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HER2 is not a cancer subtype but rather a pan-cancer event and is highly enriched in AR-driven breast tumors.

Daemen A, Manning G.

Breast Cancer Res. 2018 Jan 30;20(1):8. doi: 10.1186/s13058-018-0933-y.


Kras mutant genetically engineered mouse models of human cancers are genomically heterogeneous.

Chung WJ, Daemen A, Cheng JH, Long JE, Cooper JE, Wang BE, Tran C, Singh M, Gnad F, Modrusan Z, Foreman O, Junttila MR.

Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):E10947-E10955. doi: 10.1073/pnas.1708391114. Epub 2017 Dec 4.


Metabolic Response to NAD Depletion across Cell Lines Is Highly Variable.

Xiao Y, Kwong M, Daemen A, Belvin M, Liang X, Hatzivassiliou G, O'Brien T.

PLoS One. 2016 Oct 6;11(10):e0164166. doi: 10.1371/journal.pone.0164166. eCollection 2016.


Recurrent Loss of NFE2L2 Exon 2 Is a Mechanism for Nrf2 Pathway Activation in Human Cancers.

Goldstein LD, Lee J, Gnad F, Klijn C, Schaub A, Reeder J, Daemen A, Bakalarski CE, Holcomb T, Shames DS, Hartmaier RJ, Chmielecki J, Seshagiri S, Gentleman R, Stokoe D.

Cell Rep. 2016 Sep 6;16(10):2605-2617. doi: 10.1016/j.celrep.2016.08.010. Epub 2016 Aug 25.


Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition.

Boudreau A, Purkey HE, Hitz A, Robarge K, Peterson D, Labadie S, Kwong M, Hong R, Gao M, Del Nagro C, Pusapati R, Ma S, Salphati L, Pang J, Zhou A, Lai T, Li Y, Chen Z, Wei B, Yen I, Sideris S, McCleland M, Firestein R, Corson L, Vanderbilt A, Williams S, Daemen A, Belvin M, Eigenbrot C, Jackson PK, Malek S, Hatzivassiliou G, Sampath D, Evangelista M, O'Brien T.

Nat Chem Biol. 2016 Oct;12(10):779-86. doi: 10.1038/nchembio.2143. Epub 2016 Aug 1.


Diurnal differences in milk composition and its influence on in vitro growth of Staphylococcus aureus and Escherichia coli in bovine quarter milk.

Eisenberg SWF, Boerhout EM, Ravesloot L, Daemen AJJM, Benedictus L, Rutten VPMG, Koets AP.

J Dairy Sci. 2016 Jul;99(7):5690-5700. doi: 10.3168/jds.2015-10757. Epub 2016 May 4.


mTORC1-Dependent Metabolic Reprogramming Underlies Escape from Glycolysis Addiction in Cancer Cells.

Pusapati RV, Daemen A, Wilson C, Sandoval W, Gao M, Haley B, Baudy AR, Hatzivassiliou G, Evangelista M, Settleman J.

Cancer Cell. 2016 Apr 11;29(4):548-562. doi: 10.1016/j.ccell.2016.02.018. Epub 2016 Mar 24.


Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors.

Daemen A, Peterson D, Sahu N, McCord R, Du X, Liu B, Kowanetz K, Hong R, Moffat J, Gao M, Boudreau A, Mroue R, Corson L, O'Brien T, Qing J, Sampath D, Merchant M, Yauch R, Manning G, Settleman J, Hatzivassiliou G, Evangelista M.

Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):E4410-7. doi: 10.1073/pnas.1501605112. Epub 2015 Jul 27.


Requirement for BUB1B/BUBR1 in tumor progression of lung adenocarcinoma.

Chen H, Lee J, Kljavin NM, Haley B, Daemen A, Johnson L, Liang Y.

Genes Cancer. 2015 Mar;6(3-4):106-18.


Erratum to: Modeling precision treatment of breast cancer.

