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Items: 20

1.

High-throughput discovery of functional disordered regions: investigation of transactivation domains.

Ravarani CN, Erkina TY, De Baets G, Dudman DC, Erkine AM, Babu MM.

Mol Syst Biol. 2018 May 14;14(5):e8190. doi: 10.15252/msb.20188190.

2.

AmyPro: a database of proteins with validated amyloidogenic regions.

Varadi M, De Baets G, Vranken WF, Tompa P, Pancsa R.

Nucleic Acids Res. 2018 Jan 4;46(D1):D387-D392. doi: 10.1093/nar/gkx950.

3.

Nuclear inclusion bodies of mutant and wild-type p53 in cancer: a hallmark of p53 inactivation and proteostasis remodelling by p53 aggregation.

De Smet F, Saiz Rubio M, Hompes D, Naus E, De Baets G, Langenberg T, Hipp MS, Houben B, Claes F, Charbonneau S, Delgado Blanco J, Plaisance S, Ramkissoon S, Ramkissoon L, Simons C, van den Brandt P, Weijenberg M, Van England M, Lambrechts S, Amant F, D'Hoore A, Ligon KL, Sagaert X, Schymkowitz J, Rousseau F.

J Pathol. 2017 May;242(1):24-38. doi: 10.1002/path.4872. Epub 2017 Mar 23.

PMID:
28035683
4.

Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool.

Sannerud R, Esselens C, Ejsmont P, Mattera R, Rochin L, Tharkeshwar AK, De Baets G, De Wever V, Habets R, Baert V, Vermeire W, Michiels C, Groot AJ, Wouters R, Dillen K, Vints K, Baatsen P, Munck S, Derua R, Waelkens E, Basi GS, Mercken M, Vooijs M, Bollen M, Schymkowitz J, Rousseau F, Bonifacino JS, Van Niel G, De Strooper B, Annaert W.

Cell. 2016 Jun 30;166(1):193-208. doi: 10.1016/j.cell.2016.05.020. Epub 2016 Jun 9.

5.

Solubis: a webserver to reduce protein aggregation through mutation.

Van Durme J, De Baets G, Van Der Kant R, Ramakers M, Ganesan A, Wilkinson H, Gallardo R, Rousseau F, Schymkowitz J.

Protein Eng Des Sel. 2016 Aug;29(8):285-9. doi: 10.1093/protein/gzw019. Epub 2016 Jun 9.

PMID:
27284085
6.

Structural hot spots for the solubility of globular proteins.

Ganesan A, Siekierska A, Beerten J, Brams M, Van Durme J, De Baets G, Van der Kant R, Gallardo R, Ramakers M, Langenberg T, Wilkinson H, De Smet F, Ulens C, Rousseau F, Schymkowitz J.

Nat Commun. 2016 Feb 24;7:10816. doi: 10.1038/ncomms10816.

7.

Drosophila screen connects nuclear transport genes to DPR pathology in c9ALS/FTD.

Boeynaems S, Bogaert E, Michiels E, Gijselinck I, Sieben A, Jovičić A, De Baets G, Scheveneels W, Steyaert J, Cuijt I, Verstrepen KJ, Callaerts P, Rousseau F, Schymkowitz J, Cruts M, Van Broeckhoven C, Van Damme P, Gitler AD, Robberecht W, Van Den Bosch L.

Sci Rep. 2016 Feb 12;6:20877. doi: 10.1038/srep20877.

8.

Loss of TBK1 is a frequent cause of frontotemporal dementia in a Belgian cohort.

Gijselinck I, Van Mossevelde S, van der Zee J, Sieben A, Philtjens S, Heeman B, Engelborghs S, Vandenbulcke M, De Baets G, Bäumer V, Cuijt I, Van den Broeck M, Peeters K, Mattheijssens M, Rousseau F, Vandenberghe R, De Jonghe P, Cras P, De Deyn PP, Martin JJ, Cruts M, Van Broeckhoven C; BELNEU Consortium.

Neurology. 2015 Dec 15;85(24):2116-25. doi: 10.1212/WNL.0000000000002220. Epub 2015 Nov 18.

9.

Increased Aggregation Is More Frequently Associated to Human Disease-Associated Mutations Than to Neutral Polymorphisms.

De Baets G, Van Doorn L, Rousseau F, Schymkowitz J.

PLoS Comput Biol. 2015 Sep 4;11(9):e1004374. doi: 10.1371/journal.pcbi.1004374. eCollection 2015 Sep.

