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Items: 30


In situ measurements of mitochondrial matrix enzyme activities using plasma and mitochondrial membrane permeabilization agents.

Divakaruni AS, Andreyev AY, Rogers GW, Murphy AN.

Anal Biochem. 2017 Oct 4. pii: S0003-2697(17)30385-8. doi: 10.1016/j.ab.2017.09.019. [Epub ahead of print]


Impaired mitophagy facilitates mitochondrial damage in Danon disease.

Hashem SI, Murphy AN, Divakaruni AS, Klos ML, Nelson BC, Gault EC, Rowland TJ, Perry CN, Gu Y, Dalton ND, Bradford WH, Devaney EJ, Peterson KL, Jones KL, Taylor MRG, Chen J, Chi NC, Adler ED.

J Mol Cell Cardiol. 2017 Jul;108:86-94. doi: 10.1016/j.yjmcc.2017.05.007. Epub 2017 May 16.


Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death.

Divakaruni AS, Wallace M, Buren C, Martyniuk K, Andreyev AY, Li E, Fields JA, Cordes T, Reynolds IJ, Bloodgood BL, Raymond LA, Metallo CM, Murphy AN.

J Cell Biol. 2017 Apr 3;216(4):1091-1105. doi: 10.1083/jcb.201612067. Epub 2017 Mar 2.


LKB1 promotes metabolic flexibility in response to energy stress.

Parker SJ, Svensson RU, Divakaruni AS, Lefebvre AE, Murphy AN, Shaw RJ, Metallo CM.

Metab Eng. 2017 Sep;43(Pt B):208-217. doi: 10.1016/j.ymben.2016.12.010. Epub 2016 Dec 26.


Distinct Metabolic States Can Support Self-Renewal and Lipogenesis in Human Pluripotent Stem Cells under Different Culture Conditions.

Zhang H, Badur MG, Divakaruni AS, Parker SJ, Jäger C, Hiller K, Murphy AN, Metallo CM.

Cell Rep. 2016 Aug 9;16(6):1536-1547. doi: 10.1016/j.celrep.2016.06.102. Epub 2016 Jul 28.


Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels.

Cordes T, Wallace M, Michelucci A, Divakaruni AS, Sapcariu SC, Sousa C, Koseki H, Cabrales P, Murphy AN, Hiller K, Metallo CM.

J Biol Chem. 2016 Jul 1;291(27):14274-84. doi: 10.1074/jbc.M115.685792. Epub 2016 May 9.


Sestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell death.

Ding B, Parmigiani A, Divakaruni AS, Archer K, Murphy AN, Budanov AV.

Sci Rep. 2016 Mar 2;6:22538. doi: 10.1038/srep22538.


Critical Role of Glucose Metabolism in Rheumatoid Arthritis Fibroblast-like Synoviocytes.

Garcia-Carbonell R, Divakaruni AS, Lodi A, Vicente-Suarez I, Saha A, Cheroutre H, Boss GR, Tiziani S, Murphy AN, Guma M.

Arthritis Rheumatol. 2016 Jul;68(7):1614-26. doi: 10.1002/art.39608.


HIV alters neuronal mitochondrial fission/fusion in the brain during HIV-associated neurocognitive disorders.

Fields JA, Serger E, Campos S, Divakaruni AS, Kim C, Smith K, Trejo M, Adame A, Spencer B, Rockenstein E, Murphy AN, Ellis RJ, Letendre S, Grant I, Masliah E.

Neurobiol Dis. 2016 Feb;86:154-69. doi: 10.1016/j.nbd.2015.11.015. Epub 2015 Nov 22.


Branched-chain amino acid catabolism fuels adipocyte differentiation and lipogenesis.

Green CR, Wallace M, Divakaruni AS, Phillips SA, Murphy AN, Ciaraldi TP, Metallo CM.

Nat Chem Biol. 2016 Jan;12(1):15-21. doi: 10.1038/nchembio.1961. Epub 2015 Nov 16.


