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Items: 1 to 50 of 435

1.

Reply: ATAD1 encephalopathy and stiff baby syndrome: a recognizable clinical presentation.

Piard J, Essien Umanah GK, Harms FL, Abalde-Atristain L, Amram D, Chang M, Chen R, Alawi M, Salpietro V, Rees MI, Chung SK, Houlden H, Verloes A, Dawson TM, Dawson VL, Van Maldergem L, Kutsche K.

Brain. 2018 Apr 12. doi: 10.1093/brain/awy100. [Epub ahead of print] No abstract available.

PMID:
29659731
2.

The AAA + ATPase Thorase is neuroprotective against ischemic injury.

Zhang J, Yang J, Wang H, Sherbini O, Keuss MJ, Umanah GK, Pai EL, Chi Z, Paldanius KM, He W, Wang H, Andrabi SA, Dawson TM, Dawson VL.

J Cereb Blood Flow Metab. 2018 Jan 1:271678X18769770. doi: 10.1177/0271678X18769770. [Epub ahead of print]

PMID:
29658368
3.

DISC1 regulates lactate metabolism in astrocytes: implications for psychiatric disorders.

Jouroukhin Y, Kageyama Y, Misheneva V, Shevelkin A, Andrabi S, Prandovszky E, Yolken RH, Dawson VL, Dawson TM, Aja S, Sesaki H, Pletnikov MV.

Transl Psychiatry. 2018 Apr 12;8(1):76. doi: 10.1038/s41398-018-0123-9.

4.

Sex differences in progression to mild cognitive impairment and dementia in Parkinson's disease.

Cholerton B, Johnson CO, Fish B, Quinn JF, Chung KA, Peterson-Hiller AL, Rosenthal LS, Dawson TM, Albert MS, Hu SC, Mata IF, Leverenz JB, Poston KL, Montine TJ, Zabetian CP, Edwards KL.

Parkinsonism Relat Disord. 2018 Feb 9. pii: S1353-8020(18)30043-9. doi: 10.1016/j.parkreldis.2018.02.007. [Epub ahead of print]

PMID:
29478836
5.

Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration.

Jeong GR, Jang EH, Bae JR, Jun S, Kang HC, Park CH, Shin JH, Yamamoto Y, Tanaka-Yamamoto K, Dawson VL, Dawson TM, Hur EM, Lee BD.

Mol Neurodegener. 2018 Feb 13;13(1):8. doi: 10.1186/s13024-018-0240-1.

6.

Nitric Oxide Signaling in Neurodegeneration and Cell Death.

Dawson TM, Dawson VL.

Adv Pharmacol. 2018;82:57-83. doi: 10.1016/bs.apha.2017.09.003. Epub 2017 Oct 25.

PMID:
29413528
7.

A homozygous ATAD1 mutation impairs postsynaptic AMPA receptor trafficking and causes a lethal encephalopathy.

Piard J, Umanah GKE, Harms FL, Abalde-Atristain L, Amram D, Chang M, Chen R, Alawi M, Salpietro V, Rees MI, Chung SK, Houlden H, Verloes A, Dawson TM, Dawson VL, Van Maldergem L, Kutsche K.

Brain. 2018 Jan 30. doi: 10.1093/brain/awx377. [Epub ahead of print]

PMID:
29390050
8.

Two approaches reveal a new paradigm of 'switchable or genetics-influenced allele-specific DNA methylation' with potential in human disease.

Martos SN, Li T, Ramos RB, Lou D, Dai H, Xu JC, Gao G, Gao Y, Wang Q, An C, Zhang X, Jia Y, Dawson VL, Dawson TM, Ji H, Wang Z.

Cell Discov. 2017 Nov 14;3:17038. doi: 10.1038/celldisc.2017.38. eCollection 2017.

9.

Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice.

Xiong Y, Neifert S, Karuppagounder SS, Liu Q, Stankowski JN, Lee BD, Ko HS, Lee Y, Grima JC, Mao X, Jiang H, Kang SU, Swing DA, Iacovitti L, Tessarollo L, Dawson TM, Dawson VL.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):1635-1640. doi: 10.1073/pnas.1712648115. Epub 2018 Jan 31.

