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Metaboloptics: Visualization of the tumor functional landscape via metabolic and vascular imaging.

Martinez AF, McCachren SS 3rd, Lee M, Murphy HA, Zhu C, Crouch BT, Martin HL, Erkanli A, Rajaram N, Ashcraft KA, Fontanella AN, Dewhirst MW, Ramanujam N.

Sci Rep. 2018 Mar 8;8(1):4171. doi: 10.1038/s41598-018-22480-w.


Technological Advances, Biologic Rationales, and the Associated Success of Chemotherapy With Hyperthermia in Improved Outcomes in Patients With Sarcoma.

Dewhirst MW, Kirsch D.

JAMA Oncol. 2018 Feb 15. doi: 10.1001/jamaoncol.2017.4941. [Epub ahead of print] No abstract available.


Differential response to exercise in claudin-low breast cancer.

Glass OK, Bowie M, Fuller J, Darr D, Usary J, Boss K, Choudhury KR, Liu X, Zhang Z, Locasale JW, Williams C, Dewhirst MW, Jones LW, Seewaldt V.

Oncotarget. 2017 Sep 19;8(60):100989-101004. doi: 10.18632/oncotarget.21054. eCollection 2017 Nov 24.


Endothelial cell-surface tissue transglutaminase inhibits neutrophil adhesion by binding and releasing nitric oxide.

Lai TS, Lindberg RA, Zhou HL, Haroon ZA, Dewhirst MW, Hausladen A, Juang YL, Stamler JS, Greenberg CS.

Sci Rep. 2017 Nov 23;7(1):16163. doi: 10.1038/s41598-017-16342-0.


Nanoparticle formulation improves doxorubicin efficacy by enhancing host antitumor immunity.

Mastria EM, Cai LY, Kan MJ, Li X, Schaal JL, Fiering S, Gunn MD, Dewhirst MW, Nair SK, Chilkoti A.

J Control Release. 2018 Jan 10;269:364-373. doi: 10.1016/j.jconrel.2017.11.021. Epub 2017 Nov 13.


Transport of drugs from blood vessels to tumour tissue.

Dewhirst MW, Secomb TW.

Nat Rev Cancer. 2017 Dec;17(12):738-750. doi: 10.1038/nrc.2017.93. Epub 2017 Nov 10. Review.


NIR-emissive PEG-b-TCL micelles for breast tumor imaging and minimally invasive pharmacokinetic analysis.

Hofmann CL, O'Sullivan MC, Detappe A, Yu Y, Yang X, Qi W, Landon CD, Therien MJ, Dewhirst MW, Ghoroghchian PP, Palmer GM.

Nanoscale. 2017 Sep 21;9(36):13465-13476. doi: 10.1039/c7nr02363d.


Development of enhanced ethanol ablation as an alternative to surgery in treatment of superficial solid tumors.

Morhard R, Nief C, Barrero Castedo C, Hu F, Madonna M, Mueller JL, Dewhirst MW, Katz DF, Ramanujam N.

Sci Rep. 2017 Aug 18;7(1):8750. doi: 10.1038/s41598-017-09371-2.


Potential for a novel manganese porphyrin compound as adjuvant canine lymphoma therapy.

Boss MK, Dewhirst MW, Sampaio RS, Bennett A, Tovmasyan A, Berman KG, Beaven AW, Rizzieri DA, Batinic-Haberle I, Hauck ML, Spasojevic I.

Cancer Chemother Pharmacol. 2017 Aug;80(2):421-431. doi: 10.1007/s00280-017-3372-z. Epub 2017 Jul 6.


Subtype-Specific Radiation Response and Therapeutic Effect of FAS Death Receptor Modulation in Human Breast Cancer.

Lee CT, Zhou Y, Roy-Choudhury K, Siamakpour-Reihani S, Young K, Hoang P, Kirkpatrick JP, Chi JA, Dewhirst MW, Horton JK.

Radiat Res. 2017 Aug;188(2):169-180. doi: 10.1667/RR14664.1. Epub 2017 Jun 9.


Inhibition of the Continuum of Radiation-Induced Normal Tissue Injury by a Redox-Active Mn Porphyrin.

