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Items: 44

1.

Goniotomy with a single-use dual blade: Short-term results.

Greenwood MD, Seibold LK, Radcliffe NM, Dorairaj SK, Aref AA, Román JJ, Lazcano-Gomez GS, Darlington JK, Abdullah S, Jasek MC, Bahjri KA, Berdahl JP.

J Cataract Refract Surg. 2017 Sep;43(9):1197-1201. doi: 10.1016/j.jcrs.2017.06.046.

2.

Nurses' Communication of Safety Events to Nursing Home Residents and Families.

Wagner LM, Driscoll L, Darlington JL, Flores V, Kim J, Melino K, Patel HD, Spetz J.

J Gerontol Nurs. 2018 Feb 1;44(2):25-32. doi: 10.3928/00989134-20171002-01. Epub 2017 Oct 9.

PMID:
28990635
3.

Formants provide honest acoustic cues to body size in American alligators.

Reber SA, Janisch J, Torregrosa K, Darlington J, Vliet KA, Fitch WT.

Sci Rep. 2017 May 12;7(1):1816. doi: 10.1038/s41598-017-01948-1.

4.

Identification of 4-(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2).

Rowbottom MW, Bain G, Calderon I, Lasof T, Lonergan D, Lai A, Huang F, Darlington J, Prodanovich P, Santini AM, King CD, Goulet L, Shannon KE, Ma GL, Nguyen K, MacKenna DA, Evans JF, Hutchinson JH.

J Med Chem. 2017 May 25;60(10):4403-4423. doi: 10.1021/acs.jmedchem.7b00345. Epub 2017 May 15.

PMID:
28471663
5.

Small Molecule Lysyl Oxidase-like 2 (LOXL2) Inhibitors: The Identification of an Inhibitor Selective for LOXL2 over LOX.

Hutchinson JH, Rowbottom MW, Lonergan D, Darlington J, Prodanovich P, King CD, Evans JF, Bain G.

ACS Med Chem Lett. 2017 Mar 1;8(4):423-427. doi: 10.1021/acsmedchemlett.7b00014. eCollection 2017 Apr 13.

6.

Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis.

Bain G, Shannon KE, Huang F, Darlington J, Goulet L, Prodanovich P, Ma GL, Santini AM, Stein AJ, Lonergan D, King CD, Calderon I, Lai A, Hutchinson JH, Evans JF.

J Pharmacol Exp Ther. 2017 Jan;360(1):1-13. Epub 2016 Oct 17.

7.

Structural Basis for Inhibition of Human Autotaxin by Four Potent Compounds with Distinct Modes of Binding.

Stein AJ, Bain G, Prodanovich P, Santini AM, Darlington J, Stelzer NM, Sidhu RS, Schaub J, Goulet L, Lonergan D, Calderon I, Evans JF, Hutchinson JH.

Mol Pharmacol. 2015 Dec;88(6):982-92. doi: 10.1124/mol.115.100404. Epub 2015 Sep 14.

9.

Impact of co-administration of protonated nanostructured aluminum silicate (cholesterol absorption inhibitor) on the absorption of lipid soluble vitamins D3 and K1: an assessment of pharmacokinetic and in vitro intraluminal processing.

Ibrahim F, Sivak O, Wong C, Hopkins P, Midha A, Gordon J, Darlington JW, Wasan KM.

Eur J Pharm Sci. 2013 May 13;49(2):125-32. doi: 10.1016/j.ejps.2013.02.008. Epub 2013 Feb 27.

PMID:
23454011
10.

A simple and sensitive method for determination of vitamins D3 and K1 in rat plasma: application for an in vivo pharmacokinetic study.

Gershkovich P, Ibrahim F, Sivak O, Darlington JW, Wasan KM.

Drug Dev Ind Pharm. 2014 Mar;40(3):338-44. doi: 10.3109/03639045.2012.762016. Epub 2013 Feb 4.

PMID:
23373428
11.

RAPPORT: running scientific high-performance computing applications on the cloud.