Daemen A, Griffith OL, Heiser LM, Wang NJ, Enache OM, Sanborn Z, Pepin F, Durinck S, Korkola JE, Griffith M, Hur JS, Huh N, Chung J, Cope L, Fackler MJ, Umbricht C, Sukumar S, Seth P, Sukhatme VP, Jakkula LR, Lu Y, Mills GB, Cho RJ, Collisson EA, Van't Veer LJ, Spellman PT, Gray JW.

Genome Biol. 2015 May 12;16:95. doi: 10.1186/s13059-015-0658-5.


Metabolic and transcriptional profiling reveals pyruvate dehydrogenase kinase 4 as a mediator of epithelial-mesenchymal transition and drug resistance in tumor cells.

Sun Y, Daemen A, Hatzivassiliou G, Arnott D, Wilson C, Zhuang G, Gao M, Liu P, Boudreau A, Johnson L, Settleman J.

Cancer Metab. 2014 Nov 3;2(1):20. doi: 10.1186/2049-3002-2-20. eCollection 2014.


Hominoid-specific enzyme GLUD2 promotes growth of IDH1R132H glioma.

Chen R, Nishimura MC, Kharbanda S, Peale F, Deng Y, Daemen A, Forrest WF, Kwong M, Hedehus M, Hatzivassiliou G, Friedman LS, Phillips HS.

Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):14217-22. doi: 10.1073/pnas.1409653111. Epub 2014 Sep 15.


Transmission of Actinobacillus pleuropneumoniae among weaned piglets on endemically infected farms.

Tobias TJ, Bouma A, van den Broek J, van Nes A, Daemen AJ, Wagenaar JA, Stegeman JA, Klinkenberg D.

Prev Vet Med. 2014 Nov 1;117(1):207-14. doi: 10.1016/j.prevetmed.2014.07.017. Epub 2014 Aug 10.


Maximum Likelihood Estimation of GEVD: Applications in Bioinformatics.

Thomas M, Daemen A, De Moor B.

IEEE/ACM Trans Comput Biol Bioinform. 2014 Jul-Aug;11(4):673-80. doi: 10.1109/TCBB.2014.2304292.


A cohort study on Actinobacillus pleuropneumoniae colonisation in suckling piglets.

Tobias TJ, Klinkenberg D, Bouma A, van den Broek J, Daemen AJ, Wagenaar JA, Stegeman JA.

Prev Vet Med. 2014 Jun 1;114(3-4):223-30. doi: 10.1016/j.prevetmed.2014.02.008. Epub 2014 Mar 1.


Modeling precision treatment of breast cancer.

Daemen A, Griffith OL, Heiser LM, Wang NJ, Enache OM, Sanborn Z, Pepin F, Durinck S, Korkola JE, Griffith M, Hur JS, Huh N, Chung J, Cope L, Fackler MJ, Umbricht C, Sukumar S, Seth P, Sukhatme VP, Jakkula LR, Lu Y, Mills GB, Cho RJ, Collisson EA, van't Veer LJ, Spellman PT, Gray JW.

Genome Biol. 2013;14(10):R110. Erratum in: Genome Biol. 2015;16:95.


Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target.

Timmerman LA, Holton T, Yuneva M, Louie RJ, PadrĂ³ M, Daemen A, Hu M, Chan DA, Ethier SP, van 't Veer LJ, Polyak K, McCormick F, Gray JW.

Cancer Cell. 2013 Oct 14;24(4):450-65. doi: 10.1016/j.ccr.2013.08.020. Epub 2013 Oct 3.


Defining the relationship between fetal Doppler indices, abdominal circumference and growth rate in severe fetal growth restriction using functional linear discriminant analysis.

Talmor A, Daemen A, Murdoch E, Missfelder-Lobos H, Timmerman D, Bourne T, Giussani DA, Lees C.

J R Soc Interface. 2013 Aug 21;10(88):20130376. doi: 10.1098/rsif.2013.0376. Print 2013 Nov 6.


Reply: To PMID 22323094.

Naji O, Daemen A, Smith A, Abdallah Y, Bradburn E, Giggens R, Chan DC, Stalder C, Ghaem-Maghami S, Timmerman D, Bourne T.