Birer SR, Lee CT, Choudhury KR, Young KH, Spasojevic I, Batinic-Haberle I, Crapo JD, Dewhirst MW, Ashcraft KA.

Radiat Res. 2017 Jul;188(1):94-104. doi: 10.1667/RR14757.1.S1. Epub 2017 May 18.


Inflammatory breast cancer tumor emboli express high levels of anti-apoptotic proteins: use of a quantitative high content and high-throughput 3D IBC spheroid assay to identify targeting strategies.

Arora J, Sauer SJ, Tarpley M, Vermeulen P, Rypens C, Van Laere S, Williams KP, Devi GR, Dewhirst MW.

Oncotarget. 2017 Apr 18;8(16):25848-25863. doi: 10.18632/oncotarget.15667.


Multidisciplinary Mentoring Programs to Enhance Junior Faculty Research Grant Success.

Freel SA, Smith PC, Burns EN, Downer JB, Brown AJ, Dewhirst MW.

Acad Med. 2017 Oct;92(10):1410-1415. doi: 10.1097/ACM.0000000000001620.


Evidence for Feedback Regulation Following Cholesterol Lowering Therapy in a Prostate Cancer Xenograft Model.

Masko EM, Alfaqih MA, Solomon KR, Barry WT, Newgard CB, Muehlbauer MJ, Valilis NA, Phillips TE, Poulton SH, Freedland AR, Sun S, Dambal SK, Sanders SE, Macias E, Freeman MR, Dewhirst MW, Pizzo SV, Freedland SJ.

Prostate. 2017 Apr;77(5):446-457. doi: 10.1002/pros.23282. Epub 2016 Nov 30.


Oxygen and Perfusion Kinetics in Response to Fractionated Radiation Therapy in FaDu Head and Neck Cancer Xenografts Are Related to Treatment Outcome.

Hu F, Vishwanath K, Salama JK, Erkanli A, Peterson B, Oleson JR, Lee WT, Brizel DM, Ramanujam N, Dewhirst MW.

Int J Radiat Oncol Biol Phys. 2016 Oct 1;96(2):462-469. doi: 10.1016/j.ijrobp.2016.06.007. Epub 2016 Jun 14.


X-Ray Psoralen Activated Cancer Therapy (X-PACT).

Oldham M, Yoon P, Fathi Z, Beyer WF, Adamson J, Liu L, Alcorta D, Xia W, Osada T, Liu C, Yang XY, Dodd RD, Herndon JE 2nd, Meng B, Kirsch DG, Lyerly HK, Dewhirst MW, Fecci P, Walder H, Spector NL.

PLoS One. 2016 Sep 1;11(9):e0162078. doi: 10.1371/journal.pone.0162078. eCollection 2016.


Efficacy and Mechanisms of Aerobic Exercise on Cancer Initiation, Progression, and Metastasis: A Critical Systematic Review of In Vivo Preclinical Data.

Ashcraft KA, Peace RM, Betof AS, Dewhirst MW, Jones LW.

Cancer Res. 2016 Jul 15;76(14):4032-50. doi: 10.1158/0008-5472.CAN-16-0887. Epub 2016 Jul 5. Review.


Discovery of Manassantin A Protein Targets Using Large-Scale Protein Folding and Stability Measurements.

Geer Wallace MA, Kwon DY, Weitzel DH, Lee CT, Stephenson TN, Chi JT, Mook RA Jr, Dewhirst MW, Hong J, Fitzgerald MC.

J Proteome Res. 2016 Aug 5;15(8):2688-96. doi: 10.1021/acs.jproteome.6b00237. Epub 2016 Jul 8.


Implications of Increase in Vascular Permeability in Tumors by VEGF: A Commentary on the Pioneering Work of Harold Dvorak.

Dewhirst MW, Ashcraft KA.

Cancer Res. 2016 Jun 1;76(11):3118-20. doi: 10.1158/0008-5472.CAN-16-1292.


Neurobehavioral radiation mitigation to standard brain cancer therapy regimens by Mn(III) n-butoxyethylpyridylporphyrin-based redox modifier.

