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Items: 1 to 50 of 156

1.

Down regulation of miR-202 modulates Mxd1 and Sin3A repressor complexes to induce apoptosis of pancreatic cancer cells.

Farhana L, Dawson MI, Fontana JA.

Cancer Biol Ther. 2015;16(1):115-24. doi: 10.4161/15384047.2014.987070.

2.

NF-κB p65 recruited SHP regulates PDCD5-mediated apoptosis in cancer cells.

Murshed F, Farhana L, Dawson MI, Fontana JA.

Apoptosis. 2014 Mar;19(3):506-17. doi: 10.1007/s10495-013-0939-y.

PMID:
24343129
3.

Upregulation of miR-150* and miR-630 induces apoptosis in pancreatic cancer cells by targeting IGF-1R.

Farhana L, Dawson MI, Murshed F, Das JK, Rishi AK, Fontana JA.

PLoS One. 2013 May 10;8(5):e61015. doi: 10.1371/journal.pone.0061015. Print 2013.

4.

Relative impact of 3- and 5-hydroxyl groups of cytosporone B on cancer cell viability.

Xia Z, Cao X, Rico-Bautista E, Yu J, Chen L, Chen J, Bobkov A, Wolf DA, Zhang XK, Dawson MI.

Medchemcomm. 2013 Feb 1;4(2):332-339. doi: 10.1039/C2MD20243C. Epub 2012 Nov 7.

5.

Reversal by RARα agonist Am580 of c-Myc-induced imbalance in RARα/RARγ expression during MMTV-Myc tumorigenesis.

Bosch A, Bertran SP, Lu Y, Garcia A, Jones AM, Dawson MI, Farias EF.

Breast Cancer Res. 2012 Aug 24;14(4):R121. doi: 10.1186/bcr3247.

6.

HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promoter.

Kiselyuk A, Lee SH, Farber-Katz S, Zhang M, Athavankar S, Cohen T, Pinkerton AB, Ye M, Bushway P, Richardson AD, Hostetler HA, Rodriguez-Lee M, Huang L, Spangler B, Smith L, Higginbotham J, Cashman J, Freeze H, Itkin-Ansari P, Dawson MI, Schroeder F, Cang Y, Mercola M, Levine F.

Chem Biol. 2012 Jul 27;19(7):806-18. doi: 10.1016/j.chembiol.2012.05.014.

7.

Adamantyl Retinoid-Related Molecules Induce Apoptosis in Pancreatic Cancer Cells by Inhibiting IGF-1R and Wnt/β-Catenin Pathways.

Farhana L, Dawson MI, Das JK, Murshed F, Xia Z, Hadden TJ, Hatfield J, Fontana JA.

J Oncol. 2012;2012:796729. doi: 10.1155/2012/796729. Epub 2012 Apr 5.

8.
9.

The retinoid X receptors and their ligands.

Dawson MI, Xia Z.

Biochim Biophys Acta. 2012 Jan;1821(1):21-56. doi: 10.1016/j.bbalip.2011.09.014. Epub 2011 Oct 1. Review.

10.

Heteroatom-substituted analogues of orphan nuclear receptor small heterodimer partner ligand and apoptosis inducer (E)-4-[3-(1-Adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid.

Xia Z, Farhana L, Correa RG, Das JK, Castro DJ, Yu J, Oshima RG, Reed JC, Fontana JA, Dawson MI.

J Med Chem. 2011 Jun 9;54(11):3793-816. doi: 10.1021/jm200051z. Epub 2011 May 6.

PMID:
21548569
11.

A strong case for personalized, targeted cancer prevention.

Dawson MI.

Cancer Prev Res (Phila). 2011 Feb;4(2):173-6. doi: 10.1158/1940-6207.CAPR-10-0386.

12.

Chromosome number variation in two antipodean floras.

Peruzzi L, Dawson MI, Bedini G.

AoB Plants. 2011;2011:plr020. doi: 10.1093/aobpla/plr020. Epub 2011 Aug 2.

13.

Adamantyl-substituted retinoid-related molecules induce apoptosis in human acute myelogenous leukemia cells.

Farhana L, Dawson MI, Xia Z, Aboukameel A, Xu L, Liu G, Das JK, Hatfield J, Levi E, Mohammad R, Fontana JA.

Mol Cancer Ther. 2010 Nov;9(11):2903-13. doi: 10.1158/1535-7163.MCT-10-0546. Epub 2010 Nov 9.

