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Items: 1 to 50 of 59

1.

Mechanism of action of the atypical retinoid ST1926 in colorectal cancer: DNA damage and DNA polymerase α.

Abdel-Samad R, Aouad P, Gali-Muhtasib H, Sweidan Z, Hmadi R, Kadara H, D'Andrea EL, Fucci A, Pisano C, Darwiche N.

Am J Cancer Res. 2018 Jan 1;8(1):39-55. eCollection 2018.

2.

Genome-wide gene expression changes in the normal-appearing airway during the evolution of smoking-associated lung adenocarcinoma.

Kantrowitz J, Sinjab A, Xu L, McDowell TL, Sivakumar S, Lang W, Nunomura-Nakamura S, Fukuoka J, Nemer G, Darwiche N, Chami H, Tfayli A, Wistuba II, Scheet P, Fujimoto J, Spira AE, Kadara H.

Cancer Prev Res (Phila). 2018 Jan 30. pii: canprevres.0295.2017. doi: 10.1158/1940-6207.CAPR-17-0295. [Epub ahead of print]

PMID:
29382653
3.

Antitumor activity of the synthetic retinoid ST1926 on primary effusion lymphoma in vitro and in vivo models.

Karam L, Houshaymi B, Abdel-Samad R, Jaafar M, Halloum I, Pisano C, Neipel F, Darwiche N, Abou Merhi R.

Oncol Rep. 2018 Feb;39(2):721-730. doi: 10.3892/or.2017.6137. Epub 2017 Dec 5.

PMID:
29207182
4.

Antitumor Effect of the Atypical Retinoid ST1926 in Acute Myeloid Leukemia and Nanoparticle Formulation Prolongs Lifespan and Reduces Tumor Burden of Xenograft Mice.

El-Houjeiri L, Saad W, Hayar B, Aouad P, Tawil N, Abdel-Samad R, Hleihel R, Hamie M, Mancinelli A, Pisano C, El Hajj H, Darwiche N.

Mol Cancer Ther. 2017 Oct;16(10):2047-2057. doi: 10.1158/1535-7163.MCT-16-0785. Epub 2017 Jun 15.

PMID:
28619754
5.

Antitumor activities of the synthetic retinoid ST1926 in two-dimensional and three-dimensional human breast cancer models.

Aouad P, Saikali M, Abdel-Samad R, Fostok S, El-Houjeiri L, Pisano C, Talhouk R, Darwiche N.

Anticancer Drugs. 2017 Aug;28(7):757-770. doi: 10.1097/CAD.0000000000000511.

PMID:
28471809
6.

Retinoids: a journey from the molecular structures and mechanisms of action to clinical uses in dermatology and adverse effects.

Khalil S, Bardawil T, Stephan C, Darwiche N, Abbas O, Kibbi AG, Nemer G, Kurban M.

J Dermatolog Treat. 2017 Dec;28(8):684-696. doi: 10.1080/09546634.2017.1309349. Epub 2017 Apr 2.

PMID:
28318351
7.

The synthetic retinoid ST1926 as a novel therapeutic agent in rhabdomyosarcoma.

Basma H, Ghayad SE, Rammal G, Mancinelli A, Harajly M, Ghamloush F, Dweik L, El-Eit R, Zalzali H, Rabeh W, Pisano C, Darwiche N, Saab R.

Int J Cancer. 2016 Mar 15;138(6):1528-37. doi: 10.1002/ijc.29886. Epub 2015 Oct 22.

8.

Cell death mechanisms of plant-derived anticancer drugs: beyond apoptosis.

Gali-Muhtasib H, Hmadi R, Kareh M, Tohme R, Darwiche N.

Apoptosis. 2015 Dec;20(12):1531-62. doi: 10.1007/s10495-015-1169-2. Review.

PMID:
26362468
9.

Retinoic acid and arsenic trioxide trigger degradation of mutated NPM1, resulting in apoptosis of AML cells.

El Hajj H, Dassouki Z, Berthier C, Raffoux E, Ades L, Legrand O, Hleihel R, Sahin U, Tawil N, Salameh A, Zibara K, Darwiche N, Mohty M, Dombret H, Fenaux P, de Thé H, Bazarbachi A.

Blood. 2015 May 28;125(22):3447-54. doi: 10.1182/blood-2014-11-612416. Epub 2015 Mar 23.

10.

Identification of several mutations in ATP2C1 in Lebanese families: insight into the pathogenesis of Hailey-Hailey disease.