Ultrasound Obstet Gynecol. 2013 Jul;42(1):121-2. doi: 10.1002/uog.12491. No abstract available.


Association between transmission rate and disease severity for Actinobacillus pleuropneumoniae infection in pigs.

Tobias TJ, Bouma A, Daemen AJ, Wagenaar JA, Stegeman A, Klinkenberg D.

Vet Res. 2013 Jan 11;44:2. doi: 10.1186/1297-9716-44-2.


Changes in Cesarean section scar dimensions during pregnancy: a prospective longitudinal study.

Naji O, Daemen A, Smith A, Abdallah Y, Saso S, Stalder C, Sayasneh A, McIndoe A, Ghaem-Maghami S, Timmerman D, Bourne T.

Ultrasound Obstet Gynecol. 2013 May;41(5):556-62. doi: 10.1002/uog.12334.


Cross-platform pathway-based analysis identifies markers of response to the PARP inhibitor olaparib.

Daemen A, Wolf DM, Korkola JE, Griffith OL, Frankum JR, Brough R, Jakkula LR, Wang NJ, Natrajan R, Reis-Filho JS, Lord CJ, Ashworth A, Spellman PT, Gray JW, van't Veer LJ.

Breast Cancer Res Treat. 2012 Sep;135(2):505-17. doi: 10.1007/s10549-012-2188-0. Epub 2012 Aug 9.


Impact of ovulation and implantation timing on first-trimester crown-rump length and gestational age.

Mahendru AA, Daemen A, Everett TR, Wilkinson IB, McEniery CM, Abdallah Y, Timmerman D, Bourne T, Lees CC.

Ultrasound Obstet Gynecol. 2012 Dec;40(6):630-5. doi: 10.1002/uog.12277.


Proteomic biomarkers predicting lymph node involvement in serum of cervical cancer patients. Limitations of SELDI-TOF MS.

Van Gorp T, Cadron I, Daemen A, De Moor B, Waelkens E, Vergote I.

Proteome Sci. 2012 Jun 13;10(1):41. doi: 10.1186/1477-5956-10-41.


Do pocket-sized ultrasound machines have the potential to be used as a tool to triage patients in obstetrics and gynecology?

Sayasneh A, Preisler J, Smith A, Saso S, Naji O, Abdallah Y, Stalder C, Daemen A, Timmerman D, Bourne T.

Ultrasound Obstet Gynecol. 2012 Aug;40(2):145-50. doi: 10.1002/uog.11184.


Loss of cell-surface laminin anchoring promotes tumor growth and is associated with poor clinical outcomes.

Akhavan A, Griffith OL, Soroceanu L, Leonoudakis D, Luciani-Torres MG, Daemen A, Gray JW, Muschler JL.

Cancer Res. 2012 May 15;72(10):2578-88. doi: 10.1158/0008-5472.CAN-11-3732.


Detection of Actinobacillus pleuropneumoniae in pigs by real-time quantitative PCR for the apxIVA gene.

Tobias TJ, Bouma A, Klinkenberg D, Daemen AJ, Stegeman JA, Wagenaar JA, Duim B.

Vet J. 2012 Aug;193(2):557-60. doi: 10.1016/j.tvjl.2012.02.004. Epub 2012 Mar 23.


Does the presence of a cesarean section scar influence the site of placental implantation and subsequent migration in future pregnancies: a prospective case-control study.

Naji O, Daemen A, Smith A, Abdallah Y, Bradburn E, Giggens R, Chan DC, Stalder C, Ghaem-Maghami S, Timmerman D, Bourne T.

Ultrasound Obstet Gynecol. 2012 Nov;40(5):557-61. doi: 10.1002/uog.11133.


Visibility and measurement of cesarean section scars in pregnancy: a reproducibility study.

Naji O, Daemen A, Smith A, Abdallah Y, Saso S, Stalder C, Sayasneh A, McIndoe A, Ghaem-Maghami S, Timmerman D, Bourne T.

Ultrasound Obstet Gynecol. 2012 Nov;40(5):549-56. doi: 10.1002/uog.11132.


