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Items: 1 to 50 of 193

1.

Reprint of: Amorfrutin-type phytocannabinoids from Helichrysum umbraculigerum.

Pollastro F, De Petrocellis L, Schiano-Moriello A, Chianese G, Heyman H, Appendino G, Taglialatela-Scafati O.

Fitoterapia. 2018 Apr 11. pii: S0367-326X(18)30527-6. doi: 10.1016/j.fitote.2018.04.002. [Epub ahead of print] No abstract available.

PMID:
29655820
2.

Iodine-Promoted Aromatization of p-Menthane-Type Phytocannabinoids.

Pollastro F, Caprioglio D, Marotta P, Moriello AS, De Petrocellis L, Taglialatela-Scafati O, Appendino G.

J Nat Prod. 2018 Mar 23;81(3):630-633. doi: 10.1021/acs.jnatprod.7b00946. Epub 2017 Dec 14.

PMID:
29240420
3.

Anorexigenic effects induced by RVD-hemopressin(α) administration.

Ferrante C, Recinella L, Leone S, Chiavaroli A, Di Nisio C, Martinotti S, Mollica A, Macedonio G, Stefanucci A, Dvorácskó S, Tömböly C, De Petrocellis L, Vacca M, Brunetti L, Orlando G.

Pharmacol Rep. 2017 Dec;69(6):1402-1407. doi: 10.1016/j.pharep.2017.05.015. Epub 2017 Jun 3.

PMID:
29145068
4.

Emotional disorders induced by Hemopressin and RVD-hemopressin(α) administration in rats.

Leone S, Recinella L, Chiavaroli A, Martinotti S, Ferrante C, Mollica A, Macedonio G, Stefanucci A, Dvorácskó S, Tömböly C, De Petrocellis L, Vacca M, Brunetti L, Orlando G.

Pharmacol Rep. 2017 Dec;69(6):1247-1253. doi: 10.1016/j.pharep.2017.06.010. Epub 2017 Jun 23.

PMID:
29128806
5.

Amorfrutin-type phytocannabinoids from Helichrysum umbraculigerum.

Pollastro F, De Petrocellis L, Schiano-Moriello A, Chianese G, Heyman H, Appendino G, Taglialatela-Scafati O.

Fitoterapia. 2017 Nov;123:13-17. doi: 10.1016/j.fitote.2017.09.010. Epub 2017 Sep 20. No abstract available.

PMID:
28941742
6.

Effects of curcumin and curcumin analogues on TRP channels.

Nalli M, Ortar G, Schiano Moriello A, Di Marzo V, De Petrocellis L.

Fitoterapia. 2017 Oct;122:126-131. doi: 10.1016/j.fitote.2017.09.007. Epub 2017 Sep 10. Review.

PMID:
28903060
7.

Actions and Regulation of Ionotropic Cannabinoid Receptors.

De Petrocellis L, Nabissi M, Santoni G, Ligresti A.

Adv Pharmacol. 2017;80:249-289. doi: 10.1016/bs.apha.2017.04.001. Epub 2017 Jun 12. Review.

PMID:
28826537
8.

Extracts and compounds active on TRP ion channels from Waldheimia glabra, a ritual medicinal plant from Himalaya.

Giorgi A, Bassoli A, Borgonovo G, Panseri S, Manzo A, Pentimalli D, Schiano Moriello A, De Petrocellis L.

Phytomedicine. 2017 Aug 15;32:80-87. doi: 10.1016/j.phymed.2017.04.012. Epub 2017 May 1.

PMID:
28732812
9.

Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474.

van Esbroeck ACM, Janssen APA, Cognetta AB 3rd, Ogasawara D, Shpak G, van der Kroeg M, Kantae V, Baggelaar MP, de Vrij FMS, Deng H, Allarà M, Fezza F, Lin Z, van der Wel T, Soethoudt M, Mock ED, den Dulk H, Baak IL, Florea BI, Hendriks G, De Petrocellis L, Overkleeft HS, Hankemeier T, De Zeeuw CI, Di Marzo V, Maccarrone M, Cravatt BF, Kushner SA, van der Stelt M.

