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Items: 1 to 50 of 81

1.

Apigenin, by activating p53 and inhibiting STAT3, modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death.

Granato M, Gilardini Montani MS, Santarelli R, D'Orazi G, Faggioni A, Cirone M.

J Exp Clin Cancer Res. 2017 Nov 28;36(1):167. doi: 10.1186/s13046-017-0632-z.

2.

Chloroquine supplementation increases the cytotoxic effect of curcumin against Her2/neu overexpressing breast cancer cells in vitro and in vivo in nude mice while counteracts it in immune competent mice.

Masuelli L, Granato M, Benvenuto M, Mattera R, Bernardini R, Mattei M, d'Amati G, D'Orazi G, Faggioni A, Bei R, Cirone M.

Oncoimmunology. 2017 Jul 31;6(11):e1356151. doi: 10.1080/2162402X.2017.1356151. eCollection 2017.

PMID:
29147611
3.

Metformin triggers apoptosis in PEL cells and alters bortezomib-induced Unfolded Protein Response increasing its cytotoxicity and inhibiting KSHV lytic cycle activation.

Granato M, Gilardini Montani MS, Romeo MA, Santarelli R, Gonnella R, D'Orazi G, Faggioni A, Cirone M.

Cell Signal. 2017 Dec;40:239-247. doi: 10.1016/j.cellsig.2017.09.020. Epub 2017 Sep 28.

PMID:
28964970
4.

p53-Dependent PUMA to DRAM antagonistic interplay as a key molecular switch in cell-fate decision in normal/high glucose conditions.

Garufi A, Pistritto G, Baldari S, Toietta G, Cirone M, D'Orazi G.

J Exp Clin Cancer Res. 2017 Sep 11;36(1):126. doi: 10.1186/s13046-017-0596-z.

5.

Oxidant species are involved in T/B-mediated ERK1/2 phosphorylation that activates p53-p21 axis to promote KSHV lytic cycle in PEL cells.

Gonnella R, Yadav S, Gilardini Montani MS, Granato M, Santarelli R, Garufi A, D'Orazi G, Faggioni A, Cirone M.

Free Radic Biol Med. 2017 Nov;112:327-335. doi: 10.1016/j.freeradbiomed.2017.08.005. Epub 2017 Aug 8.

PMID:
28801242
6.

Histone deacetylase inhibitors VPA and TSA induce apoptosis and autophagy in pancreatic cancer cells.

Gilardini Montani MS, Granato M, Santoni C, Del Porto P, Merendino N, D'Orazi G, Faggioni A, Cirone M.

Cell Oncol (Dordr). 2017 Apr;40(2):167-180. doi: 10.1007/s13402-017-0314-z. Epub 2017 Feb 3.

PMID:
28160167
7.

Quercetin induces apoptosis and autophagy in primary effusion lymphoma cells by inhibiting PI3K/AKT/mTOR and STAT3 signaling pathways.

Granato M, Rizzello C, Gilardini Montani MS, Cuomo L, Vitillo M, Santarelli R, Gonnella R, D'Orazi G, Faggioni A, Cirone M.

J Nutr Biochem. 2017 Mar;41:124-136. doi: 10.1016/j.jnutbio.2016.12.011. Epub 2017 Jan 5.

PMID:
28092744
8.

Hyperglycemia triggers HIPK2 protein degradation.

Baldari S, Garufi A, Granato M, Cuomo L, Pistritto G, Cirone M, D'Orazi G.

Oncotarget. 2017 Jan 3;8(1):1190-1203. doi: 10.18632/oncotarget.13595.

9.

Concomitant reduction of c-Myc expression and PI3K/AKT/mTOR signaling by quercetin induces a strong cytotoxic effect against Burkitt's lymphoma.

Granato M, Rizzello C, Romeo MA, Yadav S, Santarelli R, D'Orazi G, Faggioni A, Cirone M.

Int J Biochem Cell Biol. 2016 Oct;79:393-400. doi: 10.1016/j.biocel.2016.09.006. Epub 2016 Sep 9.

