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Items: 43


The endotoxin-induced pulmonary inflammatory response is enhanced during the acute phase of influenza infection.

Koch RM, Diavatopoulos DA, Ferwerda G, Pickkers P, de Jonge MI, Kox M.

Intensive Care Med Exp. 2018 Jul 5;6(1):15. doi: 10.1186/s40635-018-0182-5.


Bacillus Calmette-Guérin-Induced Trained Immunity Is Not Protective for Experimental Influenza A/Anhui/1/2013 (H7N9) Infection in Mice.

de Bree CLCJ, Marijnissen RJ, Kel JM, Rosendahl Huber SK, Aaby P, Benn CS, Wijnands MVW, Diavatopoulos DA, van Crevel R, Joosten LAB, Netea MG, Dulos J.

Front Immunol. 2018 Apr 30;9:869. doi: 10.3389/fimmu.2018.00869. eCollection 2018.


Bordetella pertussis isolates vary in their interactions with human complement components.

Brookes C, Freire-Martin I, Cavell B, Alexander F, Taylor S, Persaud R, Fry N, Preston A, Diavatopoulos D, Gorringe A.

Emerg Microbes Infect. 2018 May 9;7(1):81. doi: 10.1038/s41426-018-0084-3.


The complement system contributes to functional antibody-mediated responses induced by immunization with Plasmodium falciparum malaria sporozoites.

Behet MC, Kurtovic L, van Gemert GJ, Haukes CM, Siebelink-Stoter R, Graumans W, van de Vegte-Bolmer MG, Scholzen A, Langereis JD, Diavatopoulos DA, Beeson JG, Sauerwein RW.

Infect Immun. 2018 May 7. pii: IAI.00920-17. doi: 10.1128/IAI.00920-17. [Epub ahead of print]


Adaptation of Bordetella pertussis to the Respiratory Tract.

van Beek LF, de Gouw D, Eleveld MJ, Bootsma HJ, de Jonge MI, Mooi FR, Zomer A, Diavatopoulos DA.

J Infect Dis. 2018 May 25;217(12):1987-1996. doi: 10.1093/infdis/jiy125.


Development of Endotoxin Tolerance Does Not Influence the Response to a Challenge with the Mucosal Live-Attenuated Influenza Vaccine in Humans In Vivo.

Koch RM, Kox M, Thijs EJM, Rahamat-Langendoen JC, van de Veerdonk FL, Gerretsen J, Schloesser J, Diavatopoulos D, Rimmelzwaan GF, Netea MG, van der Hoeven JG, de Jonge MI, Pickkers P.

Front Immunol. 2017 Dec 11;8:1600. doi: 10.3389/fimmu.2017.01600. eCollection 2017.


Investigating Bordetella pertussis colonisation and immunity: protocol for an inpatient controlled human infection model.

de Graaf H, Gbesemete D, Gorringe AR, Diavatopoulos DA, Kester KE, Faust SN, Read RC.

BMJ Open. 2017 Oct 11;7(10):e018594. doi: 10.1136/bmjopen-2017-018594.


Genetic background impacts vaccine-induced reduction of pneumococcal colonization.

Kuipers K, van Selm S, van Opzeeland F, Langereis JD, Verhagen LM, Diavatopoulos DA, de Jonge MI.

Vaccine. 2017 Sep 18;35(39):5235-5241. doi: 10.1016/j.vaccine.2017.08.023. Epub 2017 Aug 17.


Monitoring of dynamic changes in Keyhole Limpet Hemocyanin (KLH)-specific B cells in KLH-vaccinated cancer patients.

Wimmers F, de Haas N, Scholzen A, Schreibelt G, Simonetti E, Eleveld MJ, Brouwers HM, Beldhuis-Valkis M, Joosten I, de Jonge MI, Gerritsen WR, de Vries IJ, Diavatopoulos DA, Jacobs JF.

Sci Rep. 2017 Mar 7;7:43486. doi: 10.1038/srep43486.


What Is Wrong with Pertussis Vaccine Immunity? Why Immunological Memory to Pertussis Is Failing.

Diavatopoulos DA, Edwards KM.

Cold Spring Harb Perspect Biol. 2017 Dec 1;9(12). pii: a029553. doi: 10.1101/cshperspect.a029553. Review.


A novel flow cytometry-based assay for the quantification of antibody-dependent pneumococcal agglutination.

Habets MN, van Selm S, van der Gaast-de Jongh CE, Diavatopoulos DA, de Jonge MI.

