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Structure and Biological Activity of a Turripeptide from Unedogemmula bisaya Venom.

Omaga CA, Carpio LD, Imperial JS, Daly NL, Gajewiak J, Flores MS, Espino SS, Christensen S, Filchakova OM, López-Vera E, Raghuraman S, Olivera BM, Concepcion GP.

Biochemistry. 2017 Nov 14;56(45):6051-6060. doi: 10.1021/acs.biochem.7b00485. Epub 2017 Nov 1.


The Aromatic Head Group of Spider Toxin Polyamines Influences Toxicity to Cancer Cells.

Wilson D, Boyle GM, McIntyre L, Nolan MJ, Parsons PG, Smith JJ, Tribolet L, Loukas A, Liddell MJ, Rash LD, Daly NL.

Toxins (Basel). 2017 Oct 27;9(11). pii: E346. doi: 10.3390/toxins9110346.


Conotoxin Φ-MiXXVIIA from the Superfamily G2 Employs a Novel Cysteine Framework that Mimics Granulin and Displays Anti-Apoptotic Activity.

Jin AH, Dekan Z, Smout MJ, Wilson D, Dutertre S, Vetter I, Lewis RJ, Loukas A, Daly NL, Alewood PF.

Angew Chem Int Ed Engl. 2017 Nov 20;56(47):14973-14976. doi: 10.1002/anie.201708927. Epub 2017 Oct 24.


An engineered cyclic peptide alleviates symptoms of inflammation in a murine model of inflammatory bowel disease.

Cobos Caceres C, Bansal PS, Navarro S, Wilson D, Don L, Giacomin P, Loukas A, Daly NL.

J Biol Chem. 2017 Jun 16;292(24):10288-10294. doi: 10.1074/jbc.M117.779215. Epub 2017 May 4.


Development of a Potent Wound Healing Agent Based on the Liver Fluke Granulin Structural Fold.

Bansal PS, Smout MJ, Wilson D, Cobos Caceres C, Dastpeyman M, Sotillo J, Seifert J, Brindley PJ, Loukas A, Daly NL.

J Med Chem. 2017 May 25;60(10):4258-4266. doi: 10.1021/acs.jmedchem.7b00047. Epub 2017 May 3.


Dual-targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy.

Chan LY, Craik DJ, Daly NL.

Sci Rep. 2016 Oct 13;6:35347. doi: 10.1038/srep35347.


The N-terminal pro-domain of the kalata B1 cyclotide precursor is intrinsically unstructured.

Daly NL, Gunasekera S, Clark RJ, Lin F, Wade JD, Anderson MA, Craik DJ.

Biopolymers. 2016 Nov;106(6):825-833. doi: 10.1002/bip.22977.


Disulfide Bridges: Bringing Together Frustrated Structure in a Bioactive Peptide.

Zhang Y, Schulten K, Gruebele M, Bansal PS, Wilson D, Daly NL.

Biophys J. 2016 Apr 26;110(8):1744-1752. doi: 10.1016/j.bpj.2016.03.027.


Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidase.

Harris KS, Durek T, Kaas Q, Poth AG, Gilding EK, Conlan BF, Saska I, Daly NL, van der Weerden NL, Craik DJ, Anderson MA.

Nat Commun. 2015 Dec 18;6:10199. doi: 10.1038/ncomms10199.


Design of substrate-based BCR-ABL kinase inhibitors using the cyclotide scaffold.

Huang YH, Henriques ST, Wang CK, Thorstholm L, Daly NL, Kaas Q, Craik DJ.

Sci Rep. 2015 Aug 12;5:12974. doi: 10.1038/srep12974.


Transforming conotoxins into cyclotides: Backbone cyclization of P-superfamily conotoxins.

Akcan M, Clark RJ, Daly NL, Conibear AC, de Faoite A, Heghinian MD, Sahil T, Adams DJ, Marí F, Craik DJ.

Biopolymers. 2015 Nov;104(6):682-92. doi: 10.1002/bip.22699.


Identifying the immunomodulatory components of helminths.

Shepherd C, Navarro S, Wangchuk P, Wilson D, Daly NL, Loukas A.

Parasite Immunol. 2015 Jun;37(6):293-303. doi: 10.1111/pim.12192. Review.


A defined α-helix in the bifunctional O-glycosylated natriuretic peptide TcNPa from the venom of Tropidechis carinatus.

Reeks T, Jones A, Brust A, Sridharan S, Corcilius L, Wilkinson BL, Thaysen-Andersen M, Payne RJ, Kini RM, Daly NL, Alewood PF.

