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Items: 1 to 50 of 254

1.

ClinVar miner: Demonstrating utility of a web-based tool for viewing and filtering clinvar data.

Henrie A, Hemphill SE, Ruiz-Schultz N, Cushman B, DiStefano MT, Azzariti D, Harrison SM, Rehm HL, Eilbeck K.

Hum Mutat. 2018 May 23. doi: 10.1002/humu.23555. [Epub ahead of print]

PMID:
29790234
2.

Isoprenoids and protein prenylation: implications in the pathogenesis and therapeutic intervention of Alzheimer's disease.

Jeong A, Suazo KF, Wood WG, Distefano MD, Li L.

Crit Rev Biochem Mol Biol. 2018 Jun;53(3):279-310. doi: 10.1080/10409238.2018.1458070.

PMID:
29718780
3.

Incidence of Hepatocellular Carcinoma in Patients with HCV-associated Cirrhosis Treated with Direct-Acting Antiviral Agents.

Calvaruso V, Cabibbo G, Cacciola I, Petta S, Madonia S, Bellia A, Tinè F, Distefano M, Licata A, Giannitrapani L, Prestileo T, Mazzola G, Di Rosolini MA, Larocca L, Bertino G, Digiacomo A, Benanti F, Guarneri L, Averna A, Iacobello C, Magro A, Scalisi I, Cartabellotta F, Savalli F, Barbara M, Davì A, Russello M, Scifo G, Squadrito G, Cammà C, Raimondo G, Craxì A, Di Marco V; Rete Sicilia Selezione Terapia - HCV (RESIST-HCV).

Gastroenterology. 2018 Apr 12. pii: S0016-5085(18)30441-4. doi: 10.1053/j.gastro.2018.04.008. [Epub ahead of print]

PMID:
29655836
4.

A mechanistic pan-cancer pathway model informed by multi-omics data interprets stochastic cell fate responses to drugs and mitogens.

Bouhaddou M, Barrette AM, Stern AD, Koch RJ, DiStefano MS, Riesel EA, Santos LC, Tan AL, Mertz AE, Birtwistle MR.

PLoS Comput Biol. 2018 Mar 26;14(3):e1005985. doi: 10.1371/journal.pcbi.1005985. eCollection 2018 Mar.

5.

Photo-immobilized EGF chemical gradients differentially impact breast cancer cell invasion and drug response in defined 3D hydrogels.

Fisher SA, Tam RY, Fokina A, Mahmoodi MM, Distefano MD, Shoichet MS.

Biomaterials. 2018 Feb 13. pii: S0142-9612(18)30047-4. doi: 10.1016/j.biomaterials.2018.01.032. [Epub ahead of print]

PMID:
29452913
6.

Analysis of copy number loss of the ErbB4 receptor tyrosine kinase in glioblastoma.

Jones DC, Scanteianu A, DiStefano M, Bouhaddou M, Birtwistle MR.

PLoS One. 2018 Jan 17;13(1):e0190664. doi: 10.1371/journal.pone.0190664. eCollection 2018.

7.

Efficient farnesylation of an extended C-terminal C(x)3X sequence motif expands the scope of the prenylated proteome.

Blanden MJ, Suazo KF, Hildebrandt ER, Hardgrove DS, Patel M, Saunders WP, Distefano MD, Schmidt WK, Hougland JL.

J Biol Chem. 2018 Feb 23;293(8):2770-2785. doi: 10.1074/jbc.M117.805770. Epub 2017 Dec 27.

PMID:
29282289
8.

a-Factor Analogues Containing Alkyne- and Azide-Functionalized Isoprenoids Are Efficiently Enzymatically Processed and Retain Wild-Type Bioactivity.

Diaz-Rodriguez V, Hsu ET, Ganusova E, Werst ER, Becker JM, Hrycyna CA, Distefano MD.

Bioconjug Chem. 2018 Feb 21;29(2):316-323. doi: 10.1021/acs.bioconjchem.7b00648. Epub 2017 Dec 20.

9.

Aortic dissection in the thrombolysis era: Rare but potentially fatal cause of stroke.

Pilato F, Iodice F, Distefano M, Profice P, Coli A, Calandrelli R.

Neurol India. 2017 Nov-Dec;65(6):1395-1399. doi: 10.4103/0028-3886.217931. No abstract available.

