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Dabigatran in patients with myocardial injury after non-cardiac surgery (MANAGE): an international, randomised, placebo-controlled trial.

Devereaux PJ, Duceppe E, Guyatt G, Tandon V, Rodseth R, Biccard BM, Xavier D, Szczeklik W, Meyhoff CS, Vincent J, Franzosi MG, Srinathan SK, Erb J, Magloire P, Neary J, Rao M, Rahate PV, Chaudhry NK, Mayosi B, de Nadal M, Iglesias PP, Berwanger O, Villar JC, Botto F, Eikelboom JW, Sessler DI, Kearon C, Pettit S, Sharma M, Connolly SJ, Bangdiwala SI, Rao-Melacini P, Hoeft A, Yusuf S; MANAGE Investigators.

Lancet. 2018 Jun 9;391(10137):2325-2334. doi: 10.1016/S0140-6736(18)30832-8.


Suboptimal Outcome of Myocardial Infarction After Noncardiac Surgery: Physicians Can and Should Do More.

Devereaux PJ.

Circulation. 2018 May 29;137(22):2340-2343. doi: 10.1161/CIRCULATIONAHA.118.033766. No abstract available.


Troponin T monitoring to detect myocardial injury after noncardiac surgery: a cost-consequence analysis.

Buse GL, Manns B, Lamy A, Guyatt G, Polanczyk CA, Chan MTV, Wang CY, Villar JC, Sigamani A, Sessler DI, Berwanger O, Biccard BM, Pearse R, Urrútia G, Szczeklik W, Garutti I, Srinathan S, Malaga G, Abraham V, Chow CK, Jacka MJ, Tiboni M, Ackland G, Macneil D, Sapsford R, Leuwer M, Le Manach Y, Devereaux PJ.

Can J Surg. 2018 Jun;61(3):185-194.


The role of randomized cluster crossover trials for comparative effectiveness testing in anesthesia: design of the Benzodiazepine-Free Cardiac Anesthesia for Reduction in Postoperative Delirium (B-Free) trial.

Spence J, Belley-Côté E, Lee SF, Bangdiwala S, Whitlock R, LeManach Y, Syed S, Lamy A, Jacobsohn E, MacIsaac S, Devereaux PJ, Connolly S.

Can J Anaesth. 2018 Jul;65(7):813-821. doi: 10.1007/s12630-018-1130-2. Epub 2018 Apr 18.


Myocardial Injury is More Common than Deep Venous Thrombosis after Vascular Surgery and is Associated with a High One Year Mortality Risk.

Górka J, Polok K, Fronczek J, Górka K, Kózka M, Iwaszczuk P, Frołow M, Devereaux PJ, Biccard B, Musiał J, Szczeklik W.

Eur J Vasc Endovasc Surg. 2018 Mar 23. pii: S1078-5884(18)30102-3. doi: 10.1016/j.ejvs.2018.02.005. [Epub ahead of print]


Incidence of thrombosis in perioperative and non-operative myocardial infarction.

Sheth T, Natarajan MK, Hsieh V, Valettas N, Rokoss M, Mehta S, Jolly S, Tandon V, Bezerra H, Devereaux PJ.

Br J Anaesth. 2018 Apr;120(4):725-733. doi: 10.1016/j.bja.2017.11.063. Epub 2017 Nov 21.


Steroids in cardiac surgery: a systematic review and meta-analysis.

Dvirnik N, Belley-Cote EP, Hanif H, Devereaux PJ, Lamy A, Dieleman JM, Vincent J, Whitlock RP.

Br J Anaesth. 2018 Apr;120(4):657-667. doi: 10.1016/j.bja.2017.10.025. Epub 2018 Feb 8. Review.


Frailty, the Elderly, and the Guidelines on Perioperative Cardiac Risk Assessment and Management in Noncardiac Surgery.

Parlow JL, Duceppe E, Devereaux PJ.

Can J Cardiol. 2018 Mar;34(3):343.e13. doi: 10.1016/j.cjca.2017.12.013. Epub 2017 Dec 20. No abstract available.


