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Coordinated Pulses of mRNA and of Protein Translation or Degradation Produce EGF-Induced Protein Bursts.

Golan-Lavi R, Giacomelli C, Fuks G, Zeisel A, Sonntag J, Sinha S, Köstler W, Wiemann S, Korf U, Yarden Y, Domany E.

Cell Rep. 2017 Mar 28;18(13):3129-3142. doi: 10.1016/j.celrep.2017.03.014.


Parkinson disease (PARK) genes are somatically mutated in cutaneous melanoma.

Inzelberg R, Samuels Y, Azizi E, Qutob N, Inzelberg L, Domany E, Schechtman E, Friedman E.

Neurol Genet. 2016 Apr 13;2(3):e70. doi: 10.1212/NXG.0000000000000070. eCollection 2016 Jun.


Tumor Evolution Inferred by Patterns of microRNA Expression through the Course of Disease, Therapy, and Recurrence in Breast Cancer.

Dadiani M, Bossel Ben-Moshe N, Paluch-Shimon S, Perry G, Balint N, Marin I, Pavlovski A, Morzaev D, Kahana-Edwin S, Yosepovich A, Gal-Yam EN, Berger R, Barshack I, Domany E, Kaufman B.

Clin Cancer Res. 2016 Jul 15;22(14):3651-62. doi: 10.1158/1078-0432.CCR-15-2313. Epub 2016 Mar 8.


Down-regulation of LATS kinases alters p53 to promote cell migration.

Furth N, Bossel Ben-Moshe N, Pozniak Y, Porat Z, Geiger T, Domany E, Aylon Y, Oren M.

Genes Dev. 2015 Nov 15;29(22):2325-30. doi: 10.1101/gad.268185.115.


Guanine polynucleotides are self-antigens for human natural autoantibodies and are significantly reduced in the human genome.

Fattal I, Shental N, Ben-Dor S, Molad Y, Gabrielli A, Pokroy-Shapira E, Oren S, Livneh A, Langevitz P, Zandman-Goddard G, Sarig O, Margalit R, Gafter U, Domany E, Cohen IR.

Immunology. 2015 Nov;146(3):401-10. doi: 10.1111/imm.12514. Epub 2015 Sep 7.


Pathway-based personalized analysis of breast cancer expression data.

Livshits A, Git A, Fuks G, Caldas C, Domany E.

Mol Oncol. 2015 Aug;9(7):1471-83. doi: 10.1016/j.molonc.2015.04.006. Epub 2015 Apr 29.


Integration of gene expression and GWAS results supports involvement of calcium signaling in Schizophrenia.

Hertzberg L, Katsel P, Roussos P, Haroutunian V, Domany E.

Schizophr Res. 2015 May;164(1-3):92-9. doi: 10.1016/j.schres.2015.02.001. Epub 2015 Feb 20.


Chromosome 7 gain and DNA hypermethylation at the HOXA10 locus are associated with expression of a stem cell related HOX-signature in glioblastoma.

Kurscheid S, Bady P, Sciuscio D, Samarzija I, Shay T, Vassallo I, Criekinge WV, Daniel RT, van den Bent MJ, Marosi C, Weller M, Mason WP, Domany E, Stupp R, Delorenzi M, Hegi ME.

Genome Biol. 2015 Jan 27;16:16. doi: 10.1186/s13059-015-0583-7.


Reactivation of epigenetically silenced miR-512 and miR-373 sensitizes lung cancer cells to cisplatin and restricts tumor growth.

Adi Harel S, Bossel Ben-Moshe N, Aylon Y, Bublik DR, Moskovits N, Toperoff G, Azaiza D, Biagoni F, Fuchs G, Wilder S, Hellman A, Blandino G, Domany E, Oren M.

Cell Death Differ. 2015 Aug;22(8):1328-40. doi: 10.1038/cdd.2014.221. Epub 2015 Jan 16.


Identification of novel DNA-damage tolerance genes reveals regulation of translesion DNA synthesis by nucleophosmin.

Ziv O, Zeisel A, Mirlas-Neisberg N, Swain U, Nevo R, Ben-Chetrit N, Martelli MP, Rossi R, Schiesser S, Canman CE, Carell T, Geacintov NE, Falini B, Domany E, Livneh Z.

