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Items: 11

1.

Endoxifen, 4-Hydroxytamoxifen and an Estrogenic Derivative Modulate Estrogen Receptor Complex Mediated Apoptosis in Breast Cancer.

Maximov PY, Abderrahman B, Fanning SW, Sengupta S, Fan P, Curpan RF, Quintana Rincon DM, Greenland JA, Rajan SS, Greene GL, Jordan VC.

Mol Pharmacol. 2018 May 8. pii: mol.117.111385. doi: 10.1124/mol.117.111385. [Epub ahead of print]

2.

A unifying biology of sex steroid-induced apoptosis in prostate and breast cancers.

Maximov PY, Abderrahman B, Curpan RF, Hawsawi YM, Fan P, Jordan VC.

Endocr Relat Cancer. 2018 Feb;25(2):R83-R113. doi: 10.1530/ERC-17-0416. Epub 2017 Nov 21. Review.

3.

The molecular, cellular and clinical consequences of targeting the estrogen receptor following estrogen deprivation therapy.

Fan P, Maximov PY, Curpan RF, Abderrahman B, Jordan VC.

Mol Cell Endocrinol. 2015 Dec 15;418 Pt 3:245-63. doi: 10.1016/j.mce.2015.06.004. Epub 2015 Jun 5. Review.

4.

Pharmacological relevance of endoxifen in a laboratory simulation of breast cancer in postmenopausal patients.

Maximov PY, McDaniel RE, Fernandes DJ, Bhatta P, Korostyshevskiy VR, Curpan RF, Jordan VC.

J Natl Cancer Inst. 2014 Sep 24;106(10). pii: dju283. doi: 10.1093/jnci/dju283. Print 2014 Oct.

5.

Influence of the length and positioning of the antiestrogenic side chain of endoxifen and 4-hydroxytamoxifen on gene activation and growth of estrogen receptor positive cancer cells.

Maximov PY, Fernandes DJ, McDaniel RE, Myers CB, Curpan RF, Jordan VC.

J Med Chem. 2014 Jun 12;57(11):4569-83. doi: 10.1021/jm500569h. Epub 2014 May 22.

6.

Selective Bcl-2 Inhibitor Probes.

Zou J, Ardecky R, Pinkerton AB, Sergienko E, Su Y, Stonich D, Curpan RF, Simons PC, Zhai D, Diaz P, Young SM, Carter MB, Bologa GC, Oprea TI, Edwards BS, Satterhwait AC, Mangravita-Novo A, Vicchiarelli M, McAnally D, Smith LH, Diwan J, Chung TDY, Reed JC, Sklar LA.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2011 Oct 31 [updated 2013 Feb 28].

7.

The Conformation of the Estrogen Receptor Directs Estrogen-Induced Apoptosis in Breast Cancer: A Hypothesis.

Maximov P, Sengupta S, Lewis-Wambi JS, Kim HR, Curpan RF, Jordan VC.

Horm Mol Biol Clin Investig. 2011 Mar 1;5(1):27-34.

8.

High-throughput screen for the chemical inhibitors of antiapoptotic bcl-2 family proteins by multiplex flow cytometry.

Curpan RF, Simons PC, Zhai D, Young SM, Carter MB, Bologa CG, Oprea TI, Satterthwait AC, Reed JC, Edwards BS, Sklar LA.

Assay Drug Dev Technol. 2011 Oct;9(5):465-74. doi: 10.1089/adt.2010.0363. Epub 2011 May 11.

9.

Structure-function relationships of estrogenic triphenylethylenes related to endoxifen and 4-hydroxytamoxifen.

Maximov PY, Myers CB, Curpan RF, Lewis-Wambi JS, Jordan VC.

J Med Chem. 2010 Apr 22;53(8):3273-83. doi: 10.1021/jm901907u.

10.

A crowdsourcing evaluation of the NIH chemical probes.

Oprea TI, Bologa CG, Boyer S, Curpan RF, Glen RC, Hopkins AL, Lipinski CA, Marshall GR, Martin YC, Ostopovici-Halip L, Rishton G, Ursu O, Vaz RJ, Waller C, Waldmann H, Sklar LA.

Nat Chem Biol. 2009 Jul;5(7):441-7. doi: 10.1038/nchembio0709-441. Erratum in: Nat Chem Biol. 2009 Aug;5(8):600.

11.

Detection of intracellular granularity induction in prostate cancer cell lines by small molecules using the HyperCyt high-throughput flow cytometry system.

Haynes MK, Strouse JJ, Waller A, Leitao A, Curpan RF, Bologa C, Oprea TI, Prossnitz ER, Edwards BS, Sklar LA, Thompson TA.

J Biomol Screen. 2009 Jul;14(6):596-609. doi: 10.1177/1087057109335671. Epub 2009 May 21.

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