10.

Optimizing treatment in recurrent epithelial ovarian cancer.

Corrado G, Salutari V, Palluzzi E, Distefano MG, Scambia G, Ferrandina G.

Expert Rev Anticancer Ther. 2017 Dec;17(12):1147-1158. doi: 10.1080/14737140.2017.1398088. Epub 2017 Nov 6. Review.

PMID:
29086618
11.

Clinical and ultrasound features of non-gestational ovarian choriocarcinoma.

Mascilini F, Moro F, Di Grazia FM, Leombroni M, Distefano M, Fanfani F, Scambia G, Testa AC.

Ultrasound Obstet Gynecol. 2017 Oct 27. doi: 10.1002/uog.18943. [Epub ahead of print]

PMID:
29080278
12.

Could lymphadenectomy be avoided in locally advanced cervical cancer patients administered preoperative chemoradiation? A large-scale retrospective study.

Ferrandina G, Distefano M, Mascilini F, Gallotta V, Chiantera V, Cosentino F, Costantini B, Ercoli A, Pedone Anchora L, Fanfani F, Margariti AP, Valentini V, Scambia G.

Eur J Surg Oncol. 2017 Dec;43(12):2270-2276. doi: 10.1016/j.ejso.2017.09.013. Epub 2017 Sep 23.

PMID:
28988767
13.

Is early recurrence of hepatocellular carcinoma in HCV cirrhotic patients affected by treatment with direct-acting antivirals? A prospective multicentre study.

Cabibbo G, Petta S, Calvaruso V, Cacciola I, Cannavò MR, Madonia S, Distefano M, Larocca L, Prestileo T, Tinè F, Bertino G, Giannitrapani L, Benanti F, Licata A, Scalisi I, Mazzola G, Cartabellotta F, Alessi N, Barbàra M, Russello M, Scifo G, Squadrito G, Raimondo G, Craxì A, Di Marco V, Cammà C; Rete Sicilia Selezione Terapia - HCV (RESIST-HCV).

Aliment Pharmacol Ther. 2017 Oct;46(7):688-695. doi: 10.1111/apt.14256. Epub 2017 Aug 9.

PMID:
28791711
14.

Recurrent miller fisher: a new case report and a literature review.

Barbato F, Di Paolantonio A, Distefano M, Mastrorosa A, Sabatelli M, Servidei S, Luigetti M.

Clin Ter. 2017 May-Jun;168(3):e208-e213. doi: 10.7417/T.2017.2008. Review.

15.

Map4k4 impairs energy metabolism in endothelial cells and promotes insulin resistance in obesity.

Roth Flach RJ, DiStefano MT, Danai LV, Senol-Cosar O, Yawe JC, Kelly M, Garcia Menendez L, Czech MP.

Am J Physiol Endocrinol Metab. 2017 Sep 1;313(3):E303-E313. doi: 10.1152/ajpendo.00037.2017. Epub 2017 Jun 13.

PMID:
28611026
16.

Real-World Management of Trabectedin/Pegylated Liposomal Doxorubicin in Platinum-Sensitive Recurrent Ovarian Cancer Patients: A National Survey.

Ferrandina G, Amadio G, Paris I, Distefano M, Palluzzi E, de Vincenzo R, Ricci C, Scambia G.

Int J Gynecol Cancer. 2017 Jul;27(6):1141-1148. doi: 10.1097/IGC.0000000000001058.

PMID:
28574933
17.

Evaluating the Clinical Validity of Gene-Disease Associations: An Evidence-Based Framework Developed by the Clinical Genome Resource.

Strande NT, Riggs ER, Buchanan AH, Ceyhan-Birsoy O, DiStefano M, Dwight SS, Goldstein J, Ghosh R, Seifert BA, Sneddon TP, Wright MW, Milko LV, Cherry JM, Giovanni MA, Murray MF, O'Daniel JM, Ramos EM, Santani AB, Scott AF, Plon SE, Rehm HL, Martin CL, Berg JS.

Am J Hum Genet. 2017 Jun 1;100(6):895-906. doi: 10.1016/j.ajhg.2017.04.015. Epub 2017 May 25.

18.

Fluorescence and NMR spectroscopy together with molecular simulations reveal amphiphilic characteristics of a Burkholderia biofilm exopolysaccharide.