PMID:
29386392
10.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G.

Cell Death Differ. 2018 Mar;25(3):486-541. doi: 10.1038/s41418-017-0012-4. Epub 2018 Jan 23. Review.

11.

Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy.

Kaji S, Maki T, Kinoshita H, Uemura N, Ayaki T, Kawamoto Y, Furuta T, Urushitani M, Hasegawa M, Kinoshita Y, Ono Y, Mao X, Quach TH, Iwai K, Dawson VL, Dawson TM, Takahashi R.

Stem Cell Reports. 2018 Feb 13;10(2):356-365. doi: 10.1016/j.stemcr.2017.12.001. Epub 2018 Jan 11.

12.

GBA1 deficiency negatively affects physiological α-synuclein tetramers and related multimers.

Kim S, Yun SP, Lee S, Umanah GE, Bandaru VVR, Yin X, Rhee P, Karuppagounder SS, Kwon SH, Lee H, Mao X, Kim D, Pandey A, Lee G, Dawson VL, Dawson TM, Ko HS.

Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):798-803. doi: 10.1073/pnas.1700465115. Epub 2018 Jan 8.

PMID:
29311330
13.

α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism.

Yun SP, Kim D, Kim S, Kim S, Karuppagounder SS, Kwon SH, Lee S, Kam TI, Lee S, Ham S, Park JH, Dawson VL, Dawson TM, Lee Y, Ko HS.

Mol Neurodegener. 2018 Jan 8;13(1):1. doi: 10.1186/s13024-017-0233-5.

14.

Thorase variants are associated with defects in glutamatergic neurotransmission that can be rescued by Perampanel.

Umanah GKE, Pignatelli M, Yin X, Chen R, Crawford J, Neifert S, Scarffe L, Behensky AA, Guiberson N, Chang M, Ma E, Kim JW, Castro CC, Mao X, Chen L, Andrabi SA, Pletnikov MV, Pulver AE, Avramopoulos D, Bonci A, Valle D, Dawson TM, Dawson VL.

Sci Transl Med. 2017 Dec 13;9(420). pii: eaah4985. doi: 10.1126/scitranslmed.aah4985.

PMID:
29237760
15.

Markers of impaired motor and cognitive volition in Parkinson's disease: Correlates of dopamine dysregulation syndrome, impulse control disorder, and dyskinesias.

Hinkle JT, Perepezko K, Rosenthal LS, Mills KA, Pantelyat A, Mari Z, Tochen L, Bang JY, Gudavalli M, Yoritomo N, Butala A, Bakker CC, Johnson V, Moukheiber E, Dawson TM, Pontone GM.

Parkinsonism Relat Disord. 2018 Feb;47:50-56. doi: 10.1016/j.parkreldis.2017.11.338. Epub 2017 Nov 21.

PMID:
29198499
16.

c-Abl and Parkinson's Disease: Mechanisms and Therapeutic Potential.

Brahmachari S, Karuppagounder SS, Ge P, Lee S, Dawson VL, Dawson TM, Ko HS.

J Parkinsons Dis. 2017;7(4):589-601. doi: 10.3233/JPD-171191.

17.

Erratum: T cells from patients with Parkinson's disease recognize α-synuclein peptides.

Sulzer D, Alcalay RN, Garretti F, Cote L, Kanter E, Agin-Liebes J, Liong C, McMurtrey C, Hildebrand WH, Mao X, Dawson VL, Dawson TM, Oseroff C, Pham J, Sidney J, Dillon MB, Carpenter C, Weiskopf D, Phillips E, Mallal S, Peters B, Frazier A, Arlehamn CSL, Sette A.

Nature. 2017 Sep 13;549(7671):292. doi: 10.1038/nature23896.

PMID:
28905919
18.

Toward the human cellular microRNAome.

McCall MN, Kim MS, Adil M, Patil AH, Lu Y, Mitchell CJ, Leal-Rojas P, Xu J, Kumar M, Dawson VL, Dawson TM, Baras AS, Rosenberg AZ, Arking DE, Burns KH, Pandey A, Halushka MK.