PMID:
27620077
10.

Reactivation of mutant p53 by capsaicin, the major constituent of peppers.

Garufi A, Pistritto G, Cirone M, D'Orazi G.

J Exp Clin Cancer Res. 2016 Sep 6;35(1):136. doi: 10.1186/s13046-016-0417-9.

11.

ZnCl2 sustains the adriamycin-induced cell death inhibited by high glucose.

Garufi A, Trisciuoglio D, Cirone M, D'Orazi G.

Cell Death Dis. 2016 Jun 30;7(6):e2280. doi: 10.1038/cddis.2016.178.

12.

Mutant p53 proteins alter cancer cell secretome and tumour microenvironment: Involvement in cancer invasion and metastasis.

Cordani M, Pacchiana R, Butera G, D'Orazi G, Scarpa A, Donadelli M.

Cancer Lett. 2016 Jul 1;376(2):303-9. doi: 10.1016/j.canlet.2016.03.046. Epub 2016 Apr 1. Review.

PMID:
27045472
13.

Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies.

Pistritto G, Trisciuoglio D, Ceci C, Garufi A, D'Orazi G.

Aging (Albany NY). 2016 Apr;8(4):603-19. doi: 10.18632/aging.100934. Review.

14.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC Jr, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR Jr, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, Ciarcia R, Ciechomska IA, Ciriolo MR, Cirone M, Claerhout S, Clague MJ, Clària J, Clarke PG, Clarke R, Clementi E, Cleyrat C, Cnop M, Coccia EM, Cocco T, Codogno P, Coers J, Cohen EE, Colecchia D, Coletto L, Coll NS, Colucci-Guyon E, Comincini S, Condello M, Cook KL, Coombs GH, Cooper CD, Cooper JM, Coppens I, Corasaniti MT, Corazzari M, Corbalan R, Corcelle-Termeau E, Cordero MD, Corral-Ramos C, Corti O, Cossarizza A, Costelli P, Costes S, Cotman SL, Coto-Montes A, Cottet S, Couve E, Covey LR, Cowart LA, Cox JS, Coxon FP, Coyne CB, Cragg MS, Craven RJ, Crepaldi T, Crespo JL, Criollo A, Crippa V, Cruz MT, Cuervo AM, Cuezva JM, Cui T, Cutillas PR, Czaja MJ, Czyzyk-Krzeska MF, Dagda RK, Dahmen U, Dai C, Dai W, Dai Y, Dalby KN, Dalla Valle L, Dalmasso G, D'Amelio M, Damme M, Darfeuille-Michaud A, Dargemont C, Darley-Usmar VM, Dasarathy S, Dasgupta B, Dash S, Dass CR, Davey HM, Davids LM, Dávila D, Davis RJ, Dawson TM, Dawson VL, Daza P, de Belleroche J, de Figueiredo P, de Figueiredo RC, de la Fuente J, De Martino L, De Matteis A, De Meyer GR, De Milito A, De Santi M, de Souza W, De Tata V, De Zio D, Debnath J, Dechant R, Decuypere JP, Deegan S, Dehay B, Del Bello B, Del Re DP, Delage-Mourroux R, Delbridge LM, Deldicque L, Delorme-Axford E, Deng Y, Dengjel J, Denizot M, Dent P, Der CJ, Deretic V, Derrien B, Deutsch E, Devarenne