14.

Novel cis-trans interactions are involved in post-transcriptional regulation of cyclin-dependent kinase inhibitor p21WAF1/CIP1 mRNA.

Zhang L, Wali A, Fontana JA, Dawson MI, Rishi AK.

J Mol Signal. 2010 Aug 12;5:12. doi: 10.1186/1750-2187-5-12.

15.

Maximal adamantyl-substituted retinoid-related molecule-induced apoptosis requires NF-κB noncanonical and canonical pathway activation.

Farhana L, Dawson MI, Murshed F, Fontana JA.

Cell Death Differ. 2011 Jan;18(1):164-73. doi: 10.1038/cdd.2010.84. Epub 2010 Jul 30.

17.

Inhibition of mammary carcinoma cell growth by RXR is mediated by the receptor's oligomeric switch.

Yasmin R, Kannan-Thulasiraman P, Kagechika H, Dawson MI, Noy N.

J Mol Biol. 2010 Apr 16;397(5):1121-31. doi: 10.1016/j.jmb.2010.02.030. Epub 2010 Feb 24.

18.

The effect of antagonists on the conformational exchange of the retinoid X receptor alpha ligand-binding domain.

Lu J, Dawson MI, Hu QY, Xia Z, Dambacher JD, Ye M, Zhang XK, Li E.

Magn Reson Chem. 2009 Dec;47(12):1071-80. doi: 10.1002/mrc.2515.

19.

SHP and Sin3A expression are essential for adamantyl-substituted retinoid-related molecule-mediated nuclear factor-kappaB activation, c-Fos/c-Jun expression, and cellular apoptosis.

Farhana L, Dawson MI, Dannenberg JH, Xu L, Fontana JA.

Mol Cancer Ther. 2009 Jun;8(6):1625-35. doi: 10.1158/1535-7163.MCT-08-0964. Epub 2009 Jun 9. Erratum in: Mol Cancer Ther. 2009 Oct;8(10):2981. Dannenberg, Jan-Hermen [added].

20.

Studies of cannabinoid-1 receptor antagonists for the treatment of obesity: hologram QSAR model for biarylpyrazolyl oxadiazole ligands.

Ye M, Dawson MI.

Bioorg Med Chem Lett. 2009 Jun 15;19(12):3310-5. doi: 10.1016/j.bmcl.2009.04.072. Epub 2009 Apr 22.

PMID:
19427207
21.

Derivation of a retinoid X receptor scaffold from peroxisome proliferator-activated receptor gamma ligand 1-Di(1H-indol-3-yl)methyl-4-trifluoromethylbenzene.

Dawson MI, Ye M, Cao X, Farhana L, Hu QY, Zhao Y, Xu LP, Kiselyuk A, Correa RG, Yang L, Hou T, Reed JC, Itkin-Ansari P, Levine F, Sanner MF, Fontana JA, Zhang XK.

ChemMedChem. 2009 Jul;4(7):1106-19. doi: 10.1002/cmdc.200800447.

22.

Conjugation of antisense oligonucleotides to PEGylated carbon nanotubes enables efficient knockdown of PTPN22 in T lymphocytes.

Delogu LG, Magrini A, Bergamaschi A, Rosato N, Dawson MI, Bottini N, Bottini M.

Bioconjug Chem. 2009 Mar 18;20(3):427-31. doi: 10.1021/bc800540j.

PMID:
19243140
23.

3D-QSAR and QSSR studies of 3,8-diazabicyclo[4.2.0]octane derivatives as neuronal nicotinic acetylcholine receptors by comparative molecular field analysis (CoMFA).

Ye M, Dawson MI.

Bioorg Med Chem Lett. 2009 Jan 1;19(1):127-31. doi: 10.1016/j.bmcl.2008.11.016. Epub 2008 Nov 9.

PMID:
19026537
24.

Adamantyl-substituted retinoid-derived molecules that interact with the orphan nuclear receptor small heterodimer partner: effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and inhibition of SRC homology 2 domain-containing protein tyrosine phosphatase-2 activity.

Dawson MI, Xia Z, Jiang T, Ye M, Fontana JA, Farhana L, Patel B, Xue LP, Bhuiyan M, Pellicciari R, Macchiarulo A, Nuti R, Zhang XK, Han YH, Tautz L, Hobbs PD, Jong L, Waleh N, Chao WR, Feng GS, Pang Y, Su Y.