Science. 2017 Jun 9;356(6342):1084-1087. doi: 10.1126/science.aaf7497.

PMID:
28596366
10.

Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity.

Soethoudt M, Grether U, Fingerle J, Grim TW, Fezza F, de Petrocellis L, Ullmer C, Rothenhäusler B, Perret C, van Gils N, Finlay D, MacDonald C, Chicca A, Gens MD, Stuart J, de Vries H, Mastrangelo N, Xia L, Alachouzos G, Baggelaar MP, Martella A, Mock ED, Deng H, Heitman LH, Connor M, Di Marzo V, Gertsch J, Lichtman AH, Maccarrone M, Pacher P, Glass M, van der Stelt M.

Nat Commun. 2017 Jan 3;8:13958. doi: 10.1038/ncomms13958.

11.

From Phytocannabinoids to Cannabinoid Receptors and Endocannabinoids: Pleiotropic Physiological and Pathological Roles Through Complex Pharmacology.

Ligresti A, De Petrocellis L, Di Marzo V.

Physiol Rev. 2016 Oct;96(4):1593-659. doi: 10.1152/physrev.00002.2016. Review.

12.

Correction to Tetrahydroisoquinoline-Derived Urea and 2,5-Diketopiperazine Derivatives as Selective Antagonists of the Transient Receptor Potential Melastatin 8 (TRPM8) Channel Receptor and Antiprostate Cancer Agents.

De Petrocellis L, Arroyo FJ, Orlando P, Schiano Moriello A, Vitale RM, Amodeo P, Sánchez A, Roncero C, Bianchini G, Martín MA, López-Alvarado P, Menéndez JC.

J Med Chem. 2016 Aug 25;59(16):7697. doi: 10.1021/acs.jmedchem.6b01091. Epub 2016 Aug 3. No abstract available.

PMID:
27487560
13.

Neuroactive and Anti-inflammatory Frankincense Cembranes: A Structure-Activity Study.

Pollastro F, Golin S, Chianese G, Putra MY, Schiano Moriello A, De Petrocellis L, García V, Munoz E, Taglialatela-Scafati O, Appendino G.

J Nat Prod. 2016 Jul 22;79(7):1762-8. doi: 10.1021/acs.jnatprod.6b00141. Epub 2016 Jun 28.

PMID:
27352042
14.

Assay of TRPV1 Receptor Signaling.

Moriello AS, De Petrocellis L.

Methods Mol Biol. 2016;1412:65-76. doi: 10.1007/978-1-4939-3539-0_7.

PMID:
27245892
15.

Tetrahydroisoquinoline-Derived Urea and 2,5-Diketopiperazine Derivatives as Selective Antagonists of the Transient Receptor Potential Melastatin 8 (TRPM8) Channel Receptor and Antiprostate Cancer Agents.

De Petrocellis L, Arroyo FJ, Orlando P, Schiano Moriello A, Vitale RM, Amodeo P, Sánchez A, Roncero C, Bianchini G, Martín MA, López-Alvarado P, Menéndez JC.

J Med Chem. 2016 Jun 23;59(12):5661-83. doi: 10.1021/acs.jmedchem.5b01448. Epub 2016 Jun 14.

PMID:
27232526
16.

Evaluation of the analgesic effect of 4-anilidopiperidine scaffold containing ureas and carbamates.

Monti L, Stefanucci A, Pieretti S, Marzoli F, Fidanza L, Mollica A, Mirzaie S, Carradori S, De Petrocellis L, Schiano Moriello A, Benyhe S, Zádor F, Szűcs E, Ötvös F, Erdei AI, Samavati R, Dvorácskó S, Tömböly C, Novellino E.