GLP-1 Cleavage Product Reverses Persistent ROS Generation After Transient Hyperglycemia by Disrupting an ROS-Generating Feedback Loop.

Giacco F, Du X, Carratú A, Gerfen GJ, D'Apolito M, Giardino I, Rasola A, Marin O, Divakaruni AS, Murphy AN, Shah MS, Brownlee M.

Diabetes. 2015 Sep;64(9):3273-84. doi: 10.2337/db15-0084.


Proteomic and Metabolic Analyses of S49 Lymphoma Cells Reveal Novel Regulation of Mitochondria by cAMP and Protein Kinase A.

Wilderman A, Guo Y, Divakaruni AS, Perkins G, Zhang L, Murphy AN, Taylor SS, Insel PA.

J Biol Chem. 2015 Sep 4;290(36):22274-86. doi: 10.1074/jbc.M115.658153. Epub 2015 Jul 22.


Mitochondrial reprogramming induced by CaMKIIδ mediates hypertrophy decompensation.

Westenbrink BD, Ling H, Divakaruni AS, Gray CB, Zambon AC, Dalton ND, Peterson KL, Gu Y, Matkovich SJ, Murphy AN, Miyamoto S, Dorn GW 2nd, Heller Brown J.

Circ Res. 2015 Feb 27;116(5):e28-39. doi: 10.1161/CIRCRESAHA.116.304682. Epub 2015 Jan 20.


Regulation of substrate utilization by the mitochondrial pyruvate carrier.

Vacanti NM, Divakaruni AS, Green CR, Parker SJ, Henry RR, Ciaraldi TP, Murphy AN, Metallo CM.

Mol Cell. 2014 Nov 6;56(3):425-35. doi: 10.1016/j.molcel.2014.09.024. Epub 2014 Oct 30.


Analysis and interpretation of microplate-based oxygen consumption and pH data.

Divakaruni AS, Paradyse A, Ferrick DA, Murphy AN, Jastroch M.

Methods Enzymol. 2014;547:309-54. doi: 10.1016/B978-0-12-801415-8.00016-3.


Intravenous (-)-epicatechin reduces myocardial ischemic injury by protecting mitochondrial function.

Yamazaki KG, Andreyev AY, Ortiz-Vilchis P, Petrosyan S, Divakaruni AS, Wiley SE, De La Fuente C, Perkins G, Ceballos G, Villarreal F, Murphy AN.

Int J Cardiol. 2014 Aug 1;175(2):297-306. doi: 10.1016/j.ijcard.2014.05.009. Epub 2014 May 15.


Assessment of fatty acid beta oxidation in cells and isolated mitochondria.

Rogers GW, Nadanaciva S, Swiss R, Divakaruni AS, Will Y.

Curr Protoc Toxicol. 2014 May 27;60:25.3.1-19. doi: 10.1002/0471140856.tx2503s60.


Measuring Mitochondrial Function in Permeabilized Cells Using the Seahorse XF Analyzer or a Clark-Type Oxygen Electrode.

Divakaruni AS, Rogers GW, Murphy AN.

Curr Protoc Toxicol. 2014 May 27;60:25.2.1-16. doi: 10.1002/0471140856.tx2502s60.


IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism.

Grassian AR, Parker SJ, Davidson SM, Divakaruni AS, Green CR, Zhang X, Slocum KL, Pu M, Lin F, Vickers C, Joud-Caldwell C, Chung F, Yin H, Handly ED, Straub C, Growney JD, Vander Heiden MG, Murphy AN, Pagliarini R, Metallo CM.

Cancer Res. 2014 Jun 15;74(12):3317-31. doi: 10.1158/0008-5472.CAN-14-0772-T. Epub 2014 Apr 22.


Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane.

