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Analysis of Cellular DNA Content by Flow Cytometry.

Darzynkiewicz Z, Huang X, Zhao H.

Curr Protoc Immunol. 2017 Nov 1;119:5.7.1-5.7.20. doi: 10.1002/cpim.36.


Analysis of Cellular DNA Content by Flow Cytometry.

Darzynkiewicz Z, Huang X, Zhao H.

Curr Protoc Cytom. 2017 Oct 2;82:7.5.1-7.5.20. doi: 10.1002/cpcy.28.


Nuclear Gene 33/Mig6 regulates the DNA damage response through an ATM serine/threonine kinase-dependent mechanism.

Li C, Park S, Zhang X, Eisenberg LM, Zhao H, Darzynkiewicz Z, Xu D.

J Biol Chem. 2017 Oct 6;292(40):16746-16759. doi: 10.1074/jbc.M117.803338. Epub 2017 Aug 25.


Rapid Detection of DNA Strand Breaks in Apoptotic Cells by Flow- and Image-Cytometry.

Zhao H, Darzynkiewicz Z.

Methods Mol Biol. 2017;1644:139-149. doi: 10.1007/978-1-4939-7187-9_12.


Fluorochrome-Labeled Inhibitors of Caspases: Expedient In Vitro and In Vivo Markers of Apoptotic Cells for Rapid Cytometric Analysis.

Darzynkiewicz Z, Zhao H, Dorota Halicka H, Pozarowski P, Lee B.

Methods Mol Biol. 2017;1644:61-73. doi: 10.1007/978-1-4939-7187-9_5.


ATM Activation and H2AX Phosphorylation Induced by Genotoxic Agents Assessed by Flow- and Laser Scanning Cytometry.

Zhao H, Halicka HD, Garcia J, Li J, Darzynkiewicz Z.

Methods Mol Biol. 2017;1599:183-196. doi: 10.1007/978-1-4939-6955-5_14.


Of Cytometry, Stem Cells and Fountain of Youth.

Galkowski D, Ratajczak MZ, Kocki J, Darzynkiewicz Z.

Stem Cell Rev. 2017 Aug;13(4):465-481. doi: 10.1007/s12015-017-9733-5. Review.


Instructive Role of the Microenvironment in Preventing Renal Fibrosis.

Matsumoto K, Xavier S, Chen J, Kida Y, Lipphardt M, Ikeda R, Gevertz A, Caviris M, Hatzopoulos AK, Kalajzic I, Dutton J, Ratliff BB, Zhao H, Darzynkiewicz Z, Rose-John S, Goligorsky MS.

Stem Cells Transl Med. 2017 Mar;6(3):992-1005. doi: 10.5966/sctm.2016-0095. Epub 2016 Oct 5.


Prolonged Growth Hormone/Insulin/Insulin-like Growth Factor Nutrient Response Signaling Pathway as a Silent Killer of Stem Cells and a Culprit in Aging.

Ratajczak MZ, Bartke A, Darzynkiewicz Z.

Stem Cell Rev. 2017 Aug;13(4):443-453. doi: 10.1007/s12015-017-9728-2. Review.


microRNA-494 and ATF3 the targets of onconase(?).

Darzynkiewicz Z.

Oncotarget. 2017 Feb 14;8(7):10769-10770. doi: 10.18632/oncotarget.13799. No abstract available.


DNA Damage Response Resulting from Replication Stress Induced by Synchronization of Cells by Inhibitors of DNA Replication: Analysis by Flow Cytometry.

Halicka D, Zhao H, Li J, Garcia J, Podhorecka M, Darzynkiewicz Z.

Methods Mol Biol. 2017;1524:107-119.


Synergy of 2-deoxy-D-glucose combined with berberine in inducing the lysosome/autophagy and transglutaminase activation-facilitated apoptosis.

Halicka HD, Garcia J, Li J, Zhao H, Darzynkiewicz Z.

Apoptosis. 2017 Feb;22(2):229-238. doi: 10.1007/s10495-016-1315-5.


Low level phosphorylation of histone H2AX on serine 139 (γH2AX) is not associated with DNA double-strand breaks.

Rybak P, Hoang A, Bujnowicz L, Bernas T, Berniak K, Zarębski M, Darzynkiewicz Z, Dobrucki J.

Oncotarget. 2016 Aug 2;7(31):49574-49587. doi: 10.18632/oncotarget.10411.