PLoS One. 2017 Mar 13;12(3):e0170884. doi: 10.1371/journal.pone.0170884. eCollection 2017.


Host and Environmental Factors Influencing Individual Human Cytokine Responses.

Ter Horst R, Jaeger M, Smeekens SP, Oosting M, Swertz MA, Li Y, Kumar V, Diavatopoulos DA, Jansen AFM, Lemmers H, Toenhake-Dijkstra H, van Herwaarden AE, Janssen M, van der Molen RG, Joosten I, Sweep FCGJ, Smit JW, Netea-Maier RT, Koenders MMJF, Xavier RJ, van der Meer JWM, Dinarello CA, Pavelka N, Wijmenga C, Notebaart RA, Joosten LAB, Netea MG.

Cell. 2016 Nov 3;167(4):1111-1124.e13. doi: 10.1016/j.cell.2016.10.018.


Antigen-Independent Restriction of Pneumococcal Density by Mucosal Adjuvant Cholera Toxin Subunit B.

Kuipers K, Diavatopoulos DA, van Opzeeland F, Simonetti E, van den Kieboom CH, Kerstholt M, Borczyk M, van IngenSchenau D, Brandsma ET, Netea MG, de Jonge MI.

J Infect Dis. 2016 Nov 15;214(10):1588-1596. Epub 2016 Apr 24.


Role of antibodies and IL17-mediated immunity in protection against pneumococcal otitis media.

Habets MN, van Selm S, van Opzeeland FJ, Simonetti E, Hermans PWM, de Jonge MI, Diavatopoulos DA.

Vaccine. 2016 Nov 21;34(48):5968-5974. doi: 10.1016/j.vaccine.2016.09.057. Epub 2016 Oct 19.


Reduced Expression of HLA-DR on Monocytes During Severe Respiratory Syncytial Virus Infections.

Ahout IM, Jans J, Haroutiounian L, Simonetti ER, van der Gaast-de Jongh C, Diavatopoulos DA, de Jonge MI, de Groot R, Ferwerda G.

Pediatr Infect Dis J. 2016 Mar;35(3):e89-96. doi: 10.1097/INF.0000000000001007.


A novel quantitative PCR assay for the detection of Streptococcus pneumoniae using the competence regulator gene target comX.

Habets MN, Cremers AJ, Bos MP, Savelkoul P, Eleveld MJ, Meis JF, Hermans PW, Melchers WJ, de Jonge MI, Diavatopoulos DA.

J Med Microbiol. 2016 Feb;65(2):129-36. doi: 10.1099/jmm.0.000204. Epub 2015 Dec 1.


Ability of Antibiotic-Resistant Nonvaccine-Type Pneumococcal Clones to Cause Otitis Media in an Infant Mouse Model of Pneumococcal-Influenza Virus Coinfection.

Frazão N, Hermans P, van Selm S, Sá-Leão R, de Lencastre H, Tomasz A, Diavatopoulos D.

Microb Drug Resist. 2016 Jan;22(1):97-101. doi: 10.1089/mdr.2015.0109. Epub 2015 Sep 14.


BCG Vaccination Enhances the Immunogenicity of Subsequent Influenza Vaccination in Healthy Volunteers: A Randomized, Placebo-Controlled Pilot Study.

Leentjens J, Kox M, Stokman R, Gerretsen J, Diavatopoulos DA, van Crevel R, Rimmelzwaan GF, Pickkers P, Netea MG.

J Infect Dis. 2015 Dec 15;212(12):1930-8. doi: 10.1093/infdis/jiv332. Epub 2015 Jun 12.


The vaccine potential of Bordetella pertussis biofilm-derived membrane proteins.

de Gouw D, Serra DO, de Jonge MI, Hermans PW, Wessels HJ, Zomer A, Yantorno OM, Diavatopoulos DA, Mooi FR.

Emerg Microbes Infect. 2014 Aug;3(8):e58. doi: 10.1038/emi.2014.58. Epub 2014 Aug 20.


Proteomics-identified Bvg-activated autotransporters protect against bordetella pertussis in a mouse model.

de Gouw D, de Jonge MI, Hermans PW, Wessels HJ, Zomer A, Berends A, Pratt C, Berbers GA, Mooi FR, Diavatopoulos DA.