TP, Devenish RJ, Di Bartolomeo S, Di Daniele N, Di Domenico F, Di Nardo A, Di Paola S, Di Pietro A, Di Renzo L, DiAntonio A, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dickey CA, Dickson RC, Diederich M, Digard P, Dikic I, Dinesh-Kumar SP, Ding C, Ding WX, Ding Z, Dini L, Distler JH, Diwan A, Djavaheri-Mergny M, Dmytruk K, Dobson RC, Doetsch V, Dokladny K, Dokudovskaya S, Donadelli M, Dong XC, Dong X, Dong Z, Donohue TM Jr, Doran KS, D'Orazi G, Dorn GW 2nd, Dosenko V, Dridi S, Drucker L, Du J, Du LL, Du L, du Toit A, Dua P, Duan L, Duann P, Dubey VK, Duchen MR, Duchosal MA, Duez H, Dugail I, Dumit VI, Duncan MC, Dunlop EA, Dunn WA Jr, Dupont N, Dupuis L, Durán RV, Durcan TM, Duvezin-Caubet S, Duvvuri U, Eapen V, Ebrahimi-Fakhari D, Echard A, Eckhart L, Edelstein CL, Edinger AL, Eichinger L, Eisenberg T, Eisenberg-Lerner A, Eissa NT, El-Deiry WS, El-Khoury V, Elazar Z, Eldar-Finkelman H, Elliott CJ, Emanuele E, Emmenegger U, Engedal N, Engelbrecht AM, Engelender S, Enserink JM, Erdmann R, Erenpreisa J, Eri R, Eriksen JL, Erman A, Escalante R, Eskelinen EL, Espert L, Esteban-Martínez L, Evans TJ, Fabri M, Fabrias G, Fabrizi C, Facchiano A, Færgeman NJ, Faggioni A, Fairlie WD, Fan C, Fan D, Fan J, Fang S, Fanto M, Fanzani A, Farkas T, Faure M, Favier FB, Fearnhead H, Federici M, Fei E, Felizardo TC, Feng H, Feng Y, Feng Y, Ferguson TA, Fernández ÁF, Fernandez-Barrena MG, Fernandez-Checa JC, Fernández-López A, Fernandez-Zapico ME, Feron O, Ferraro E, Ferreira-Halder CV, Fesus L, Feuer R, Fiesel FC, Filippi-Chiela EC, Filomeni G, Fimia GM, Fingert JH, Finkbeiner S, Finkel T, Fiorito F, Fisher PB, Flajolet M, Flamigni F, Florey O, Florio S, Floto RA, Folini M, Follo C, Fon EA, Fornai F, Fortunato F, Fraldi A, Franco R, Francois A, François A, Frankel LB, Fraser ID, Frey N, Freyssenet DG, Frezza C, Friedman SL, Frigo DE, Fu D, Fuentes JM, Fueyo J, Fujitani Y, Fujiwara Y, Fujiya M, Fukuda M, Fulda S, Fusco C, Gabryel B, Gaestel M, Gailly P, Gajewska M, Galadari S, Galili G, Galindo I, Galindo MF, Galliciotti G, Galluzzi L, Galluzzi L, Galy V, Gammoh N, Gandy S, Ganesan AK, Ganesan S, Ganley IG, Gannagé M, Gao FB, Gao F, Gao JX, García Nannig L, García Véscovi E, Garcia-Macía M, Garcia-Ruiz C, Garg AD, Garg PK, Gargini R, Gassen NC, Gatica D, Gatti E, Gavard J, Gavathiotis E, Ge L, Ge P, Ge S, Gean PW, Gelmetti V, Genazzani AA, Geng J, Genschik P, Gerner L, Gestwicki JE, Gewirtz DA, Ghavami S, Ghigo E, Ghosh