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Structure and evolution of the Fam20 kinases.

Zhang H, Zhu Q, Cui J, Wang Y, Chen MJ, Guo X, Tagliabracci VS, Dixon JE, Xiao J.

Nat Commun. 2018 Mar 23;9(1):1218. doi: 10.1038/s41467-018-03615-z.


Oral delivery of anti-diabetes therapeutics using cell penetrating and transcytosing peptide strategies.

Rehmani S, Dixon JE.

Peptides. 2018 Feb;100:24-35. doi: 10.1016/j.peptides.2017.12.014.


Post-Modified Polypeptides with UCST-Type Behavior for Control of Cell Attachment in Physiological Conditions.

Xue X, Thiagarajan L, Dixon JE, Saunders BR, Shakesheff KM, Alexander C.

Materials (Basel). 2018 Jan 9;11(1). pii: E95. doi: 10.3390/ma11010095.


Osteogenic Programming of Human Mesenchymal Stem Cells with Highly Efficient Intracellular Delivery of RUNX2.

Thiagarajan L, Abu-Awwad HAM, Dixon JE.

Stem Cells Transl Med. 2017 Dec;6(12):2146-2159. doi: 10.1002/sctm.17-0137. Epub 2017 Oct 31.


Phosphorylation of serine96 of histidine-rich calcium-binding protein by the Fam20C kinase functions to prevent cardiac arrhythmia.

Pollak AJ, Haghighi K, Kunduri S, Arvanitis DA, Bidwell PA, Liu GS, Singh VP, Gonzalez DJ, Sanoudou D, Wiley SE, Dixon JE, Kranias EG.

Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):9098-9103. doi: 10.1073/pnas.1706441114. Epub 2017 Aug 7.


Controlled release of GAG-binding enhanced transduction (GET) peptides for sustained and highly efficient intracellular delivery.

Abu-Awwad HAM, Thiagarajan L, Dixon JE.

Acta Biomater. 2017 Jul 15;57:225-237. doi: 10.1016/j.actbio.2017.04.028. Epub 2017 Apr 27.


Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding.

Cui J, Zhu Q, Zhang H, Cianfrocco MA, Leschziner AE, Dixon JE, Xiao J.

Elife. 2017 Apr 22;6. pii: e23990. doi: 10.7554/eLife.23990.


Genomics and evolution of protein phosphatases.

Chen MJ, Dixon JE, Manning G.

Sci Signal. 2017 Apr 11;10(474). pii: eaag1796. doi: 10.1126/scisignal.aag1796.


Molecular Details Underlying Dynamic Structures and Regulation of the Human 26S Proteasome.

Wang X, Cimermancic P, Yu C, Schweitzer A, Chopra N, Engel JL, Greenberg C, Huszagh AS, Beck F, Sakata E, Yang Y, Novitsky EJ, Leitner A, Nanni P, Kahraman A, Guo X, Dixon JE, Rychnovsky SD, Aebersold R, Baumeister W, Sali A, Huang L.

Mol Cell Proteomics. 2017 May;16(5):840-854. doi: 10.1074/mcp.M116.065326. Epub 2017 Mar 14.


Structure of protein O-mannose kinase reveals a unique active site architecture.

Zhu Q, Venzke D, Walimbe AS, Anderson ME, Fu Q, Kinch LN, Wang W, Chen X, Grishin NV, Huang N, Yu L, Dixon JE, Campbell KP, Xiao J.

Elife. 2016 Nov 23;5. pii: e22238. doi: 10.7554/eLife.22238.


Highly efficient intracellular transduction in three-dimensional gradients for programming cell fate.

Eltaher HM, Yang J, Shakesheff KM, Dixon JE.

Acta Biomater. 2016 Sep 1;41:181-92. doi: 10.1016/j.actbio.2016.06.004. Epub 2016 Jun 3.


Phosphorylation of spore coat proteins by a family of atypical protein kinases.

Nguyen KB, Sreelatha A, Durrant ES, Lopez-Garrido J, Muszewska A, Dudkiewicz M, Grynberg M, Yee S, Pogliano K, Tomchick DR, Pawłowski K, Dixon JE, Tagliabracci VS.

Proc Natl Acad Sci U S A. 2016 Jun 21;113(25):E3482-91. doi: 10.1073/pnas.1605917113. Epub 2016 May 16.


Chirality of nanophotonic waveguide with embedded quantum emitter for unidirectional spin transfer.

Coles RJ, Price DM, Dixon JE, Royall B, Clarke E, Kok P, Skolnick MS, Fox AM, Makhonin MN.

