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Coordinated Regulation of Metabolic Transporters and Migration/Invasion by Carbonic Anhydrase IX.

McDonald PC, Swayampakula M, Dedhar S.

Metabolites. 2018 Mar 8;8(1). pii: E20. doi: 10.3390/metabo8010020. Review.


Addition of carbonic anhydrase 9 inhibitor SLC-0111 to temozolomide treatment delays glioblastoma growth in vivo.

Boyd NH, Walker K, Fried J, Hackney JR, McDonald PC, Benavides GA, Spina R, Audia A, Scott SE, Libby CJ, Tran AN, Bevensee MO, Griguer C, Nozell S, Gillespie GY, Nabors B, Bhat KP, Bar EE, Darley-Usmar V, Xu B, Gordon E, Cooper SJ, Dedhar S, Hjelmeland AB.

JCI Insight. 2017 Dec 21;2(24). pii: 92928. doi: 10.1172/jci.insight.92928. [Epub ahead of print]


Stat3 in mitosis: A new role in clustering excess centrosomes.

Morris EJ, Dedhar S.

Cell Cycle. 2017;16(17):1557-1559. doi: 10.1080/15384101.2017.1348064. Epub 2017 Aug 7. No abstract available.


Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition.

Yoon SO, Shin S, Karreth FA, Buel GR, Jedrychowski MP, Plas DR, Dedhar S, Gygi SP, Roux PP, Dephoure N, Blenis J.

Mol Cell. 2017 Aug 3;67(3):512-527.e4. doi: 10.1016/j.molcel.2017.06.033. Epub 2017 Jul 27.


The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/MMP14-mediated invasion.

Swayampakula M, McDonald PC, Vallejo M, Coyaud E, Chafe SC, Westerback A, Venkateswaran G, Shankar J, Gao G, Laurent EMN, Lou Y, Bennewith KL, Supuran CT, Nabi IR, Raught B, Dedhar S.

Oncogene. 2017 Nov 9;36(45):6244-6261. doi: 10.1038/onc.2017.219. Epub 2017 Jul 10.


Stat3 regulates centrosome clustering in cancer cells via Stathmin/PLK1.

Morris EJ, Kawamura E, Gillespie JA, Balgi A, Kannan N, Muller WJ, Roberge M, Dedhar S.

Nat Commun. 2017 May 5;8:15289. doi: 10.1038/ncomms15289.


Tetraspanin 8 is a novel regulator of ILK-driven β1 integrin adhesion and signaling in invasive melanoma cells.

El Kharbili M, Robert C, Witkowski T, Danty-Berger E, Barbollat-Boutrand L, Masse I, Gadot N, de la Fouchardière A, McDonald PC, Dedhar S, Le Naour F, Degoul F, Berthier-Vergnes O.

Oncotarget. 2017 Mar 7;8(10):17140-17155. doi: 10.18632/oncotarget.15084.


A novel inhibitory effect of oxazol-5-one compounds on ROCKII signaling in human coronary artery vascular smooth muscle cells.

Al-Ghabkari A, Deng JT, McDonald PC, Dedhar S, Alshehri M, Walsh MP, MacDonald JA.

Sci Rep. 2016 Aug 30;6:32118. doi: 10.1038/srep32118.


Overcoming Hypoxia-Mediated Tumor Progression: Combinatorial Approaches Targeting pH Regulation, Angiogenesis and Immune Dysfunction.

McDonald PC, Chafe SC, Dedhar S.

Front Cell Dev Biol. 2016 Mar 31;4:27. doi: 10.3389/fcell.2016.00027. eCollection 2016. Review.


Targeting hypoxic response for cancer therapy.

Paolicchi E, Gemignani F, Krstic-Demonacos M, Dedhar S, Mutti L, Landi S.

Oncotarget. 2016 Mar 22;7(12):13464-78. doi: 10.18632/oncotarget.7229. Review.


Carving out its niche: A role for carbonic anhydrase IX in pre-metastatic niche development.

Chafe SC, Dedhar S.

Oncoimmunology. 2015 Jun 26;4(12):e1048955. eCollection 2015 Dec.


Induction of the intestinal stem cell signature gene SMOC-2 is required for L1-mediated colon cancer progression.

Shvab A, Haase G, Ben-Shmuel A, Gavert N, Brabletz T, Dedhar S, Ben-Ze'ev A.

Oncogene. 2016 Feb 4;35(5):549-57. doi: 10.1038/onc.2015.127. Epub 2015 Apr 27.


Carbonic anhydrase IX promotes myeloid-derived suppressor cell mobilization and establishment of a metastatic niche by stimulating G-CSF production.

Chafe SC, Lou Y, Sceneay J, Vallejo M, Hamilton MJ, McDonald PC, Bennewith KL, Möller A, Dedhar S.