Absolute vs Additive Net Reclassification Index-Reply.

Alba AC, Devereaux PJ, Guyatt G.

JAMA. 2018 Feb 13;319(6):617. doi: 10.1001/jama.2017.20548. No abstract available.


Design of a Randomized Placebo-Controlled Trial to Assess Dabigatran and Omeprazole in Patients with Myocardial Injury after Noncardiac Surgery (MANAGE).

Duceppe E, Yusuf S, Tandon V, Rodseth R, Biccard BM, Xavier D, Szczeklik W, Meyhoff CS, Franzosi MG, Vincent J, Srinathan SK, Parlow J, Magloire P, Neary J, Rao M, Chaudhry NK, Mayosi B, de Nadal M, Popova E, Villar JC, Botto F, Berwanger O, Guyatt G, Eikelboom JW, Sessler DI, Kearon C, Pettit S, Connolly SJ, Sharma M, Bangdiwala SI, Devereaux PJ.

Can J Cardiol. 2018 Mar;34(3):295-302. doi: 10.1016/j.cjca.2018.01.020. Epub 2018 Feb 2.


Age Does Not Affect Metoprolol's Effect on Perioperative Outcomes (From the POISE Database).

Jacka MJ, Guyatt G, Mizera R, Van Vlymen J, Ponce de Leon D, Schricker T, Bahari MY, Lv B, Afzal L, Plou García MP, Wu X, Nigro Maia L, Arrieta M, Rao-Melacini P, Devereaux PJ.

Anesth Analg. 2018 Apr;126(4):1150-1157. doi: 10.1213/ANE.0000000000002804.


Performance of high-sensitivity cardiac troponin in the emergency department for myocardial infarction and a composite cardiac outcome across different estimated glomerular filtration rates.

Kavsak PA, Worster A, Shortt C, Ma J, Clayton N, Sherbino J, Hill SA, McQueen M, Griffith LE, Mehta SR, McRae AD, Devereaux PJ.

Clin Chim Acta. 2018 Apr;479:166-170. doi: 10.1016/j.cca.2018.01.034. Epub 2018 Feb 3.


Benzodiazepine administration during adult cardiac surgery: a survey of current practice among Canadian anesthesiologists working in academic centres.

Spence J, Belley-Côté E, Devereaux PJ, Whitlock R, Um K, McClure G, Lamy A, LeManach Y, Connolly S, Syed S.

Can J Anaesth. 2018 Mar;65(3):263-271. doi: 10.1007/s12630-017-1047-1. Epub 2017 Dec 18.


Colchicine for Prevention of Perioperative Atrial Fibrillation in patients undergoing lung resection surgery: a pilot randomized controlled study.

Bessissow A, Agzarian J, Shargall Y, Srinathan S, Neary J, Tandon V, Finley C, Healey JS, Conen D, Rodseth R, Pettit S, Dechert W, Regalado O, Ramasundarahettige C, Alshalash S, Devereaux PJ.

Eur J Cardiothorac Surg. 2018 May 1;53(5):945-951. doi: 10.1093/ejcts/ezx422.


Period-dependent Associations between Hypotension during and for Four Days after Noncardiac Surgery and a Composite of Myocardial Infarction and Death: A Substudy of the POISE-2 Trial.

Sessler DI, Meyhoff CS, Zimmerman NM, Mao G, Leslie K, Vásquez SM, Balaji P, Alvarez-Garcia J, Cavalcanti AB, Parlow JL, Rahate PV, Seeberger MD, Gossetti B, Walker SA, Premchand RK, Dahl RM, Duceppe E, Rodseth R, Botto F, Devereaux PJ.

Anesthesiology. 2018 Feb;128(2):317-327. doi: 10.1097/ALN.0000000000001985.


The effect of colchicine administration on postoperative pleural effusion following lung resection: a randomized blinded placebo-controlled feasibility pilot study.