J Med Chem. 2008 Sep 25;51(18):5650-62. doi: 10.1021/jm800456k. Epub 2008 Aug 30.

25.

Cell-type specific and cytoplasmic targeting of PEGylated carbon nanotube-based nanoassemblies.

Cato MH, D'Annibale F, Mills DM, Cerignoli F, Dawson MI, Bergamaschi E, Bottini N, Magrini A, Bergamaschi A, Rosato N, Rickert RC, Mustelin T, Bottini M.

J Nanosci Nanotechnol. 2008 May;8(5):2259-69.

PMID:
18572636
26.

Noncovalently silylated carbon nanotubes decorated with quantum dots.

Bottini M, Magrini A, Dawson MI, Rosato N, Bergamaschi A, Mustelin T.

Carbon N Y. 2007 Mar;45(3):673-676.

27.

Retinoic acid (RA) regulates 17beta-hydroxysteroid dehydrogenase type 2 expression in endometrium: interaction of RA receptors with specificity protein (SP) 1/SP3 for estradiol metabolism.

Cheng YH, Yin P, Xue Q, Yilmaz B, Dawson MI, Bulun SE.

J Clin Endocrinol Metab. 2008 May;93(5):1915-23. doi: 10.1210/jc.2007-1536. Epub 2008 Feb 12.

28.

Quantum dot-doped silica nanoparticles as probes for targeting of T-lymphocytes.

Bottini M, D'Annibale F, Magrini A, Cerignoli F, Arimura Y, Dawson MI, Bergamaschi E, Rosato N, Bergamaschi A, Mustelin T.

Int J Nanomedicine. 2007;2(2):227-33.

29.

An adamantyl-substituted retinoid-derived molecule that inhibits cancer cell growth and angiogenesis by inducing apoptosis and binds to small heterodimer partner nuclear receptor: effects of modifying its carboxylate group on apoptosis, proliferation, and protein-tyrosine phosphatase activity.

Dawson MI, Xia Z, Liu G, Ye M, Fontana JA, Farhana L, Patel BB, Arumugarajah S, Bhuiyan M, Zhang XK, Han YH, Stallcup WB, Fukushi J, Mustelin T, Tautz L, Su Y, Harris DL, Waleh N, Hobbs PD, Jong L, Chao WR, Schiff LJ, Sani BP.

J Med Chem. 2007 May 31;50(11):2622-39. Epub 2007 May 10. Erratum in: J Med Chem. 2008 Oct 9;51(19):6236. Ye, Mao [added].

30.

Adamantyl-substituted retinoid-related molecules bind small heterodimer partner and modulate the Sin3A repressor.

Farhana L, Dawson MI, Leid M, Wang L, Moore DD, Liu G, Xia Z, Fontana JA.

Cancer Res. 2007 Jan 1;67(1):318-25.

31.

Full-length single-walled carbon nanotubes decorated with streptavidin-conjugated quantum dots as multivalent intracellular fluorescent nanoprobes.

Bottini M, Cerignoli F, Dawson MI, Magrini A, Rosato N, Mustelin T.

Biomacromolecules. 2006 Aug;7(8):2259-63.

PMID:
16903668
32.

Investigation of ligand interactions with human RXRalpha by hydrogen/deuterium exchange and mass spectrometry.

Yan X, Deinzer ML, Schimerlik MI, Broderick D, Leid ME, Dawson MI.

J Am Soc Mass Spectrom. 2006 Nov;17(11):1510-7. Epub 2006 Jul 26.

33.

Synthesis and characterization of supramolecular nanostructures of carbon nanotubes and ruthenium-complex Luminophores.

Bottini M, Magrini A, Di Venere A, Bellucci S, Dawson MI, Rosato N, Bergamaschi A, Mustelin T.

J Nanosci Nanotechnol. 2006 May;6(5):1381-6.

PMID:
16792368
34.

Isolation and characterization of fluorescent nanoparticles from pristine and oxidized electric arc-produced single-walled carbon nanotubes.

Bottini M, Balasubramanian C, Dawson MI, Bergamaschi A, Bellucci S, Mustelin T.

J Phys Chem B. 2006 Jan 19;110(2):831-6.

PMID:
16471611
35.

Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt.

Han YH, Cao X, Lin B, Lin F, Kolluri SK, Stebbins J, Reed JC, Dawson MI, Zhang XK.

Oncogene. 2006 May 18;25(21):2974-86.