10.

Solubis: optimize your protein.

De Baets G, Van Durme J, van der Kant R, Schymkowitz J, Rousseau F.

Bioinformatics. 2015 Aug 1;31(15):2580-2. doi: 10.1093/bioinformatics/btv162. Epub 2015 Mar 19.

PMID:
25792555
11.

Selectivity of aggregation-determining interactions.

Ganesan A, Debulpaep M, Wilkinson H, Van Durme J, De Baets G, Jonckheere W, Ramakers M, Ivarsson Y, Zimmermann P, Van Eldere J, Schymkowitz J, Rousseau F.

J Mol Biol. 2015 Jan 30;427(2):236-47. doi: 10.1016/j.jmb.2014.09.027. Epub 2014 Nov 7.

PMID:
25451783
12.

Sequence-dependent internalization of aggregating peptides.

Couceiro JR, Gallardo R, De Smet F, De Baets G, Baatsen P, Annaert W, Roose K, Saelens X, Schymkowitz J, Rousseau F.

J Biol Chem. 2015 Jan 2;290(1):242-58. doi: 10.1074/jbc.M114.586636. Epub 2014 Nov 12.

13.

Predicting aggregation-prone sequences in proteins.

De Baets G, Schymkowitz J, Rousseau F.

Essays Biochem. 2014;56:41-52. doi: 10.1042/bse0560041. Review.

PMID:
25131585
14.

Horizontal gene transfer from human host to HIV-1 reverse transcriptase confers drug resistance and partly compensates for replication deficits.

Megens S, Vaira D, De Baets G, Dekeersmaeker N, Schrooten Y, Li G, Schymkowitz J, Rousseau F, Vandamme AM, Moutschen M, Van Laethem K.

Virology. 2014 May;456-457:310-8. doi: 10.1016/j.virol.2014.03.023. Epub 2014 Apr 25.

15.

A genome-wide sequence-structure analysis suggests aggregation gatekeepers constitute an evolutionary constrained functional class.

De Baets G, Van Durme J, Rousseau F, Schymkowitz J.

J Mol Biol. 2014 Jun 12;426(12):2405-12. doi: 10.1016/j.jmb.2014.04.007. Epub 2014 Apr 13.

PMID:
24735868
16.

A comparative analysis of the aggregation behavior of amyloid-β peptide variants.

Vandersteen A, Hubin E, Sarroukh R, De Baets G, Schymkowitz J, Rousseau F, Subramaniam V, Raussens V, Wenschuh H, Wildemann D, Broersen K.

FEBS Lett. 2012 Nov 30;586(23):4088-93. doi: 10.1016/j.febslet.2012.10.022. Epub 2012 Oct 24.

17.

Molecular plasticity regulates oligomerization and cytotoxicity of the multipeptide-length amyloid-β peptide pool.

Vandersteen A, Masman MF, De Baets G, Jonckheere W, van der Werf K, Marrink SJ, Rozenski J, Benilova I, De Strooper B, Subramaniam V, Schymkowitz J, Rousseau F, Broersen K.

J Biol Chem. 2012 Oct 26;287(44):36732-43. doi: 10.1074/jbc.M112.394635. Epub 2012 Sep 19.

18.

α-Galactosidase aggregation is a determinant of pharmacological chaperone efficacy on Fabry disease mutants.

Siekierska A, De Baets G, Reumers J, Gallardo R, Rudyak S, Broersen K, Couceiro J, Van Durme J, Schymkowitz J, Rousseau F.

J Biol Chem. 2012 Aug 17;287(34):28386-97. doi: 10.1074/jbc.M112.351056. Epub 2012 Jul 6.

19.

SNPeffect 4.0: on-line prediction of molecular and structural effects of protein-coding variants.

De Baets G, Van Durme J, Reumers J, Maurer-Stroh S, Vanhee P, Dopazo J, Schymkowitz J, Rousseau F.

Nucleic Acids Res. 2012 Jan;40(Database issue):D935-9. doi: 10.1093/nar/gkr996. Epub 2011 Nov 10.

20.

An evolutionary trade-off between protein turnover rate and protein aggregation favors a higher aggregation propensity in fast degrading proteins.

De Baets G, Reumers J, Delgado Blanco J, Dopazo J, Schymkowitz J, Rousseau F.

PLoS Comput Biol. 2011 Jun;7(6):e1002090. doi: 10.1371/journal.pcbi.1002090. Epub 2011 Jun 23.

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