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Items: 1 to 50 of 66

1.

A quarter of patients with type 1 diabetes have co-existing non-islet autoimmunity; the findings of a UK population-based family study.

Kozhakhmetova A, Wyatt RC, Caygill C, Williams C, Long AE, Chandler K, Aitken RJ, Wenzlau JM, Davidson HW, Gillespie KM, Williams AJK.

Clin Exp Immunol. 2018 Feb 12. doi: 10.1111/cei.13115. [Epub ahead of print]

PMID:
29431870
2.

Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors.

Culina S, Lalanne AI, Afonso G, Cerosaletti K, Pinto S, Sebastiani G, Kuranda K, Nigi L, Eugster A, Østerbye T, Maugein A, McLaren JE, Ladell K, Larger E, Beressi JP, Lissina A, Appay V, Davidson HW, Buus S, Price DA, Kuhn M, Bonifacio E, Battaglia M, Caillat-Zucman S, Dotta F, Scharfmann R, Kyewski B, Mallone R; ImMaDiab Study Group.

Sci Immunol. 2018 Feb 2;3(20). pii: eaao4013. doi: 10.1126/sciimmunol.aao4013.

PMID:
29429978
3.

Combinatorial detection of autoreactive CD8+ T cells with HLA-A2 multimers: a multi-centre study by the Immunology of Diabetes Society T Cell Workshop.

James EA, Abreu JRF, McGinty JW, Odegard JM, Fillié YE, Hocter CN, Culina S, Ladell K, Price DA, Alkanani A, Rihanek M, Fitzgerald-Miller L, Skowera A, Speake C, Gottlieb P, Davidson HW, Wong FS, Roep B, Mallone R; Immunology of Diabetes Society T Cell Workshop Committee.

Diabetologia. 2018 Mar;61(3):658-670. doi: 10.1007/s00125-017-4508-8. Epub 2017 Dec 1.

PMID:
29196783
4.

Luminescent Immunoprecipitation System (LIPS) for Detection of Autoantibodies Against ATP4A and ATP4B Subunits of Gastric Proton Pump H+,K+-ATPase in Atrophic Body Gastritis Patients.

Lahner E, Brigatti C, Marzinotto I, Carabotti M, Scalese G, Davidson HW, Wenzlau JM, Bosi E, Piemonti L, Annibale B, Lampasona V.

Clin Transl Gastroenterol. 2017 Jan 19;8(1):e215. doi: 10.1038/ctg.2016.71.

5.

Characterization of immune response to novel HLA-A2-restricted epitopes from zinc transporter 8 in type 1 diabetes.

Xu X, Gu Y, Bian L, Shi Y, Cai Y, Chen Y, Chen H, Qian L, Wu X, Xu K, Mallone R, Davidson HW, Yu L, She J, Zhang M, Yang T.

Vaccine. 2016 Feb 3;34(6):854-62. doi: 10.1016/j.vaccine.2015.10.108. Epub 2015 Nov 3.

PMID:
26541133
6.

Changes in Zinc Transporter 8 Autoantibodies Following Type 1 Diabetes Onset: The Type 1 Diabetes Genetics Consortium Autoantibody Workshop.

Wenzlau JM, Frisch LM, Hutton JC, Fain PR, Davidson HW.

Diabetes Care. 2015 Oct;38 Suppl 2:S14-20. doi: 10.2337/dcs15-2004.

7.

Regulatory vs. inflammatory cytokine T-cell responses to mutated insulin peptides in healthy and type 1 diabetic subjects.

Nakayama M, McDaniel K, Fitzgerald-Miller L, Kiekhaefer C, Snell-Bergeon JK, Davidson HW, Rewers M, Yu L, Gottlieb P, Kappler JW, Michels A.

Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4429-34. doi: 10.1073/pnas.1502967112. Epub 2015 Mar 23.

8.

Preexisting insulin autoantibodies predict efficacy of otelixizumab in preserving residual β-cell function in recent-onset type 1 diabetes.