Homologous whole bacterin vaccination is not able to reduce Streptococcus suis serotype 9 strain 7997 transmission among pigs or colonization.

Dekker CN, Bouma A, Daemen AJ, van Leengoed LA, Jonker FH, Wagenaar JA, Stegeman JA.

Vaccine. 2012 Feb 8;30(7):1379-87. doi: 10.1016/j.vaccine.2011.12.035. Epub 2011 Dec 29.


Improved modeling of clinical data with kernel methods.

Daemen A, Timmerman D, Van den Bosch T, Bottomley C, Kirk E, Van Holsbeke C, Valentin L, Bourne T, De Moor B.

Artif Intell Med. 2012 Feb;54(2):103-14. doi: 10.1016/j.artmed.2011.11.001. Epub 2011 Nov 30.


Limitations of current definitions of miscarriage using mean gestational sac diameter and crown-rump length measurements: a multicenter observational study.

Abdallah Y, Daemen A, Kirk E, Pexsters A, Naji O, Stalder C, Gould D, Ahmed S, Guha S, Syed S, Bottomley C, Timmerman D, Bourne T.

Ultrasound Obstet Gynecol. 2011 Nov;38(5):497-502. doi: 10.1002/uog.10109. Epub 2011 Oct 13.


Gestational sac and embryonic growth are not useful as criteria to define miscarriage: a multicenter observational study.

Abdallah Y, Daemen A, Guha S, Syed S, Naji O, Pexsters A, Kirk E, Stalder C, Gould D, Ahmed S, Bottomley C, Timmerman D, Bourne T.

Ultrasound Obstet Gynecol. 2011 Nov;38(5):503-9. doi: 10.1002/uog.10075. Epub 2011 Oct 13.


Umbilical artery pulsatility index and fetal abdominal circumference in isolated gastroschisis.

Hussain U, Daemen A, Missfelder-Lobos H, De Moor B, Timmerman D, Bourne T, Lees C.

Ultrasound Obstet Gynecol. 2011 Nov;38(5):538-42. doi: 10.1002/uog.8947.


HE4 and CA125 as a diagnostic test in ovarian cancer: prospective validation of the Risk of Ovarian Malignancy Algorithm.

Van Gorp T, Cadron I, Despierre E, Daemen A, Leunen K, Amant F, Timmerman D, De Moor B, Vergote I.

Br J Cancer. 2011 Mar 1;104(5):863-70. doi: 10.1038/sj.bjc.6606092. Epub 2011 Feb 8.


Lidocaine does not reduce pain perception during gel instillation sonography or subsequent office hysteroscopy: results of a randomized trial.

Van den Bosch T, Van Schoubroeck D, Daemen A, Domali E, Vandenbroucke V, De Moor B, Deprest J, Timmerman D.

Gynecol Obstet Invest. 2011;71(4):236-9. doi: 10.1159/000319240. Epub 2010 Dec 16.


Is serum human chorionic gonadotrophin follow-up necessary after suspected spillage of trophoblast at the time of laparoscopic surgery for ectopic pregnancy?

Bora SA, Kirk E, Daemen A, Timmerman D, Bourne T.

Gynecol Obstet Invest. 2011;71(4):225-8. doi: 10.1159/000318221. Epub 2010 Dec 15.


Prediction of lymph node involvement in breast cancer from primary tumor tissue using gene expression profiling and miRNAs.

Smeets A, Daemen A, Vanden Bempt I, Gevaert O, Claes B, Wildiers H, Drijkoningen R, Van Hummelen P, Lambrechts D, De Moor B, Neven P, Sotiriou C, Vandorpe T, Paridaens R, Christiaens MR.

Breast Cancer Res Treat. 2011 Oct;129(3):767-76. doi: 10.1007/s10549-010-1265-5. Epub 2010 Nov 30.


Effect of cancer prevalence on the use of risk-assessment cut-off levels and the performance of mathematical models to distinguish malignant from benign adnexal masses.

Daemen A, Jurkovic D, Van Holsbeke C, Guerriero S, Testa AC, Czekierdowski A, Fruscio R, Paladini D, Neven P, Rossi A, Bourne T, De Moor B, Timmerman D.