Kuttel MM, Cescutti P, Distefano M, Rizzo R.

J Biol Chem. 2017 Jun 30;292(26):11034-11042. doi: 10.1074/jbc.M117.785048. Epub 2017 May 3.

PMID:
28468829
19.

The Caregiver Perspective on Unscheduled 72-Hour Return Visits to Pediatric Acute Care Sites: A Focus on Discharge Processes.

Navanandan N, Schmidt SK, Cabrera N, DiStefano MC, Mistry RD.

Acad Pediatr. 2017 Sep - Oct;17(7):755-761. doi: 10.1016/j.acap.2017.02.003. Epub 2017 Feb 12.

PMID:
28215655
20.

a-Factor: a chemical biology tool for the study of protein prenylation.

Diaz-Rodriguez V, Distefano MD.

Curr Top Pept Protein Res. 2017;18:133-151.

21.

Wearable Biometric Technologies and Public Health.

DiStefano MJ.

Am J Bioeth. 2017 Jan;17(1):79-81. No abstract available.

PMID:
27996903
22.

Limited Abdominal Sonography for Evaluation of Children With Right Lower Quadrant Pain.

Munden MM, Wai S, DiStefano MC, Zhang W.

J Ultrasound Med. 2017 Jan;36(1):183-186. doi: 10.7863/ultra.16.01102. Epub 2016 Nov 30.

PMID:
27925670
23.

Global proteomic analysis of prenylated proteins in Plasmodium falciparum using an alkyne-modified isoprenoid analogue.

Suazo KF, Schaber C, Palsuledesai CC, Odom John AR, Distefano MD.

Sci Rep. 2016 Dec 7;6:38615. doi: 10.1038/srep38615.

24.

Drug response consistency in CCLE and CGP.

Bouhaddou M, DiStefano MS, Riesel EA, Carrasco E, Holzapfel HY, Jones DC, Smith GR, Stern AD, Somani SS, Thompson TV, Birtwistle MR.

Nature. 2016 Nov 30;540(7631):E9-E10. doi: 10.1038/nature20580. No abstract available.

25.

Adipocyte-specific Hypoxia-inducible gene 2 promotes fat deposition and diet-induced insulin resistance.

DiStefano MT, Roth Flach RJ, Senol-Cosar O, Danai LV, Virbasius JV, Nicoloro SM, Straubhaar J, Dagdeviren S, Wabitsch M, Gupta OT, Kim JK, Czech MP.

Mol Metab. 2016 Sep 28;5(12):1149-1161. eCollection 2016 Dec.

26.

Metabolic Labeling with an Alkyne-modified Isoprenoid Analog Facilitates Imaging and Quantification of the Prenylome in Cells.

Palsuledesai CC, Ochocki JD, Kuhns MM, Wang YC, Warmka JK, Chernick DS, Wattenberg EV, Li L, Arriaga EA, Distefano MD.

ACS Chem Biol. 2016 Oct 21;11(10):2820-2828. Epub 2016 Aug 31.

27.

Bypass of DNA-Protein Cross-links Conjugated to the 7-Deazaguanine Position of DNA by Translesion Synthesis Polymerases.

Wickramaratne S, Ji S, Mukherjee S, Su Y, Pence MG, Lior-Hoffmann L, Fu I, Broyde S, Guengerich FP, Distefano M, Schärer OD, Sham YY, Tretyakova N.

J Biol Chem. 2016 Nov 4;291(45):23589-23603. Epub 2016 Sep 12.

28.

6-Bromo-7-hydroxy-3-methylcoumarin (mBhc) is an efficient multi-photon labile protecting group for thiol caging and three-dimensional chemical patterning.

Mahmoodi MM, Fisher SA, Tam RY, Goff PC, Anderson RB, Wissinger JE, Blank DA, Shoichet MS, Distefano MD.

Org Biomol Chem. 2016 Sep 21;14(35):8289-300. doi: 10.1039/c6ob01045h. Epub 2016 Aug 16.

29.

mHealth for Tuberculosis Treatment Adherence: A Framework to Guide Ethical Planning, Implementation, and Evaluation.

DiStefano MJ, Schmidt H.

Glob Health Sci Pract. 2016 Jun 27;4(2):211-21. doi: 10.9745/GHSP-D-16-00018. Print 2016 Jun 20. No abstract available.

