyngaa R, Hadrup SR, Sewell AK, Svane IM.

Clin Cancer Res. 2017 Oct 1;23(19):5779-5788. doi: 10.1158/1078-0432.CCR-16-1692. Epub 2017 Jul 5.


Acquired Immune Resistance Follows Complete Tumor Regression without Loss of Target Antigens or IFNγ Signaling.

Donia M, Harbst K, van Buuren M, Kvistborg P, Lindberg MF, Andersen R, Idorn M, Munir Ahmad S, Ellebæk E, Mueller A, Fagone P, Nicoletti F, Libra M, Lauss M, Hadrup SR, Schmidt H, Andersen MH, Thor Straten P, Nilsson JA, Schumacher TN, Seliger B, Jönsson G, Svane IM.

Cancer Res. 2017 Sep 1;77(17):4562-4566. doi: 10.1158/0008-5472.CAN-16-3172. Epub 2017 Jun 27.


Influence of ipilimumab on expanded tumour derived T cells from patients with metastatic melanoma.

Bjoern J, Lyngaa R, Andersen R, Rosenkrantz LH, Hadrup SR, Donia M, Svane IM.

Oncotarget. 2017 Apr 18;8(16):27062-27074. doi: 10.18632/oncotarget.16003.


Genomic Methods and Microbiological Technologies for Profiling Novel and Extreme Environments for the Extreme Microbiome Project (XMP).

Tighe S, Afshinnekoo E, Rock TM, McGrath K, Alexander N, McIntyre A, Ahsanuddin S, Bezdan D, Green SJ, Joye S, Stewart Johnson S, Baldwin DA, Bivens N, Ajami N, Carmical JR, Herriott IC, Colwell R, Donia M, Foox J, Greenfield N, Hunter T, Hoffman J, Hyman J, Jorgensen E, Krawczyk D, Lee J, Levy S, Garcia-Reyero N, Settles M, Thomas K, Gómez F, Schriml L, Kyrpides N, Zaikova E, Penterman J, Mason CE.

J Biomol Tech. 2017 Apr;28(1):31-39. doi: 10.7171/jbt.17-2801-004. Epub 2017 Mar 10. Erratum in: J Biomol Tech. 2017 Jul;28(2):93.


The majority of patients with metastatic melanoma are not represented in pivotal phase III immunotherapy trials.

Donia M, Kimper-Karl ML, Høyer KL, Bastholt L, Schmidt H, Svane IM.

Eur J Cancer. 2017 Mar;74:89-95. doi: 10.1016/j.ejca.2016.12.017. Epub 2017 Feb 12.


Screening for novel central nervous system biomarkers in veterans with Gulf War Illness.

Abou-Donia MB, Conboy LA, Kokkotou E, Jacobson E, Elmasry EM, Elkafrawy P, Neely M, Bass CR', Sullivan K.

Neurotoxicol Teratol. 2017 May;61:36-46. doi: 10.1016/ Epub 2017 Mar 9.


Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases.

Guo CJ, Chang FY, Wyche TP, Backus KM, Acker TM, Funabashi M, Taketani M, Donia MS, Nayfach S, Pollard KS, Craik CS, Cravatt BF, Clardy J, Voigt CA, Fischbach MA.

Cell. 2017 Jan 26;168(3):517-526.e18. doi: 10.1016/j.cell.2016.12.021. Epub 2017 Jan 19.


CCL22-specific T Cells: Modulating the immunosuppressive tumor microenvironment.

Martinenaite E, Munir Ahmad S, Hansen M, Met Ö, Westergaard MW, Larsen SK, Klausen TW, Donia M, Svane IM, Andersen MH.

Oncoimmunology. 2016 Sep 30;5(11):e1238541. doi: 10.1080/2162402X.2016.1238541. eCollection 2016.


Cancer immunotherapy in patients with preexisting autoimmune disorders.

Donia M, Pedersen M, Svane IM.

Semin Immunopathol. 2017 Apr;39(3):333-337. doi: 10.1007/s00281-016-0595-8. Epub 2016 Oct 11. Review.


Sarin (GB, O-isopropyl methylphosphonofluoridate) neurotoxicity: critical review.

Abou-Donia MB, Siracuse B, Gupta N, Sobel Sokol A.

Crit Rev Toxicol. 2016 Nov;46(10):845-875. Epub 2016 Oct 5. Review.


PD-L1 peptide co-stimulation increases immunogenicity of a dendritic cell-based cancer vaccine.

Munir Ahmad S, Martinenaite E, Hansen M, Junker N, Borch TH, Met Ö, Donia M, Svane IM, Andersen MH.

Oncoimmunology. 2016 Jul 1;5(8):e1202391. doi: 10.1080/2162402X.2016.1202391. eCollection 2016 Aug.


Large-scale detection of antigen-specific T cells using peptide-MHC-I multimers labeled with DNA barcodes.