Angew Chem Int Ed Engl. 2015 Apr 13;54(16):4828-31. doi: 10.1002/anie.201411914. Epub 2015 Mar 3.


α-Conotoxin MrIC is a biased agonist at α7 nicotinic acetylcholine receptors.

Mueller A, Starobova H, Inserra MC, Jin AH, Deuis JR, Dutertre S, Lewis RJ, Alewood PF, Daly NL, Vetter I.

Biochem Pharmacol. 2015 Mar 15;94(2):155-63. doi: 10.1016/j.bcp.2015.01.011. Epub 2015 Jan 31.


In vivo efficacy of anuran trypsin inhibitory peptides against staphylococcal skin infection and the impact of peptide cyclization.

Malik U, Silva ON, Fensterseifer IC, Chan LY, Clark RJ, Franco OL, Daly NL, Craik DJ.

Antimicrob Agents Chemother. 2015 Apr;59(4):2113-21. doi: 10.1128/AAC.04324-14. Epub 2015 Jan 26.


Solution structure, aggregation behavior, and flexibility of human relaxin-2.

Haugaard-Kedström LM, Hossain MA, Daly NL, Bathgate RA, Rinderknecht E, Wade JD, Craik DJ, Rosengren KJ.

ACS Chem Biol. 2015 Mar 20;10(3):891-900. doi: 10.1021/cb500918v. Epub 2015 Jan 15.


Exploring the therapeutic potential of jellyfish venom.

Daly NL, Seymour J, Wilson D.

Future Med Chem. 2014 Oct;6(15):1715-24. doi: 10.4155/fmc.14.108. Review.


Holocyclotoxin-1, a cystine knot toxin from Ixodes holocyclus.

Vink S, Daly NL, Steen N, Craik DJ, Alewood PF.

Toxicon. 2014 Nov;90:308-17. doi: 10.1016/j.toxicon.2014.08.068. Epub 2014 Aug 27.


Effects of arginine 10 to lysine substitution on ω-conotoxin CVIE and CVIF block of Cav2.2 channels.

Berecki G, Daly NL, Huang YH, Vink S, Craik DJ, Alewood PF, Adams DJ.

Br J Pharmacol. 2014 Jul;171(13):3313-27. doi: 10.1111/bph.12686.


A tarantula-venom peptide antagonizes the TRPA1 nociceptor ion channel by binding to the S1-S4 gating domain.

Gui J, Liu B, Cao G, Lipchik AM, Perez M, Dekan Z, Mobli M, Daly NL, Alewood PF, Parker LL, King GF, Zhou Y, Jordt SE, Nitabach MN.

Curr Biol. 2014 Mar 3;24(5):473-83. doi: 10.1016/j.cub.2014.01.013. Epub 2014 Feb 13.


The C-terminal propeptide of a plant defensin confers cytoprotective and subcellular targeting functions.

Lay FT, Poon S, McKenna JA, Connelly AA, Barbeta BL, McGinness BS, Fox JL, Daly NL, Craik DJ, Heath RL, Anderson MA.

BMC Plant Biol. 2014 Feb 5;14:41. doi: 10.1186/1471-2229-14-41.


Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro.

Schroeder CI, Swedberg JE, Withka JM, Rosengren KJ, Akcan M, Clayton DJ, Daly NL, Cheneval O, Borzilleri KA, Griffor M, Stock I, Colless B, Walsh P, Sunderland P, Reyes A, Dullea R, Ammirati M, Liu S, McClure KF, Tu M, Bhattacharya SK, Liras S, Price DA, Craik DJ.

Chem Biol. 2014 Feb 20;21(2):284-94. doi: 10.1016/j.chembiol.2013.11.014. Epub 2014 Jan 16.


Solution structure, membrane interactions, and protein binding partners of the tetraspanin Sm-TSP-2, a vaccine antigen from the human blood fluke Schistosoma mansoni.

Jia X, Schulte L, Loukas A, Pickering D, Pearson M, Mobli M, Jones A, Rosengren KJ, Daly NL, Gobert GN, Jones MK, Craik DJ, Mulvenna J.

J Biol Chem. 2014 Mar 7;289(10):7151-63. doi: 10.1074/jbc.M113.531558. Epub 2014 Jan 15.


Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design.

Koehbach J, O'Brien M, Muttenthaler M, Miazzo M, Akcan M, Elliott AG, Daly NL, Harvey PJ, Arrowsmith S, Gunasekera S, Smith TJ, Wray S, Göransson U, Dawson PE, Craik DJ, Freissmuth M, Gruber CW.

Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):21183-8. doi: 10.1073/pnas.1311183110. Epub 2013 Nov 18.


Lipid core peptide targeting the cathepsin D hemoglobinase of Schistosoma mansoni as a component of a schistosomiasis vaccine.

Dougall AM, Skwarczynski M, Khoshnejad M, Chandrudu S, Daly NL, Toth I, Loukas A.

Hum Vaccin Immunother. 2014;10(2):399-409. doi: 10.4161/hv.27057. Epub 2013 Nov 14.


Structural insights into the role of the cyclic backbone in a squash trypsin inhibitor.

Daly NL, Thorstholm L, Greenwood KP, King GJ, Rosengren KJ, Heras B, Martin JL, Craik DJ.

J Biol Chem. 2013 Dec 13;288(50):36141-8. doi: 10.1074/jbc.M113.528240. Epub 2013 Oct 29.


Novel inhibitor cystine knot peptides from Momordica charantia.

He WJ, Chan LY, Clark RJ, Tang J, Zeng GZ, Franco OL, Cantacessi C, Craik DJ, Daly NL, Tan NH.

PLoS One. 2013 Oct 8;8(10):e75334. doi: 10.1371/journal.pone.0075334. eCollection 2013.


Vicinal disulfide constrained cyclic peptidomimetics: a turn mimetic scaffold targeting the norepinephrine transporter.

Brust A, Wang CI, Daly NL, Kennerly J, Sadeghi M, Christie MJ, Lewis RJ, Mobli M, Alewood PF.

Angew Chem Int Ed Engl. 2013 Nov 11;52(46):12020-3. doi: 10.1002/anie.201304660. Epub 2013 Sep 24. No abstract available.


Isolation of an orally active insecticidal toxin from the venom of an Australian tarantula.

Hardy MC, Daly NL, Mobli M, Morales RA, King GF.

PLoS One. 2013 Sep 11;8(9):e73136. doi: 10.1371/journal.pone.0073136. eCollection 2013.


Isolation and characterization of α-conotoxin LsIA with potent activity at nicotinic acetylcholine receptors.

Inserra MC, Kompella SN, Vetter I, Brust A, Daly NL, Cuny H, Craik DJ, Alewood PF, Adams DJ, Lewis RJ.

Biochem Pharmacol. 2013 Sep 15;86(6):791-9. doi: 10.1016/j.bcp.2013.07.016. Epub 2013 Aug 4.


The self-association of the cyclotide kalata B2 in solution is guided by hydrophobic interactions.

Rosengren KJ, Daly NL, Harvey PJ, Craik DJ.

Biopolymers. 2013 Sep;100(5):453-60. doi: 10.1002/bip.22269. Erratum in: Biopolymers. 2014 Jan;102(1):136.


High-affinity cyclic peptide matriptase inhibitors.

Quimbar P, Malik U, Sommerhoff CP, Kaas Q, Chan LY, Huang YH, Grundhuber M, Dunse K, Craik DJ, Anderson MA, Daly NL.

J Biol Chem. 2013 May 10;288(19):13885-96. doi: 10.1074/jbc.M113.460030. Epub 2013 Apr 2.


Anthelminthic activity of the cyclotides (kalata B1 and B2) against schistosome parasites.

Malagón D, Botterill B, Gray DJ, Lovas E, Duke M, Gray C, Kopp SR, Knott LM, McManus DP, Daly NL, Mulvenna J, Craik DJ, Jones MK.

Biopolymers. 2013 Sep;100(5):461-70. doi: 10.1002/bip.22229.


The cyclic cystine ladder in θ-defensins is important for structure and stability, but not antibacterial activity.

Conibear AC, Rosengren KJ, Daly NL, Henriques ST, Craik DJ.

J Biol Chem. 2013 Apr 12;288(15):10830-40. doi: 10.1074/jbc.M113.451047. Epub 2013 Feb 21.


Cyclization of the antimicrobial peptide gomesin with native chemical ligation: influences on stability and bioactivity.

Chan LY, Zhang VM, Huang YH, Waters NC, Bansal PS, Craik DJ, Daly NL.

Chembiochem. 2013 Mar 18;14(5):617-24. doi: 10.1002/cbic.201300034. Epub 2013 Feb 20.


Quantification of small cyclic disulfide-rich peptides.

Conibear AC, Daly NL, Craik DJ.

Biopolymers. 2012;98(6):518-24. doi: 10.1002/bip.22121.