Agzarian J, Bessissow A, Srinathan S, Devereaux PJ, Neary J, Decher W, Gandy L, Schneider L, Finley CJ, Schieman C, Hanna WC, Shargall Y.

Eur J Cardiothorac Surg. 2018 Apr 1;53(4):822-827. doi: 10.1093/ejcts/ezx401.


Myocardial injury after endovascular revascularization in critical limb ischemia predicts 1-year mortality: a prospective observational cohort study.

Szczeklik W, Krzanowski M, Maga P, Partyka Ł, Kościelniak J, Kaczmarczyk P, Maga M, Pieczka P, Suska A, Wachsmann A, Górka J, Biccard B, Devereaux PJ.

Clin Res Cardiol. 2018 Apr;107(4):319-328. doi: 10.1007/s00392-017-1185-z. Epub 2017 Nov 24.


High-sensitivity cardiac troponin concentrations at emergency department presentation in females and males with an acute cardiac outcome.

Kavsak PA, Worster A, Shortt C, Ma J, Clayton N, Sherbino J, Hill SA, McQueen M, Griffith L, Mehta SR, Devereaux PJ.

Ann Clin Biochem. 2017 Jan 1:4563217743997. doi: 10.1177/0004563217743997. [Epub ahead of print]


Aspirin in Patients With Previous Percutaneous Coronary Intervention Undergoing Noncardiac Surgery.

Graham MM, Sessler DI, Parlow JL, Biccard BM, Guyatt G, Leslie K, Chan MTV, Meyhoff CS, Xavier D, Sigamani A, Kumar PA, Mrkobrada M, Cook DJ, Tandon V, Alvarez-Garcia J, Villar JC, Painter TW, Landoni G, Fleischmann E, Lamy A, Whitlock R, Le Manach Y, Aphang-Lam M, Cata JP, Gao P, Terblanche NCS, Ramana PV, Jamieson KA, Bessissow A, Mendoza GR, Ramirez S, Diemunsch PA, Yusuf S, Devereaux PJ.

Ann Intern Med. 2018 Feb 20;168(4):237-244. doi: 10.7326/M17-2341. Epub 2018 Nov 14.


Assessment of safety and efficacy of mesenchymal stromal cell therapy in preclinical models of acute myocardial infarction: a systematic review protocol.

Barron CC, Lalu MM, Stewart DJ, Fergusson D, Yang H, Moher D, Liu P, Mazer D, Devereaux PJ, McIntyre L; Canadian Perioperative Anesthesia Clinical Trials Group.

Syst Rev. 2017 Nov 7;6(1):226. doi: 10.1186/s13643-017-0601-9.


A Prospective International Multicentre Cohort Study of Intraoperative Heart Rate and Systolic Blood Pressure and Myocardial Injury After Noncardiac Surgery: Results of the VISION Study.

Abbott TEF, Pearse RM, Archbold RA, Ahmad T, Niebrzegowska E, Wragg A, Rodseth RN, Devereaux PJ, Ackland GL.

Anesth Analg. 2018 Jun;126(6):1936-1945. doi: 10.1213/ANE.0000000000002560.


Discrimination and Calibration of Clinical Prediction Models: Users' Guides to the Medical Literature.

Alba AC, Agoritsas T, Walsh M, Hanna S, Iorio A, Devereaux PJ, McGinn T, Guyatt G.

JAMA. 2017 Oct 10;318(14):1377-1384. doi: 10.1001/jama.2017.12126.


Red blood cell storage and in-hospital mortality: a secondary analysis of the INFORM randomised controlled trial.

Cook RJ, Heddle NM, Lee KA, Arnold DM, Crowther MA, Devereaux PJ, Ellis M, Figueroa P, Kurz A, Roxby D, Sessler DI, Sharon Y, Sobieraj-Teague M, Warkentin TE, Webert KE, Barty R, Liu Y, Eikelboom JW.

Lancet Haematol. 2017 Nov;4(11):e544-e552. doi: 10.1016/S2352-3026(17)30169-2. Epub 2017 Oct 8.