Nat Commun. 2016 Mar 31;7:11183. doi: 10.1038/ncomms11183.


The 26S proteasome: A cell cycle regulator regulated by cell cycle.

Guo X, Dixon JE.

Cell Cycle. 2016;15(7):875-6. doi: 10.1080/15384101.2016.1151728. Epub 2016 Mar 3. No abstract available.


Highly efficient delivery of functional cargoes by the synergistic effect of GAG binding motifs and cell-penetrating peptides.

Dixon JE, Osman G, Morris GE, Markides H, Rotherham M, Bayoussef Z, El Haj AJ, Denning C, Shakesheff KM.

Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):E291-9. doi: 10.1073/pnas.1518634113. Epub 2016 Jan 5. Erratum in: Proc Natl Acad Sci U S A. 2017 May 16;114(20):E4112-E4114.


Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis.

Guo X, Wang X, Wang Z, Banerjee S, Yang J, Huang L, Dixon JE.

Nat Cell Biol. 2016 Feb;18(2):202-12. doi: 10.1038/ncb3289. Epub 2015 Dec 14.


A Single Kinase Generates the Majority of the Secreted Phosphoproteome.

Tagliabracci VS, Wiley SE, Guo X, Kinch LN, Durrant E, Wen J, Xiao J, Cui J, Nguyen KB, Engel JL, Coon JJ, Grishin N, Pinna LA, Pagliarini DJ, Dixon JE.

Cell. 2015 Jun 18;161(7):1619-32. doi: 10.1016/j.cell.2015.05.028.


A new role for sphingosine: Up-regulation of Fam20C, the genuine casein kinase that phosphorylates secreted proteins.

Cozza G, Salvi M, Banerjee S, Tibaldi E, Tagliabracci VS, Dixon JE, Pinna LA.

Biochim Biophys Acta. 2015 Oct;1854(10 Pt B):1718-26. doi: 10.1016/j.bbapap.2015.04.023. Epub 2015 Apr 30.


A potent and selective inhibitor for the UBLCP1 proteasome phosphatase.

He Y, Guo X, Yu ZH, Wu L, Gunawan AM, Zhang Y, Dixon JE, Zhang ZY.

Bioorg Med Chem. 2015 Jun 15;23(12):2798-809. doi: 10.1016/j.bmc.2015.03.066. Epub 2015 Mar 31.


An automated fabrication strategy to create patterned tubular architectures at cell and tissue scales.

Othman R, E Morris G, Shah DA, Hall S, Hall G, Wells K, Shakesheff KM, Dixon JE.

Biofabrication. 2015 Apr 14;7(2):025003. doi: 10.1088/1758-5090/7/2/025003.


A secretory kinase complex regulates extracellular protein phosphorylation.

Cui J, Xiao J, Tagliabracci VS, Wen J, Rahdar M, Dixon JE.

Elife. 2015 Mar 19;4:e06120. doi: 10.7554/eLife.06120.


Waveguide coupled resonance fluorescence from on-chip quantum emitter.

Makhonin MN, Dixon JE, Coles RJ, Royall B, Luxmoore IJ, Clarke E, Hugues M, Skolnick MS, Fox AM.

Nano Lett. 2014 Dec 10;14(12):6997-7002. doi: 10.1021/nl5032937. Epub 2014 Nov 21.


Xylose phosphorylation functions as a molecular switch to regulate proteoglycan biosynthesis.

Wen J, Xiao J, Rahdar M, Choudhury BP, Cui J, Taylor GS, Esko JD, Dixon JE.

Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):15723-8. doi: 10.1073/pnas.1417993111. Epub 2014 Oct 20.


Unpacking the unfolded protein response.

Worby CA, Dixon JE.

Cell. 2014 Sep 11;158(6):1221-1224. doi: 10.1016/j.cell.2014.08.025.


A secreted tyrosine kinase acts in the extracellular environment.

Bordoli MR, Yum J, Breitkopf SB, Thon JN, Italiano JE Jr, Xiao J, Worby C, Wong SK, Lin G, Edenius M, Keller TL, Asara JM, Dixon JE, Yeo CY, Whitman M.

Cell. 2014 Aug 28;158(5):1033-1044. doi: 10.1016/j.cell.2014.06.048. Erratum in: Cell. 2014 Nov 6;159(4):955.



Worby CA, Dixon JE.

Annu Rev Biochem. 2014;83:641-69. doi: 10.1146/annurev-biochem-082411-113907. Review.


Transient accumulation of 5-carboxylcytosine indicates involvement of active demethylation in lineage specification of neural stem cells.

