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Items: 24

1.

Generation of iPSCs carrying a common LRRK2 risk allele for in vitro modeling of idiopathic Parkinson's disease.

Marrone L, Bus C, Schöndorf D, Fitzgerald JC, Kübler M, Schmid B, Reinhardt P, Reinhardt L, Deleidi M, Levin T, Meixner A, Klink B, Glatza M, Gloeckner CJ, Gasser T, Sterneckert J.

PLoS One. 2018 Mar 7;13(3):e0192497. doi: 10.1371/journal.pone.0192497. eCollection 2018.

2.

The GBAP1 pseudogene acts as a ceRNA for the glucocerebrosidase gene GBA by sponging miR-22-3p.

Straniero L, Rimoldi V, Samarani M, Goldwurm S, Di Fonzo A, Krüger R, Deleidi M, Aureli M, Soldà G, Duga S, Asselta R.

Sci Rep. 2017 Oct 5;7(1):12702. doi: 10.1038/s41598-017-12973-5.

3.

Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways.

Khurana V, Peng J, Chung CY, Auluck PK, Fanning S, Tardiff DF, Bartels T, Koeva M, Eichhorn SW, Benyamini H, Lou Y, Nutter-Upham A, Baru V, Freyzon Y, Tuncbag N, Costanzo M, San Luis BJ, Schöndorf DC, Barrasa MI, Ehsani S, Sanjana N, Zhong Q, Gasser T, Bartel DP, Vidal M, Deleidi M, Boone C, Fraenkel E, Berger B, Lindquist S.

Cell Syst. 2017 Feb 22;4(2):157-170.e14. doi: 10.1016/j.cels.2016.12.011. Epub 2017 Jan 25.

4.

Mitochondrial Antigen Presentation: A Vacuolar Path to Autoimmunity in Parkinson's Disease.

Baden P, Deleidi M.

Trends Immunol. 2016 Nov;37(11):719-721. doi: 10.1016/j.it.2016.08.016. Epub 2016 Sep 13.

PMID:
27638127
5.

Genome editing in pluripotent stem cells: research and therapeutic applications.

Deleidi M, Yu C.

Biochem Biophys Res Commun. 2016 May 6;473(3):665-74. doi: 10.1016/j.bbrc.2016.02.113. Epub 2016 Feb 27. Review.

PMID:
26930470
6.

Immune aging, dysmetabolism, and inflammation in neurological diseases.

Deleidi M, Jäggle M, Rubino G.

Front Neurosci. 2015 Jun 3;9:172. doi: 10.3389/fnins.2015.00172. eCollection 2015. Review.

7.

Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease.

Hallett PJ, Deleidi M, Astradsson A, Smith GA, Cooper O, Osborn TM, Sundberg M, Moore MA, Perez-Torres E, Brownell AL, Schumacher JM, Spealman RD, Isacson O.

Cell Stem Cell. 2015 Mar 5;16(3):269-74. doi: 10.1016/j.stem.2015.01.018. Epub 2015 Feb 26.

8.

Concise review: modeling multiple sclerosis with stem cell biological platforms: toward functional validation of cellular and molecular phenotypes in inflammation-induced neurodegeneration.

Orack JC, Deleidi M, Pitt D, Mahajan K, Nicholas JA, Boster AL, Racke MK, Comabella M, Watanabe F, Imitola J.

Stem Cells Transl Med. 2015 Mar;4(3):252-60. doi: 10.5966/sctm.2014-0133. Epub 2015 Jan 15. Review.

9.

iPSC-derived neurons from GBA1-associated Parkinson's disease patients show autophagic defects and impaired calcium homeostasis.

Schöndorf DC, Aureli M, McAllister FE, Hindley CJ, Mayer F, Schmid B, Sardi SP, Valsecchi M, Hoffmann S, Schwarz LK, Hedrich U, Berg D, Shihabuddin LS, Hu J, Pruszak J, Gygi SP, Sonnino S, Gasser T, Deleidi M.

Nat Commun. 2014 Jun 6;5:4028. doi: 10.1038/ncomms5028.

PMID:
24905578
10.

Combined flow cytometric analysis of surface and intracellular antigens reveals surface molecule markers of human neuropoiesis.

Turaç G, Hindley CJ, Thomas R, Davis JA, Deleidi M, Gasser T, Karaöz E, Pruszak J.

PLoS One. 2013 Jun 24;8(6):e68519. doi: 10.1371/journal.pone.0068519. Print 2013.

11.

The role of inflammation in sporadic and familial Parkinson's disease.

Deleidi M, Gasser T.

Cell Mol Life Sci. 2013 Nov;70(22):4259-73. doi: 10.1007/s00018-013-1352-y. Epub 2013 May 12. Review.