J Enzyme Inhib Med Chem. 2016 Dec;31(6):1638-47. doi: 10.3109/14756366.2016.1160902. Epub 2016 Apr 11.

PMID:
27063555
17.

Design and Synthesis of New Transient Receptor Potential Vanilloid Type-1 (TRPV1) Channel Modulators: Identification, Molecular Modeling Analysis, and Pharmacological Characterization of the N-(4-Hydroxy-3-methoxybenzyl)-4-(thiophen-2-yl)butanamide, a Small Molecule Endowed with Agonist TRPV1 Activity and Protective Effects against Oxidative Stress.

Aiello F, Badolato M, Pessina F, Sticozzi C, Maestrini V, Aldinucci C, Luongo L, Guida F, Ligresti A, Artese A, Allarà M, Costa G, Frosini M, Schiano Moriello A, De Petrocellis L, Valacchi G, Alcaro S, Maione S, Di Marzo V, Corelli F, Brizzi A.

ACS Chem Neurosci. 2016 Jun 15;7(6):737-48. doi: 10.1021/acschemneuro.5b00333. Epub 2016 Mar 22.

PMID:
26942555
18.

Arylboronic acids as dual-action FAAH and TRPV1 ligands.

Morera E, Di Marzo V, Monti L, Allarà M, Schiano Moriello A, Nalli M, Ortar G, De Petrocellis L.

Bioorg Med Chem Lett. 2016 Mar 1;26(5):1401-5. doi: 10.1016/j.bmcl.2016.01.071. Epub 2016 Jan 25.

PMID:
26850005
19.

TRPA1 channels as targets for resveratrol and related stilbenoids.

Nalli M, Ortar G, Moriello AS, Morera E, Di Marzo V, De Petrocellis L.

Bioorg Med Chem Lett. 2016 Feb 1;26(3):899-902. doi: 10.1016/j.bmcl.2015.12.065. Epub 2015 Dec 19.

PMID:
26750258
20.

Prospects for Creation of Cardioprotective Drugs Based on Cannabinoid Receptor Agonists.

Maslov LN, Khaliulin I, Zhang Y, Krylatov AV, Naryzhnaya NV, Mechoulam R, De Petrocellis L, Downey JM.

J Cardiovasc Pharmacol Ther. 2016 May;21(3):262-72. doi: 10.1177/1074248415612593. Epub 2015 Oct 19. Review.

PMID:
26487546
21.

Inhibitory effect of positively charged triazine antagonists of prokineticin receptors on the transient receptor vanilloid type-1 (TRPV1) channel.

De Petrocellis L, Schiano Moriello A, Byun JS, Sohn JM, Lee JY, Vázquez-Romero A, Garrido M, Messeguer A, Zhang FX, Zamponi GW, Deplano A, Congiu C, Onnis V, Balboni G, Di Marzo V.

Pharmacol Res. 2015 Sep;99:362-9. doi: 10.1016/j.phrs.2015.07.009. Epub 2015 Jul 17.

PMID:
26192347
22.

TRPV1 modulators: Synthesis and in vitro evaluation of 1-heteroaryl piperidinecarboxamide and piperazinylurea derivatives.

Congiu C, Onnis V, Balboni G, Schiano-Moriello A, Di Marzo V, De Petrocellis L.

Eur J Med Chem. 2015 Jul 15;100:129-38. doi: 10.1016/j.ejmech.2015.05.041. Epub 2015 Jun 6.

PMID:
26079089
23.

Structure-activity relationships of the prototypical TRPM8 agonist icilin.

De Petrocellis L, Ortar G, Schiano Moriello A, Serum EM, Rusterholz DB.

Bioorg Med Chem Lett. 2015 Jun 1;25(11):2285-90. doi: 10.1016/j.bmcl.2015.04.032. Epub 2015 Apr 16.

PMID:
25935641
24.