Cancer Res. 2015 Mar 15;75(6):996-1008. doi: 10.1158/0008-5472.CAN-14-3000. Epub 2015 Jan 26.


Integrin-linked kinase regulates tubular aquaporin-2 content and intracellular location: a link between the extracellular matrix and water reabsorption.

Cano-Peñalver JL, Griera M, Serrano I, Rodríguez-Puyol D, Dedhar S, de Frutos S, Rodríguez-Puyol M.

FASEB J. 2014 Aug;28(8):3645-59. doi: 10.1096/fj.13-249250. Epub 2014 May 1.


LIMD2 is a small LIM-only protein overexpressed in metastatic lesions that regulates cell motility and tumor progression by directly binding to and activating the integrin-linked kinase.

Peng H, Talebzadeh-Farrooji M, Osborne MJ, Prokop JW, McDonald PC, Karar J, Hou Z, He M, Kebebew E, Orntoft T, Herlyn M, Caton AJ, Fredericks W, Malkowicz B, Paterno CS, Carolin AS, Speicher DW, Skordalakes E, Huang Q, Dedhar S, Borden KLB, Rauscher FJ 3rd.

Cancer Res. 2014 Mar 1;74(5):1390-1403. doi: 10.1158/0008-5472.CAN-13-1275.


Integrin linked kinase (ILK) is required for lens epithelial cell survival, proliferation and differentiation.

Teo ZL, McQueen-Miscamble L, Turner K, Martinez G, Madakashira B, Dedhar S, Robinson ML, de Iongh RU.

Exp Eye Res. 2014 Apr;121:130-42. doi: 10.1016/j.exer.2014.01.013. Epub 2014 Jan 25.


Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase.

Serrano I, McDonald PC, Lock F, Muller WJ, Dedhar S.

Nat Commun. 2013;4:2976. doi: 10.1038/ncomms3976.


Deep sequence analysis of gene expression identifies osteopontin as a downstream effector of integrin-linked kinase (ILK) in cardiac-specific ILK knockout mice.

Dai J, Matsui T, Abel ED, Dedhar S, Gerszten RE, Seidman CE, Seidman JG, Rosenzweig A.

Circ Heart Fail. 2014 Jan;7(1):184-93. doi: 10.1161/CIRCHEARTFAILURE.113.000649. Epub 2013 Dec 6.


Carbonic anhydrase IX (CAIX) as a mediator of hypoxia-induced stress response in cancer cells.

McDonald PC, Dedhar S.

Subcell Biochem. 2014;75:255-69. doi: 10.1007/978-94-007-7359-2_13. Review.


Inactivation of the integrin-linked kinase (ILK) in osteoblasts increases mineralization.

El-Hoss J, Arabian A, Dedhar S, St-Arnaud R.

Gene. 2014 Jan 1;533(1):246-52. doi: 10.1016/j.gene.2013.09.074. Epub 2013 Oct 2.


Identification of novel small molecule inhibitors of centrosome clustering in cancer cells.

Kawamura E, Fielding AB, Kannan N, Balgi A, Eaves CJ, Roberge M, Dedhar S.

Oncotarget. 2013 Oct;4(10):1763-76.


Interaction of smoothened with integrin-linked kinase in primary cilia mediates Hedgehog signalling.

Barakat B, Yu L, Lo C, Vu D, De Luca E, Cain JE, Martelotto LG, Dedhar S, Sadler AJ, Wang D, Watkins DN, Hannigan GE.

EMBO Rep. 2013 Sep;14(9):837-44. doi: 10.1038/embor.2013.110. Epub 2013 Jul 23. Erratum in: EMBO Rep. 2013 Oct;14(10):945. Martellotto, Luciano G [corrected to Martelotto, Luciano G].


f-[18F]fluoroethanol and 3-[18F]fluoropropanol: facile preparation, biodistribution in mice, and their application as nucleophiles in the synthesis of [18F]fluoroalkyl aryl ester and ether PET tracers.

Pan J, Pourghiasian M, Hundal N, Lau J, Bénard F, Dedhar S, Lin KS.

Nucl Med Biol. 2013 Aug;40(6):850-7. doi: 10.1016/j.nucmedbio.2013.04.009. Epub 2013 Jun 14.


Ilk conditional deletion in adult animals increases cyclic GMP-dependent vasorelaxation.

Serrano I, De Frutos S, Griera M, Medrano D, Rodríguez-Puyol M, Dedhar S, Ruiz-Torres MP, Rodríguez-Puyol D.

Cardiovasc Res. 2013 Aug 1;99(3):535-44. doi: 10.1093/cvr/cvt131. Epub 2013 May 27. Erratum in: Cardiovasc Res. 2016 Mar 1;109(3):408.


Synthesis and evaluation of 18F-labeled carbonic anhydrase IX inhibitors for imaging with positron emission tomography.