Bentzen AK, Marquard AM, Lyngaa R, Saini SK, Ramskov S, Donia M, Such L, Furness AJ, McGranahan N, Rosenthal R, Straten PT, Szallasi Z, Svane IM, Swanton C, Quezada SA, Jakobsen SN, Eklund AC, Hadrup SR.

Nat Biotechnol. 2016 Oct;34(10):1037-1045. doi: 10.1038/nbt.3662. Epub 2016 Aug 29.


Targeting of cancer neoantigens with donor-derived T cell receptor repertoires.

Strønen E, Toebes M, Kelderman S, van Buuren MM, Yang W, van Rooij N, Donia M, Böschen ML, Lund-Johansen F, Olweus J, Schumacher TN.

Science. 2016 Jun 10;352(6291):1337-41. doi: 10.1126/science.aaf2288. Epub 2016 May 19.


The controversial role of TNF in melanoma.

Donia M, Kjeldsen JW, Svane IM.

Oncoimmunology. 2015 Oct 29;5(4):e1107699. eCollection 2016 Apr.


A Toolbox for Microbiome Engineering.

Donia MS.

Cell Syst. 2015 Jul 29;1(1):21-3. doi: 10.1016/j.cels.2015.07.003. Epub 2015 Jul 29.


Effect of Perceived Politics and Perceived Support on Bullying and Emotional Exhaustion: The Moderating Role of Type A Personality.

Naseer S, Raja U, Donia MB.

J Psychol. 2016 Jul 3;150(5):606-24. doi: 10.1080/00223980.2016.1154809. Epub 2016 Mar 23.


Long-Lasting Complete Responses in Patients with Metastatic Melanoma after Adoptive Cell Therapy with Tumor-Infiltrating Lymphocytes and an Attenuated IL2 Regimen.

Andersen R, Donia M, Ellebaek E, Borch TH, Kongsted P, Iversen TZ, Hölmich LR, Hendel HW, Met Ö, Andersen MH, Thor Straten P, Svane IM.

Clin Cancer Res. 2016 Aug 1;22(15):3734-45. doi: 10.1158/1078-0432.CCR-15-1879. Epub 2016 Mar 22.


Tumor-infiltrating lymphocytes for the treatment of metastatic cancer.

Geukes Foppen MH, Donia M, Svane IM, Haanen JB.

Mol Oncol. 2015 Dec;9(10):1918-35. doi: 10.1016/j.molonc.2015.10.018. Epub 2015 Oct 30. Review.


A Phase-Variable Surface Layer from the Gut Symbiont Bacteroides thetaiotaomicron.

Taketani M, Donia MS, Jacobson AN, Lambris JD, Fischbach MA.

MBio. 2015 Sep 29;6(5):e01339-15. doi: 10.1128/mBio.01339-15.


New developments in the management of advanced melanoma - role of pembrolizumab.

Improta G, Leone I, Donia M, Gieri S, Pelosi G, Fraggetta F.

Onco Targets Ther. 2015 Sep 14;8:2535-43. doi: 10.2147/OTT.S72823. eCollection 2015. Review.


Tumor infiltrating lymphocyte therapy for ovarian cancer and renal cell carcinoma.

Andersen R, Donia M, Westergaard MC, Pedersen M, Hansen M, Svane IM.

Hum Vaccin Immunother. 2015;11(12):2790-5. doi: 10.1080/21645515.2015.1075106.


Minimum Information about a Biosynthetic Gene cluster.

Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kötter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nützmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gómez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Höfte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Müller R, Neilan BA, Nett M, Nielsen J, O'Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Süssmuth RD, Tahlan K, Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glöckner FO.

Nat Chem Biol. 2015 Sep;11(9):625-31. doi: 10.1038/nchembio.1890. No abstract available.


Genome-Directed Lead Discovery: Biosynthesis, Structure Elucidation, and Biological Evaluation of Two Families of Polyene Macrolactams against Trypanosoma brucei.

Schulze CJ, Donia MS, Siqueira-Neto JL, Ray D, Raskatov JA, Green RE, McKerrow JH, Fischbach MA, Linington RG.

ACS Chem Biol. 2015 Oct 16;10(10):2373-81. doi: 10.1021/acschembio.5b00308. Epub 2015 Aug 13.


HUMAN MICROBIOTA. Small molecules from the human microbiota.

Donia MS, Fischbach MA.

Science. 2015 Jul 24;349(6246):1254766. doi: 10.1126/science.1254766. Epub 2015 Jul 23. Review.


Reorienting the immune system in the treatment of cancer by using anti-PD-1 and anti-PD-L1 antibodies.

Borch TH, Donia M, Andersen MH, Svane IM.

Drug Discov Today. 2015 Sep;20(9):1127-34. doi: 10.1016/j.drudis.2015.07.003. Epub 2015 Jul 17. Review.