Weitzel DH, Tovmasyan A, Ashcraft KA, Boico A, Birer SR, Roy Choudhury K, Herndon J 2nd, Rodriguiz RM, Wetsel WC, Peters KB, Spasojevic I, Batinic-Haberle I, Dewhirst MW.

Environ Mol Mutagen. 2016 Jun;57(5):372-81. doi: 10.1002/em.22021. Epub 2016 May 25.


Improving the Predictive Value of Preclinical Studies in Support of Radiotherapy Clinical Trials.

Coleman CN, Higgins GS, Brown JM, Baumann M, Kirsch DG, Willers H, Prasanna PG, Dewhirst MW, Bernhard EJ, Ahmed MM.

Clin Cancer Res. 2016 Jul 1;22(13):3138-47. doi: 10.1158/1078-0432.CCR-16-0069. Epub 2016 May 6. Review.


Effects of hyperthermia in neutralising mechanisms of drug resistance in non-muscle-invasive bladder cancer.

van der Heijden AG, Dewhirst MW.

Int J Hyperthermia. 2016 Jun;32(4):434-45. doi: 10.3109/02656736.2016.1155761. Epub 2016 Apr 20. Review.


ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer.

Park S, Chang CY, Safi R, Liu X, Baldi R, Jasper JS, Anderson GR, Liu T, Rathmell JC, Dewhirst MW, Wood KC, Locasale JW, McDonnell DP.

Cell Rep. 2016 Apr 12;15(2):323-35. doi: 10.1016/j.celrep.2016.03.026. Epub 2016 Mar 31.


The future of biology in driving the field of hyperthermia.

Dewhirst MW, Lee CT, Ashcraft KA.

Int J Hyperthermia. 2016;32(1):4-13. doi: 10.3109/02656736.2015.1091093. Epub 2016 Feb 5. Review.


Oxygen-Enhanced MRI Is a Major Advance in Tumor Hypoxia Imaging.

Dewhirst MW, Birer SR.

Cancer Res. 2016 Feb 15;76(4):769-72. doi: 10.1158/0008-5472.CAN-15-2818. Epub 2016 Feb 2. Review. No abstract available.


Novel Manganese-Porphyrin Superoxide Dismutase-Mimetic Widens the Therapeutic Margin in a Preclinical Head and Neck Cancer Model.

Ashcraft KA, Boss MK, Tovmasyan A, Roy Choudhury K, Fontanella AN, Young KH, Palmer GM, Birer SR, Landon CD, Park W, Das SK, Weitner T, Sheng H, Warner DS, Brizel DM, Spasojevic I, Batinic-Haberle I, Dewhirst MW.

Int J Radiat Oncol Biol Phys. 2015 Nov 15;93(4):892-900. doi: 10.1016/j.ijrobp.2015.07.2283. Epub 2015 Jul 29.


Anticancer therapeutic potential of Mn porphyrin/ascorbate system.

Tovmasyan A, Sampaio RS, Boss MK, Bueno-Janice JC, Bader BH, Thomas M, Reboucas JS, Orr M, Chandler JD, Go YM, Jones DP, Venkatraman TN, Haberle S, Kyui N, Lascola CD, Dewhirst MW, Spasojevic I, Benov L, Batinic-Haberle I.

Free Radic Biol Med. 2015 Dec;89:1231-47. doi: 10.1016/j.freeradbiomed.2015.10.416. Epub 2015 Oct 20.


FAS Death Receptor: A Breast Cancer Subtype-Specific Radiation Response Biomarker and Potential Therapeutic Target.

Horton JK, Siamakpour-Reihani S, Lee CT, Zhou Y, Chen W, Geradts J, Fels DR, Hoang P, Ashcraft KA, Groth J, Kung HN, Dewhirst MW, Chi JT.

Radiat Res. 2015 Nov;184(5):456-69. doi: 10.1667/RR14089.1. Epub 2015 Oct 21.


Synthesis and Biological Evaluation of Manassantin Analogues for Hypoxia-Inducible Factor 1α Inhibition.

Kwon DY, Lee HE, Weitzel DH, Park K, Lee SH, Lee CT, Stephenson TN, Park H, Fitzgerald MC, Chi JT, Mook RA Jr, Dewhirst MW, Lee YM, Hong J.