Epoxyeicosatrienoic Acids Regulate Adipocyte Differentiation of Mouse 3T3 Cells, Via PGC-1α Activation, Which Is Required for HO-1 Expression and Increased Mitochondrial Function.

Waldman M, Bellner L, Vanella L, Schragenheim J, Sodhi K, Singh SP, Lin D, Lakhkar A, Li J, Hochhauser E, Arad M, Darzynkiewicz Z, Kappas A, Abraham NG.

Stem Cells Dev. 2016 Jul 15;25(14):1084-94. doi: 10.1089/scd.2016.0072. Epub 2016 Jun 27.


How Diet Intervention via Modulation of DNA Damage Response through MicroRNAs May Have an Effect on Cancer Prevention and Aging, an in Silico Study.

Carotenuto F, Albertini MC, Coletti D, Vilmercati A, Campanella L, Darzynkiewicz Z, Teodori L.

Int J Mol Sci. 2016 May 19;17(5). pii: E752. doi: 10.3390/ijms17050752. Review.


Assessment of red blood cell distribution width as a prognostic marker in chronic lymphocytic leukemia.

Podhorecka M, Halicka D, Szymczyk A, Macheta A, Chocholska S, Hus M, Darzynkiewicz Z.

Oncotarget. 2016 May 31;7(22):32846-53. doi: 10.18632/oncotarget.9055.


Subnuclear localization, rates and effectiveness of UVC-induced unscheduled DNA synthesis visualized by fluorescence widefield, confocal and super-resolution microscopy.

Pierzyńska-Mach A, Szczurek A, Cella Zanacchi F, Pennacchietti F, Drukała J, Diaspro A, Cremer C, Darzynkiewicz Z, Dobrucki JW.

Cell Cycle. 2016;15(8):1156-67. doi: 10.1080/15384101.2016.1158377.


Gene 33/Mig6 inhibits hexavalent chromium-induced DNA damage and cell transformation in human lung epithelial cells.

Park S, Li C, Zhao H, Darzynkiewicz Z, Xu D.

Oncotarget. 2016 Feb 23;7(8):8916-30. doi: 10.18632/oncotarget.6866.


Hyperactive ERK and persistent mTOR signaling characterize vemurafenib resistance in papillary thyroid cancer cells.

Hanly EK, Tuli NY, Bednarczyk RB, Suriano R, Geliebter J, Moscatello AL, Darzynkiewicz Z, Tiwari RK.

Oncotarget. 2016 Feb 23;7(8):8676-87. doi: 10.18632/oncotarget.6779.


Rapid and simple detection of gero-suppressive agents.

Darzynkiewicz Z.

Oncotarget. 2015 Sep 15;6(27):23050-1. No abstract available.


mTOR inhibitors sensitize thyroid cancer cells to cytotoxic effect of vemurafenib.

Hanly EK, Bednarczyk RB, Tuli NY, Moscatello AL, Halicka HD, Li J, Geliebter J, Darzynkiewicz Z, Tiwari RK.

Oncotarget. 2015 Nov 24;6(37):39702-13. doi: 10.18632/oncotarget.4052.


Effect of different N7 substitution of dinucleotide cap analogs on the hydrolytic susceptibility towards scavenger decapping enzymes (DcpS).

Piecyk K, Darzynkiewicz ZM, Jankowska-Anyszka M, Ferenc-Mrozek A, Stepinski J, Darzynkiewicz E, Bojarska E.

Biochem Biophys Res Commun. 2015 Aug 14;464(1):89-93. doi: 10.1016/j.bbrc.2015.06.001. Epub 2015 Jun 4.


Biguanides and targeted anti-cancer treatments.

Hanly EK, Darzynkiewicz Z, Tiwari RK.

Genes Cancer. 2015 Mar;6(3-4):82-3. No abstract available.


Expression of the p12 subunit of human DNA polymerase δ (Pol δ), CDK inhibitor p21(WAF1), Cdt1, cyclin A, PCNA and Ki-67 in relation to DNA replication in individual cells.

Zhao H, Zhang S, Xu D, Lee MY, Zhang Z, Lee EY, Darzynkiewicz Z.

Cell Cycle. 2014;13(22):3529-40. doi: 10.4161/15384101.2014.958910.


Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes.