Discovery of non-electrophilic capsaicinoid-type TRPA1 ligands.

Del Prete D, Caprioglio D, Appendino G, Minassi A, Schiano-Moriello A, Di Marzo V, De Petrocellis L.

Bioorg Med Chem Lett. 2015 Mar 1;25(5):1009-11. doi: 10.1016/j.bmcl.2015.01.039. Epub 2015 Jan 28.

PMID:
25666822
25.

The anti-inflammatory mediator palmitoylethanolamide enhances the levels of 2-arachidonoyl-glycerol and potentiates its actions at TRPV1 cation channels.

Petrosino S, Schiano Moriello A, Cerrato S, Fusco M, Puigdemont A, De Petrocellis L, Di Marzo V.

Br J Pharmacol. 2016 Apr;173(7):1154-62. doi: 10.1111/bph.13084. Epub 2015 Mar 26.

26.

Effects of metabolites of the analgesic agent dipyrone (metamizol) on rostral ventromedial medulla cell activity in mice.

Maione S, Radanova L, De Gregorio D, Luongo L, De Petrocellis L, Di Marzo V, Imming P.

Eur J Pharmacol. 2015 Feb 5;748:115-22. doi: 10.1016/j.ejphar.2014.12.022. Epub 2014 Dec 31.

PMID:
25557763
27.

Effect of acyclic monoterpene alcohols and their derivatives on TRP channels.

Ortar G, Schiano Moriello A, Morera E, Nalli M, Di Marzo V, De Petrocellis L.

Bioorg Med Chem Lett. 2014 Dec 1;24(23):5507-11. doi: 10.1016/j.bmcl.2014.10.012. Epub 2014 Oct 12.

PMID:
25455494
28.

Colon carcinogenesis is inhibited by the TRPM8 antagonist cannabigerol, a Cannabis-derived non-psychotropic cannabinoid.

Borrelli F, Pagano E, Romano B, Panzera S, Maiello F, Coppola D, De Petrocellis L, Buono L, Orlando P, Izzo AA.

Carcinogenesis. 2014 Dec;35(12):2787-97. doi: 10.1093/carcin/bgu205. Epub 2014 Sep 30.

PMID:
25269802
29.

Structure-affinity relationships and pharmacological characterization of new alkyl-resorcinol cannabinoid receptor ligands: Identification of a dual cannabinoid receptor/TRPA1 channel agonist.

Brizzi A, Aiello F, Marini P, Cascio MG, Corelli F, Brizzi V, De Petrocellis L, Ligresti A, Luongo L, Lamponi S, Maione S, Pertwee RG, Di Marzo V.

Bioorg Med Chem. 2014 Sep 1;22(17):4770-83. doi: 10.1016/j.bmc.2014.07.006. Epub 2014 Jul 12.

PMID:
25065940
30.

Modulation of the TRPV1 channel: current clinical trials and recent patents with focus on neurological conditions.

De Petrocellis L, Moriello AS.

Recent Pat CNS Drug Discov. 2013 Dec;8(3):180-204. Review.

PMID:
24330123
31.

3-Ylidenephthalides as a new class of transient receptor potential channel TRPA1 and TRPM8 modulators.

Ortar G, Schiano Moriello A, Morera E, Nalli M, Di Marzo V, De Petrocellis L.

Bioorg Med Chem Lett. 2013 Oct 15;23(20):5614-8. doi: 10.1016/j.bmcl.2013.08.039. Epub 2013 Aug 14.

PMID:
23993334
32.

Some like it pungent and vile. TRPA1 as a molecular target for the malodorous vinyl disulfides from asafoetida.

Shokoohinia Y, Chianese G, Appendino G, Di Marzo V, De Petrocellis L, Ghannadi A, Taghvayi R, Fattahian K, Soltani R, Taglialatela-Scafati O.

Fitoterapia. 2013 Oct;90:247-51. doi: 10.1016/j.fitote.2013.08.001. Epub 2013 Aug 13.