D, Giammarioli AM, Giampieri F, Giampietri C, Giatromanolaki A, Gibbings DJ, Gibellini L, Gibson SB, Ginet V, Giordano A, Giorgini F, Giovannetti E, Girardin SE, Gispert S, Giuliano S, Gladson CL, Glavic A, Gleave M, Godefroy N, Gogal RM Jr, Gokulan K, Goldman GH, Goletti D, Goligorsky MS, Gomes AV, Gomes LC, Gomez H, Gomez-Manzano C, Gómez-Sánchez R, Gonçalves DA, Goncu E, Gong Q, Gongora C, Gonzalez CB, Gonzalez-Alegre P, Gonzalez-Cabo P, González-Polo RA, Goping IS, Gorbea C, Gorbunov NV, Goring DR, Gorman AM, Gorski SM, Goruppi S, Goto-Yamada S, Gotor C, Gottlieb RA, Gozes I, Gozuacik D, Graba Y, Graef M, Granato GE, Grant GD, Grant S, Gravina GL, Green DR, Greenhough A, Greenwood MT, Grimaldi B, Gros F, Grose C, Groulx JF, Gruber F, Grumati P, Grune T, Guan JL, Guan KL, Guerra B, Guillen C, Gulshan K, Gunst J, Guo C, Guo L, Guo M, Guo W, Guo XG, Gust AA, Gustafsson ÅB, Gutierrez E, Gutierrez MG, Gwak HS, Haas A, Haber JE, Hadano S, Hagedorn M, Hahn DR, Halayko AJ, Hamacher-Brady A, Hamada K, Hamai A, Hamann A, Hamasaki M, Hamer I, Hamid Q, Hammond EM, Han F, Han W, Handa JT, Hanover JA, Hansen M, Harada M, Harhaji-Trajkovic L, Harper JW, Harrath AH, 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Kawula T, Kaynar AM, Ke PY, Ke ZJ, Kehrl JH, Keller KE, Kemper JK, Kenworthy AK, Kepp O, Kern A, Kesari S, Kessel D, Ketteler R, Kettelhut Ido C, Khambu B, Khan MM, Khandelwal VK, Khare S, Kiang JG, Kiger AA, Kihara A, Kim AL, Kim CH, Kim DR, Kim DH, Kim EK, Kim HY, Kim HR, Kim JS, Kim JH, Kim JC, Kim JH, Kim KW, Kim MD, Kim MM, Kim PK, Kim SW, Kim SY, Kim YS, Kim Y, Kimchi A, Kimmelman AC, Kimura T, King JS, Kirkegaard K, Kirkin V, Kirshenbaum LA, Kishi S, Kitajima Y, Kitamoto K, Kitaoka Y, Kitazato K, Kley RA, Klimecki WT, Klinkenberg M, Klucken J, Knævelsrud H, Knecht E, Knuppertz L, Ko JL, Kobayashi S, Koch JC, Koechlin-Ramonatxo C, Koenig U, Koh YH, Köhler K, Kohlwein SD, Koike M, Komatsu M, Kominami E, Kong D, Kong HJ, Konstantakou EG, Kopp BT, Korcsmaros T, Korhonen L, Korolchuk VI, Koshkina NV, Kou Y, Koukourakis MI, Koumenis C, Kovács AL, Kovács T, Kovacs WJ, Koya D, Kraft C, Krainc D, Kramer H, Kravic-Stevovic T, Krek W, Kretz-Remy C, Krick R, Krishnamurthy M, Kriston-Vizi J, 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Autophagy. 2016;12(1):1-222. doi: 10.1080/15548627.2015.1100356. No abstract available. Erratum in: Autophagy. 2016;12(2):443. Selliez, Iban [corrected to Seiliez, Iban].