Comparison of the ability of double-robust estimators to correct bias in propensity score matching analysis. A Monte Carlo simulation study.

Nguyen TL, Collins GS, Spence J, Devereaux PJ, Daurès JP, Landais P, Le Manach Y.

Pharmacoepidemiol Drug Saf. 2017 Dec;26(12):1513-1519. doi: 10.1002/pds.4325. Epub 2017 Oct 6.


Association between preoperative pulse pressure and perioperative myocardial injury: an international observational cohort study of patients undergoing non-cardiac surgery.

Abbott TEF, Pearse RM, Archbold RA, Wragg A, Kam E, Ahmad T, Khan AW, Niebrzegowska E, Rodseth RN, Devereaux PJ, Ackland GL.

Br J Anaesth. 2017 Jul 1;119(1):78-86. doi: 10.1093/bja/aex165.


Bleeding impacting mortality after noncardiac surgery: a protocol to establish diagnostic criteria, estimate prognostic importance, and develop and validate a prediction guide in an international prospective cohort study.

Roshanov PS, Eikelboom JW, Crowther M, Tandon V, Borges FK, Kearon C, Lamy A, Whitlock R, Biccard BM, Szczeklik W, Guyatt GH, Panju M, Spence J, Garg AX, McGillion M, VanHelder T, Kavsak PA, de Beer J, Winemaker M, Sessler DI, Le Manach Y, Sheth T, Pinthus JH, Thabane L, Simunovic MRI, Mizera R, Ribas S, Devereaux PJ; Vascular Events In Noncardiac Surgery Patients Cohort Evaluation (VISION) Investigators.

CMAJ Open. 2017 Aug 4;5(3):E594-E603. doi: 10.9778/cmajo.20160106.


In Reply.

Roshanov PS, Devereaux PJ.

Anesthesiology. 2017 Oct;127(4):722. doi: 10.1097/ALN.0000000000001802. No abstract available.


Effect of Body Mass Index on Clinical Events After Acute Coronary Syndromes.

Lamelas P, Schwalm JD, Quazi I, Mehta S, Devereaux PJ, Jolly S, Yusuf S.

Am J Cardiol. 2017 Nov 1;120(9):1453-1459. doi: 10.1016/j.amjcard.2017.07.043. Epub 2017 Jul 29.


High-Sensitivity Troponin Levels, Ischemia, and Mortality-Reply.

Devereaux PJ, Biccard BM, Chan MTV.

JAMA. 2017 Sep 5;318(9):865. doi: 10.1001/jama.2017.9198. No abstract available.


Tranexamic Acid Administration During On-Pump Cardiac Surgery: A Survey of Current Practices Among Canadian Anesthetists Working in Academic Centers.

Spence J, Long S, Tidy A, Raymer K, Devereaux PJ, Lamy A, Whitlock R, Syed S.

Anesth Analg. 2017 Dec;125(6):1863-1870. doi: 10.1213/ANE.0000000000002422.


Benefits and safety of gabapentinoids in chronic low back pain: A systematic review and meta-analysis of randomized controlled trials.

Shanthanna H, Gilron I, Rajarathinam M, AlAmri R, Kamath S, Thabane L, Devereaux PJ, Bhandari M.

PLoS Med. 2017 Aug 15;14(8):e1002369. doi: 10.1371/journal.pmed.1002369. eCollection 2017 Aug. Review.


Survival After Isolated Post-Operative Troponin Elevation.

Beattie WS, Wijeysundera DN, Chan MTV, Peyton PJ, Leslie K, Paech MJ, Devereaux PJ, Sessler DI, Wallace S, Myles PS; ANZCA Clinical Trials Network and the ENIGMA-II Investigators.

J Am Coll Cardiol. 2017 Aug 15;70(7):907-908. doi: 10.1016/j.jacc.2017.06.023. No abstract available.


Preoperative pregabalin or gabapentin for acute and chronic postoperative pain among patients undergoing breast cancer surgery: A systematic review and meta-analysis of randomized controlled trials.