Cohen J, Filippis I, Woodbridge M, Bauer D, Hong NC, Jackson M, Butcher S, Colling D, Darlington J, Fuchs B, Harvey M.

Philos Trans A Math Phys Eng Sci. 2012 Dec 10;371(1983):20120073. doi: 10.1098/rsta.2012.0073. Print 2013 Jan 28.

12.

Inhibition of cholesterol absorption: targeting the intestine.

Lee SD, Gershkovich P, Darlington JW, Wasan KM.

Pharm Res. 2012 Dec;29(12):3235-50. doi: 10.1007/s11095-012-0858-6. Epub 2012 Aug 25. Review.

PMID:
22923351
13.

5-Lipoxygenase-activating protein (FLAP) inhibitors. Part 4: development of 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid (AM803), a potent, oral, once daily FLAP inhibitor.

Stock NS, Bain G, Zunic J, Li Y, Ziff J, Roppe J, Santini A, Darlington J, Prodanovich P, King CD, Baccei C, Lee C, Rong H, Chapman C, Broadhead A, Lorrain D, Correa L, Hutchinson JH, Evans JF, Prasit P.

J Med Chem. 2011 Dec 8;54(23):8013-29. doi: 10.1021/jm2008369. Epub 2011 Nov 7.

PMID:
22059882
14.

Assessment of cholesterol absorption inhibitors nanostructured aluminosilicate and cholestyramine using in vitro lipolysis model.

Gershkovich P, Sivak O, Contreras-Whitney S, Darlington JW, Wasan KM.

J Pharm Sci. 2012 Jan;101(1):291-300. doi: 10.1002/jps.22770. Epub 2011 Sep 20.

PMID:
21935955
15.

Pharmacology of AM211, a potent and selective prostaglandin D2 receptor type 2 antagonist that is active in animal models of allergic inflammation.

Bain G, Lorrain DS, Stebbins KJ, Broadhead AR, Santini AM, Prodanovich P, Darlington J, King CD, Lee C, Baccei C, Stearns B, Troung Y, Hutchinson JH, Prasit P, Evans JF.

J Pharmacol Exp Ther. 2011 Jul;338(1):290-301. doi: 10.1124/jpet.111.180430. Epub 2011 Apr 12.

16.

Sodium [2'-[(cyclopropanecarbonyl-ethyl-amino)-methyl]-4'-(6-ethoxy-pyridin-3-yl)-6-methoxy-biphenyl-3-yl]-acetate (AM432): a potent, selective prostaglandin D2 receptor antagonist.

Stock N, Volkots D, Stebbins K, Broadhead A, Stearns B, Roppe J, Parr T, Baccei C, Bain G, Chapman C, Correa L, Darlington J, King C, Lee C, Lorrain DS, Prodanovich P, Santini A, Evans JF, Hutchinson JH, Prasit P.

Bioorg Med Chem Lett. 2011 Feb 1;21(3):1036-40. doi: 10.1016/j.bmcl.2010.12.016. Epub 2010 Dec 9.

PMID:
21211969
17.

Pharmacokinetic and pharmacodynamic characterization of an oral lysophosphatidic acid type 1 receptor-selective antagonist.

Swaney JS, Chapman C, Correa LD, Stebbins KJ, Broadhead AR, Bain G, Santini AM, Darlington J, King CD, Baccei CS, Lee C, Parr TA, Roppe JR, Seiders TJ, Ziff J, Prasit P, Hutchinson JH, Evans JF, Lorrain DS.

J Pharmacol Exp Ther. 2011 Mar;336(3):693-700. doi: 10.1124/jpet.110.175901. Epub 2010 Dec 15.

18.

Synthesis of 1,5-diarylpyrazol-3-propanoic acids towards inhibition of cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4 formation.

Ergün BC, Nuñez MT, Labeaga L, Ledo F, Darlington J, Bain G, Cakir B, Banoglu E.

Arzneimittelforschung. 2010;60(8):497-505. doi: 10.1055/s-0031-1296318.