PMID:
23665870
12.

Protein clearance mechanisms of alpha-synuclein and amyloid-Beta in lewy body disorders.

Deleidi M, Maetzler W.

Int J Alzheimers Dis. 2012;2012:391438. doi: 10.1155/2012/391438. Epub 2012 Oct 22.

13.

Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease.

Cooper O, Seo H, Andrabi S, Guardia-Laguarta C, Graziotto J, Sundberg M, McLean JR, Carrillo-Reid L, Xie Z, Osborn T, Hargus G, Deleidi M, Lawson T, Bogetofte H, Perez-Torres E, Clark L, Moskowitz C, Mazzulli J, Chen L, Volpicelli-Daley L, Romero N, Jiang H, Uitti RJ, Huang Z, Opala G, Scarffe LA, Dawson VL, Klein C, Feng J, Ross OA, Trojanowski JQ, Lee VM, Marder K, Surmeier DJ, Wszolek ZK, Przedborski S, Krainc D, Dawson TM, Isacson O.

Sci Transl Med. 2012 Jul 4;4(141):141ra90. doi: 10.1126/scitranslmed.3003985.

14.

Viral and inflammatory triggers of neurodegenerative diseases.

Deleidi M, Isacson O.

Sci Transl Med. 2012 Feb 15;4(121):121ps3. doi: 10.1126/scitranslmed.3003492. Review.

15.
16.

Oct4-induced reprogramming is required for adult brain neural stem cell differentiation into midbrain dopaminergic neurons.

Deleidi M, Cooper O, Hargus G, Levy A, Isacson O.

PLoS One. 2011;6(5):e19926. doi: 10.1371/journal.pone.0019926. Epub 2011 May 31.

17.

Development of histocompatible primate-induced pluripotent stem cells for neural transplantation.

Deleidi M, Hargus G, Hallett P, Osborn T, Isacson O.

Stem Cells. 2011 Jul;29(7):1052-63. doi: 10.1002/stem.662.

18.

The Toll-like receptor-3 agonist polyinosinic:polycytidylic acid triggers nigrostriatal dopaminergic degeneration.

Deleidi M, Hallett PJ, Koprich JB, Chung CY, Isacson O.

J Neurosci. 2010 Dec 1;30(48):16091-101. doi: 10.1523/JNEUROSCI.2400-10.2010.

19.

Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats.

Hargus G, Cooper O, Deleidi M, Levy A, Lee K, Marlow E, Yow A, Soldner F, Hockemeyer D, Hallett PJ, Osborn T, Jaenisch R, Isacson O.

Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15921-6. doi: 10.1073/pnas.1010209107. Epub 2010 Aug 23.

20.

Differentiation of human ES and Parkinson's disease iPS cells into ventral midbrain dopaminergic neurons requires a high activity form of SHH, FGF8a and specific regionalization by retinoic acid.

Cooper O, Hargus G, Deleidi M, Blak A, Osborn T, Marlow E, Lee K, Levy A, Perez-Torres E, Yow A, Isacson O.

Mol Cell Neurosci. 2010 Nov;45(3):258-66. doi: 10.1016/j.mcn.2010.06.017. Epub 2010 Jul 24.

21.

Persistent inflammation alters the function of the endogenous brain stem cell compartment.

Pluchino S, Muzio L, Imitola J, Deleidi M, Alfaro-Cervello C, Salani G, Porcheri C, Brambilla E, Cavasinni F, Bergamaschi A, Garcia-Verdugo JM, Comi G, Khoury SJ, Martino G.

Brain. 2008 Oct;131(Pt 10):2564-78. doi: 10.1093/brain/awn198. Epub 2008 Aug 30.

22.

Gene and stem cell therapy for autoimmune demyelination.

Pluchino S, Bacigaluppi M, Bucello S, Butti E, Deleidi M, Zanotti L, Martino G, Furlan R.

Ernst Schering Res Found Workshop. 2005;(53):133-46. Review. No abstract available.

PMID:
16315612
23.

Immunological patterns identifying disease course and evolution in multiple sclerosis patients.

Furlan R, Rovaris M, Martinelli Boneschi F, Khademi M, Bergami A, Gironi M, Deleidi M, Agosta F, Franciotta D, Scarpini E, Uccelli A, Zaffaroni M, Kurne A, Comi G, Olsson T, Filippi M, Martino G.

J Neuroimmunol. 2005 Aug;165(1-2):192-200.

PMID:
15949850
24.

Neural stem cells and their use as therapeutic tool in neurological disorders.

Pluchino S, Zanotti L, Deleidi M, Martino G.

Brain Res Brain Res Rev. 2005 Apr;48(2):211-9. Epub 2005 Jan 20. Review.

PMID:
15850660

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