Btadini W, Abou Hassan OK, Saadeh D, Abbas O, Ballout F, Kibbi AG, Dbaibo G, Darwiche N, Nemer G, Kurban M.

PLoS One. 2015 Feb 6;10(2):e0115530. doi: 10.1371/journal.pone.0115530. eCollection 2015.

11.

ST1926, an orally active synthetic retinoid, induces apoptosis in chronic myeloid leukemia cells and prolongs survival in a murine model.

Nasr RR, Hmadi RA, El-Eit RM, Iskandarani AN, Jabbour MN, Zaatari GS, Mahon FX, Pisano CC, Darwiche ND.

Int J Cancer. 2015 Aug 1;137(3):698-709. doi: 10.1002/ijc.29407. Epub 2015 Jan 21.

12.

Preclinical efficacy of the synthetic retinoid ST1926 for treating adult T-cell leukemia/lymphoma.

El Hajj H, Khalil B, Ghandour B, Nasr R, Shahine S, Ghantous A, Abdel-Samad R, Sinjab A, Hasegawa H, Jabbour M, Hall WW, Zaatari G, Dbaibo G, Pisano C, Bazarbachi A, Darwiche N.

Blood. 2014 Sep 25;124(13):2072-80. doi: 10.1182/blood-2014-03-560060. Epub 2014 Jul 17.

13.

Differential growth inhibitory effects of highly oxygenated guaianolides isolated from the Middle Eastern indigenous plant Achillea falcata in HCT-116 colorectal cancer cells.

Tohme R, Al Aaraj L, Ghaddar T, Gali-Muhtasib H, Saliba NA, Darwiche N.

Molecules. 2013 Jul 15;18(7):8275-88. doi: 10.3390/molecules18078275.

14.

Hollow-fiber membrane bioreactor for the treatment of high-strength landfill leachate.

Rizkallah M, El-Fadel M, Saikaly PE, Ayoub GM, Darwiche N, Hashisho J.

Waste Manag Res. 2013 Oct;31(10):1041-51. doi: 10.1177/0734242X13497075. Epub 2013 Jul 15.

PMID:
23856789
15.

Parthenolide: from plant shoots to cancer roots.

Ghantous A, Sinjab A, Herceg Z, Darwiche N.

Drug Discov Today. 2013 Sep;18(17-18):894-905. doi: 10.1016/j.drudis.2013.05.005. Epub 2013 May 17. Review.

PMID:
23688583
16.

Inhibition of tumor promotion by parthenolide: epigenetic modulation of p21.

Ghantous A, Saikali M, Rau T, Gali-Muhtasib H, Schneider-Stock R, Darwiche N.

Cancer Prev Res (Phila). 2012 Nov;5(11):1298-309. doi: 10.1158/1940-6207.CAPR-12-0230. Epub 2012 Oct 4.

17.

Synergistic anticancer activities of the plant-derived sesquiterpene lactones salograviolide A and iso-seco-tanapartholide.

Salla M, Fakhoury I, Saliba N, Darwiche N, Gali-Muhtasib H.

J Nat Med. 2013 Jul;67(3):468-79. doi: 10.1007/s11418-012-0703-6. Epub 2012 Sep 14.

PMID:
22976170
18.

Sesquiterpene lactones isolated from indigenous Middle Eastern plants inhibit tumor promoter-induced transformation of JB6 cells.

Saikali M, Ghantous A, Halawi R, Talhouk SN, Saliba NA, Darwiche N.

BMC Complement Altern Med. 2012 Jul 9;12:89. doi: 10.1186/1472-6882-12-89.

19.

Epigenetic mechanisms of plant-derived anticancer drugs.

Schneider-Stock R, Ghantous A, Bajbouj K, Saikali M, Darwiche N.

Front Biosci (Landmark Ed). 2012 Jan 1;17:129-73. Review.

PMID:
22201736
20.

A journey under the sea: the quest for marine anti-cancer alkaloids.

Tohme R, Darwiche N, Gali-Muhtasib H.

Molecules. 2011 Nov 23;16(11):9665-96. doi: 10.3390/molecules16119665. Review.

21.

Inhibition of mammalian target of rapamycin signaling by everolimus induces senescence in adult T-cell leukemia/lymphoma and apoptosis in peripheral T-cell lymphomas.

Darwiche N, Sinjab A, Abou-Lteif G, Chedid MB, Hermine O, Dbaibo G, Bazarbachi A.

Int J Cancer. 2011 Aug 15;129(4):993-1004. doi: 10.1002/ijc.25742. Epub 2010 Dec 9.

22.

What made sesquiterpene lactones reach cancer clinical trials?