Demeester S, Keymeulen B, Kaufman L, Van Dalem A, Balti EV, Van de Velde U, Goubert P, Verhaeghen K, Davidson HW, Wenzlau JM, Weets I, Pipeleers DG, Gorus FK.

Diabetes Care. 2015 Apr;38(4):644-51. doi: 10.2337/dc14-1575. Epub 2015 Jan 12.

9.

Autoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetes.

Yang J, Chow IT, Sosinowski T, Torres-Chinn N, Greenbaum CJ, James EA, Kappler JW, Davidson HW, Kwok WW.

Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14840-5. doi: 10.1073/pnas.1416864111. Epub 2014 Sep 29.

10.

Zinc transporter 8 (ZnT8) and β cell function.

Davidson HW, Wenzlau JM, O'Brien RM.

Trends Endocrinol Metab. 2014 Aug;25(8):415-24. doi: 10.1016/j.tem.2014.03.008. Epub 2014 Apr 18. Review.

11.

Monoclonal antibody blocking the recognition of an insulin peptide-MHC complex modulates type 1 diabetes.

Zhang L, Crawford F, Yu L, Michels A, Nakayama M, Davidson HW, Kappler JW, Eisenbarth GS.

Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2656-61. doi: 10.1073/pnas.1323436111. Epub 2014 Feb 3.

12.

Mapping I-A(g7) restricted epitopes in murine G6PC2.

Yang T, Hohenstein AC, Lee CE, Hutton JC, Davidson HW.

Immunol Res. 2013 Mar;55(1-3):91-9. doi: 10.1007/s12026-012-8368-5.

13.

Zinc transporter (ZnT)8(186-194) is an immunodominant CD8+ T cell epitope in HLA-A2+ type 1 diabetic patients.

Scotto M, Afonso G, Larger E, Raverdy C, Lemonnier FA, Carel JC, Dubois-Laforgue D, Baz B, Levy D, Gautier JF, Launay O, Bruno G, Boitard C, Sechi LA, Hutton JC, Davidson HW, Mallone R.

Diabetologia. 2012 Jul;55(7):2026-31. doi: 10.1007/s00125-012-2543-z. Epub 2012 Apr 20.

14.

Glycotoxin and autoantibodies are additive environmentally determined predictors of type 1 diabetes: a twin and population study.

Beyan H, Riese H, Hawa MI, Beretta G, Davidson HW, Hutton JC, Burger H, Schlosser M, Snieder H, Boehm BO, Leslie RD.

Diabetes. 2012 May;61(5):1192-8. doi: 10.2337/db11-0971. Epub 2012 Mar 6.

15.

Development of a novel autoantibody assay for autoimmune gastritis in type 1 diabetic individuals.

Wenzlau JM, Gardner TJ, Frisch LM, Davidson HW, Hutton JC.

Diabetes Metab Res Rev. 2011 Nov;27(8):887-90. doi: 10.1002/dmrr.1267.

16.

Mapping of conformational autoantibody epitopes in ZNT8.

Wenzlau JM, Frisch LM, Hutton JC, Davidson HW.

Diabetes Metab Res Rev. 2011 Nov;27(8):883-6. doi: 10.1002/dmrr.1266.

17.

Human type 1 diabetes is associated with T cell autoimmunity to zinc transporter 8.

Dang M, Rockell J, Wagner R, Wenzlau JM, Yu L, Hutton JC, Gottlieb PA, Davidson HW.

J Immunol. 2011 May 15;186(10):6056-63. doi: 10.4049/jimmunol.1003815. Epub 2011 Apr 6.

18.

[Value of zinc transporter 8 autoantibody in the diagnostic classification of acute-onset diabetics].

YANG L, LUO SM, HUANG G, PENG J, YAN X, WENZLAU J, DAVIDSON HW, HUTTON JC, ZHOU ZG.

Zhonghua Yi Xue Za Zhi. 2010 Sep 28;90(36):2536-40. Chinese.

PMID:
21092458
19.

The diagnostic value of zinc transporter 8 autoantibody (ZnT8A) for type 1 diabetes in Chinese.