Nat Commun. 2014 Nov 25;5:5437. doi: 10.1038/ncomms6437.


Diurnal suppression of EGFR signalling by glucocorticoids and implications for tumour progression and treatment.

Lauriola M, Enuka Y, Zeisel A, D'Uva G, Roth L, Sharon-Sevilla M, Lindzen M, Sharma K, Nevo N, Feldman M, Carvalho S, Cohen-Dvashi H, Kedmi M, Ben-Chetrit N, Chen A, Solmi R, Wiemann S, Schmitt F, Domany E, Yarden Y.

Nat Commun. 2014 Oct 3;5:5073. doi: 10.1038/ncomms6073.


Using high-throughput transcriptomic data for prognosis: a critical overview and perspectives.

Domany E.

Cancer Res. 2014 Sep 1;74(17):4612-21. doi: 10.1158/0008-5472.CAN-13-3338. Review.


Pemphigus vulgaris is characterized by low IgG reactivities to specific self-antigens along with high IgG reactivity to desmoglein 3.

Fattal I, Rimer J, Shental N, Molad Y, Gabrielli A, Livneh A, Sarig O, Goldberg I, Gafter U, Domany E, Cohen IR.

Immunology. 2014 Nov;143(3):374-80. doi: 10.1111/imm.12316.


Blastocyst implantation failure relates to impaired translational machinery gene expression.

Plaks V, Gershon E, Zeisel A, Jacob-Hirsch J, Neeman M, Winterhager E, Rechavi G, Domany E, Dekel N.

Reproduction. 2014 Jul;148(1):87-98. doi: 10.1530/REP-13-0395. Epub 2014 Apr 3.


Epidermal growth-factor-induced transcript isoform variation drives mammary cell migration.

Köstler WJ, Zeisel A, Körner C, Tsai JM, Jacob-Hirsch J, Ben-Chetrit N, Sharma K, Cohen-Dvashi H, Yitzhaky A, Lader E, Tschulena U, Rechavi G, Domany E, Wiemann S, Yarden Y.

PLoS One. 2013 Dec 6;8(12):e80566. doi: 10.1371/journal.pone.0080566. eCollection 2013.


Epstein-Barr virus antibodies mark systemic lupus erythematosus and scleroderma patients negative for anti-DNA.

Fattal I, Shental N, Molad Y, Gabrielli A, Pokroy-Shapira E, Oren S, Livneh A, Langevitz P, Pauzner R, Sarig O, Gafter U, Domany E, Cohen IR.

Immunology. 2014 Feb;141(2):276-85. doi: 10.1111/imm.12200.


Expression of TP53 mutation-associated microRNAs predicts clinical outcome in head and neck squamous cell carcinoma patients.

Ganci F, Sacconi A, Bossel Ben-Moshe N, Manciocco V, Sperduti I, Strigari L, Covello R, Benevolo M, Pescarmona E, Domany E, Muti P, Strano S, Spriano G, Fontemaggi G, Blandino G.

Ann Oncol. 2013 Dec;24(12):3082-8. doi: 10.1093/annonc/mdt380. Epub 2013 Oct 9.


c-Kit is suppressed in human colon cancer tissue and contributes to L1-mediated metastasis.

Gavert N, Shvab A, Sheffer M, Ben-Shmuel A, Haase G, Bakos E, Domany E, Ben-Ze'ev A.

Cancer Res. 2013 Sep 15;73(18):5754-63. doi: 10.1158/0008-5472.CAN-13-0576. Epub 2013 Sep 5.


Imperforate hymen presenting as chronic low back pain.

Domany E, Gilad O, Shwarz M, Vulfsons S, Garty BZ.

Pediatrics. 2013 Sep;132(3):e768-70. doi: 10.1542/peds.2012-1040. Epub 2013 Aug 19.


The locus of microRNA-10b: a critical target for breast cancer insurgence and dissemination.

Biagioni F, Bossel Ben-Moshe N, Fontemaggi G, Yarden Y, Domany E, Blandino G.

Cell Cycle. 2013 Aug 1;12(15):2371-5. doi: 10.4161/cc.25380. Epub 2013 Jun 26. Review.