Kowalska J, Wypijewska del Nogal A, Darzynkiewicz ZM, Buck J, Nicola C, Kuhn AN, Lukaszewicz M, Zuberek J, Strenkowska M, Ziemniak M, Maciejczyk M, Bojarska E, Rhoads RE, Darzynkiewicz E, Sahin U, Jemielity J.

Nucleic Acids Res. 2014;42(16):10245-64. doi: 10.1093/nar/gku757. Epub 2014 Aug 22.


Attenuation of replication stress-induced premature cellular senescence to assess anti-aging modalities.

Zhao H, Darzynkiewicz Z.

Curr Protoc Cytom. 2014 Jul 1;69:9.47.1-9.47.10. doi: 10.1002/0471142956.cy0947s69.


Different rates of DNA replication at early versus late S-phase sections: multiscale modeling of stochastic events related to DNA content/EdU (5-ethynyl-2'deoxyuridine) incorporation distributions.

Li B, Zhao H, Rybak P, Dobrucki JW, Darzynkiewicz Z, Kimmel M.

Cytometry A. 2014 Sep;85(9):785-97. doi: 10.1002/cyto.a.22484. Epub 2014 Jun 3.


Cytotoxic activity of the amphibian ribonucleases onconase and r-amphinase on tumor cells from B cell lymphoproliferative disorders.

Smolewski P, Witkowska M, Zwolinska M, Cebula-Obrzut B, Majchrzak A, Jeske A, Darzynkiewicz Z, Ardelt W, Ardelt B, Robak T.

Int J Oncol. 2014 Jul;45(1):419-25. doi: 10.3892/ijo.2014.2405. Epub 2014 Apr 28.


In search of antiaging modalities: evaluation of mTOR- and ROS/DNA damage-signaling by cytometry.

Darzynkiewicz Z, Zhao H, Halicka HD, Li J, Lee YS, Hsieh TC, Wu JM.

Cytometry A. 2014 May;85(5):386-99. doi: 10.1002/cyto.a.22452. Epub 2014 Feb 22. Review.


Disruption of mutated BRAF signaling modulates thyroid cancer phenotype.

Hanly EK, Rajoria S, Darzynkiewicz Z, Zhao H, Suriano R, Tuli N, George AL, Bednarczyk R, Shin EJ, Geliebter J, Tiwari RK.

BMC Res Notes. 2014 Mar 28;7:187. doi: 10.1186/1756-0500-7-187.


Multivariate analysis of apoptotic markers versus cell cycle phase in living human cancer cells by microfluidic cytometry.

Akagi J, Skommer J, Matuszek A, Takeda K, Fujimura Y, Khoshmanesh K, Kalantar-Zadeh K, Mitchell A, Errington R, Smith PJ, Darzynkiewicz Z, Wlodkowic D.

Proc SPIE Int Soc Opt Eng. 2013 Mar 9;8615. doi: 10.1117/12.2001474.


In vitro cytotoxicity of ranpirnase (onconase) in combination with components of R-CHOP regimen against diffuse large B cell lymphoma (DLBCL) cell line.

Majchrzak A, Witkowska M, Mędra A, Zwolińska M, Bogusz J, Cebula-Obrzut B, Darzynkiewicz Z, Robak T, Smolewski P.

Postepy Hig Med Dosw (Online). 2013 Dec 2;67:1166-72.


NFAT5 is protective against ischemic acute kidney injury.

Hao S, Bellner L, Zhao H, Ratliff BB, Darzynkiewicz Z, Vio CP, Ferreri NR.

Hypertension. 2014 Mar;63(3):e46-52. doi: 10.1161/HYPERTENSIONAHA.113.02476. Epub 2013 Dec 30.


The tail that wags the dog: p12, the smallest subunit of DNA polymerase δ, is degraded by ubiquitin ligases in response to DNA damage and during cell cycle progression.

Lee MY, Zhang S, Lin SH, Wang X, Darzynkiewicz Z, Zhang Z, Lee EY.

Cell Cycle. 2014;13(1):23-31. doi: 10.4161/cc.27407. Epub 2013 Dec 3.


Myron Melamed, 1927-2013.

Darzynkiewicz Z, Kamentsky L, Holden E.

Cytometry A. 2013 Dec;83(12):1047-50. doi: 10.1002/cyto.a.22413. No abstract available.


DNA damage signaling, impairment of cell cycle progression, and apoptosis triggered by 5-ethynyl-2'-deoxyuridine incorporated into DNA.