PLoS One. 2014 Aug 18;9(8):e105011. doi: 10.1371/journal.pone.0105011. eCollection 2014. Erratum in: PLoS One. 2014 Nov;9(11):e113322. Gouw, Daan de [corrected to de Gouw, Daan; Jonge, Marien I de [corrected to de Jonge, Marien I].


Differentially expressed genes in Bordetella pertussis strains belonging to a lineage which recently spread globally.

de Gouw D, Hermans PW, Bootsma HJ, Zomer A, Heuvelman K, Diavatopoulos DA, Mooi FR.

PLoS One. 2014 Jan 8;9(1):e84523. doi: 10.1371/journal.pone.0084523. eCollection 2014. Erratum in: PLoS One. 2014;9(1). doi: 10.1371/annotation/1b2cfe52-aaea-4148-aa72-a74c78550192.


An in vitro model to study immune responses of human peripheral blood mononuclear cells to human respiratory syncytial virus infection.

Vissers M, Habets MN, Ahout IM, Jans J, de Jonge MI, Diavatopoulos DA, Ferwerda G.

J Vis Exp. 2013 Dec 10;(82):e50766. doi: 10.3791/50766.


A Novel Method Linking Antigen Presentation by Human Monocyte-Derived Macrophages to CD8(+) T Cell Polyfunctionality.

Short KR, Grant EJ, Vissers M, Reading PC, Diavatopoulos DA, Kedzierska K.

Front Immunol. 2013 Nov 21;4:389. doi: 10.3389/fimmu.2013.00389. eCollection 2013.


Antibodies mediate formation of neutrophil extracellular traps in the middle ear and facilitate secondary pneumococcal otitis media.

Short KR, von Köckritz-Blickwede M, Langereis JD, Chew KY, Job ER, Armitage CW, Hatcher B, Fujihashi K, Reading PC, Hermans PW, Wijburg OL, Diavatopoulos DA.

Infect Immun. 2014 Jan;82(1):364-70. doi: 10.1128/IAI.01104-13. Epub 2013 Nov 4.


Bacterial lipopolysaccharide inhibits influenza virus infection of human macrophages and the consequent induction of CD8+ T cell immunity.

Short KR, Vissers M, de Kleijn S, Zomer AL, Kedzierska K, Grant E, Reading PC, Hermans PW, Ferwerda G, Diavatopoulos DA.

J Innate Immun. 2014;6(2):129-39. doi: 10.1159/000353905. Epub 2013 Aug 20.


Influenza A virus induced bacterial otitis media is independent of virus tropism for α2,6-linked sialic acid.

Short KR, Habets MN, Payne J, Reading PC, Diavatopoulos DA, Wijburg OL.

Virol J. 2013 Apr 23;10:128. doi: 10.1186/1743-422X-10-128.


Influenza-induced inflammation drives pneumococcal otitis media.

Short KR, Reading PC, Brown LE, Pedersen J, Gilbertson B, Job ER, Edenborough KM, Habets MN, Zomer A, Hermans PW, Diavatopoulos DA, Wijburg OL.

Infect Immun. 2013 Mar;81(3):645-52. doi: 10.1128/IAI.01278-12. Epub 2013 Jan 14.


Increased nasopharyngeal bacterial titers and local inflammation facilitate transmission of Streptococcus pneumoniae.

Short KR, Reading PC, Wang N, Diavatopoulos DA, Wijburg OL.

MBio. 2012 Sep 25;3(5). pii: e00255-12. doi: 10.1128/mBio.00255-12. Print 2012.


Modified lipooligosaccharide structure protects nontypeable Haemophilus influenzae from IgM-mediated complement killing in experimental otitis media.

Langereis JD, Stol K, Schweda EK, Twelkmeyer B, Bootsma HJ, de Vries SP, Burghout P, Diavatopoulos DA, Hermans PW.

MBio. 2012 Jul 3;3(4):e00079-12. doi: 10.1128/mBio.00079-12. Print 2012.


Respiratory syncytial virus infection augments NOD2 signaling in an IFN-β-dependent manner in human primary cells.

Vissers M, Remijn T, Oosting M, de Jong DJ, Diavatopoulos DA, Hermans PW, Ferwerda G.

Eur J Immunol. 2012 Oct;42(10):2727-35. doi: 10.1002/eji.201242396. Epub 2012 Aug 20.


Inflammation in the middle ear of children with recurrent or chronic otitis media is associated with bacterial load.

Stol K, Diavatopoulos DA, Graamans K, Engel JA, Melchers WJ, Savelkoul HF, Hays JP, Warris A, Hermans PW.