Pan J, Lau J, Mesak F, Hundal N, Pourghiasian M, Liu Z, Bénard F, Dedhar S, Supuran CT, Lin KS.

J Enzyme Inhib Med Chem. 2014 Apr;29(2):249-55. doi: 10.3109/14756366.2013.773994. Epub 2013 Mar 7.


Integrin-linked kinase regulates interphase and mitotic microtubule dynamics.

Lim S, Kawamura E, Fielding AB, Maydan M, Dedhar S.

PLoS One. 2013;8(1):e53702. doi: 10.1371/journal.pone.0053702. Epub 2013 Jan 21.


Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche.

Lock FE, McDonald PC, Lou Y, Serrano I, Chafe SC, Ostlund C, Aparicio S, Winum JY, Supuran CT, Dedhar S.

Oncogene. 2013 Oct 31;32(44):5210-9. doi: 10.1038/onc.2012.550. Epub 2012 Dec 3.


Integrin-linked kinase as a target for ERG-mediated invasive properties in prostate cancer models.

Becker-Santos DD, Guo Y, Ghaffari M, Vickers ED, Lehman M, Altamirano-Dimas M, Oloumi A, Furukawa J, Sharma M, Wang Y, Dedhar S, Cox ME.

Carcinogenesis. 2012 Dec;33(12):2558-67. doi: 10.1093/carcin/bgs285. Epub 2012 Oct 1.


Integrin-linked kinase (ILK) modulates wound healing through regulation of hepatocyte growth factor (HGF).

Serrano I, Díez-Marqués ML, Rodríguez-Puyol M, Herrero-Fresneda I, Raimundo García del M, Dedhar S, Ruiz-Torres MP, Rodríguez-Puyol D.

Exp Cell Res. 2012 Nov 15;318(19):2470-81. doi: 10.1016/j.yexcr.2012.08.001. Epub 2012 Aug 23.


Integrin-linked kinase deletion in the developing lens leads to capsule rupture, impaired fiber migration and non-apoptotic epithelial cell death.

Cammas L, Wolfe J, Choi SY, Dedhar S, Beggs HE.

Invest Ophthalmol Vis Sci. 2012 May 17;53(6):3067-81. doi: 10.1167/iovs.11-9128.


Role of the integrin-linked kinase (ILK)/Rictor complex in TGFβ-1-induced epithelial-mesenchymal transition (EMT).

Serrano I, McDonald PC, Lock FE, Dedhar S.

Oncogene. 2013 Jan 3;32(1):50-60. doi: 10.1038/onc.2012.30. Epub 2012 Feb 6.


Recent developments in targeting carbonic anhydrase IX for cancer therapeutics.

McDonald PC, Winum JY, Supuran CT, Dedhar S.

Oncotarget. 2012 Jan;3(1):84-97. Review.


Targeting hypoxic tumour cells to overcome metastasis.

Bennewith KL, Dedhar S.

BMC Cancer. 2011 Nov 30;11:504. doi: 10.1186/1471-2407-11-504. Review.


Glycosyl coumarin carbonic anhydrase IX and XII inhibitors strongly attenuate the growth of primary breast tumors.

Touisni N, Maresca A, McDonald PC, Lou Y, Scozzafava A, Dedhar S, Winum JY, Supuran CT.

J Med Chem. 2011 Dec 22;54(24):8271-7. doi: 10.1021/jm200983e. Epub 2011 Nov 22.


Role of epithelial integrin-linked kinase in promoting intestinal inflammation: effects on CCL2, fibronectin and the T cell repertoire.

Assi K, Patterson S, Dedhar S, Owen D, Levings M, Salh B.

BMC Immunol. 2011 Aug 1;12:42. doi: 10.1186/1471-2172-12-42.


Aortic aneurysm generation in mice with targeted deletion of integrin-linked kinase in vascular smooth muscle cells.

Shen D, Li J, Lepore JJ, Anderson TJ, Sinha S, Lin AY, Cheng L, Cohen ED, Roberts JD Jr, Dedhar S, Parmacek MS, Gerszten RE.

Circ Res. 2011 Sep 2;109(6):616-28. doi: 10.1161/CIRCRESAHA.110.239343. Epub 2011 Jul 21.


Integrin-linked kinase: not so 'pseudo' after all.

Hannigan GE, McDonald PC, Walsh MP, Dedhar S.

Oncogene. 2011 Oct 27;30(43):4375-85. doi: 10.1038/onc.2011.177. Epub 2011 May 23. Review.


Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors.

Lou Y, McDonald PC, Oloumi A, Chia S, Ostlund C, Ahmadi A, Kyle A, Auf dem Keller U, Leung S, Huntsman D, Clarke B, Sutherland BW, Waterhouse D, Bally M, Roskelley C, Overall CM, Minchinton A, Pacchiano F, Carta F, Scozzafava A, Touisni N, Winum JY, Supuran CT, Dedhar S.