Pathway-based personalized analysis of cancer.

Drier Y, Sheffer M, Domany E.

Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6388-93. doi: 10.1073/pnas.1219651110. Epub 2013 Apr 1.


An accessible database for mouse and human whole transcriptome qPCR primers.

Zeisel A, Yitzhaky A, Bossel Ben-Moshe N, Domany E.

Bioinformatics. 2013 May 15;29(10):1355-6. doi: 10.1093/bioinformatics/btt145. Epub 2013 Mar 28.


miR-10b*, a master inhibitor of the cell cycle, is down-regulated in human breast tumours.

Biagioni F, Bossel Ben-Moshe N, Fontemaggi G, Canu V, Mori F, Antoniani B, Di Benedetto A, Santoro R, Germoni S, De Angelis F, Cambria A, Avraham R, Grasso G, Strano S, Muti P, Mottolese M, Yarden Y, Domany E, Blandino G.

EMBO Mol Med. 2012 Nov;4(11):1214-29. doi: 10.1002/emmm.201201483.


Diagnostic performances of hepatitis C virus-NS4 antigen in patients with different liver pathologies.

Attallah AM, Omran MM, Nasif WA, Ghaly MF, El-Shanshoury Ael-R, Abdalla MS, Sharada HM, Farid K, El-Shony W, Moussa el-SM, El-Domany EB, Nour E, Eldosoky I.

Arch Med Res. 2012 Oct;43(7):555-62. doi: 10.1016/j.arcmed.2012.09.010. Epub 2012 Oct 17.


qCMA: a desktop application for quantitative collective cell migration analysis.

Zeisel A, Yitzhaky A, Koerner C, Lauriola M, Cohen-Dvashi H, Köstler WJ, Yarden Y, Wiemann S, Domany E.

J Biomol Screen. 2013 Mar;18(3):356-60. doi: 10.1177/1087057112461940. Epub 2012 Oct 5.


Context-specific microRNA analysis: identification of functional microRNAs and their mRNA targets.

Bossel Ben-Moshe N, Avraham R, Kedmi M, Zeisel A, Yitzhaky A, Yarden Y, Domany E.

Nucleic Acids Res. 2012 Nov;40(21):10614-27. doi: 10.1093/nar/gks841. Epub 2012 Sep 12.


RNF20 and USP44 regulate stem cell differentiation by modulating H2B monoubiquitylation.

Fuchs G, Shema E, Vesterman R, Kotler E, Wolchinsky Z, Wilder S, Golomb L, Pribluda A, Zhang F, Haj-Yahya M, Feldmesser E, Brik A, Yu X, Hanna J, Aberdam D, Domany E, Oren M.

Mol Cell. 2012 Jun 8;46(5):662-73. doi: 10.1016/j.molcel.2012.05.023. Erratum in: Mol Cell. 2015 Oct 15;60(2):338.


Genome-wide analysis discloses reversal of the hypoxia-induced changes of gene expression in colon cancer cells by zinc supplementation.

Sheffer M, Simon AJ, Jacob-Hirsch J, Rechavi G, Domany E, Givol D, D'Orazi G.

Oncotarget. 2011 Dec;2(12):1191-202.


EGR1 and the ERK-ERF axis drive mammary cell migration in response to EGF.

Tarcic G, Avraham R, Pines G, Amit I, Shay T, Lu Y, Zwang Y, Katz M, Ben-Chetrit N, Jacob-Hirsch J, Virgilio L, Rechavi G, Mavrothalassitis G, Mills GB, Domany E, Yarden Y.

FASEB J. 2012 Apr;26(4):1582-92. doi: 10.1096/fj.11-194654. Epub 2011 Dec 23.


Modeling invasive breast cancer: growth factors propel progression of HER2-positive premalignant lesions.

Pradeep CR, Zeisel A, Köstler WJ, Lauriola M, Jacob-Hirsch J, Haibe-Kains B, Amariglio N, Ben-Chetrit N, Emde A, Solomonov I, Neufeld G, Piccart M, Sagi I, Sotiriou C, Rechavi G, Domany E, Desmedt C, Yarden Y.

Oncogene. 2012 Aug 2;31(31):3569-83. doi: 10.1038/onc.2011.547. Epub 2011 Dec 5.