Aberrant Expression of MHC Class II in Melanoma Attracts Inflammatory Tumor-Specific CD4+ T- Cells, Which Dampen CD8+ T-cell Antitumor Reactivity.

Donia M, Andersen R, Kjeldsen JW, Fagone P, Munir S, Nicoletti F, Andersen MH, Thor Straten P, Svane IM.

Cancer Res. 2015 Sep 15;75(18):3747-59. doi: 10.1158/0008-5472.CAN-14-2956. Epub 2015 Jul 16.


More tricks with tetramers: a practical guide to staining T cells with peptide-MHC multimers.

Dolton G, Tungatt K, Lloyd A, Bianchi V, Theaker SM, Trimby A, Holland CJ, Donia M, Godkin AJ, Cole DK, Straten PT, Peakman M, Svane IM, Sewell AK.

Immunology. 2015 Sep;146(1):11-22. doi: 10.1111/imm.12499. Review.


Broadening the repertoire of melanoma-associated T-cell epitopes.

Frøsig TM, Lyngaa R, Met Ö, Larsen SK, Donia M, Svane IM, Thor Straten P, Hadrup SR.

Cancer Immunol Immunother. 2015 May;64(5):609-20. doi: 10.1007/s00262-015-1664-x. Epub 2015 Feb 18.


Antibody stabilization of peptide-MHC multimers reveals functional T cells bearing extremely low-affinity TCRs.

Tungatt K, Bianchi V, Crowther MD, Powell WE, Schauenburg AJ, Trimby A, Donia M, Miles JJ, Holland CJ, Cole DK, Godkin AJ, Peakman M, Straten PT, Svane IM, Sewell AK, Dolton G.

J Immunol. 2015 Jan 1;194(1):463-74. doi: 10.4049/jimmunol.1401785. Epub 2014 Dec 1.


Atypical site and size of atrial myxoma.

Abdelsalam GG, Saad H, Donia M, Elnady H, Elmahdy MF.

Cardiovasc Revasc Med. 2015 Mar;16(2):129-30. doi: 10.1016/j.carrev.2014.08.007. Epub 2014 Aug 29. No abstract available.


Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine.

Williams BB, Van Benschoten AH, Cimermancic P, Donia MS, Zimmermann M, Taketani M, Ishihara A, Kashyap PC, Fraser JS, Fischbach MA.

Cell Host Microbe. 2014 Oct 8;16(4):495-503. doi: 10.1016/j.chom.2014.09.001. Epub 2014 Sep 25.


A systematic analysis of biosynthetic gene clusters in the human microbiome reveals a common family of antibiotics.

Donia MS, Cimermancic P, Schulze CJ, Wieland Brown LC, Martin J, Mitreva M, Clardy J, Linington RG, Fischbach MA.

Cell. 2014 Sep 11;158(6):1402-1414. doi: 10.1016/j.cell.2014.08.032.


"Immunotherapy of cancer: present status and future promise": Danish Cancer Society Symposium, Copenhagen, Denmark, 23rd-25th September 2013.

Donia M, Lyngaa R, Hadrup SR.

Cancer Immunol Immunother. 2014 Sep;63(9):985-9. doi: 10.1007/s00262-014-1585-0. Epub 2014 Jul 24. No abstract available.


Simplified protocol for clinical-grade tumor-infiltrating lymphocyte manufacturing with use of the Wave bioreactor.

Donia M, Larsen SM, Met O, Svane IM.

Cytotherapy. 2014 Aug;16(8):1117-20. doi: 10.1016/j.jcyt.2014.02.004. Epub 2014 May 13.


Host control of symbiont natural product chemistry in cryptic populations of the tunicate Lissoclinum patella.

Kwan JC, Tianero MD, Donia MS, Wyche TP, Bugni TS, Schmidt EW.

PLoS One. 2014 May 2;9(5):e95850. doi: 10.1371/journal.pone.0095850. eCollection 2014.


Biological insights into BRAFV600 mutations in melanoma patient: Not mere therapeutic targets.

Improta G, Pelosi G, Tamborini E, Donia M, Santinami M, de Braud F, Fraggetta F.

Oncoimmunology. 2013 Aug 1;2(8):e25594. Epub 2013 Jul 3.


A metabolomic view of how the human gut microbiota impacts the host metabolome using humanized and gnotobiotic mice.

Marcobal A, Kashyap PC, Nelson TA, Aronov PA, Donia MS, Spormann A, Fischbach MA, Sonnenburg JL.

ISME J. 2013 Oct;7(10):1933-43. doi: 10.1038/ismej.2013.89. Epub 2013 Jun 6.


Autoantibodies to nervous system-specific proteins are elevated in sera of flight crew members: biomarkers for nervous system injury.

Abou-Donia MB, Abou-Donia MM, ElMasry EM, Monro JA, Mulder MF.

J Toxicol Environ Health A. 2013;76(6):363-80. doi: 10.1080/15287394.2013.765369.


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