PMID:
16434970
36.

Apoptosis induction by a novel retinoid-related molecule requires nuclear factor-kappaB activation.

Farhana L, Dawson MI, Fontana JA.

Cancer Res. 2005 Jun 1;65(11):4909-17.

37.

Covalent decoration of multi-walled carbon nanotubes with silica nanoparticles.

Bottini M, Tautz L, Huynh H, Monosov E, Bottini N, Dawson MI, Bellucci S, Mustelin T.

Chem Commun (Camb). 2005 Feb 14;(6):758-60. Epub 2004 Dec 15.

PMID:
15685328
38.

Retinoid X receptor regulates Nur77/TR3-dependent apoptosis [corrected] by modulating its nuclear export and mitochondrial targeting.

Cao X, Liu W, Lin F, Li H, Kolluri SK, Lin B, Han YH, Dawson MI, Zhang XK.

Mol Cell Biol. 2004 Nov;24(22):9705-25. Erratum in: Mol Cell Biol. 2005 Jan;25(1):524.

39.

Determinants of retinoid X receptor transcriptional antagonism.

Cavasotto CN, Liu G, James SY, Hobbs PD, Peterson VJ, Bhattacharya AA, Kolluri SK, Zhang XK, Leid M, Abagyan R, Liddington RC, Dawson MI.

J Med Chem. 2004 Aug 26;47(18):4360-72.

PMID:
15317450
40.

Antagonist analogue of 6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-2-naphthalenecarboxylic acid (AHPN) family of apoptosis inducers that effectively blocks AHPN-induced apoptosis but not cell-cycle arrest.

Dawson MI, Harris DL, Liu G, Hobbs PD, Lange CW, Jong L, Bruey-Sedano N, James SY, Zhang XK, Peterson VJ, Leid M, Farhana L, Rishi AK, Fontana JA.

J Med Chem. 2004 Jul 1;47(14):3518-36.

PMID:
15214780
41.

Synthetic retinoids and their nuclear receptors.

Dawson MI.

Curr Med Chem Anticancer Agents. 2004 May;4(3):199-230. Review.

PMID:
15134501
42.

Apoptosis signaling by the novel compound 3-Cl-AHPC involves increased EGFR proteolysis and accompanying decreased phosphatidylinositol 3-kinase and AKT kinase activities.

Farhana L, Dawson MI, Huang Y, Zhang Y, Rishi AK, Reddy KB, Freeman RS, Fontana JA.

Oncogene. 2004 Mar 11;23(10):1874-84.

PMID:
14981538
43.

Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3.

Lin B, Kolluri SK, Lin F, Liu W, Han YH, Cao X, Dawson MI, Reed JC, Zhang XK.

Cell. 2004 Feb 20;116(4):527-40.

44.

Mitogenic effect of orphan receptor TR3 and its regulation by MEKK1 in lung cancer cells.

Kolluri SK, Bruey-Sedano N, Cao X, Lin B, Lin F, Han YH, Dawson MI, Zhang XK.

Mol Cell Biol. 2003 Dec;23(23):8651-67.

45.

Induction of apoptosis in retinoid-refractory acute myelogenous leukemia by a novel AHPN analog.

Zhang Y, Dawson MI, Ning Y, Polin L, Parchment RE, Corbett T, Mohamed AN, Feng KC, Farhana L, Rishi AK, Hogge D, Leid M, Peterson VJ, Zhang XK, Mohammad R, Lu JS, Willman C, VanBuren E, Biggar S, Edelstein M, Eilender D, Fontana JA.

Blood. 2003 Nov 15;102(10):3743-52. Epub 2003 Jul 31.

46.
47.

Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis signaling by retinoid CD437.

Rishi AK, Zhang L, Boyanapalli M, Wali A, Mohammad RM, Yu Y, Fontana JA, Hatfield JS, Dawson MI, Majumdar AP, Reichert U.

J Biol Chem. 2003 Aug 29;278(35):33422-35. Epub 2003 Jun 18.

48.

Induction of apoptosis of human B-CLL and ALL cells by a novel retinoid and its nonretinoidal analog.

Zhang Y, Dawson MI, Mohammad R, Rishi AK, Farhana L, Feng KC, Leid M, Peterson V, Zhang XK, Edelstein M, Eilander D, Biggar S, Wall N, Reichert U, Fontana JA.

Blood. 2002 Oct 15;100(8):2917-25.

49.

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