Wheldon LM, Abakir A, Ferjentsik Z, Dudnakova T, Strohbuecker S, Christie D, Dai N, Guan S, Foster JM, Corrêa IR Jr, Loose M, Dixon JE, Sottile V, Johnson AD, Ruzov A.

Cell Rep. 2014 Jun 12;7(5):1353-1361. doi: 10.1016/j.celrep.2014.05.003. Epub 2014 May 29.


A novel technique for the production of electrospun scaffolds with tailored three-dimensional micro-patterns employing additive manufacturing.

Rogers CM, Morris GE, Gould TW, Bail R, Toumpaniari S, Harrington H, Dixon JE, Shakesheff KM, Segal J, Rose FR.

Biofabrication. 2014 Sep;6(3):035003. doi: 10.1088/1758-5082/6/3/035003. Epub 2014 Apr 11.


Dynamic regulation of FGF23 by Fam20C phosphorylation, GalNAc-T3 glycosylation, and furin proteolysis.

Tagliabracci VS, Engel JL, Wiley SE, Xiao J, Gonzalez DJ, Nidumanda Appaiah H, Koller A, Nizet V, White KE, Dixon JE.

Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5520-5. doi: 10.1073/pnas.1402218111. Epub 2014 Mar 26.


Combined hydrogels that switch human pluripotent stem cells from self-renewal to differentiation.

Dixon JE, Shah DA, Rogers C, Hall S, Weston N, Parmenter CD, McNally D, Denning C, Shakesheff KM.

Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5580-5. doi: 10.1073/pnas.1319685111. Epub 2014 Mar 27. Erratum in: Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):E8940-E8942.


Phenol soluble modulin (PSM) variants of community-associated methicillin-resistant Staphylococcus aureus (MRSA) captured using mass spectrometry-based molecular networking.

Gonzalez DJ, Vuong L, Gonzalez IS, Keller N, McGrosso D, Hwang JH, Hung J, Zinkernagel A, Dixon JE, Dorrestein PC, Nizet V.

Mol Cell Proteomics. 2014 May;13(5):1262-72. doi: 10.1074/mcp.M113.031336. Epub 2014 Feb 24.


ZFX controls propagation and prevents differentiation of acute T-lymphoblastic and myeloid leukemia.

Weisberg SP, Smith-Raska MR, Esquilin JM, Zhang J, Arenzana TL, Lau CM, Churchill M, Pan H, Klinakis A, Dixon JE, Mirny LA, Mukherjee S, Reizis B.

Cell Rep. 2014 Feb 13;6(3):528-40. doi: 10.1016/j.celrep.2014.01.007. Epub 2014 Jan 30.


Spatial control of phospholipid flux restricts endoplasmic reticulum sheet formation to allow nuclear envelope breakdown.

Bahmanyar S, Biggs R, Schuh AL, Desai A, Müller-Reichert T, Audhya A, Dixon JE, Oegema K.

Genes Dev. 2014 Jan 15;28(2):121-6. doi: 10.1101/gad.230599.113.


Recognition of the protein kinase AVRPPHB SUSCEPTIBLE1 by the disease resistance protein RESISTANCE TO PSEUDOMONAS SYRINGAE5 is dependent on s-acylation and an exposed loop in AVRPPHB SUSCEPTIBLE1.

Qi D, Dubiella U, Kim SH, Sloss DI, Dowen RH, Dixon JE, Innes RW.

Plant Physiol. 2014 Jan;164(1):340-51. doi: 10.1104/pp.113.227686. Epub 2013 Nov 13.


Effect of Fontan fenestration on regional venous oxygen saturation during exercise: further insights into Fontan fenestration closure.

Loomba RS, Danduran ME, Dixon JE, Rao RP.

Pediatr Cardiol. 2014 Mar;35(3):514-20. doi: 10.1007/s00246-013-0817-y. Epub 2013 Oct 23.


The EBAX-type Cullin-RING E3 ligase and Hsp90 guard the protein quality of the SAX-3/Robo receptor in developing neurons.

Wang Z, Hou Y, Guo X, van der Voet M, Boxem M, Dixon JE, Chisholm AD, Jin Y.

Neuron. 2013 Sep 4;79(5):903-16. doi: 10.1016/j.neuron.2013.06.035.


Response to Wang et al.: Secreted protein kinases?

Tagliabracci VS, Pinna LA, Dixon JE.

Trends Biochem Sci. 2013 Sep;38(9):425. doi: 10.1016/j.tibs.2013.06.007. No abstract available.


