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Development and translational application of a minimal physiologically-based pharmacokinetic (mPBPK) model for a monoclonal antibody (mAb) against interleukin 23 (IL-23) in IL-23-induced psoriasis-like (PsL) mice.

Chen X, Jiang X, Doddareddy R, Geist B, McIntosh T, Jusko WJ, Zhou H, Wang W.

J Pharmacol Exp Ther. 2018 Feb 2. pii: jpet.117.244855. doi: 10.1124/jpet.117.244855. [Epub ahead of print]


Deciphering the In Vivo Performance of a Monoclonal Antibody to Neutralize Its Soluble Target at the Site of Action in a Mouse Collagen-Induced Arthritis Model.

Wang W, McIntosh TS, Jiang X, Doddareddy R, Dell EC, Zhou H.

Pharm Res. 2016 Apr;33(4):1040-9. doi: 10.1007/s11095-015-1850-8. Epub 2015 Dec 30.


Mechanistic pharmacokinetic/target engagement/pharmacodynamic (PK/TE/PD) modeling in deciphering interplay between a monoclonal antibody and its soluble target in cynomolgus monkeys.

Wang W, Wang X, Doddareddy R, Fink D, McIntosh T, Davis HM, Zhou H.

AAPS J. 2014 Jan;16(1):129-39. doi: 10.1208/s12248-013-9545-8. Epub 2013 Nov 28.

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