Yang L, Luo S, Huang G, Peng J, Li X, Yan X, Lin J, Wenzlau JM, Davidson HW, Hutton JC, Zhou Z.

Diabetes Metab Res Rev. 2010 Oct;26(7):579-84. doi: 10.1002/dmrr.1128.

20.

Kinetics of the post-onset decline in zinc transporter 8 autoantibodies in type 1 diabetic human subjects.

Wenzlau JM, Walter M, Gardner TJ, Frisch LM, Yu L, Eisenbarth GS, Ziegler AG, Davidson HW, Hutton JC.

J Clin Endocrinol Metab. 2010 Oct;95(10):4712-9. doi: 10.1210/jc.2010-0169. Epub 2010 Jul 7.

21.

Getting beta all the time: discovery of reliable markers of beta cell mass.

Hutton JC, Davidson HW.

Diabetologia. 2010 Jul;53(7):1254-7. doi: 10.1007/s00125-010-1762-4. Epub 2010 Apr 22. No abstract available.

PMID:
20411233
22.

Cytokine-induced dicing and splicing in the beta-cell and the immune response in type 1 diabetes.

Hutton JC, Davidson HW.

Diabetes. 2010 Feb;59(2):335-6. doi: 10.2337/db09-1767. No abstract available.

23.

Cytokine-mediated induction of anti-apoptotic genes that are linked to nuclear factor kappa-B (NF-kappaB) signalling in human islets and in a mouse beta cell line.

Sarkar SA, Kutlu B, Velmurugan K, Kizaka-Kondoh S, Lee CE, Wong R, Valentine A, Davidson HW, Hutton JC, Pugazhenthi S.

Diabetologia. 2009 Jun;52(6):1092-101. doi: 10.1007/s00125-009-1331-x. Epub 2009 Apr 3.

PMID:
19343319
24.

Novel antigens in type 1 diabetes: the importance of ZnT8.

Wenzlau JM, Frisch LM, Gardner TJ, Sarkar S, Hutton JC, Davidson HW.

Curr Diab Rep. 2009 Apr;9(2):105-12. Review.

PMID:
19323954
25.

Isolation of dense core secretory vesicles from pancreatic endocrine cells by differential and density gradient centrifugation.

Hutton JC, Wong R, Davidson HW.

Curr Protoc Cell Biol. 2009 Mar;Chapter 3:Unit 3.32. doi: 10.1002/0471143030.cb0332s42.

PMID:
19283733
26.

SlC30A8 is a major target of humoral autoimmunity in type 1 diabetes and a predictive marker in prediabetes.

Wenzlau JM, Moua O, Sarkar SA, Yu L, Rewers M, Eisenbarth GS, Davidson HW, Hutton JC.

Ann N Y Acad Sci. 2008 Dec;1150:256-9. doi: 10.1196/annals.1447.029.

PMID:
19120307
27.

Identification of a major humoral epitope in Slc30A8 (ZnT8).

Wenzlau JM, Moua O, Liu Y, Eisenbarth GS, Hutton JC, Davidson HW.

Ann N Y Acad Sci. 2008 Dec;1150:252-5. doi: 10.1196/annals.1447.028.

PMID:
19120306
28.

Conserved epitopes in the protein tyrosine phosphatase family of diabetes autoantigens.

Liu Y, Wenzlau JM, Yu L, Patel C, Eisenbarth GS, Hutton JC, Davidson HW.

Ann N Y Acad Sci. 2008 Dec;1150:245-7. doi: 10.1196/annals.1447.035.

PMID:
19120304
29.

Association between anti-ZnT8 autoantibody specificities and SLC30A8 Arg325Trp variant in Japanese patients with type 1 diabetes.

Kawasaki E, Uga M, Nakamura K, Kuriya G, Satoh T, Fujishima K, Ozaki M, Abiru N, Yamasaki H, Wenzlau JM, Davidson HW, Hutton JC, Eguchi K.

Diabetologia. 2008 Dec;51(12):2299-302. doi: 10.1007/s00125-008-1165-y. Epub 2008 Oct 11.

PMID:
18850084
30.

New antigenic targets in type 1 diabetes.