Ghantous A, Gali-Muhtasib H, Vuorela H, Saliba NA, Darwiche N.

Drug Discov Today. 2010 Aug;15(15-16):668-78. doi: 10.1016/j.drudis.2010.06.002. Epub 2010 Jun 9. Review.

PMID:
20541036
23.

Structure-activity relationship of seco-tanapartholides isolated from Achillea falcata for inhibition of HaCaT cell growth.

Ghantous A, Nasser N, Saab I, Darwiche N, Saliba NA.

Eur J Med Chem. 2009 Sep;44(9):3794-7. doi: 10.1016/j.ejmech.2009.04.029. Epub 2009 May 4.

PMID:
19464086
24.

Purified salograviolide A isolated from centaurea ainetensis causes growth inhibition and apoptosis in neoplastic epidermal cells.

Ghantous A, Tayyoun AA, Lteif GA, Saliba NA, Gali-Muhtasib H, El-Sabban M, Darwiche N.

Int J Oncol. 2008 Apr;32(4):841-9.

PMID:
18360711
25.

Anti-colon cancer effects of Salograviolide A isolated from Centaurea ainetensis.

El-Najjar N, Dakdouki S, Darwiche N, El-Sabban M, Saliba NA, Gali-Muhtasib H.

Oncol Rep. 2008 Apr;19(4):897-904.

PMID:
18357373
26.

Arsenic trioxide induces accumulation of cytotoxic levels of ceramide in acute promyelocytic leukemia and adult T-cell leukemia/lymphoma cells through de novo ceramide synthesis and inhibition of glucosylceramide synthase activity.

Dbaibo GS, Kfoury Y, Darwiche N, Panjarian S, Kozhaya L, Nasr R, Abdallah M, Hermine O, El-Sabban M, de Thé H, Bazarbachi A.

Haematologica. 2007 Jun;92(6):753-62.

27.

The high-risk benign tumor: evidence from the two-stage skin cancer model and relevance for human cancer.

Glick A, Ryscavage A, Perez-Lorenzo R, Hennings H, Yuspa S, Darwiche N.

Mol Carcinog. 2007 Aug;46(8):605-10. Review.

PMID:
17538943
28.

Expression profile of skin papillomas with high cancer risk displays a unique genetic signature that clusters with squamous cell carcinomas and predicts risk for malignant conversion.

Darwiche N, Ryscavage A, Perez-Lorenzo R, Wright L, Bae DS, Hennings H, Yuspa SH, Glick AB.

Oncogene. 2007 Oct 18;26(48):6885-95. Epub 2007 May 21.

PMID:
17525749
29.

Cell cycle modulatory and apoptotic effects of plant-derived anticancer drugs in clinical use or development.

Darwiche N, El-Banna S, Gali-Muhtasib H.

Expert Opin Drug Discov. 2007 Mar;2(3):361-79. doi: 10.1517/17460441.2.3.361.

PMID:
23484647
30.
31.

Human T-cell lymphotropic virus type I-transformed T-cells have a partial defect in ceramide synthesis in response to N-(4-hydroxyphenyl)retinamide.

Darwiche N, Abou-Lteif G, Najdi T, Kozhaya L, Tayoun AA, Bazarbachi A, Dbaibo GS.

Biochem J. 2005 Nov 15;392(Pt 1):231-9. Erratum in: Biochem J. 2012 Jun 15;444(3):619. Abou Tayyoun, Ahmad [corrected to Tayoun, Ahmad Abou].

32.

Regulation of ultraviolet B radiation-mediated activation of AP1 signaling by retinoids in primary keratinocytes.

Darwiche N, Bazzi H, El-Touni L, Abou-Lteif G, Doueiri R, Hatoum A, Maalouf S, Gali-Muhtasib H.

Radiat Res. 2005 Mar;163(3):296-306.

PMID:
15733037
33.

Potential trisomy 21 misdiagnosis by amniocentesis due to a resorbed twin.

Zahed L, Oreibi G, Darwiche N, Mitri F.

Prenat Diagn. 2004 Dec 15;24(12):1013. No abstract available.

PMID:
15612060
34.

Stage-specific effect of N-(4-hydroxyphenyl)retinamide on cell growth in squamous cell carcinogenesis.

Kabbout M, Hatoum A, Abou-Lteif G, Chakroun I, Homaidan FR, Darwiche N.

Mol Carcinog. 2004 May;40(1):12-23.

PMID:
15108326
35.

Molecular pathway for thymoquinone-induced cell-cycle arrest and apoptosis in neoplastic keratinocytes.