Kenwood BM, Weaver JL, Bajwa A, Poon IK, Byrne FL, Murrow BA, Calderone JA, Huang L, Divakaruni AS, Tomsig JL, Okabe K, Lo RH, Cameron Coleman G, Columbus L, Yan Z, Saucerman JJ, Smith JS, Holmes JW, Lynch KR, Ravichandran KS, Uchiyama S, Santos WL, Rogers GW, Okusa MD, Bayliss DA, Hoehn KL.

Mol Metab. 2013 Nov 28;3(2):114-23. doi: 10.1016/j.molmet.2013.11.005. eCollection 2014 Apr.


Wolfram Syndrome protein, Miner1, regulates sulphydryl redox status, the unfolded protein response, and Ca2+ homeostasis.

Wiley SE, Andreyev AY, Divakaruni AS, Karisch R, Perkins G, Wall EA, van der Geer P, Chen YF, Tsai TF, Simon MI, Neel BG, Dixon JE, Murphy AN.

EMBO Mol Med. 2013 Jun;5(6):904-18. doi: 10.1002/emmm.201201429. Epub 2013 May 24.


Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT)--relationship to newly identified mitochondrial pyruvate carrier proteins.

Colca JR, McDonald WG, Cavey GS, Cole SL, Holewa DD, Brightwell-Conrad AS, Wolfe CL, Wheeler JS, Coulter KR, Kilkuskie PM, Gracheva E, Korshunova Y, Trusgnich M, Karr R, Wiley SE, Divakaruni AS, Murphy AN, Vigueira PA, Finck BN, Kletzien RF.

PLoS One. 2013 May 15;8(5):e61551. doi: 10.1371/journal.pone.0061551. Print 2013.


Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier.

Divakaruni AS, Wiley SE, Rogers GW, Andreyev AY, Petrosyan S, Loviscach M, Wall EA, Yadava N, Heuck AP, Ferrick DA, Henry RR, McDonald WG, Colca JR, Simon MI, Ciaraldi TP, Murphy AN.

Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5422-7. doi: 10.1073/pnas.1303360110. Epub 2013 Mar 19.


Fatty acids change the conformation of uncoupling protein 1 (UCP1).

Divakaruni AS, Humphrey DM, Brand MD.

J Biol Chem. 2012 Oct 26;287(44):36845-53. doi: 10.1074/jbc.M112.381780. Epub 2012 Sep 5.


Cell biology. A mitochondrial mystery, solved.

Divakaruni AS, Murphy AN.

Science. 2012 Jul 6;337(6090):41-3. doi: 10.1126/science.1225601. No abstract available.


The regulation and physiology of mitochondrial proton leak.

Divakaruni AS, Brand MD.

Physiology (Bethesda). 2011 Jun;26(3):192-205. doi: 10.1152/physiol.00046.2010. Review.


Mitochondrial proton and electron leaks.

Jastroch M, Divakaruni AS, Mookerjee S, Treberg JR, Brand MD.

Essays Biochem. 2010;47:53-67. doi: 10.1042/bse0470053. Review.


Mitochondrial uncoupling and lifespan.

Mookerjee SA, Divakaruni AS, Jastroch M, Brand MD.

Mech Ageing Dev. 2010 Jul-Aug;131(7-8):463-72. doi: 10.1016/j.mad.2010.03.010. Epub 2010 Apr 2. Review.


The regulation and turnover of mitochondrial uncoupling proteins.

Azzu V, Jastroch M, Divakaruni AS, Brand MD.

Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):785-91. doi: 10.1016/j.bbabio.2010.02.035. Epub 2010 Mar 6. Review.


Real-time visualization of cytoplasmic calpain activation and calcium deregulation in acute glutamate excitotoxicity.

Gerencser AA, Mark KA, Hubbard AE, Divakaruni AS, Mehrabian Z, Nicholls DG, Polster BM.

J Neurochem. 2009 Aug;110(3):990-1004. doi: 10.1111/j.1471-4159.2009.06194.x. Epub 2009 May 29.

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