Rai AS, Khan JS, Dhaliwal J, Busse JW, Choi S, Devereaux PJ, Clarke H.

J Plast Reconstr Aesthet Surg. 2017 Oct;70(10):1317-1328. doi: 10.1016/j.bjps.2017.05.054. Epub 2017 Jun 9. Review.


In Reply.

Eikelboom JW, Devereaux PJ.

Anesthesiology. 2017 Aug;127(2):401-402. doi: 10.1097/ALN.0000000000001729. No abstract available.


The Effects of Steroids on Coagulation Dysfunction Induced by Cardiopulmonary Bypass: A Steroids in Cardiac Surgery (SIRS) Trial Substudy.

Paparella D, Parolari A, Rotunno C, Vincent J, Myasoedova V, Guida P, De Palo M, Margari V, Devereaux PJ, Lamy A, Alamanni F, Yusuf S, Whitlock R.

Semin Thorac Cardiovasc Surg. 2017 Spring;29(1):35-44. doi: 10.1053/j.semtcvs.2017.01.007. Epub 2017 Feb 22.


High-Sensitivity Cardiac Troponin Risk Cutoffs for Acute Cardiac Outcomes at Emergency Department Presentation.

Kavsak PA, Worster A, Ma J, Shortt C, Clayton N, Sherbino J, Hill SA, McQueen M, Mehta SR, Devereaux PJ.

Can J Cardiol. 2017 Jul;33(7):898-903. doi: 10.1016/j.cjca.2017.04.011. Epub 2017 May 3.


Predictors, Prognosis, and Management of New Clinically Important Atrial Fibrillation After Noncardiac Surgery: A Prospective Cohort Study.

Alonso-Coello P, Cook D, Xu SC, Sigamani A, Berwanger O, Sivakumaran S, Yang H, Xavier D, Martinez LX, Ibarra P, Rao-Melacini P, Pogue J, Zarnke K, Paniagua P, Ostrander J, Yusuf S, Devereaux PJ; POISE Investigators.

Anesth Analg. 2017 Jul;125(1):162-169. doi: 10.1213/ANE.0000000000002111.


Efficacy and safety of inhaled anaesthetic for postoperative sedation during mechanical ventilation in adult cardiac surgery patients: a systematic review and meta-analysis.

Spence J, Belley-Côté E, Ma HK, Donald S, Centofanti J, Hussain S, Gupta S, Devereaux PJ, Whitlock R.

Br J Anaesth. 2017 May 1;118(5):658-669. doi: 10.1093/bja/aex087.


Altered preoperative coagulation and fibrinolysis are associated with myocardial injury after non-cardiac surgery.

Górka J, Polok K, Iwaniec T, Górka K, Wludarczyk A, Fronczek J, Devereaux PJ, Eikelboom JW, Musial J, Szczeklik W.

Br J Anaesth. 2017 May 1;118(5):713-719. doi: 10.1093/bja/aex081.


Myocardial Injury After Noncardiac Surgery (MINS) in Vascular Surgical Patients: A Prospective Observational Cohort Study.

Biccard BM, Scott DJA, Chan MTV, Archbold A, Wang CY, Sigamani A, Urrútia G, Cruz P, Srinathan SK, Szalay D, Harlock J, Tittley JG, Rapanos T, Elias F, Jacka MJ, Malaga G, Abraham V, Berwanger O, Montes FR, Heels-Ansdell DM, Hutcherson MT, Chow CK, Polanczyk CA, Szczeklik W, Ackland GL, Dubois L, Sapsford RJ, Williams C, Cortés OL, Le Mananch Y, Devereaux PJ.

Ann Surg. 2017 May 8. doi: 10.1097/SLA.0000000000002290. [Epub ahead of print]


Does Knowledge of the Coronary Anatomy Save Lives in Patients With Unstable Angina?

Jolly SS, Devereaux PJ.

Ann Intern Med. 2017 Jun 6;166(11):848-849. doi: 10.7326/M17-0947. Epub 2017 May 2. No abstract available.