30.

Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia.

Roth Flach RJ, Danai LV, DiStefano MT, Kelly M, Menendez LG, Jurczyk A, Sharma RB, Jung DY, Kim JH, Kim JK, Bortell R, Alonso LC, Czech MP.

J Biol Chem. 2016 Jul 29;291(31):16221-30. doi: 10.1074/jbc.M116.718932. Epub 2016 May 20.

31.

Rab7b at the intersection of intracellular trafficking and cell migration.

Distefano MB, Kjos I, Bakke O, Progida C.

Commun Integr Biol. 2015 Aug 27;8(6):e1023492. doi: 10.1080/19420889.2015.1023492. eCollection 2015 Nov-Dec.

32.

Nitrodibenzofuran: A One- and Two-Photon Sensitive Protecting Group That Is Superior to Brominated Hydroxycoumarin for Thiol Caging in Peptides.

Mahmoodi MM, Abate-Pella D, Pundsack TJ, Palsuledesai CC, Goff PC, Blank DA, Distefano MD.

J Am Chem Soc. 2016 May 11;138(18):5848-59. doi: 10.1021/jacs.5b11759. Epub 2016 May 2.

33.

Health-related quality of life and functional changes in DMD: A 12-month longitudinal cohort study.

Messina S, Vita GL, Sframeli M, Mondello S, Mazzone E, D'Amico A, Berardinelli A, La Rosa M, Bruno C, Distefano MG, Baranello G, Barcellona C, Scutifero M, Marcato S, Palmieri A, Politano L, Morandi L, Mongini T, Pegoraro E, D'Angelo MG, Pane M, Rodolico C, Minetti C, Bertini E, Vita G, Mercuri E.

Neuromuscul Disord. 2016 Mar;26(3):189-96. doi: 10.1016/j.nmd.2016.01.003. Epub 2016 Feb 2.

34.

Tenomodulin promotes human adipocyte differentiation and beneficial visceral adipose tissue expansion.

Senol-Cosar O, Flach RJ, DiStefano M, Chawla A, Nicoloro S, Straubhaar J, Hardy OT, Noh HL, Kim JK, Wabitsch M, Scherer PE, Czech MP.

Nat Commun. 2016 Feb 16;7:10686. doi: 10.1038/ncomms10686.

35.

Analogs of farnesyl diphosphate alter CaaX substrate specificity and reactions rates of protein farnesyltransferase.

Jennings BC, Danowitz AM, Wang YC, Gibbs RA, Distefano MD, Fierke CA.

Bioorg Med Chem Lett. 2016 Feb 15;26(4):1333-6. doi: 10.1016/j.bmcl.2015.12.079. Epub 2015 Dec 22.

36.

Synthetic isoprenoid analogues for the study of prenylated proteins: Fluorescent imaging and proteomic applications.

Wang YC, Distefano MD.

Bioorg Chem. 2016 Feb;64:59-65. doi: 10.1016/j.bioorg.2015.12.003. Epub 2015 Dec 10. Review.

37.

8-Hydroxyquinoline-based inhibitors of the Rce1 protease disrupt Ras membrane localization in human cells.

Mohammed I, Hampton SE, Ashall L, Hildebrandt ER, Kutlik RA, Manandhar SP, Floyd BJ, Smith HE, Dozier JK, Distefano MD, Schmidt WK, Dore TM.

Bioorg Med Chem. 2016 Jan 15;24(2):160-78. doi: 10.1016/j.bmc.2015.11.043. Epub 2015 Nov 30.

38.

Simultaneous Site-Specific Dual Protein Labeling Using Protein Prenyltransferases.

Zhang Y, Blanden MJ, Sudheer Ch, Gangopadhyay SA, Rashidian M, Hougland JL, Distefano MD.

Bioconjug Chem. 2015 Dec 16;26(12):2542-53. doi: 10.1021/acs.bioconjchem.5b00553. Epub 2015 Dec 4.

39.

Site-Specific PEGylation of Therapeutic Proteins.

Dozier JK, Distefano MD.

Int J Mol Sci. 2015 Oct 28;16(10):25831-64. doi: 10.3390/ijms161025831. Review.

40.