Phosphorylation of substrates destined for secretion by the Fam20 kinases.

Tagliabracci VS, Xiao J, Dixon JE.

Biochem Soc Trans. 2013 Aug;41(4):1061-5. doi: 10.1042/BST20130059. Review.


Crystal structure of the Golgi casein kinase.

Xiao J, Tagliabracci VS, Wen J, Kim SA, Dixon JE.

Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10574-9. doi: 10.1073/pnas.1309211110. Epub 2013 Jun 10.


Wolfram Syndrome protein, Miner1, regulates sulphydryl redox status, the unfolded protein response, and Ca2+ homeostasis.

Wiley SE, Andreyev AY, Divakaruni AS, Karisch R, Perkins G, Wall EA, van der Geer P, Chen YF, Tsai TF, Simon MI, Neel BG, Dixon JE, Murphy AN.

EMBO Mol Med. 2013 Jun;5(6):904-18. doi: 10.1002/emmm.201201429. Epub 2013 May 24.


Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension.

Kelly CE, Thymiakou E, Dixon JE, Tanaka S, Godwin J, Episkopou V.

PLoS Biol. 2013;11(4):e1001538. doi: 10.1371/journal.pbio.1001538. Epub 2013 Apr 16.


Allele-specific RNA interference rescues the long-QT syndrome phenotype in human-induced pluripotency stem cell cardiomyocytes.

Matsa E, Dixon JE, Medway C, Georgiou O, Patel MJ, Morgan K, Kemp PJ, Staniforth A, Mellor I, Denning C.

Eur Heart J. 2014 Apr;35(16):1078-87. doi: 10.1093/eurheartj/eht067. Epub 2013 Mar 6.


Identification of a mammalian-type phosphatidylglycerophosphate phosphatase in the Eubacterium Rhodopirellula baltica.

Teh PG, Chen MJ, Engel JL, Worby CA, Manning G, Dixon JE, Zhang J.

J Biol Chem. 2013 Feb 15;288(7):5176-85. doi: 10.1074/jbc.M112.413617. Epub 2013 Jan 4.


Secreted protein kinases.

Tagliabracci VS, Pinna LA, Dixon JE.

Trends Biochem Sci. 2013 Mar;38(3):121-30. doi: 10.1016/j.tibs.2012.11.008. Epub 2012 Dec 29. Review.


Widespread dynamic DNA methylation in response to biotic stress.

Dowen RH, Pelizzola M, Schmitz RJ, Lister R, Dowen JM, Nery JR, Dixon JE, Ecker JR.

Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):E2183-91. doi: 10.1073/pnas.1209329109. Epub 2012 Jun 25.


Secreted kinase phosphorylates extracellular proteins that regulate biomineralization.

Tagliabracci VS, Engel JL, Wen J, Wiley SE, Worby CA, Kinch LN, Xiao J, Grishin NV, Dixon JE.

Science. 2012 Jun 1;336(6085):1150-3. doi: 10.1126/science.1217817. Epub 2012 May 10.


Rapid micropatterning of cell lines and human pluripotent stem cells on elastomeric membranes.

Paik I, Scurr DJ, Morris B, Hall G, Denning C, Alexander MR, Shakesheff KM, Dixon JE.

Biotechnol Bioeng. 2012 Oct;109(10):2630-41. doi: 10.1002/bit.24529. Epub 2012 Apr 24.


Novel phenol-soluble modulin derivatives in community-associated methicillin-resistant Staphylococcus aureus identified through imaging mass spectrometry.

Gonzalez DJ, Okumura CY, Hollands A, Kersten R, Akong-Moore K, Pence MA, Malone CL, Derieux J, Moore BS, Horswill AR, Dixon JE, Dorrestein PC, Nizet V.

J Biol Chem. 2012 Apr 20;287(17):13889-98. doi: 10.1074/jbc.M112.349860. Epub 2012 Feb 27.


Near-infrared spectroscopic monitoring during cardiopulmonary exercise testing detects anaerobic threshold.

Rao RP, Danduran MJ, Loomba RS, Dixon JE, Hoffman GM.

Pediatr Cardiol. 2012 Jun;33(5):791-6. doi: 10.1007/s00246-012-0217-8. Epub 2012 Feb 19.


Optimisation of T₂*-weighted MRI for the detection of small veins in multiple sclerosis at 3 T and 7 T.

Dixon JE, Simpson A, Mistry N, Evangelou N, Morris PG.

Eur J Radiol. 2013 May;82(5):719-27. doi: 10.1016/j.ejrad.2011.09.023. Epub 2011 Dec 3.


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