PMID:
23954176
33.

Effect of chirality and lipophilicity in the functional activity of evodiamine and its analogues at TRPV1 channels.

De Petrocellis L, Schiano Moriello A, Fontana G, Sacchetti A, Passarella D, Appendino G, Di Marzo V.

Br J Pharmacol. 2014 May;171(10):2608-20. doi: 10.1111/bph.12320.

34.

Analogues of perillaketone as highly potent agonists of TRPA1 channel.

Bassoli A, Borgonovo G, Morini G, De Petrocellis L, Schiano Moriello A, Di Marzo V.

Food Chem. 2013 Dec 1;141(3):2044-51. doi: 10.1016/j.foodchem.2013.05.063. Epub 2013 May 24.

PMID:
23870926
35.

Full inhibition of spinal FAAH leads to TRPV1-mediated analgesic effects in neuropathic rats and possible lipoxygenase-mediated remodeling of anandamide metabolism.

Starowicz K, Makuch W, Korostynski M, Malek N, Slezak M, Zychowska M, Petrosino S, De Petrocellis L, Cristino L, Przewlocka B, Di Marzo V.

PLoS One. 2013;8(4):e60040. doi: 10.1371/journal.pone.0060040. Epub 2013 Apr 3.

36.

Biaryl tetrazolyl ureas as inhibitors of endocannabinoid metabolism: modulation at the N-portion and distal phenyl ring.

Ortar G, Morera E, De Petrocellis L, Ligresti A, Schiano Moriello A, Morera L, Nalli M, Ragno R, Pirolli A, Di Marzo V.

Eur J Med Chem. 2013 May;63:118-32. doi: 10.1016/j.ejmech.2013.02.005. Epub 2013 Feb 15.

PMID:
23474898
37.

Tetrahydro-β-carboline derivatives targeting fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channels.

Ortar G, De Petrocellis L, Moriello AS, Allarà M, Morera E, Nalli M, Di Marzo V.

Bioorg Med Chem Lett. 2013 Jan 1;23(1):138-42. doi: 10.1016/j.bmcl.2012.10.137. Epub 2012 Nov 12.

PMID:
23206861
38.

Leucettamols, bifunctionalized marine sphingoids, act as modulators of TRPA1 and TRPM8 channels.

Chianese G, Fattorusso E, Putra MY, Calcinai B, Bavestrello G, Moriello AS, De Petrocellis L, Di Marzo V, Taglialatela-Scafati O.

Mar Drugs. 2012 Nov 2;10(11):2435-47. doi: 10.3390/md10112435.

39.

2-Amino-4-arylthiazole compounds as TRPA1 antagonists (WO 2012085662): a patent evaluation.

De Petrocellis L, Schiano Moriello A.

Expert Opin Ther Pat. 2013 Jan;23(1):119-47. doi: 10.1517/13543776.2013.736496. Epub 2012 Nov 6.

PMID:
23126422
40.

Why do cannabinoid receptors have more than one endogenous ligand?

Di Marzo V, De Petrocellis L.

Philos Trans R Soc Lond B Biol Sci. 2012 Dec 5;367(1607):3216-28. doi: 10.1098/rstb.2011.0382. Review.

41.

A re-evaluation of 9-HODE activity at TRPV1 channels in comparison with anandamide: enantioselectivity and effects at other TRP channels and in sensory neurons.

De Petrocellis L, Schiano Moriello A, Imperatore R, Cristino L, Starowicz K, Di Marzo V.

Br J Pharmacol. 2012 Dec;167(8):1643-51. doi: 10.1111/j.1476-5381.2012.02122.x.

42.

Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1.

Stock K, Kumar J, Synowitz M, Petrosino S, Imperatore R, Smith ES, Wend P, Purfürst B, Nuber UA, Gurok U, Matyash V, Wälzlein JH, Chirasani SR, Dittmar G, Cravatt BF, Momma S, Lewin GR, Ligresti A, De Petrocellis L, Cristino L, Di Marzo V, Kettenmann H, Glass R.