Mutant p53 oncogenic functions are sustained by Plk2 kinase through an autoregulatory feedback loop.

Valenti F, Fausti F, Biagioni F, Shay T, Fontemaggi G, Domany E, Yaffe MB, Strano S, Blandino G, Di Agostino S.

Cell Cycle. 2011 Dec 15;10(24):4330-40. doi: 10.4161/cc.10.24.18682. Epub 2011 Dec 15.


Coupled pre-mRNA and mRNA dynamics unveil operational strategies underlying transcriptional responses to stimuli.

Zeisel A, Köstler WJ, Molotski N, Tsai JM, Krauthgamer R, Jacob-Hirsch J, Rechavi G, Soen Y, Jung S, Yarden Y, Domany E.

Mol Syst Biol. 2011 Sep 13;7:529. doi: 10.1038/msb.2011.62.


Elevated red cell distribution width predicts poor outcome in young patients with community acquired pneumonia.

Braun E, Domany E, Kenig Y, Mazor Y, Makhoul BF, Azzam ZS.

Crit Care. 2011 Aug 11;15(4):R194. doi: 10.1186/cc10355.


Modeling ductal carcinoma in situ: a HER2-Notch3 collaboration enables luminal filling.

Pradeep CR, Köstler WJ, Lauriola M, Granit RZ, Zhang F, Jacob-Hirsch J, Rechavi G, Nair HB, Hennessy BT, Gonzalez-Angulo AM, Tekmal RR, Ben-Porath I, Mills GB, Domany E, Yarden Y.

Oncogene. 2012 Feb 16;31(7):907-17. doi: 10.1038/onc.2011.279. Epub 2011 Jul 11.


The Wnt inhibitory factor 1 (WIF1) is targeted in glioblastoma and has a tumor suppressing function potentially by induction of senescence.

Lambiv WL, Vassallo I, Delorenzi M, Shay T, Diserens AC, Misra A, Feuerstein B, Murat A, Migliavacca E, Hamou MF, Sciuscio D, Burger R, Domany E, Stupp R, Hegi ME.

Neuro Oncol. 2011 Jul;13(7):736-47. doi: 10.1093/neuonc/nor036. Epub 2011 Jun 3.


Two phases of mitogenic signaling unveil roles for p53 and EGR1 in elimination of inconsistent growth signals.

Zwang Y, Sas-Chen A, Drier Y, Shay T, Avraham R, Lauriola M, Shema E, Lidor-Nili E, Jacob-Hirsch J, Amariglio N, Lu Y, Mills GB, Rechavi G, Oren M, Domany E, Yarden Y.

Mol Cell. 2011 May 20;42(4):524-35. doi: 10.1016/j.molcel.2011.04.017.


Gene expression following exposure to celecoxib in humans: pathways of inflammation and carcinogenesis are activated in tumors but not normal tissues.

Sagiv E, Sheffer M, Kazanov D, Shapira S, Naumov I, Kraus S, Domany E, Arber N.

Digestion. 2011;84(3):169-84. doi: 10.1159/000322688. Epub 2011 May 5.


Do two machine-learning based prognostic signatures for breast cancer capture the same biological processes?

Drier Y, Domany E.

PLoS One. 2011 Mar 14;6(3):e17795. doi: 10.1371/journal.pone.0017795.


Amplification of the 20q chromosomal arm occurs early in tumorigenic transformation and may initiate cancer.

Tabach Y, Kogan-Sakin I, Buganim Y, Solomon H, Goldfinger N, Hovland R, Ke XS, Oyan AM, Kalland KH, Rotter V, Domany E.

PLoS One. 2011 Jan 31;6(1):e14632. doi: 10.1371/journal.pone.0014632.


Integrative analysis correlates donor transcripts to recipient autoantibodies in primary graft dysfunction after lung transplantation.

Hagedorn PH, Burton CM, Sahar E, Domany E, Cohen IR, Flyvbjerg H, Iversen M.

Immunology. 2011 Mar;132(3):394-400. doi: 10.1111/j.1365-2567.2010.03373.x. Epub 2010 Nov 11.


The effect of simulated microgravity on human mesenchymal stem cells cultured in an osteogenic differentiation system: a bioinformatics study.