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High glucose and hyperglycemic sera from type 2 diabetic patients impair DC differentiation by inducing ROS and activating Wnt/β-catenin and p38 MAPK.

Gilardini Montani MS, Granato M, Cuomo L, Valia S, Di Renzo L, D'Orazi G, Faggioni A, Cirone M.

Biochim Biophys Acta. 2016 Apr;1862(4):805-813. doi: 10.1016/j.bbadis.2016.01.001. Epub 2016 Jan 6.

16.

Zn(II)-curc targets p53 in thyroid cancer cells.

Garufi A, D'Orazi V, Crispini A, D'Orazi G.

Int J Oncol. 2015 Oct;47(4):1241-8. doi: 10.3892/ijo.2015.3125. Epub 2015 Aug 13.

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The beneficial effect of Zinc(II) on low-dose chemotherapeutic sensitivity involves p53 activation in wild-type p53-carrying colorectal cancer cells.

Garufi A, Ubertini V, Mancini F, D'Orazi V, Baldari S, Moretti F, Bossi G, D'Orazi G.

J Exp Clin Cancer Res. 2015 Aug 22;34:87. doi: 10.1186/s13046-015-0206-x.

18.

Targeting MKK3 as a novel anticancer strategy: molecular mechanisms and therapeutical implications.

Baldari S, Ubertini V, Garufi A, D'Orazi G, Bossi G.

Cell Death Dis. 2015 Jan 29;6:e1621. doi: 10.1038/cddis.2014.591.

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High glucose dephosphorylates serine 46 and inhibits p53 apoptotic activity.

Garufi A, D'Orazi G.

J Exp Clin Cancer Res. 2014 Sep 27;33:79. doi: 10.1186/s13046-014-0079-4.

20.

Degradation of mutant p53H175 protein by Zn(II) through autophagy.

Garufi A, Pucci D, D'Orazi V, Cirone M, Bossi G, Avantaggiati ML, D'Orazi G.

Cell Death Dis. 2014 May 29;5:e1271. doi: 10.1038/cddis.2014.217.

21.

SLC25A1, or CIC, is a novel transcriptional target of mutant p53 and a negative tumor prognostic marker.

Kolukula VK, Sahu G, Wellstein A, Rodriguez OC, Preet A, Iacobazzi V, D'Orazi G, Albanese C, Palmieri F, Avantaggiati ML.

Oncotarget. 2014 Mar 15;5(5):1212-25.

22.

Gentian violet induces wtp53 transactivation in cancer cells.

Garufi A, D'Orazi V, Arbiser JL, D'Orazi G.

Int J Oncol. 2014 Apr;44(4):1084-90. doi: 10.3892/ijo.2014.2304. Epub 2014 Feb 14.

23.

Kaposi sarcoma associated herpesvirus (KSHV) induces AKT hyperphosphorylation, bortezomib-resistance and GLUT-1 plasma membrane exposure in THP-1 monocytic cell line.

Gonnella R, Santarelli R, Farina A, Granato M, D'Orazi G, Faggioni A, Cirone M.

J Exp Clin Cancer Res. 2013 Oct 23;32:79. doi: 10.1186/1756-9966-32-79.

24.

Zinc supplementation is required for the cytotoxic and immunogenic effects of chemotherapy in chemoresistant p53-functionally deficient cells.

Cirone M, Garufi A, Di Renzo L, Granato M, Faggioni A, D'Orazi G.

Oncoimmunology. 2013 Sep 1;2(9):e26198. Epub 2013 Sep 12.

25.

A fluorescent curcumin-based Zn(II)-complex reactivates mutant (R175H and R273H) p53 in cancer cells.

Garufi A, Trisciuoglio D, Porru M, Leonetti C, Stoppacciaro A, D'Orazi V, Avantaggiati M, Crispini A, Pucci D, D'Orazi G.

J Exp Clin Cancer Res. 2013 Oct 7;32:72. doi: 10.1186/1756-9966-32-72.

26.

JNK and macroautophagy activation by bortezomib has a pro-survival effect in primary effusion lymphoma cells.

Granato M, Santarelli R, Lotti LV, Di Renzo L, Gonnella R, Garufi A, Trivedi P, Frati L, D'Orazi G, Faggioni A, Cirone M.

PLoS One. 2013 Sep 26;8(9):e75965. doi: 10.1371/journal.pone.0075965. eCollection 2013.

27.

HSP70 inhibition by 2-phenylethynesulfonamide induces lysosomal cathepsin D release and immunogenic cell death in primary effusion lymphoma.

Granato M, Lacconi V, Peddis M, Lotti LV, Di Renzo L, Gonnella R, Santarelli R, Trivedi P, Frati L, D'Orazi G, Faggioni A, Cirone M.

Cell Death Dis. 2013 Jul 18;4:e730. doi: 10.1038/cddis.2013.263. Erratum in: Cell Death Dis. 2014;5:e2154. Renzo, L D [corrected to Di Renzo, L].

28.

Glucose restriction induces cell death in parental but not in homeodomain-interacting protein kinase 2-depleted RKO colon cancer cells: molecular mechanisms and implications for tumor therapy.

