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Items: 39

1.

Total Synthesis of L-156,373 and an oxoPiz Analogue via a Submonomer Approach.

Elbatrawi YM, Kang CW, Del Valle JR.

Org Lett. 2018 Apr 18. doi: 10.1021/acs.orglett.8b00912. [Epub ahead of print]

PMID:
29667833
2.

Secretory IgM exacerbates tumor progression by inducing accumulations of MDSCs in mice.

Tang CH, Chang S, Hashimoto A, Chen YJ, Kang CW, Mato AR, Del Valle JR, Gabrilovich D, Hu CC.

Cancer Immunol Res. 2018 Apr 12. pii: canimm.0582.2017. doi: 10.1158/2326-6066.CIR-17-0582. [Epub ahead of print]

PMID:
29650518
3.

Phosphorylation of IRE1 at S729 regulates RIDD in B cells and antibody production after immunization.

Tang CH, Chang S, Paton AW, Paton JC, Gabrilovich DI, Ploegh HL, Del Valle JR, Hu CC.

J Cell Biol. 2018 Mar 6. pii: jcb.201709137. doi: 10.1083/jcb.201709137. [Epub ahead of print]

PMID:
29511123
4.

Inhibition of the IRE-1α/XBP-1 pathway prevents chronic GVHD and preserves the GVL effect in mice.

Schutt SD, Wu Y, Tang CH, Bastian D, Nguyen H, Sofi MH, Zhang M, Liu C, Helke K, Wilson C, Schnapp LM, Del Valle JR, Hu CC, Yu XZ.

Blood Adv. 2018 Feb 27;2(4):414-427. doi: 10.1182/bloodadvances.2017009068.

5.

IRE1α RNase-dependent lipid homeostasis promotes survival in Myc-transformed cancers.

Xie H, Tang CH, Song JH, Mancuso A, Del Valle JR, Cao J, Xiang Y, Dang CV, Lan R, Sanchez DJ, Keith B, Hu CC, Simon MC.

J Clin Invest. 2018 Apr 2;128(4):1300-1316. doi: 10.1172/JCI95864. Epub 2018 Feb 26.

6.

Synthesis and β-sheet propensity of constrained N-amino peptides.

Sarnowski MP, Pedretty KP, Giddings N, Woodcock HL, Del Valle JR.

Bioorg Med Chem. 2018 Mar 15;26(6):1162-1166. doi: 10.1016/j.bmc.2017.08.017. Epub 2017 Aug 31.

PMID:
28882503
7.

Regulated IRE1-dependent mRNA decay sets the threshold for dendritic cell survival.

Tavernier SJ, Osorio F, Vandersarren L, Vetters J, Vanlangenakker N, Van Isterdael G, Vergote K, De Rycke R, Parthoens E, van de Laar L, Iwawaki T, Del Valle JR, Hu CC, Lambrecht BN, Janssens S.

Nat Cell Biol. 2017 Jun;19(6):698-710. doi: 10.1038/ncb3518. Epub 2017 May 1.

8.

Peptide N-Amination Supports β-Sheet Conformations.

Sarnowski MP, Kang CW, Elbatrawi YM, Wojtas L, Del Valle JR.

Angew Chem Int Ed Engl. 2017 Feb 13;56(8):2083-2086. doi: 10.1002/anie.201609395. Epub 2017 Jan 20.

PMID:
28106315
9.

Access to Enantiopure α-Hydrazino Acids for N-Amino Peptide Synthesis.

Kang CW, Sarnowski MP, Elbatrawi YM, Del Valle JR.

J Org Chem. 2017 Feb 3;82(3):1833-1841. doi: 10.1021/acs.joc.6b02718. Epub 2017 Jan 24.

PMID:
28075135
10.

Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells.

Tang CH, Zundell JA, Ranatunga S, Lin C, Nefedova Y, Del Valle JR, Hu CC.

Cancer Res. 2016 Apr 15;76(8):2137-52. doi: 10.1158/0008-5472.CAN-15-1885. Epub 2016 Mar 7.

11.

β-Strand mimics based on tetrahydropyridazinedione (tpd) peptide stitching.