Sheyn D, Pelled G, Netanely D, Domany E, Gazit D.

Tissue Eng Part A. 2010 Nov;16(11):3403-12. doi: 10.1089/ten.tea.2009.0834. Epub 2010 Aug 31.


BMP-mediated inhibition of FGF signaling promotes cardiomyocyte differentiation of anterior heart field progenitors.

Tirosh-Finkel L, Zeisel A, Brodt-Ivenshitz M, Shamai A, Yao Z, Seger R, Domany E, Tzahor E.

Development. 2010 Sep;137(18):2989-3000. doi: 10.1242/dev.051649. Epub 2010 Aug 11.


Gene expression signature is shared by patients with Alzheimer's disease and schizophrenia at the superior temporal gyrus.

Horesh Y, Katsel P, Haroutunian V, Domany E.

Eur J Neurol. 2011 Mar;18(3):410-24. doi: 10.1111/j.1468-1331.2010.03166.x.


Mutant p53(R175H) upregulates Twist1 expression and promotes epithelial-mesenchymal transition in immortalized prostate cells.

Kogan-Sakin I, Tabach Y, Buganim Y, Molchadsky A, Solomon H, Madar S, Kamer I, Stambolsky P, Shelly A, Goldfinger N, Valsesia-Wittmann S, Puisieux A, Zundelevich A, Gal-Yam EN, Avivi C, Barshack I, Brait M, Sidransky D, Domany E, Rotter V.

Cell Death Differ. 2011 Feb;18(2):271-81. doi: 10.1038/cdd.2010.94. Epub 2010 Aug 6.


Intensity dependent estimation of noise in microarrays improves detection of differentially expressed genes.

Zeisel A, Amir A, Köstler WJ, Domany E.

BMC Bioinformatics. 2010 Jul 27;11:400. doi: 10.1186/1471-2105-11-400.


A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal.

Milyavsky M, Gan OI, Trottier M, Komosa M, Tabach O, Notta F, Lechman E, Hermans KG, Eppert K, Konovalova Z, Ornatsky O, Domany E, Meyn MS, Dick JE.

Cell Stem Cell. 2010 Aug 6;7(2):186-97. doi: 10.1016/j.stem.2010.05.016. Epub 2010 Jul 8.


Adhesive interactions regulate transcriptional diversity in malignant B cells.

Nadav-Dagan L, Shay T, Dezorella N, Naparstek E, Domany E, Katz BZ, Geiger B.

Mol Cancer Res. 2010 Apr;8(4):482-93. doi: 10.1158/1541-7786.MCR-09-0182. Epub 2010 Apr 6.


An antibody profile of systemic lupus erythematosus detected by antigen microarray.

Fattal I, Shental N, Mevorach D, Anaya JM, Livneh A, Langevitz P, Zandman-Goddard G, Pauzner R, Lerner M, Blank M, Hincapie ME, Gafter U, Naparstek Y, Shoenfeld Y, Domany E, Cohen IR.

Immunology. 2010 Jul;130(3):337-43. doi: 10.1111/j.1365-2567.2010.03245.x. Epub 2010 Feb 26.


Chronic rejection of a lung transplant is characterized by a profile of specific autoantibodies.

Hagedorn PH, Burton CM, Carlsen J, Steinbrüchel D, Andersen CB, Sahar E, Domany E, Cohen IR, Flyvbjerg H, Iversen M.

Immunology. 2010 Jul;130(3):427-35. doi: 10.1111/j.1365-2567.2010.03246.x. Epub 2010 Feb 26.


Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report from the International BFM Study Group.

Hertzberg L, Vendramini E, Ganmore I, Cazzaniga G, Schmitz M, Chalker J, Shiloh R, Iacobucci I, Shochat C, Zeligson S, Cario G, Stanulla M, Strehl S, Russell LJ, Harrison CJ, Bornhauser B, Yoda A, Rechavi G, Bercovich D, Borkhardt A, Kempski H, te Kronnie G, Bourquin JP, Domany E, Izraeli S.

Blood. 2010 Feb 4;115(5):1006-17. doi: 10.1182/blood-2009-08-235408. Epub 2009 Nov 24.

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