Genome Res. 2017 Oct;27(10):1769-1781. doi: 10.1101/gr.222067.117. Epub 2017 Sep 6.

19.

Activation mechanisms of the E3 ubiquitin ligase parkin.

Panicker N, Dawson VL, Dawson TM.

Biochem J. 2017 Aug 30;474(18):3075-3086. doi: 10.1042/BCJ20170476. Review.

PMID:
28860335
20.

Cell Death Mechanisms of Neurodegeneration.

Fan J, Dawson TM, Dawson VL.

Adv Neurobiol. 2017;15:403-425. doi: 10.1007/978-3-319-57193-5_16.

PMID:
28674991
21.

Parkinson's disease biomarkers: perspective from the NINDS Parkinson's Disease Biomarkers Program.

Gwinn K, David KK, Swanson-Fischer C, Albin R, Hillaire-Clarke CS, Sieber BA, Lungu C, Bowman FD, Alcalay RN, Babcock D, Dawson TM, Dewey RB Jr, Foroud T, German D, Huang X, Petyuk V, Potashkin JA, Saunders-Pullman R, Sutherland M, Walt DR, West AB, Zhang J, Chen-Plotkin A, Scherzer CR, Vaillancourt DE, Rosenthal LS.

Biomark Med. 2017 May;11(6):451-473. doi: 10.2217/bmm-2016-0370. Epub 2017 Jun 23.

PMID:
28644039
22.

T cells from patients with Parkinson's disease recognize α-synuclein peptides.

Sulzer D, Alcalay RN, Garretti F, Cote L, Kanter E, Agin-Liebes J, Liong C, McMurtrey C, Hildebrand WH, Mao X, Dawson VL, Dawson TM, Oseroff C, Pham J, Sidney J, Dillon MB, Carpenter C, Weiskopf D, Phillips E, Mallal S, Peters B, Frazier A, Lindestam Arlehamn CS, Sette A.

Nature. 2017 Jun 29;546(7660):656-661. doi: 10.1038/nature22815. Epub 2017 Jun 21. Erratum in: Nature. 2017 Sep 13;549(7671):292.

23.

Domain-specific cognitive impairment in non-demented Parkinson's disease psychosis.

Hinkle JT, Perepezko K, Bakker CC, Dawson TM, Johnson V, Mari Z, Marvel CL, Mills KA, Pantelyat A, Pletnikova O, Rosenthal LS, Shepard MD, Stevens DA, Troncoso JC, Wang J, Pontone GM.

Int J Geriatr Psychiatry. 2018 Jan;33(1):e131-e139. doi: 10.1002/gps.4736. Epub 2017 May 16.

PMID:
28509347
24.

Trumping neurodegeneration: Targeting common pathways regulated by autosomal recessive Parkinson's disease genes.

Scott L, Dawson VL, Dawson TM.

Exp Neurol. 2017 Dec;298(Pt B):191-201. doi: 10.1016/j.expneurol.2017.04.008. Epub 2017 Apr 23. Review.

PMID:
28445716
25.

The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity.

Ando M, Fiesel FC, Hudec R, Caulfield TR, Ogaki K, Górka-Skoczylas P, Koziorowski D, Friedman A, Chen L, Dawson VL, Dawson TM, Bu G, Ross OA, Wszolek ZK, Springer W.

Mol Neurodegener. 2017 Apr 24;12(1):32. doi: 10.1186/s13024-017-0174-z.

26.

Reply: Heterozygous PINK1 p.G411S in rapid eye movement sleep behaviour disorder.

Puschmann A, Fiesel FC, Caulfield TR, Hudec R, Ando M, Truban D, Hou X, Ogaki K, Heckman MG, James ED, Swanberg M, Jimenez-Ferrer I, Hansson O, Opala G, Siuda J, Boczarska-Jedynak M, Friedman A, Koziorowski D, Rudzinska-Bar M, Aasly JO, Lynch T, Mellick GD, Mohan M, Silburn PA, Sanotsky Y, Vilariño-Güell C, Farrer MJ, Chen L, Dawson VL, Dawson TM, Wszolek ZK, Ross OA, Springer W.