Garufi A, Ricci A, Trisciuoglio D, Iorio E, Carpinelli G, Pistritto G, Cirone M, D'Orazi G.

Cell Death Dis. 2013 May 23;4:e639. doi: 10.1038/cddis.2013.163.

29.

Targeting COX-2/PGE(2) pathway in HIPK2 knockdown cancer cells: impact on dendritic cell maturation.

Garufi A, Pistritto G, Ceci C, Di Renzo L, Santarelli R, Faggioni A, Cirone M, D'Orazi G.

PLoS One. 2012;7(11):e48342. doi: 10.1371/journal.pone.0048342. Epub 2012 Nov 7.

30.

Updates on HIPK2: a resourceful oncosuppressor for clearing cancer.

D'Orazi G, Rinaldo C, Soddu S.

J Exp Clin Cancer Res. 2012 Aug 13;31:63. doi: 10.1186/1756-9966-31-63. Review.

31.

p53 reactivation: the link to zinc.

D'Orazi G, Givol D.

Cell Cycle. 2012 Jul 15;11(14):2581-2. doi: 10.4161/cc.21020. Epub 2012 Jul 15. No abstract available.

32.

HIPK2 downregulates vimentin and inhibits breast cancer cell invasion.

Nodale C, Sheffer M, Jacob-Hirsch J, Folgiero V, Falcioni R, Aiello A, Garufi A, Rechavi G, Givol D, D'Orazi G.

Cancer Biol Ther. 2012 Feb 15;13(4):198-205. doi: 10.4161/cbt.13.4.18694. Epub 2012 Feb 15.

PMID:
22236966
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Genome-wide analysis discloses reversal of the hypoxia-induced changes of gene expression in colon cancer cells by zinc supplementation.

Sheffer M, Simon AJ, Jacob-Hirsch J, Rechavi G, Domany E, Givol D, D'Orazi G.

Oncotarget. 2011 Dec;2(12):1191-202.

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Zinc supplementation augments in vivo antitumor effect of chemotherapy by restoring p53 function.

Margalit O, Simon AJ, Yakubov E, Puca R, Yosepovich A, Avivi C, Jacob-Hirsch J, Gelernter I, Harmelin A, Barshack I, Rechavi G, D'Orazi G, Givol D, Amariglio N.

Int J Cancer. 2012 Aug 15;131(4):E562-8. doi: 10.1002/ijc.26441. Epub 2011 Nov 30.

35.

Azurin modulates the association of Mdm2 with p53: SPR evidence from interaction of the full-length proteins.

Domenici F, Frasconi M, Mazzei F, D'Orazi G, Bizzarri AR, Cannistraro S.

J Mol Recognit. 2011 Jul-Aug;24(4):707-14. doi: 10.1002/jmr.1105.

PMID:
21584881
36.

Restoring p53 active conformation by zinc increases the response of mutant p53 tumor cells to anticancer drugs.

Puca R, Nardinocchi L, Porru M, Simon AJ, Rechavi G, Leonetti C, Givol D, D'Orazi G.

Cell Cycle. 2011 May 15;10(10):1679-89. Epub 2011 May 15.

PMID:
21508668
37.

HIF-1α antagonizes p53-mediated apoptosis by triggering HIPK2 degradation.

Nardinocchi L, Puca R, D'Orazi G.

Aging (Albany NY). 2011 Jan;3(1):33-43.

38.

Zinc downregulates HIF-1α and inhibits its activity in tumor cells in vitro and in vivo.

Nardinocchi L, Pantisano V, Puca R, Porru M, Aiello A, Grasselli A, Leonetti C, Safran M, Rechavi G, Givol D, Farsetti A, D'Orazi G.

PLoS One. 2010 Dec 13;5(12):e15048. doi: 10.1371/journal.pone.0015048.

39.

Unfolded p53 in the pathogenesis of Alzheimer's disease: is HIPK2 the link?