PMID:
20863006
19.

5-Lipoxygenase-activating protein inhibitors. Part 3: 3-{3-tert-Butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM643)-A potent FLAP inhibitor suitable for topical administration.

Stock N, Baccei C, Bain G, Chapman C, Correa L, Darlington J, King C, Lee C, Lorrain DS, Prodanovich P, Santini A, Schaab K, Evans JF, Hutchinson JH, Prasit P.

Bioorg Med Chem Lett. 2010 Aug 1;20(15):4598-601. doi: 10.1016/j.bmcl.2010.06.011. Epub 2010 Jun 8.

PMID:
20566292
20.

Pharmacology of AM803, a novel selective five-lipoxygenase-activating protein (FLAP) inhibitor in rodent models of acute inflammation.

Lorrain DS, Bain G, Correa LD, Chapman C, Broadhead AR, Santini AM, Prodanovich PP, Darlington JV, Stock NS, Zunic J, King CD, Lee C, Baccei CS, Stearns B, Roppe J, Hutchinson JH, Prasit P, Evans JF.

Eur J Pharmacol. 2010 Aug 25;640(1-3):211-8. doi: 10.1016/j.ejphar.2010.05.003. Epub 2010 May 21.

PMID:
20519143
21.

5-Lipoxygenase-activating protein inhibitors. Part 2: 3-{5-((S)-1-Acetyl-2,3-dihydro-1H-indol-2-ylmethoxy)-3-tert-butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-1H-indol-2-yl}-2,2-dimethyl-propionic acid (AM679)--a potent FLAP inhibitor.

Stock N, Baccei C, Bain G, Broadhead A, Chapman C, Darlington J, King C, Lee C, Li Y, Lorrain DS, Prodanovich P, Rong H, Santini A, Zunic J, Evans JF, Hutchinson JH, Prasit P.

Bioorg Med Chem Lett. 2010 Jan 1;20(1):213-7. doi: 10.1016/j.bmcl.2009.10.131. Epub 2009 Oct 31.

PMID:
19914828
22.

Pharmacological characterization of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103), a novel selective 5-lipoxygenase-activating protein inhibitor that reduces acute and chronic inflammation.

Lorrain DS, Bain G, Correa LD, Chapman C, Broadhead AR, Santini AM, Prodanovich P, Darlington JV, Hutchinson JH, King C, Lee C, Baccei C, Li Y, Arruda JM, Evans JF.

J Pharmacol Exp Ther. 2009 Dec;331(3):1042-50. doi: 10.1124/jpet.109.158089. Epub 2009 Sep 11.

23.

5-lipoxygenase-activating protein inhibitors: development of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103).

Hutchinson JH, Li Y, Arruda JM, Baccei C, Bain G, Chapman C, Correa L, Darlington J, King CD, Lee C, Lorrain D, Prodanovich P, Rong H, Santini A, Stock N, Prasit P, Evans JF.

J Med Chem. 2009 Oct 8;52(19):5803-15. doi: 10.1021/jm900945d.

PMID:
19739647
24.
25.

Inhibition of intestinal absorption of cholesterol by surface-modified nanostructured aluminosilicate compounds.

Gershkovich P, Darlington J, Sivak O, Constantinides PP, Wasan KM.

J Pharm Sci. 2009 Jul;98(7):2390-400. doi: 10.1002/jps.21616.

PMID:
19090562
26.

EMAAS: an extensible grid-based rich internet application for microarray data analysis and management.

Barton G, Abbott J, Chiba N, Huang DW, Huang Y, Krznaric M, Mack-Smith J, Saleem A, Sherman BT, Tiwari B, Tomlinson C, Aitman T, Darlington J, Game L, Sternberg MJ, Butcher SA.

BMC Bioinformatics. 2008 Nov 25;9:493. doi: 10.1186/1471-2105-9-493.

27.

Clinicopathologic correlation of explanted AlphaCor artificial cornea after exposure of implant.

Chow CC, Kulkarni AD, Albert DM, Darlington JK, Hardten DR.