Brain. 2017 Jun 1;140(6):e33. doi: 10.1093/brain/awx077. No abstract available.

PMID:
28379295
27.

Models of LRRK2-Associated Parkinson's Disease.

Xiong Y, Dawson TM, Dawson VL.

Adv Neurobiol. 2017;14:163-191. doi: 10.1007/978-3-319-49969-7_9.

28.

Overexpression of Parkinson's Disease-Associated Mutation LRRK2 G2019S in Mouse Forebrain Induces Behavioral Deficits and α-Synuclein Pathology.

Xiong Y, Neifert S, Karuppagounder SS, Stankowski JN, Lee BD, Grima JC, Chen G, Ko HS, Lee Y, Swing D, Tessarollo L, Dawson TM, Dawson VL.

eNeuro. 2017 Mar 17;4(2). pii: ENEURO.0004-17.2017. doi: 10.1523/ENEURO.0004-17.2017. eCollection 2017 Mar-Apr.

29.

Opportunities for the repurposing of PARP inhibitors for the therapy of non-oncological diseases.

Berger NA, Besson VC, Boulares AH, Bürkle A, Chiarugi A, Clark RS, Curtin NJ, Cuzzocrea S, Dawson TM, Dawson VL, Haskó G, Liaudet L, Moroni F, Pacher P, Radermacher P, Salzman AL, Snyder SH, Soriano FG, Strosznajder RP, Sümegi B, Swanson RA, Szabo C.

Br J Pharmacol. 2018 Jan;175(2):192-222. doi: 10.1111/bph.13748. Epub 2017 Mar 26. Review.

PMID:
28213892
30.

Precision therapy for a new disorder of AMPA receptor recycling due to mutations in ATAD1.

Ahrens-Nicklas RC, Umanah GK, Sondheimer N, Deardorff MA, Wilkens AB, Conlin LK, Santani AB, Nesbitt A, Juulsola J, Ma E, Dawson TM, Dawson VL, Marsh ED.

Neurol Genet. 2017 Feb 1;3(1):e130. doi: 10.1212/NXG.0000000000000130. eCollection 2017 Feb.

31.

PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival.

Lee Y, Stevens DA, Kang SU, Jiang H, Lee YI, Ko HS, Scarffe LA, Umanah GE, Kang H, Ham S, Kam TI, Allen K, Brahmachari S, Kim JW, Neifert S, Yun SP, Fiesel FC, Springer W, Dawson VL, Shin JH, Dawson TM.

Cell Rep. 2017 Jan 24;18(4):918-932. doi: 10.1016/j.celrep.2016.12.090.

32.

Synaptic Plasticity onto Dopamine Neurons Shapes Fear Learning.

Pignatelli M, Umanah GKE, Ribeiro SP, Chen R, Karuppagounder SS, Yau HJ, Eacker S, Dawson VL, Dawson TM, Bonci A.

Neuron. 2017 Jan 18;93(2):425-440. doi: 10.1016/j.neuron.2016.12.030.

33.

Neurotoxic reactive astrocytes are induced by activated microglia.

Liddelow SA, Guttenplan KA, Clarke LE, Bennett FC, Bohlen CJ, Schirmer L, Bennett ML, Münch AE, Chung WS, Peterson TC, Wilton DK, Frouin A, Napier BA, Panicker N, Kumar M, Buckwalter MS, Rowitch DH, Dawson VL, Dawson TM, Stevens B, Barres BA.

Nature. 2017 Jan 26;541(7638):481-487. doi: 10.1038/nature21029. Epub 2017 Jan 18.

34.

Mitochondrial Mechanisms of Neuronal Cell Death: Potential Therapeutics.

Dawson TM, Dawson VL.

Annu Rev Pharmacol Toxicol. 2017 Jan 6;57:437-454. doi: 10.1146/annurev-pharmtox-010716-105001. Review.

PMID:
28061689
35.

A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1.