Stanga S, Lanni C, Govoni S, Uberti D, D'Orazi G, Racchi M.

Aging (Albany NY). 2010 Sep;2(9):545-54. Review.

40.

Counteracting MDM2-induced HIPK2 downregulation restores HIPK2/p53 apoptotic signaling in cancer cells.

Nardinocchi L, Puca R, Givol D, D'Orazi G.

FEBS Lett. 2010 Oct 8;584(19):4253-8. doi: 10.1016/j.febslet.2010.09.018. Epub 2010 Sep 16.

41.

Regulation of p53 activity by HIPK2: molecular mechanisms and therapeutical implications in human cancer cells.

Puca R, Nardinocchi L, Givol D, D'Orazi G.

Oncogene. 2010 Aug 5;29(31):4378-87. doi: 10.1038/onc.2010.183. Epub 2010 May 31. Review.

PMID:
20514025
42.

Homeodomain interacting protein kinase 2: a target for Alzheimer's beta amyloid leading to misfolded p53 and inappropriate cell survival.

Lanni C, Nardinocchi L, Puca R, Stanga S, Uberti D, Memo M, Govoni S, D'Orazi G, Racchi M.

PLoS One. 2010 Apr 14;5(4):e10171. doi: 10.1371/journal.pone.0010171.

43.

HIPK2-a therapeutical target to be (re)activated for tumor suppression: role in p53 activation and HIF-1α inhibition.

Nardinocchi L, Puca R, Givol D, D'Orazi G.

Cell Cycle. 2010 Apr 1;9(7):1270-5. Review.

PMID:
20234185
44.

Nox1 is involved in p53 deacetylation and suppression of its transcriptional activity and apoptosis.

Puca R, Nardinocchi L, Starace G, Rechavi G, Sacchi A, Givol D, D'Orazi G.

Free Radic Biol Med. 2010 May 15;48(10):1338-46. doi: 10.1016/j.freeradbiomed.2010.02.015. Epub 2010 Feb 18.

PMID:
20171273
45.

Interaction of p53 with Mdm2 and azurin as studied by atomic force spectroscopy.

Funari G, Domenici F, Nardinocchi L, Puca R, D'Orazi G, Bizzarri AR, Cannistraro S.

J Mol Recognit. 2010 Jul-Aug;23(4):343-51. doi: 10.1002/jmr.999.

PMID:
19941302
46.

HIPK2 modulates p53 activity towards pro-apoptotic transcription.

Puca R, Nardinocchi L, Sacchi A, Rechavi G, Givol D, D'Orazi G.

Mol Cancer. 2009 Oct 14;8:85. doi: 10.1186/1476-4598-8-85.

47.

Targeting hypoxia in cancer cells by restoring homeodomain interacting protein-kinase 2 and p53 activity and suppressing HIF-1alpha.

Nardinocchi L, Puca R, Sacchi A, Rechavi G, Givol D, D'Orazi G.

PLoS One. 2009 Aug 28;4(8):e6819. doi: 10.1371/journal.pone.0006819.

48.

Negative regulation of beta4 integrin transcription by homeodomain-interacting protein kinase 2 and p53 impairs tumor progression.

Bon G, Di Carlo SE, Folgiero V, Avetrani P, Lazzari C, D'Orazi G, Brizzi MF, Sacchi A, Soddu S, Blandino G, Mottolese M, Falcioni R.

Cancer Res. 2009 Jul 15;69(14):5978-86. doi: 10.1158/0008-5472.CAN-09-0244. Epub 2009 Jun 30.

49.
50.

Transcriptional regulation of hypoxia-inducible factor 1alpha by HIPK2 suggests a novel mechanism to restrain tumor growth.

Nardinocchi L, Puca R, Guidolin D, Belloni AS, Bossi G, Michiels C, Sacchi A, Onisto M, D'Orazi G.

Biochim Biophys Acta. 2009 Feb;1793(2):368-77. doi: 10.1016/j.bbamcr.2008.10.013. Epub 2008 Nov 6.

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