Kang CW, Sarnowski MP, Ranatunga S, Wojtas L, Metcalf RS, Guida WC, Del Valle JR.

Chem Commun (Camb). 2015 Nov 21;51(90):16259-62. doi: 10.1039/c5cc07189e.

12.

Solid-phase synthesis of tetrahydropyridazinedione-constrained peptides.

Kang CW, Ranatunga S, Sarnowski MP, Del Valle JR.

Org Lett. 2014 Oct 17;16(20):5434-7. doi: 10.1021/ol5026684. Epub 2014 Oct 8.

13.

Imidazo[1,2-a]pyridine-based peptidomimetics as inhibitors of Akt.

Kim YB, Kang CW, Ranatunga S, Yang H, Sebti SM, Del Valle JR.

Bioorg Med Chem Lett. 2014 Oct 1;24(19):4650-4653. doi: 10.1016/j.bmcl.2014.08.040. Epub 2014 Aug 28.

14.

Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival.

Tang CH, Ranatunga S, Kriss CL, Cubitt CL, Tao J, Pinilla-Ibarz JA, Del Valle JR, Hu CC.

J Clin Invest. 2014 Jun;124(6):2585-98. doi: 10.1172/JCI73448. Epub 2014 May 8.

15.

Synthesis of novel tricyclic chromenone-based inhibitors of IRE-1 RNase activity.

Ranatunga S, Tang CH, Kang CW, Kriss CL, Kloppenburg BJ, Hu CC, Del Valle JR.

J Med Chem. 2014 May 22;57(10):4289-301. doi: 10.1021/jm5002452. Epub 2014 May 2.

16.

Substituted imidazo[1,2-a]pyridines as β-strand peptidomimetics.

Kang CW, Sun Y, Del Valle JR.

Org Lett. 2012 Dec 21;14(24):6162-5. doi: 10.1021/ol302850n. Epub 2012 Dec 4.

17.

Total synthesis and structural revision of lucentamycin A.

Ranatunga S, Tang CH, Hu CC, Del Valle JR.

J Org Chem. 2012 Nov 2;77(21):9859-64. doi: 10.1021/jo301723y. Epub 2012 Oct 16.

18.

Structure assignment of lucentamycin E and revision of the olefin geometries of the marine-derived lucentamycins.

Cha JW, Park JS, Sim T, Nam SJ, Kwon HC, Del Valle JR, Fenical W.

J Nat Prod. 2012 Sep 28;75(9):1648-51. Epub 2012 Sep 6.

19.

Synthesis and evaluation of substituted hexahydronaphthalenes as novel inhibitors of the Mcl-1/BimBH3 interaction.

Kim YB, Balasis ME, Doi K, Berndt N, DuBoulay C, Hu CC, Guida W, Wang HG, Sebti SM, Del Valle JR.

Bioorg Med Chem Lett. 2012 Sep 15;22(18):5961-5. doi: 10.1016/j.bmcl.2012.07.050. Epub 2012 Jul 24.

20.

Overexpression of TCL1 activates the endoplasmic reticulum stress response: a novel mechanism of leukemic progression in mice.

Kriss CL, Pinilla-Ibarz JA, Mailloux AW, Powers JJ, Tang CH, Kang CW, Zanesi N, Epling-Burnette PK, Sotomayor EM, Croce CM, Del Valle JR, Hu CC.

Blood. 2012 Aug 2;120(5):1027-38. doi: 10.1182/blood-2011-11-394346. Epub 2012 Jun 12.

21.

Synthesis of GSK3β mimetic inhibitors of Akt featuring a novel extended dipeptide surrogate.

Ranatunga S, Del Valle JR.

Bioorg Med Chem Lett. 2011 Dec 1;21(23):7166-9. doi: 10.1016/j.bmcl.2011.09.079. Epub 2011 Sep 28.

PMID:
22001093
22.

An ester enolate-Claisen rearrangement route to substituted 4-alkylideneprolines. studies toward a definitive structural revision of lucentamycin A.

Ranatunga S, Kim JS, Pal U, Del Valle JR.

J Org Chem. 2011 Nov 4;76(21):8962-76. doi: 10.1021/jo201727g. Epub 2011 Oct 5.