Double-adjustment in propensity score matching analysis: choosing a threshold for considering residual imbalance.

Nguyen TL, Collins GS, Spence J, Daurès JP, Devereaux PJ, Landais P, Le Manach Y.

BMC Med Res Methodol. 2017 Apr 28;17(1):78. doi: 10.1186/s12874-017-0338-0.


Association of Postoperative High-Sensitivity Troponin Levels With Myocardial Injury and 30-Day Mortality Among Patients Undergoing Noncardiac Surgery.

Writing Committee for the VISION Study Investigators, Devereaux PJ, Biccard BM, Sigamani A, Xavier D, Chan MTV, Srinathan SK, Walsh M, Abraham V, Pearse R, Wang CY, Sessler DI, Kurz A, Szczeklik W, Berwanger O, Villar JC, Malaga G, Garg AX, Chow CK, Ackland G, Patel A, Borges FK, Belley-Cote EP, Duceppe E, Spence J, Tandon V, Williams C, Sapsford RJ, Polanczyk CA, Tiboni M, Alonso-Coello P, Faruqui A, Heels-Ansdell D, Lamy A, Whitlock R, LeManach Y, Roshanov PS, McGillion M, Kavsak P, McQueen MJ, Thabane L, Rodseth RN, Buse GAL, Bhandari M, Garutti I, Jacka MJ, Schünemann HJ, Cortes OL, Coriat P, Dvirnik N, Botto F, Pettit S, Jaffe AS, Guyatt GH.

JAMA. 2017 Apr 25;317(16):1642-1651. doi: 10.1001/jama.2017.4360.


Magnitude and direction of missing confounders had different consequences on treatment effect estimation in propensity score analysis.

Nguyen TL, Collins GS, Spence J, Fontaine C, Daurès JP, Devereaux PJ, Landais P, Le Manach Y.

J Clin Epidemiol. 2017 Jul;87:87-97. doi: 10.1016/j.jclinepi.2017.04.001. Epub 2017 Apr 12.


Undiagnosed Obstructive Sleep Apnea and Postoperative Outcomes: A Prospective Observational Study.

Devaraj U, Rajagopala S, Kumar A, Ramachandran P, Devereaux PJ, D'Souza GA.

Respiration. 2017;94(1):18-25. doi: 10.1159/000470914. Epub 2017 Apr 11.


A laboratory score at presentation to rule-out serious cardiac outcomes or death in patients presenting with symptoms suggestive of acute coronary syndrome.

Kavsak PA, Shortt C, Ma J, Clayton N, Sherbino J, Hill SA, McQueen M, Mehta SR, Devereaux PJ, Worster A.

Clin Chim Acta. 2017 Jun;469:69-74. doi: 10.1016/j.cca.2017.03.021. Epub 2017 Mar 23.


PCI with drug-eluting stents ≤ 12 months before surgery was linked to increased MI and cardiac death after surgery.

Borges FK, Devereaux PJ.

Ann Intern Med. 2017 Mar 21;166(6):JC35. doi: 10.7326/ACPJC-2017-166-6-035. No abstract available.


Simple randomization did not protect against bias in smaller trials.

Nguyen TL, Collins GS, Lamy A, Devereaux PJ, Daurès JP, Landais P, Le Manach Y.

J Clin Epidemiol. 2017 Apr;84:105-113. doi: 10.1016/j.jclinepi.2017.02.010. Epub 2017 Feb 28.


Five-Year Outcomes after Off-Pump or On-Pump Coronary-Artery Bypass Grafting.

Lamy AR, Devereaux PJ, Yusuf S.

N Engl J Med. 2017 Mar 2;376(9):894-895. doi: 10.1056/NEJMc1700247. No abstract available.


Expedited surgery for hip fracture?

Borges FK, Bhandari M, Devereaux PJ.

CMAJ. 2017 Jan 30;189(4):E171. doi: 10.1503/cmaj.732485. No abstract available.

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