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Items: 8


Systems modelling ageing: from single senescent cells to simple multi-cellular models.

Martinez Guimera A, Welsh C, Dalle Pezze P, Fullard N, Nelson G, Roger MF, Przyborski SA, Shanley DP.

Essays Biochem. 2017 Jul 11;61(3):369-377. doi: 10.1042/EBC20160087. Print 2017 Jul 15. Review.


SBpipe: a collection of pipelines for automating repetitive simulation and analysis tasks.

Dalle Pezze P, Le Novère N.

BMC Syst Biol. 2017 Apr 10;11(1):46. doi: 10.1186/s12918-017-0423-3.


A systems study reveals concurrent activation of AMPK and mTOR by amino acids.

Dalle Pezze P, Ruf S, Sonntag AG, Langelaar-Makkinje M, Hall P, Heberle AM, Razquin Navas P, van Eunen K, Tölle RC, Schwarz JJ, Wiese H, Warscheid B, Deitersen J, Stork B, Fäßler E, Schäuble S, Hahn U, Horvatovich P, Shanley DP, Thedieck K.

Nat Commun. 2016 Nov 21;7:13254. doi: 10.1038/ncomms13254.


The systems biology format converter.

Rodriguez N, Pettit JB, Dalle Pezze P, Li L, Henry A, van Iersel MP, Jalowicki G, Kutmon M, Natarajan KN, Tolnay D, Stefan MI, Evelo CT, Le Novère N.

BMC Bioinformatics. 2016 Apr 5;17:154. doi: 10.1186/s12859-016-1000-2.


Increasing extracellular H2O2 produces a bi-phasic response in intracellular H2O2, with peroxiredoxin hyperoxidation only triggered once the cellular H2O2-buffering capacity is overwhelmed.

Tomalin LE, Day AM, Underwood ZE, Smith GR, Dalle Pezze P, Rallis C, Patel W, Dickinson BC, Bähler J, Brewer TF, Chang CJ, Shanley DP, Veal EA.

Free Radic Biol Med. 2016 Jun;95:333-48. doi: 10.1016/j.freeradbiomed.2016.02.035. Epub 2016 Mar 2.


Dynamic modelling of pathways to cellular senescence reveals strategies for targeted interventions.

Dalle Pezze P, Nelson G, Otten EG, Korolchuk VI, Kirkwood TB, von Zglinicki T, Shanley DP.

PLoS Comput Biol. 2014 Aug 28;10(8):e1003728. doi: 10.1371/journal.pcbi.1003728. eCollection 2014 Aug.


A dynamic network model of mTOR signaling reveals TSC-independent mTORC2 regulation.

Dalle Pezze P, Sonntag AG, Thien A, Prentzell MT, Gödel M, Fischer S, Neumann-Haefelin E, Huber TB, Baumeister R, Shanley DP, Thedieck K.

Sci Signal. 2012 Mar 27;5(217):ra25. doi: 10.1126/scisignal.2002469.


A modelling-experimental approach reveals insulin receptor substrate (IRS)-dependent regulation of adenosine monosphosphate-dependent kinase (AMPK) by insulin.

Sonntag AG, Dalle Pezze P, Shanley DP, Thedieck K.

FEBS J. 2012 Sep;279(18):3314-28. doi: 10.1111/j.1742-4658.2012.08582.x. Epub 2012 May 3.

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