PMID:
21942643
23.

Synthesis and conformational analysis of bicyclic extended dipeptide surrogates.

Ranatunga S, Liyanage W, Del Valle JR.

J Org Chem. 2010 Aug 6;75(15):5113-25. doi: 10.1021/jo1008433.

24.

Synthesis of Boc-protected bicycloproline.

Ranatunga S, Del Valle JR.

Tetrahedron Lett. 2009 May 27;50(21):2464-2466.

25.

Total synthesis of the putative structure of lucentamycin A.

Pal U, Ranatunga S, Ariyarathna Y, Del Valle JR.

Org Lett. 2009 Nov 19;11(22):5298-301. doi: 10.1021/ol902251c.

PMID:
19863114
26.

Total synthesis and structural revision of the presumed aeruginosins 205A and B.

Hanessian S, Wang X, Ersmark K, Del Valle JR, Klegraf E.

Org Lett. 2009 Sep 17;11(18):4232-5. doi: 10.1021/ol901702k. Erratum in: Org Lett. 2009 Dec 3;11(23):5566.

PMID:
19691354
27.

Synthesis of carbapyochelins via diastereoselective azidation of 5-(ethoxycarbonyl)methylproline derivatives.

Liyanage W, Weerasinghe L, Strong RK, Del Valle JR.

J Org Chem. 2008 Sep 19;73(18):7420-3. doi: 10.1021/jo801294p. Epub 2008 Aug 13.

28.

Chemistry and biology of the aeruginosin family of serine protease inhibitors.

Ersmark K, Del Valle JR, Hanessian S.

Angew Chem Int Ed Engl. 2008;47(7):1202-23.

PMID:
18076006
29.

A vectored measles virus induces hepatitis B surface antigen antibodies while protecting macaques against measles virus challenge.

del Valle JR, Devaux P, Hodge G, Wegner NJ, McChesney MB, Cattaneo R.

J Virol. 2007 Oct;81(19):10597-605. Epub 2007 Jul 18.

30.

Structure-based organic synthesis of unnatural aeruginosin hybrids as potent inhibitors of thrombin.

Hanessian S, Ersmark K, Wang X, Del Valle JR, Blomberg N, Xue Y, Fjellström O.

Bioorg Med Chem Lett. 2007 Jun 15;17(12):3480-5. Epub 2007 Mar 27.

PMID:
17428662
31.

Total synthesis and structural confirmation of chlorodysinosin A.

Hanessian S, Del Valle JR, Xue Y, Blomberg N.

J Am Chem Soc. 2006 Aug 16;128(32):10491-5. Erratum in: J Am Chem Soc. 2006 Sep 6;128(35):11727-8.

PMID:
16895415
32.
34.

An efficient RCM-based synthesis of orthogonally protected meso-DAP and FK565.

Del Valle JR, Goodman M.

J Org Chem. 2004 Dec 10;69(25):8946-8.

PMID:
15575780
35.

Asymmetric hydrogenations for the synthesis of Boc-protected 4-alkylprolinols and prolines.

Del Valle JR, Goodman M.

J Org Chem. 2003 May 16;68(10):3923-31.

PMID:
12737573
36.

Stereoselective synthesis of Boc-protected cis and trans-4-trifluoromethylprolines by asymmetric hydrogenation reactions.

Del Valle JR, Goodman M.

Angew Chem Int Ed Engl. 2002 May 3;41(9):1600-2. No abstract available.

PMID:
19750679
37.
38.

A new concept of Parkinson's disease as a complication of the cerebellar thoracic outlet syndrome.

Noda Fernandez EI, Lugo A, Berrios E, del Valle JR, Alvardo F, Buch MS, Fernandez JP.

Rinsho Kyobu Geka. 1987;7(3):271-5. No abstract available.

PMID:
9301790
39.

[Experience with 37 cerebral aneurysms confirmed by autopsies].

Sánchez Longo LP, De Leon CC, Del Valle JR, Fiol R.

Bol Asoc Med P R. 1970 Mar;62(3):67-72. Spanish. No abstract available.

PMID:
5270989

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