Wenzlau JM, Hutton JC, Davidson HW.

Curr Opin Endocrinol Diabetes Obes. 2008 Aug;15(4):315-20. doi: 10.1097/MED.0b013e328308192b. Review.

PMID:
18594270
31.

A common nonsynonymous single nucleotide polymorphism in the SLC30A8 gene determines ZnT8 autoantibody specificity in type 1 diabetes.

Wenzlau JM, Liu Y, Yu L, Moua O, Fowler KT, Rangasamy S, Walters J, Eisenbarth GS, Davidson HW, Hutton JC.

Diabetes. 2008 Oct;57(10):2693-7. doi: 10.2337/db08-0522. Epub 2008 Jun 30.

32.

The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes.

Wenzlau JM, Juhl K, Yu L, Moua O, Sarkar SA, Gottlieb P, Rewers M, Eisenbarth GS, Jensen J, Davidson HW, Hutton JC.

Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17040-5. Epub 2007 Oct 17.

33.

Induction of indoleamine 2,3-dioxygenase by interferon-gamma in human islets.

Sarkar SA, Wong R, Hackl SI, Moua O, Gill RG, Wiseman A, Davidson HW, Hutton JC.

Diabetes. 2007 Jan;56(1):72-9.

34.

An extended tyrosine-targeting motif for endocytosis and recycling of the dense-core vesicle membrane protein phogrin.

Wasmeier C, Burgos PV, Trudeau T, Davidson HW, Hutton JC.

Traffic. 2005 Jun;6(6):474-87.

35.
36.

(Pro)Insulin processing: a historical perspective.

Davidson HW.

Cell Biochem Biophys. 2004;40(3 Suppl):143-58. Review.

PMID:
15289650
37.

HLA-DQ8-associated T cell responses to the diabetes autoantigen phogrin (IA-2 beta) in human prediabetes.

Kelemen K, Gottlieb PA, Putnam AL, Davidson HW, Wegmann DR, Hutton JC.

J Immunol. 2004 Mar 15;172(6):3955-62.

38.

Role of 3-phosphoinositides in the maturation of Salmonella-containing vacuoles within host cells.

Scott CC, Cuellar-Mata P, Matsuo T, Davidson HW, Grinstein S.

J Biol Chem. 2002 Apr 12;277(15):12770-6. Epub 2002 Jan 30.

39.

Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation.

Vieira OV, Botelho RJ, Rameh L, Brachmann SM, Matsuo T, Davidson HW, Schreiber A, Backer JM, Cantley LC, Grinstein S.

J Cell Biol. 2001 Oct 1;155(1):19-25.

40.

In vitro assays of vesicular transport.

Cook NR, Davidson HW.

Traffic. 2001 Jan;2(1):19-25. Review.

41.

Overexpression of a rat kinase-deficient phosphoinositide 3-kinase, Vps34p, inhibits cathepsin D maturation.

Row PE, Reaves BJ, Domin J, Luzio JP, Davidson HW.

Biochem J. 2001 Feb 1;353(Pt 3):655-61.

42.
44.

Phosphoinositide 3-kinases and membrane traffic.

Shepherd PR, Reaves BJ, Davidson HW.

Trends Cell Biol. 1996 Mar;6(3):92-7.

PMID:
15157484
46.

Rab1 and Ca2+ are required for the fusion of carrier vesicles mediating endoplasmic reticulum to Golgi transport.

Pind SN, Nuoffer C, McCaffery JM, Plutner H, Davidson HW, Farquhar MG, Balch WE.

J Cell Biol. 1994 Apr;125(2):239-52.

47.

A GDP-bound of rab1 inhibits protein export from the endoplasmic reticulum and transport between Golgi compartments.

Nuoffer C, Davidson HW, Matteson J, Meinkoth J, Balch WE.

J Cell Biol. 1994 Apr;125(2):225-37.

48.
50.

Evidence for the regulation of exocytic transport by protein phosphorylation.

Davidson HW, McGowan CH, Balch WE.

J Cell Biol. 1992 Mar;116(6):1343-55.

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