J Med Chem. 2015 Oct 8;58(19):7659-71. doi: 10.1021/acs.jmedchem.5b01220. Epub 2015 Sep 22.


Prognostic significance of differential expression of angiogenic genes in women with high-grade serous ovarian carcinoma.

Siamakpour-Reihani S, Owzar K, Jiang C, Turner T, Deng Y, Bean SM, Horton JK, Berchuck A, Marks JR, Dewhirst MW, Alvarez Secord A.

Gynecol Oncol. 2015 Oct;139(1):23-9. doi: 10.1016/j.ygyno.2015.08.001. Epub 2015 Aug 7.


Dynamic treatment effect (DTE) curves reveal the mode of action for standard and experimental cancer therapies.

Choudhury KR, Keir ST, Ashcraft KA, Boss MK, Dewhirst MW.

Oncotarget. 2015 Jun 10;6(16):14656-68.


HIF-1 Alpha Regulates the Response of Primary Sarcomas to Radiation Therapy through a Cell Autonomous Mechanism.

Zhang M, Qiu Q, Li Z, Sachdeva M, Min H, Cardona DM, DeLaney TF, Han T, Ma Y, Luo L, Ilkayeva OR, Lui K, Nichols AG, Newgard CB, Kastan MB, Rathmell JC, Dewhirst MW, Kirsch DG.

Radiat Res. 2015 Jun;183(6):594-609. Epub 2015 May 14.


Common responses of tumors and wounds to hypoxia.

Payen VL, Brisson L, Dewhirst MW, Sonveaux P.

Cancer J. 2015 Mar-Apr;21(2):75-87. doi: 10.1097/PPO.0000000000000098. Review.


From the guest editor: an integrated multidisciplinary view of tumor metabolism.

Dewhirst MW.

Cancer J. 2015 Mar-Apr;21(2):47-8. doi: 10.1097/PPO.0000000000000108. No abstract available.


Genomic profiling in locally advanced and inflammatory breast cancer and its link to DCE-MRI and overall survival.

Siamakpour-Reihani S, Owzar K, Jiang C, Scarbrough PM, Craciunescu OI, Horton JK, Dressman HK, Blackwell KL, Dewhirst MW.

Int J Hyperthermia. 2015 Jun;31(4):386-95. doi: 10.3109/02656736.2015.1016557. Epub 2015 Mar 26.


Modulation of murine breast tumor vascularity, hypoxia and chemotherapeutic response by exercise.

Betof AS, Lascola CD, Weitzel D, Landon C, Scarbrough PM, Devi GR, Palmer G, Jones LW, Dewhirst MW.

J Natl Cancer Inst. 2015 Mar 16;107(5). pii: djv040. doi: 10.1093/jnci/djv040. Print 2015 May.


Luminescent difluoroboron β-diketonate PEG-PLA oxygen nanosensors for tumor imaging.

Samonina-Kosicka J, Weitzel DH, Hofmann CL, Hendargo H, Hanna G, Dewhirst MW, Palmer GM, Fraser CL.

Macromol Rapid Commun. 2015 Apr;36(7):694-9. doi: 10.1002/marc.201500022. Epub 2015 Mar 9.


Reply: Pharmacokinetic and Pharmacodynamic Modifiers of EF5 Uptake and Binding.

Chitneni SK, Bida GT, Zalutsky MR, Dewhirst MW.

J Nucl Med. 2015 Apr;56(4):653-4. doi: 10.2967/jnumed.115.154054. Epub 2015 Mar 5. No abstract available.


Doxorubicin-conjugated polypeptide nanoparticles inhibit metastasis in two murine models of carcinoma.

Mastria EM, Chen M, McDaniel JR, Li X, Hyun J, Dewhirst MW, Chilkoti A.

J Control Release. 2015 Jun 28;208:52-8. doi: 10.1016/j.jconrel.2015.01.033. Epub 2015 Jan 28.


Effects of high-dose microbeam irradiation on tumor microvascular function and angiogenesis.

Fontanella AN, Boss MK, Hadsell M, Zhang J, Schroeder T, Berman KG, Dewhirst MW, Chang S, Palmer GM.