Gali-Muhtasib HU, Abou Kheir WG, Kheir LA, Darwiche N, Crooks PA.

Anticancer Drugs. 2004 Apr;15(4):389-99.

PMID:
15057144
36.

N-(4-hydroxyphenyl)retinamide induces growth arrest and apoptosis in HTLV-I-transformed cells.

Darwiche N, Hatoum A, Dbaibo G, Kadara H, Nasr R, Abou-Lteif G, Bazzi R, Hermine O, de Thé H, Bazarbachi A.

Leukemia. 2004 Mar;18(3):607-15.

PMID:
14712289
37.

Homologous telomere association of 19q in a female with premature ovarian failure.

Zahed L, Darwiche N, Batanian JR, Awwad J.

Clin Genet. 2002 Oct;62(4):310-4.

PMID:
12372059
38.

Protective effect of vitamin E on ultraviolet B light-induced damage in keratinocytes.

Maalouf S, El-Sabban M, Darwiche N, Gali-Muhtasib H.

Mol Carcinog. 2002 Jul;34(3):121-30.

PMID:
12112306
39.

Constitutional chromosome abnormalities among patients referred for blood karyotype analysis: a 5-year study at the AUBMC.

Mahfouz R, al-Oreibi G, Darwiche N, el-Khechen S, Zahed L.

J Med Liban. 2001 Jan-Feb;49(1):6-12.

PMID:
11910963
40.

Overexpression of retinoic acid receptors alpha and gamma into neoplastic epidermal cells causes retinoic acid-induced growth arrest and apoptosis.

Hatoum A, El-Sabban ME, Khoury J, Yuspa SH, Darwiche N.

Carcinogenesis. 2001 Dec;22(12):1955-63.

PMID:
11751425
41.
42.

Karyotype of amniotic fluid cells at the AUB-MC results on 2000 cases.

Zahed L, al-Oreibi G, Darwiche N, el-Khechen S.

J Med Liban. 2000 May-Jun;48(3):121-6.

PMID:
11268563
43.

Evidence against a direct cytotoxic effect of alpha interferon and zidovudine in HTLV-I associated adult T cell leukemia/lymphoma.

Bazarbachi A, Nasr R, El-Sabban ME, Mahé A, Mahieux R, Gessain A, Darwiche N, Dbaibo G, Kersual J, Zermati Y, Dianoux L, Chelbi-Alix MK, de Thé H, Hermine O.

Leukemia. 2000 Apr;14(4):716-21.

PMID:
10764160
44.

Characterization of the components of the putative mammalian sister chromatid cohesion complex.

Darwiche N, Freeman LA, Strunnikov A.

Gene. 1999 Jun 11;233(1-2):39-47.

45.

Mouse Sprr2 genes: a clustered family of genes showing differential expression in epithelial tissues.

Song HJ, Poy G, Darwiche N, Lichti U, Kuroki T, Steinert PM, Kartasova T.

Genomics. 1999 Jan 1;55(1):28-42.

PMID:
9888996
46.

Topical retinoic acid reduces skin papilloma formation but resistant papillomas are at high risk for malignant conversion.

Tennenbaum T, Lowry D, Darwiche N, Morgan DL, Gartsbein M, Hansen L, De Luca LM, Hennings H, Yuspa SH.

Cancer Res. 1998 Apr 1;58(7):1435-43.

47.

Expression of a binding protein for FGF is associated with epithelial development and skin carcinogenesis.

Kurtz A, Wang HL, Darwiche N, Harris V, Wellstein A.

Oncogene. 1997 Jun 5;14(22):2671-81.

48.

Loss of retinoic acid receptors in mouse skin and skin tumors is associated with activation of the ras(Ha) oncogene and high risk for premalignant progression.

Darwiche N, Scita G, Jones C, Rutberg S, Greenwald E, Tennenbaum T, Collins SJ, De Luca LM, Yuspa SH.

Cancer Res. 1996 Nov 1;56(21):4942-9.

49.

Estrogen induces retinoid receptor expression in mouse cervical epithelia.

Celli G, Darwiche N, De Luca LM.

Exp Cell Res. 1996 Aug 1;226(2):273-82.

PMID:
8806431
50.

Retinoic acid down-regulation of fibronectin and retinoic acid receptor alpha proteins in NIH-3T3 cells. Blocks of this response by ras transformation.

Scita G, Darwiche N, Greenwald E, Rosenberg M, Politi K, De Luca LM.

J Biol Chem. 1996 Mar 15;271(11):6502-8.

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