Ultrasound Obstet Gynecol. 2011 Feb;37(2):226-31. doi: 10.1002/uog.8849. Epub 2011 Jan 14.


Improving the preoperative classification of adnexal masses as benign or malignant by second-stage tests.

Daemen A, Valentin L, Fruscio R, Van Holsbeke C, Melis GB, Guerriero S, Czekierdowski A, Jurkovic D, Ombelet W, Rossi A, Vergote I, Bourne T, De Moor B, Timmerman D.

Ultrasound Obstet Gynecol. 2011 Jan;37(1):100-6. doi: 10.1002/uog.8813.


Effect of Eimeria acervulina infection history on the immune response and transmission in broilers.

Velkers FC, Swinkels WJ, Rebel JM, Bouma A, Daemen AJ, Klinkenberg D, Boersma WJ, Stegeman JA, de Jong MC, Heesterbeek JA.

Vet Parasitol. 2010 Oct 29;173(3-4):184-92. doi: 10.1016/j.vetpar.2010.07.005. Epub 2010 Jul 22.


The relationship between first trimester fetal growth, pregnancy-associated plasma protein A levels and birthweight.

Habayeb O, Daemen A, Timmerman D, De Moor B, Hackett GA, Bourne T, Lees CC.

Prenat Diagn. 2010 Sep;30(9):873-8. doi: 10.1002/pd.2578.


A seven-gene set associated with chronic hypoxia of prognostic importance in hepatocellular carcinoma.

van Malenstein H, Gevaert O, Libbrecht L, Daemen A, Allemeersch J, Nevens F, Van Cutsem E, Cassiman D, De Moor B, Verslype C, van Pelt J.

Clin Cancer Res. 2010 Aug 15;16(16):4278-88. doi: 10.1158/1078-0432.CCR-09-3274. Epub 2010 Jun 30.


L2-norm multiple kernel learning and its application to biomedical data fusion.

Yu S, Falck T, Daemen A, Tranchevent LC, Suykens JA, De Moor B, Moreau Y.

BMC Bioinformatics. 2010 Jun 8;11:309. doi: 10.1186/1471-2105-11-309.


No influence of body mass index on first trimester fetal growth.

Sarris I, Bottomley C, Daemen A, Pexsters A, Timmerman D, Bourne T, Papageorghiou AT.

Hum Reprod. 2010 Aug;25(8):1895-9. doi: 10.1093/humrep/deq132. Epub 2010 Jun 2.


New crown-rump length curve based on over 3500 pregnancies.

Pexsters A, Daemen A, Bottomley C, Van Schoubroeck D, De Catte L, De Moor B, D'Hooghe T, Lees C, Timmerman D, Bourne T.

Ultrasound Obstet Gynecol. 2010 Jun;35(6):650-5. doi: 10.1002/uog.7654.


Improved microarray-based decision support with graph encoded interactome data.

Daemen A, Signoretto M, Gevaert O, Suykens JA, De Moor B.

PLoS One. 2010 Apr 19;5(4):e10225. doi: 10.1371/journal.pone.0010225.


A taxonomy of epithelial human cancer and their metastases.

Gevaert O, Daemen A, De Moor B, Libbrecht L.

BMC Med Genomics. 2009 Dec 17;2:69. doi: 10.1186/1755-8794-2-69.


Ultrasound experience substantially impacts on diagnostic performance and confidence when adnexal masses are classified using pattern recognition.

Van Holsbeke C, Daemen A, Yazbek J, Holland TK, Bourne T, Mesens T, Lannoo L, Boes AS, Joos A, Van De Vijver A, Roggen N, de Moor B, de Jonge E, Testa AC, Valentin L, Jurkovic D, Timmerman D.

Gynecol Obstet Invest. 2010;69(3):160-8. doi: 10.1159/000265012. Epub 2009 Dec 11.


Development of a kernel function for clinical data.

Daemen A, De Moor B.

Conf Proc IEEE Eng Med Biol Soc. 2009;2009:5913-7. doi: 10.1109/IEMBS.2009.5334847.


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