Nat Med. 2012 Aug;18(8):1232-8. doi: 10.1038/nm.2827. Epub 2012 Jul 22.

43.

Palvanil, a non-pungent capsaicin analogue, inhibits inflammatory and neuropathic pain with little effects on bronchopulmonary function and body temperature.

Luongo L, Costa B, D'Agostino B, Guida F, Comelli F, Gatta L, Matteis M, Sullo N, De Petrocellis L, de Novellis V, Maione S, Di Marzo V.

Pharmacol Res. 2012 Sep;66(3):243-50. doi: 10.1016/j.phrs.2012.05.005. Epub 2012 May 24.

PMID:
22634607
44.

Non-THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo: pro-apoptotic effects and underlying mechanisms.

De Petrocellis L, Ligresti A, Schiano Moriello A, Iappelli M, Verde R, Stott CG, Cristino L, Orlando P, Di Marzo V.

Br J Pharmacol. 2013 Jan;168(1):79-102. doi: 10.1111/j.1476-5381.2012.02027.x.

45.

Modulation of thermo-transient receptor potential (thermo-TRP) channels by thymol-based compounds.

Ortar G, Morera L, Moriello AS, Morera E, Nalli M, Di Marzo V, De Petrocellis L.

Bioorg Med Chem Lett. 2012 May 15;22(10):3535-9. doi: 10.1016/j.bmcl.2012.03.055. Epub 2012 Mar 20.

PMID:
22503249
46.

Synthesis and biological evaluation of [6]-gingerol analogues as transient receptor potential channel TRPV1 and TRPA1 modulators.

Morera E, De Petrocellis L, Morera L, Moriello AS, Nalli M, Di Marzo V, Ortar G.

Bioorg Med Chem Lett. 2012 Feb 15;22(4):1674-7. doi: 10.1016/j.bmcl.2011.12.113. Epub 2011 Dec 31.

PMID:
22257892
47.

The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system.

Nassini R, Materazzi S, Vriens J, Prenen J, Benemei S, De Siena G, la Marca G, Andrè E, Preti D, Avonto C, Sadofsky L, Di Marzo V, De Petrocellis L, Dussor G, Porreca F, Taglialatela-Scafati O, Appendino G, Nilius B, Geppetti P.

Brain. 2012 Feb;135(Pt 2):376-90. doi: 10.1093/brain/awr272. Epub 2011 Oct 27.

PMID:
22036959
48.

Modulation of mouse gastrointestinal motility by allyl isothiocyanate, a constituent of cruciferous vegetables (Brassicaceae): evidence for TRPA1-independent effects.

Capasso R, Aviello G, Romano B, Borrelli F, De Petrocellis L, Di Marzo V, Izzo AA.

Br J Pharmacol. 2012 Mar;165(6):1966-1977. doi: 10.1111/j.1476-5381.2011.01703.x.

49.

Bioactive prenylogous cannabinoid from fiber hemp (Cannabis sativa).

Pollastro F, Taglialatela-Scafati O, Allarà M, Muñoz E, Di Marzo V, De Petrocellis L, Appendino G.

J Nat Prod. 2011 Sep 23;74(9):2019-22. doi: 10.1021/np200500p. Epub 2011 Sep 8.

PMID:
21902175
50.

Cannabinoid actions at TRPV channels: effects on TRPV3 and TRPV4 and their potential relevance to gastrointestinal inflammation.

De Petrocellis L, Orlando P, Moriello AS, Aviello G, Stott C, Izzo AA, Di Marzo V.

Acta Physiol (Oxf). 2012 Feb;204(2):255-66. doi: 10.1111/j.1748-1716.2011.02338.x. Epub 2011 Aug 12.

PMID:
21726418

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