Zhao H, Halicka HD, Li J, Biela E, Berniak K, Dobrucki J, Darzynkiewicz Z.

Cytometry A. 2013 Nov;83(11):979-88. doi: 10.1002/cyto.a.22396. Epub 2013 Sep 30.


PDIP38 is translocated to the spliceosomes/nuclear speckles in response to UV-induced DNA damage and is required for UV-induced alternative splicing of MDM2.

Wong A, Zhang S, Mordue D, Wu JM, Zhang Z, Darzynkiewicz Z, Lee EY, Lee MY.

Cell Cycle. 2013 Oct 1;12(19):3184-93. doi: 10.4161/cc.26221. Epub 2013 Sep 3.


Berberine suppresses gero-conversion from cell cycle arrest to senescence.

Zhao H, Halicka HD, Li J, Darzynkiewicz Z.

Aging (Albany NY). 2013 Aug;5(8):623-36.


New insights into cell cycle and DNA damage response machineries through high-resolution AMICO quantitative imaging cytometry.

Tarnok A, Darzynkiewicz Z.

Cell Prolif. 2013 Oct;46(5):497-500. doi: 10.1111/cpr.12050. Epub 2013 Aug 17.


A novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase δ in response to DNA damage and during the S phase.

Zhang S, Zhao H, Darzynkiewicz Z, Zhou P, Zhang Z, Lee EY, Lee MY.

J Biol Chem. 2013 Oct 11;288(41):29550-61. doi: 10.1074/jbc.M113.490466. Epub 2013 Aug 2.


Analysis of spatial correlations between patterns of DNA damage response and DNA replication in nuclei of cells subjected to replication stress or oxidative damage.

Bernas T, Berniak K, Rybak P, Zarębski M, Zhao H, Darzynkiewicz Z, Dobrucki JW.

Cytometry A. 2013 Oct;83(10):925-32. doi: 10.1002/cyto.a.22325. Epub 2013 Jul 30.


Relationship between DNA damage response, initiated by camptothecin or oxidative stress, and DNA replication, analyzed by quantitative 3D image analysis.

Berniak K, Rybak P, Bernas T, Zarębski M, Biela E, Zhao H, Darzynkiewicz Z, Dobrucki JW.

Cytometry A. 2013 Oct;83(10):913-24. doi: 10.1002/cyto.a.22327. Epub 2013 Jul 11.


Kinetic viability assays using DRAQ7 probe.

Wlodkowic D, Akagi J, Dobrucki J, Errington R, Smith PJ, Takeda K, Darzynkiewicz Z.

Curr Protoc Cytom. 2013 Jul;Chapter 9:Unit 9.41. doi: 10.1002/0471142956.cy0941s65.


Perturbation of nucleotide metabolism--the driving force of oncogene-induced senescence.

Darzynkiewicz Z.

Oncotarget. 2013 May;4(5):649-50. No abstract available.


Col-F, a fluorescent probe for ex vivo confocal imaging of collagen and elastin in animal tissues.

Biela E, Galas J, Lee B, Johnson GL, Darzynkiewicz Z, Dobrucki JW.

Cytometry A. 2013 Jun;83(6):533-9. doi: 10.1002/cyto.a.22264. Epub 2013 Feb 12.


Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling.

Halicka HD, Zhao H, Li J, Lee YS, Hsieh TC, Wu JM, Darzynkiewicz Z.

Aging (Albany NY). 2012 Dec;4(12):952-65.


Biomarkers of cell senescence assessed by imaging cytometry.

Zhao H, Darzynkiewicz Z.

Methods Mol Biol. 2013;965:83-92. doi: 10.1007/978-1-62703-239-1_5.


Running m(o)TOR with the brakes on leads to catastrophe at mitosis.

Darzynkiewicz Z.

Cell Cycle. 2012 Dec 15;11(24):4494. doi: 10.4161/cc.22932. Epub 2012 Dec 6. No abstract available.


Real-time cell viability assays using a new anthracycline derivative DRAQ7®.

Akagi J, Kordon M, Zhao H, Matuszek A, Dobrucki J, Errington R, Smith PJ, Takeda K, Darzynkiewicz Z, Wlodkowic D.

Cytometry A. 2013 Feb;83(2):227-34. doi: 10.1002/cyto.a.22228. Epub 2012 Nov 16.

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