A new family of cystine knot peptides from the seeds of Momordica cochinchinensis.

Chan LY, He W, Tan N, Zeng G, Craik DJ, Daly NL.

Peptides. 2013 Jan;39:29-35. doi: 10.1016/j.peptides.2012.09.018. Epub 2012 Nov 3.


Design, synthesis, structural and functional characterization of novel melanocortin agonists based on the cyclotide kalata B1.

Eliasen R, Daly NL, Wulff BS, Andresen TL, Conde-Frieboes KW, Craik DJ.

J Biol Chem. 2012 Nov 23;287(48):40493-501. doi: 10.1074/jbc.M112.395442. Epub 2012 Sep 25.


Characterizing circular peptides in mixtures: sequence fragment assembly of cyclotides from a violet plant by MALDI-TOF/TOF mass spectrometry.

Hashempour H, Koehbach J, Daly NL, Ghassempour A, Gruber CW.

Amino Acids. 2013 Feb;44(2):581-95. doi: 10.1007/s00726-012-1376-x. Epub 2012 Aug 14.


Phosphatidylethanolamine binding is a conserved feature of cyclotide-membrane interactions.

Henriques ST, Huang YH, Castanho MA, Bagatolli LA, Sonza S, Tachedjian G, Daly NL, Craik DJ.

J Biol Chem. 2012 Sep 28;287(40):33629-43. Epub 2012 Aug 1.


Cyclic peptides arising by evolutionary parallelism via asparaginyl-endopeptidase-mediated biosynthesis.

Mylne JS, Chan LY, Chanson AH, Daly NL, Schaefer H, Bailey TL, Nguyencong P, Cascales L, Craik DJ.

Plant Cell. 2012 Jul;24(7):2765-78. doi: 10.1105/tpc.112.099085. Epub 2012 Jul 20.


Gly(6) of kalata B1 is critical for the selective binding to phosphatidylethanolamine membranes.

Hall K, Lee TH, Daly NL, Craik DJ, Aguilar MI.

Biochim Biophys Acta. 2012 Sep;1818(9):2354-61. doi: 10.1016/j.bbamem.2012.04.007. Epub 2012 Apr 17.


The α-defensin salt-bridge induces backbone stability to facilitate folding and confer proteolytic resistance.

Andersson HS, Figueredo SM, Haugaard-Kedström LM, Bengtsson E, Daly NL, Qu X, Craik DJ, Ouellette AJ, Rosengren KJ.

Amino Acids. 2012 Oct;43(4):1471-83.


Engineering of conotoxins for the treatment of pain.

Carstens BB, Clark RJ, Daly NL, Harvey PJ, Kaas Q, Craik DJ.

Curr Pharm Des. 2011 Dec;17(38):4242-53. Review.


RegIIA: an α4/7-conotoxin from the venom of Conus regius that potently blocks α3β4 nAChRs.

Franco A, Kompella SN, Akondi KB, Melaun C, Daly NL, Luetje CW, Alewood PF, Craik DJ, Adams DJ, Marí F.

Biochem Pharmacol. 2012 Feb 1;83(3):419-26. doi: 10.1016/j.bcp.2011.11.006. Epub 2011 Nov 16.


Engineering pro-angiogenic peptides using stable, disulfide-rich cyclic scaffolds.

Chan LY, Gunasekera S, Henriques ST, Worth NF, Le SJ, Clark RJ, Campbell JH, Craik DJ, Daly NL.

Blood. 2011 Dec 15;118(25):6709-17. doi: 10.1182/blood-2011-06-359141. Epub 2011 Oct 28.


Cyclotides: a patent review.

Smith AB, Daly NL, Craik DJ.

Expert Opin Ther Pat. 2011 Nov;21(11):1657-72. doi: 10.1517/13543776.2011.620606. Review.


A Synthetic mirror image of kalata B1 reveals that cyclotide activity is independent of a protein receptor.

Sando L, Henriques ST, Foley F, Simonsen SM, Daly NL, Hall KN, Gustafson KR, Aguilar MI, Craik DJ.

Chembiochem. 2011 Nov 4;12(16):2456-62. doi: 10.1002/cbic.201100450. Epub 2011 Sep 16.


α-Conotoxin ImI incorporating stable cystathionine bridges maintains full potency and identical three-dimensional structure.

Dekan Z, Vetter I, Daly NL, Craik DJ, Lewis RJ, Alewood PF.

J Am Chem Soc. 2011 Oct 12;133(40):15866-9. doi: 10.1021/ja206408q. Epub 2011 Sep 15.


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