Pediatr Infect Dis J. 2012 Nov;31(11):1128-34. doi: 10.1097/INF.0b013e3182611d6b.


Interactions between Streptococcus pneumoniae and influenza virus: a mutually beneficial relationship?

Short KR, Habets MN, Hermans PW, Diavatopoulos DA.

Future Microbiol. 2012 May;7(5):609-24. doi: 10.2217/fmb.12.29. Review.


NLRC4 inflammasomes in dendritic cells regulate noncognate effector function by memory CD8⁺ T cells.

Kupz A, Guarda G, Gebhardt T, Sander LE, Short KR, Diavatopoulos DA, Wijburg OL, Cao H, Waithman JC, Chen W, Fernandez-Ruiz D, Whitney PG, Heath WR, Curtiss R 3rd, Tschopp J, Strugnell RA, Bedoui S.

Nat Immunol. 2012 Jan 8;13(2):162-9. doi: 10.1038/ni.2195.


Influenza virus induces bacterial and nonbacterial otitis media.

Short KR, Diavatopoulos DA, Thornton R, Pedersen J, Strugnell RA, Wise AK, Reading PC, Wijburg OL.

J Infect Dis. 2011 Dec 15;204(12):1857-65. doi: 10.1093/infdis/jir618. Epub 2011 Sep 19.


Using bioluminescent imaging to investigate synergism between Streptococcus pneumoniae and influenza A virus in infant mice.

Short KR, Diavatopoulos DA, Reading PC, Brown LE, Rogers KL, Strugnell RA, Wijburg OL.

J Vis Exp. 2011 Apr 14;(50). pii: 2357. doi: 10.3791/2357.


Pertussis: a matter of immune modulation.

de Gouw D, Diavatopoulos DA, Bootsma HJ, Hermans PW, Mooi FR.

FEMS Microbiol Rev. 2011 May;35(3):441-74. doi: 10.1111/j.1574-6976.2010.00257.x. Epub 2011 Jan 5. Review.


Influenza A virus facilitates Streptococcus pneumoniae transmission and disease.

Diavatopoulos DA, Short KR, Price JT, Wilksch JJ, Brown LE, Briles DE, Strugnell RA, Wijburg OL.

FASEB J. 2010 Jun;24(6):1789-98. doi: 10.1096/fj.09-146779. Epub 2010 Jan 22.


Bordetella pertussis strains with increased toxin production associated with pertussis resurgence.

Mooi FR, van Loo IH, van Gent M, He Q, Bart MJ, Heuvelman KJ, de Greeff SC, Diavatopoulos D, Teunis P, Nagelkerke N, Mertsola J.

Emerg Infect Dis. 2009 Aug;15(8):1206-13. doi: 10.3201/eid1508.081511.


Comparative genomic profiling of Dutch clinical Bordetella pertussis isolates using DNA microarrays: identification of genes absent from epidemic strains.

King AJ, van Gorkom T, Pennings JL, van der Heide HG, He Q, Diavatopoulos D, Heuvelman K, van Gent M, van Leeuwen K, Mooi FR.

BMC Genomics. 2008 Jun 30;9:311. doi: 10.1186/1471-2164-9-311. Erratum in: BMC Genomics. 2010;11:196.


Secretory antibodies reduce systemic antibody responses against the gastrointestinal commensal flora.

Sait LC, Galic M, Price JD, Simpfendorfer KR, Diavatopoulos DA, Uren TK, Janssen PH, Wijburg OL, Strugnell RA.

Int Immunol. 2007 Mar;19(3):257-65. Epub 2007 Jan 24.


Characterization of a highly conserved island in the otherwise divergent Bordetella holmesii and Bordetella pertussis genomes.

Diavatopoulos DA, Cummings CA, van der Heide HG, van Gent M, Liew S, Relman DA, Mooi FR.

J Bacteriol. 2006 Dec;188(24):8385-94. Epub 2006 Oct 13.


Adaptive evolution of the Bordetella autotransporter pertactin.

Diavatopoulos DA, Hijnen M, Mooi FR.

J Evol Biol. 2006 Nov;19(6):1931-8.


Bordetella pertussis, the causative agent of whooping cough, evolved from a distinct, human-associated lineage of B. bronchiseptica.

Diavatopoulos DA, Cummings CA, Schouls LM, Brinig MM, Relman DA, Mooi FR.

PLoS Pathog. 2005 Dec;1(4):e45. Epub 2005 Dec 30.

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