Synthesis of Peptides Containing C-Terminal Esters Using Trityl Side-Chain Anchoring: Applications to the Synthesis of C-Terminal Ester Analogs of the Saccharomyces cerevisiae Mating Pheromone a-Factor.

Diaz-Rodriguez V, Ganusova E, Rappe TM, Becker JM, Distefano MD.

J Org Chem. 2015 Nov 20;80(22):11266-74. doi: 10.1021/acs.joc.5b01376. Epub 2015 Aug 24.

41.

The frequency of naive and early-activated hapten-specific B cell subsets dictates the efficacy of a therapeutic vaccine against prescription opioid abuse.

Laudenbach M, Baruffaldi F, Vervacke JS, Distefano MD, Titcombe PJ, Mueller DL, Tubo NJ, Griffith TS, Pravetoni M.

J Immunol. 2015 Jun 15;194(12):5926-36. doi: 10.4049/jimmunol.1500385. Epub 2015 May 13.

42.

The Lipid Droplet Protein Hypoxia-inducible Gene 2 Promotes Hepatic Triglyceride Deposition by Inhibiting Lipolysis.

DiStefano MT, Danai LV, Roth Flach RJ, Chawla A, Pedersen DJ, Guilherme A, Czech MP.

J Biol Chem. 2015 Jun 12;290(24):15175-84. doi: 10.1074/jbc.M115.650184. Epub 2015 Apr 28.

43.

The Landing Error Scoring System as a Screening Tool for an Anterior Cruciate Ligament Injury-Prevention Program in Elite-Youth Soccer Athletes.

Padua DA, DiStefano LJ, Beutler AI, de la Motte SJ, DiStefano MJ, Marshall SW.

J Athl Train. 2015 Jun;50(6):589-95. doi: 10.4085/1062-6050-50.1.10. Epub 2015 Mar 26.

44.

Application of meta- and para-Phenylenediamine as Enhanced Oxime Ligation Catalysts for Protein Labeling, PEGylation, Immobilization, and Release.

Mahmoodi MM, Rashidian M, Zhang Y, Distefano MD.

Curr Protoc Protein Sci. 2015 Feb 2;79:15.4.1-28. doi: 10.1002/0471140864.ps1504s79.

45.

Metronomic oral cyclophosphamide (MOC) in the salvage therapy of heavily treated recurrent ovarian cancer patients: a retrospective, multicenter study.

Ferrandina G, Corrado G, Mascilini F, Malaguti P, Samaritani R, Distefano M, Masciullo V, Di Legge A, Savarese A, Scambia G.

BMC Cancer. 2014 Dec 13;14:947. doi: 10.1186/1471-2407-14-947.

46.

Protein prenylation: enzymes, therapeutics, and biotechnology applications.

Palsuledesai CC, Distefano MD.

ACS Chem Biol. 2015 Jan 16;10(1):51-62. doi: 10.1021/cb500791f. Epub 2014 Dec 8. Review.

47.

Error-prone translesion synthesis past DNA-peptide cross-links conjugated to the major groove of DNA via C5 of thymidine.

Wickramaratne S, Boldry EJ, Buehler C, Wang YC, Distefano MD, Tretyakova NY.

J Biol Chem. 2015 Jan 9;290(2):775-87. doi: 10.1074/jbc.M114.613638. Epub 2014 Nov 12.

48.

IL-1 signaling in obesity-induced hepatic lipogenesis and steatosis.

Negrin KA, Roth Flach RJ, DiStefano MT, Matevossian A, Friedline RH, Jung D, Kim JK, Czech MP.

PLoS One. 2014 Sep 12;9(9):e107265. doi: 10.1371/journal.pone.0107265. eCollection 2014.

49.

Engineering protein farnesyltransferase for enzymatic protein labeling applications.

Dozier JK, Khatwani SL, Wollack JW, Wang YC, Schmidt-Dannert C, Distefano MD.

Bioconjug Chem. 2014 Jul 16;25(7):1203-12. doi: 10.1021/bc500240p. Epub 2014 Jul 2.

50.

Synthesis of site-specific DNA-protein conjugates and their effects on DNA replication.

Yeo JE, Wickramaratne S, Khatwani S, Wang YC, Vervacke J, Distefano MD, Tretyakova NY.

ACS Chem Biol. 2014 Aug 15;9(8):1860-8. doi: 10.1021/cb5001795. Epub 2014 Jun 26.

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