Wang Y, An R, Umanah GK, Park H, Nambiar K, Eacker SM, Kim B, Bao L, Harraz MM, Chang C, Chen R, Wang JE, Kam TI, Jeong JS, Xie Z, Neifert S, Qian J, Andrabi SA, Blackshaw S, Zhu H, Song H, Ming GL, Dawson VL, Dawson TM.

Science. 2016 Oct 7;354(6308). pii: aad6872.

36.

High-Content Genome-Wide RNAi Screen Reveals CCR3 as a Key Mediator of Neuronal Cell Death.

Zhang J, Wang H, Sherbini O, Ling-Lin Pai E, Kang SU, Kwon JS, Yang J, He W, Wang H, Eacker SM, Chi Z, Mao X, Xu J, Jiang H, Andrabi SA, Dawson TM, Dawson VL.

eNeuro. 2016 Oct 24;3(5). pii: ENEURO.0185-16.2016. eCollection 2016 Sep-Oct.

37.

Heterozygous PINK1 p.G411S increases risk of Parkinson's disease via a dominant-negative mechanism.

Puschmann A, Fiesel FC, Caulfield TR, Hudec R, Ando M, Truban D, Hou X, Ogaki K, Heckman MG, James ED, Swanberg M, Jimenez-Ferrer I, Hansson O, Opala G, Siuda J, Boczarska-Jedynak M, Friedman A, Koziorowski D, Aasly JO, Lynch T, Mellick GD, Mohan M, Silburn PA, Sanotsky Y, Vilariño-Güell C, Farrer MJ, Chen L, Dawson VL, Dawson TM, Wszolek ZK, Ross OA, Springer W.

Brain. 2017 Jan;140(1):98-117. doi: 10.1093/brain/aww261. Epub 2016 Nov 2.

38.

Cognitive impairment in Parkinson's disease: Association between patient-reported and clinically measured outcomes.

Mills KA, Mari Z, Pontone GM, Pantelyat A, Zhang A, Yoritomo N, Powers E, Brandt J, Dawson TM, Rosenthal LS.

Parkinsonism Relat Disord. 2016 Dec;33:107-114. doi: 10.1016/j.parkreldis.2016.09.025. Epub 2016 Sep 27.

39.

Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3.

Mao X, Ou MT, Karuppagounder SS, Kam TI, Yin X, Xiong Y, Ge P, Umanah GE, Brahmachari S, Shin JH, Kang HC, Zhang J, Xu J, Chen R, Park H, Andrabi SA, Kang SU, Gonçalves RA, Liang Y, Zhang S, Qi C, Lam S, Keiler JA, Tyson J, Kim D, Panicker N, Yun SP, Workman CJ, Vignali DA, Dawson VL, Ko HS, Dawson TM.

Science. 2016 Sep 30;353(6307). pii: aah3374.

40.

Gait function and locus coeruleus Lewy body pathology in 51 Parkinson's disease patients.

Mills KA, Mari Z, Bakker C, Johnson V, Pontone GM, Pantelyat A, Troncoso JC, Pletnikova O, Dawson TM, Rosenthal LS.

Parkinsonism Relat Disord. 2016 Dec;33:102-106. doi: 10.1016/j.parkreldis.2016.09.024. Epub 2016 Sep 25.

41.

Adult Conditional Knockout of PGC-1α Leads to Loss of Dopamine Neurons.

Jiang H, Kang SU, Zhang S, Karuppagounder S, Xu J, Lee YK, Kang BG, Lee Y, Zhang J, Pletnikova O, Troncoso JC, Pirooznia S, Andrabi SA, Dawson VL, Dawson TM.

eNeuro. 2016 Sep 2;3(4). pii: ENEURO.0183-16.2016. doi: 10.1523/ENEURO.0183-16.2016. eCollection 2016 Jul-Aug.

42.

Association of GBA Mutations and the E326K Polymorphism With Motor and Cognitive Progression in Parkinson Disease.