Radiat Res. 2015 Feb;183(2):147-58. doi: 10.1667/RR13712.1. Epub 2015 Jan 9.


Delivery-corrected imaging of fluorescently-labeled glucose reveals distinct metabolic phenotypes in murine breast cancer.

Frees AE, Rajaram N, McCachren SS 3rd, Fontanella AN, Dewhirst MW, Ramanujam N.

PLoS One. 2014 Dec 19;9(12):e115529. doi: 10.1371/journal.pone.0115529. eCollection 2014.


Automated measurement of microcirculatory blood flow velocity in pulmonary metastases of rats.

Blueschke G, Hanna G, Fontanella AN, Palmer GM, Boico A, Min H, Dewhirst MW, Irwin DC, Zhao Y, Schroeder T.

J Vis Exp. 2014 Nov 30;(93):e51630. doi: 10.3791/51630.


Radioprotection of the brain white matter by Mn(III) n-Butoxyethylpyridylporphyrin-based superoxide dismutase mimic MnTnBuOE-2-PyP5+.

Weitzel DH, Tovmasyan A, Ashcraft KA, Rajic Z, Weitner T, Liu C, Li W, Buckley AF, Prasad MR, Young KH, Rodriguiz RM, Wetsel WC, Peters KB, Spasojevic I, Herndon JE 2nd, Batinic-Haberle I, Dewhirst MW.

Mol Cancer Ther. 2015 Jan;14(1):70-9. doi: 10.1158/1535-7163.MCT-14-0343. Epub 2014 Oct 15.


Systemic anti-tumour effects of local thermally sensitive liposome therapy.

Viglianti BL, Dewhirst MW, Boruta RJ, Park JY, Landon C, Fontanella AN, Guo J, Manzoor A, Hofmann CL, Palmer GM.

Int J Hyperthermia. 2014 Sep;30(6):385-92. doi: 10.3109/02656736.2014.944587. Epub 2014 Aug 28.


Two phase I dose-escalation/pharmacokinetics studies of low temperature liposomal doxorubicin (LTLD) and mild local hyperthermia in heavily pretreated patients with local regionally recurrent breast cancer.

Zagar TM, Vujaskovic Z, Formenti S, Rugo H, Muggia F, O'Connor B, Myerson R, Stauffer P, Hsu IC, Diederich C, Straube W, Boss MK, Boico A, Craciunescu O, Maccarini P, Needham D, Borys N, Blackwell KL, Dewhirst MW.

Int J Hyperthermia. 2014 Aug;30(5):285-94. doi: 10.3109/02656736.2014.936049.


Verification of a novel method for tube voltage constancy measurement of orthovoltage x-ray irradiators.

Wang C, Belley MD, Chao NJ, Dewhirst MW, Yoshizumi T.

Med Phys. 2014 Aug;41(8):084101. doi: 10.1118/1.4889778.


Comparison of the Hypoxia PET Tracer (18)F-EF5 to Immunohistochemical Marker EF5 in 3 Different Human Tumor Xenograft Models.

Chitneni SK, Bida GT, Zalutsky MR, Dewhirst MW.

J Nucl Med. 2014 Jul;55(7):1192-7. doi: 10.2967/jnumed.114.137448. Epub 2014 May 22.


Linking the history of radiation biology to the hallmarks of cancer.

Boss MK, Bristow R, Dewhirst MW.

Radiat Res. 2014 Jun;181(6):561-77. doi: 10.1667/RR13675.1. Epub 2014 May 8. Review.


The additive damage model: a mathematical model for cellular responses to drug combinations.

Jones LB, Secomb TW, Dewhirst MW, El-Kareh AW.

J Theor Biol. 2014 Sep 21;357:10-20. doi: 10.1016/j.jtbi.2014.04.032. Epub 2014 May 4.


Thermal dosimetry characteristics of deep regional heating of non-muscle invasive bladder cancer.

Juang T, Stauffer PR, Craciunescu OA, Maccarini PF, Yuan Y, Das SK, Dewhirst MW, Inman BA, Vujaskovic Z.

Int J Hyperthermia. 2014 May;30(3):176-83. doi: 10.3109/02656736.2014.898338. Epub 2014 Mar 26.

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