Cancer Res. 2011 May 1;71(9):3364-76. doi: 10.1158/0008-5472.CAN-10-4261. Epub 2011 Mar 17. Erratum in: Cancer Res. 2011 Jun 15;71(12):4325. Cancer Res. 2011 Jul 1;71(13):4733.


Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis.

Pacchiano F, Carta F, McDonald PC, Lou Y, Vullo D, Scozzafava A, Dedhar S, Supuran CT.

J Med Chem. 2011 Mar 24;54(6):1896-902. doi: 10.1021/jm101541x. Epub 2011 Mar 1.


The importance of integrin-linked kinase in the regulation of bladder cancer invasion.

Matsui Y, Assi K, Ogawa O, Raven PA, Dedhar S, Gleave ME, Salh B, So AI.

Int J Cancer. 2012 Feb 1;130(3):521-31. doi: 10.1002/ijc.26008. Epub 2011 May 28.


BMP promotes motility and represses growth of smooth muscle cells by activation of tandem Wnt pathways.

Perez VA, Ali Z, Alastalo TP, Ikeno F, Sawada H, Lai YJ, Kleisli T, Spiekerkoetter E, Qu X, Rubinos LH, Ashley E, Amieva M, Dedhar S, Rabinovitch M.

J Cell Biol. 2011 Jan 10;192(1):171-88. doi: 10.1083/jcb.201008060.


Integrin-linked kinase regulates integrin signaling in human trabecular meshwork cells.

Faralli JA, Newman JR, Sheibani N, Dedhar S, Peters DM.

Invest Ophthalmol Vis Sci. 2011 Mar 25;52(3):1684-92. doi: 10.1167/iovs.10-6397. Print 2011 Mar.


Suppression of Her2/neu expression through ILK inhibition is regulated by a pathway involving TWIST and YB-1.

Kalra J, Sutherland BW, Stratford AL, Dragowska W, Gelmon KA, Dedhar S, Dunn SE, Bally MB.

Oncogene. 2010 Dec 2;29(48):6343-56. doi: 10.1038/onc.2010.366. Epub 2010 Sep 13.


A critical role of integrin-linked kinase, ch-TOG and TACC3 in centrosome clustering in cancer cells.

Fielding AB, Lim S, Montgomery K, Dobreva I, Dedhar S.

Oncogene. 2011 Feb 3;30(5):521-34. doi: 10.1038/onc.2010.431. Epub 2010 Sep 13.


Integrin-linked kinase is a functional Mn2+-dependent protein kinase that regulates glycogen synthase kinase-3β (GSK-3beta) phosphorylation.

Maydan M, McDonald PC, Sanghera J, Yan J, Rallis C, Pinchin S, Hannigan GE, Foster LJ, Ish-Horowicz D, Walsh MP, Dedhar S.

PLoS One. 2010 Aug 23;5(8):e12356. doi: 10.1371/journal.pone.0012356.


Novel matrix metalloproteinase inhibitor [18F]marimastat-aryltrifluoroborate as a probe for in vivo positron emission tomography imaging in cancer.

auf dem Keller U, Bellac CL, Li Y, Lou Y, Lange PF, Ting R, Harwig C, Kappelhoff R, Dedhar S, Adam MJ, Ruth TJ, Bénard F, Perrin DM, Overall CM.

Cancer Res. 2010 Oct 1;70(19):7562-9. doi: 10.1158/0008-5472.CAN-10-1584. Epub 2010 Aug 20.


Cooperative signaling between Wnt1 and integrin-linked kinase induces accelerated breast tumor development.

Oloumi A, Maidan M, Lock FE, Tearle H, McKinney S, Muller WJ, Aparicio SA, Dedhar S.

Breast Cancer Res. 2010;12(3):R38. doi: 10.1186/bcr2592. Epub 2010 Jun 21.


Osteoclast-specific inactivation of the integrin-linked kinase (ILK) inhibits bone resorption.

Dossa T, Arabian A, Windle JJ, Dedhar S, Teitelbaum SL, Ross FP, Roodman GD, St-Arnaud R.

J Cell Biochem. 2010 Jul 1;110(4):960-7. doi: 10.1002/jcb.22609.


Integrin-linked kinase has a critical role in ErbB2 mammary tumor progression: implications for human breast cancer.

Pontier SM, Huck L, White DE, Rayment J, Sanguin-Gendreau V, Hennessy B, Zuo D, St-Arnaud R, Mills GB, Dedhar S, Marshall CJ, Muller WJ.

Oncogene. 2010 Jun 10;29(23):3374-85. doi: 10.1038/onc.2010.86. Epub 2010 Mar 22.


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