Davis MY, Johnson CO, Leverenz JB, Weintraub D, Trojanowski JQ, Chen-Plotkin A, Van Deerlin VM, Quinn JF, Chung KA, Peterson-Hiller AL, Rosenthal LS, Dawson TM, Albert MS, Goldman JG, Stebbins GT, Bernard B, Wszolek ZK, Ross OA, Dickson DW, Eidelberg D, Mattis PJ, Niethammer M, Yearout D, Hu SC, Cholerton BA, Smith M, Mata IF, Montine TJ, Edwards KL, Zabetian CP.

JAMA Neurol. 2016 Oct 1;73(10):1217-1224. doi: 10.1001/jamaneurol.2016.2245.

43.

Augmentation of poly(ADP-ribose) polymerase-dependent neuronal cell death by acidosis.

Zhang J, Li X, Kwansa H, Kim YT, Yi L, Hong G, Andrabi SA, Dawson VL, Dawson TM, Koehler RC, Yang ZJ.

J Cereb Blood Flow Metab. 2017 Jun;37(6):1982-1993. doi: 10.1177/0271678X16658491. Epub 2016 Jan 1.

PMID:
27381826
44.

Activation of tyrosine kinase c-Abl contributes to α-synuclein-induced neurodegeneration.

Brahmachari S, Ge P, Lee SH, Kim D, Karuppagounder SS, Kumar M, Mao X, Shin JH, Lee Y, Pletnikova O, Troncoso JC, Dawson VL, Dawson TM, Ko HS.

J Clin Invest. 2016 Aug 1;126(8):2970-88. doi: 10.1172/JCI85456. Epub 2016 Jun 27.

45.

Next-generation sequencing reveals substantial genetic contribution to dementia with Lewy bodies.

Geiger JT, Ding J, Crain B, Pletnikova O, Letson C, Dawson TM, Rosenthal LS, Pantelyat A, Gibbs JR, Albert MS, Hernandez DG, Hillis AE, Stone DJ, Singleton AB; North American Brain Expression Consortium, Hardy JA, Troncoso JC, Scholz SW.

Neurobiol Dis. 2016 Oct;94:55-62. doi: 10.1016/j.nbd.2016.06.004. Epub 2016 Jun 14.

46.

Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1.

Nucifora FC Jr, Nucifora LG, Ng CH, Arbez N, Guo Y, Roby E, Shani V, Engelender S, Wei D, Wang XF, Li T, Moore DJ, Pletnikova O, Troncoso JC, Sawa A, Dawson TM, Smith W, Lim KL, Ross CA.

Nat Commun. 2016 Jun 7;7:11792. doi: 10.1038/ncomms11792.

47.

C9orf72 Hexanucleotide Repeat Analysis in Cases with Pathologically Confirmed Dementia with Lewy Bodies.

Geiger JT, Arthur KC, Dawson TM, Rosenthal LS, Pantelyat A, Albert M, Hillis AE, Crain B, Pletnikova O, Troncoso JC, Scholz SW.

Neurodegener Dis. 2016;16(5-6):370-2. doi: 10.1159/000445872. Epub 2016 May 31.

48.

Cultured networks of excitatory projection neurons and inhibitory interneurons for studying human cortical neurotoxicity.

Xu JC, Fan J, Wang X, Eacker SM, Kam TI, Chen L, Yin X, Zhu J, Chi Z, Jiang H, Chen R, Dawson TM, Dawson VL.

Sci Transl Med. 2016 Apr 6;8(333):333ra48. doi: 10.1126/scitranslmed.aad0623.

49.

LRRK2 pathobiology in Parkinson's disease - virtual inclusion.

Martin I, Kim JW, Dawson VL, Dawson TM.

J Neurochem. 2016 Oct;139 Suppl 1:75-76. doi: 10.1111/jnc.13549. Epub 2016 Feb 22.

50.

LRRK2 G2019S transgenic mice display increased susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity.

Karuppagounder SS, Xiong Y, Lee Y, Lawless MC, Kim D, Nordquist E, Martin I, Ge P, Brahmachari S, Jhaldiyal A, Kumar M, Andrabi SA, Dawson TM, Dawson VL.

J Chem Neuroanat. 2016 Oct;76(Pt B):90-97. doi: 10.1016/j.jchemneu.2016.01.007. Epub 2016 Jan 22.

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