Cornea. 2007 Sep;26(8):1004-7.

PMID:
17721307
28.

Trends of penetrating keratoplasty in the United States from 1980 to 2004.

Darlington JK, Adrean SD, Schwab IR.

Ophthalmology. 2006 Dec;113(12):2171-5. Epub 2006 Sep 25.

PMID:
16996602
29.

Corneal perforation during laser blepharoplasty.

Darlington JK, Lee WB, Schwab IR.

Ophthalmic Surg Lasers Imaging. 2006 Jul-Aug;37(4):327-9.

PMID:
16898397
30.

RealityGrid: an integrated approach to middleware through ICENI.

Cohen J, McGough AS, Darlington J, Furmento N, Kong G, Mayer A.

Philos Trans A Math Phys Eng Sci. 2005 Aug 15;363(1833):1817-27.

31.

Dendritic keratopathy in ocular rosacea.

Lee WB, Darlington JK, Mannis MJ, Schwab IR.

Cornea. 2005 Jul;24(5):632-3.

PMID:
15968176
32.

Anterior keratoconus associated with unilateral cornea guttata.

Darlington JK, Mannis MJ, Segal WA.

Cornea. 2001 Nov;20(8):881-4.

PMID:
11685071
33.

Intraocular lens power calculation after laser in situ keratomileusis for myopia and hyperopia: a standardized approach.

Feiz V, Mannis MJ, Garcia-Ferrer F, Kandavel G, Darlington JK, Kim E, Caspar J, Wang JL, Wang W.

Cornea. 2001 Nov;20(8):792-7.

PMID:
11685053
34.

Making sense of refractive surgery in 2001: why, when, for whom, and by whom?

Mannis MJ, Segal WA, Darlington JK.

Mayo Clin Proc. 2001 Aug;76(8):823-9. Review.

PMID:
11499822
35.

Peripheral nonulcerative keratitis as a presenting sign of microscopic polyangiitis.

Darlington JK, Mannis MJ, Segal WA, Feiz V, Klug DE.

Cornea. 2001 Jul;20(5):522-4.

PMID:
11413410
36.

Race, ethnicity and disasters in the United States: a review of the literature.

Fothergill A, Maestas EG, Darlington JD.

Disasters. 1999 Jun;23(2):156-73. Review.

PMID:
10379098
37.

Creutzfeld-Jakob disease: what we know.

Darlington J.

Leadersh Health Serv. 1996 Nov-Dec;5(6):44-5. No abstract available.

PMID:
10163984
38.
39.

Lenticular soil mounds in the Kenya highlands.

Darlington JP.

Oecologia. 1985 Apr;66(1):116-121. doi: 10.1007/BF00378562.

PMID:
28310822
40.

Termites and atmospheric gas production.

Zimmerman PR, Greenberg JP, Darlington JP.

Science. 1984 Apr 6;224(4644):86. No abstract available.

PMID:
17783532
41.

The effect of extracellular environment on the sensitivity of two strains of Tetrahymena to gamma rays.

Gebicki JM, Darlington JL, Baumgartner S.

Int J Radiat Biol Relat Stud Phys Chem Med. 1980 Oct;38(4):473-9. No abstract available.

PMID:
6777327
42.

The biomass and distribution of organisms in Lake George, Uganda.

Burgis MJ, Darlington JP, Dunn IG, Ganf GG, Gwahaba JJ, McGowan LM.

Proc R Soc Lond B Biol Sci. 1973 Dec 18;184(1076):271-98. No abstract available.

PMID:
4148825
43.

Reflections on preprofessional advising. A challenge to AADS and the liberal arts colleges.

Darlington JM.

J Dent Educ. 1971 Jan;35(1):7-11. No abstract available.

PMID:
5278833
44.

A SIMPLE DEVICE FOR THE PERFUSION OF THE MAMMALIAN HEART.

Wilson JW, Darlington JM.

Science. 1933 Apr 14;77(1998):370-1. No abstract available.

PMID:
17770607

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