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Items: 1 to 50 of 340

1.

Cryo-EM structure of a mammalian RNA polymerase II elongation complex inhibited by α-amanitin.

Liu X, Farnung L, Wigge C, Cramer P.

J Biol Chem. 2018 Mar 17. pii: jbc.RA118.002545. doi: 10.1074/jbc.RA118.002545. [Epub ahead of print]

2.

CLL2-BXX Phase II trials: sequential, targeted treatment for eradication of minimal residual disease in chronic lymphocytic leukemia.

Cramer P, von Tresckow J, Bahlo J, Engelke A, Langerbeins P, Fink AM, Fischer K, Wendtner CM, Kreuzer KA, Stilgenbauer S, Böttcher S, Eichhorst B, Hallek M.

Future Oncol. 2018 Mar;14(6):499-513. doi: 10.2217/fon-2017-0442. Epub 2018 Feb 21.

3.

Clonal dynamics towards the development of venetoclax resistance in chronic lymphocytic leukemia.

Herling CD, Abedpour N, Weiss J, Schmitt A, Jachimowicz RD, Merkel O, Cartolano M, Oberbeck S, Mayer P, Berg V, Thomalla D, Kutsch N, Stiefelhagen M, Cramer P, Wendtner CM, Persigehl T, Saleh A, Altmüller J, Nürnberg P, Pallasch C, Achter V, Lang U, Eichhorst B, Castiglione R, Schäfer SC, Büttner R, Kreuzer KA, Reinhardt HC, Hallek M, Frenzel LP, Peifer M.

Nat Commun. 2018 Feb 20;9(1):727. doi: 10.1038/s41467-018-03170-7.

4.

The Development of Defense Mechanisms During the Latency Period.

Cramer P.

J Nerv Ment Dis. 2018 Apr;206(4):286-289. doi: 10.1097/NMD.0000000000000793.

PMID:
29419639
5.

Aging African green monkeys manifest transcriptional, pathological, and cognitive hallmarks of human Alzheimer's disease.

Cramer PE, Gentzel RC, Tanis KQ, Vardigan J, Wang Y, Connolly B, Manfre P, Lodge K, Renger JJ, Zerbinatti C, Uslaner JM.

Neurobiol Aging. 2018 Apr;64:92-106. doi: 10.1016/j.neurobiolaging.2017.12.011. Epub 2017 Dec 20.

PMID:
29353102
6.

The Effect of Prucalopride on Small Bowel Transit Time in Hospitalized Patients Undergoing Capsule Endoscopy.

Alsahafi M, Cramer P, Chatur N, Donnellan F.

Can J Gastroenterol Hepatol. 2017;2017:2696947. doi: 10.1155/2017/2696947. Epub 2017 Nov 23.

7.

Improvement of fatigue, physical functioning, and well-being among patients with severe impairment at baseline receiving ibrutinib in combination with bendamustine and rituximab for relapsed chronic lymphocytic leukemia/small lymphocytic lymphoma in the HELIOS study.

Cramer P, Fraser G, Santucci-Silva R, Grosicki S, Dilhuydy MS, Janssens A, Loscertales J, Rule S, Goy A, Traina S, Chan EKH, Diels J, Sengupta N, Mahler M, Salman M, Howes A, Chanan-Khan A.

Leuk Lymphoma. 2018 Jan 3:1-10. doi: 10.1080/10428194.2017.1416364. [Epub ahead of print]

PMID:
29295653
8.

Acute and Subchronic Toxicity Studies of Aqueous Extract of Desmodium adscendens (Sw) DC.

Quaye O, Cramer P, Ofosuhene M, Okine LKN, Nyarko AK.

J Evid Based Complementary Altern Med. 2017 Oct;22(4):753-759. doi: 10.1177/2156587217736587. Epub 2017 Nov 7.

9.

Structural Basis of Mitochondrial Transcription Initiation.

Hillen HS, Morozov YI, Sarfallah A, Temiakov D, Cramer P.

Cell. 2017 Nov 16;171(5):1072-1081.e10. doi: 10.1016/j.cell.2017.10.036.

PMID:
29149603
10.

Structures of transcription pre-initiation complex with TFIIH and Mediator.

Schilbach S, Hantsche M, Tegunov D, Dienemann C, Wigge C, Urlaub H, Cramer P.

Nature. 2017 Nov 9;551(7679):204-209. doi: 10.1038/nature24282. Epub 2017 Nov 1.

PMID:
29088706
11.

Mechanism of RNA polymerase II stalling by DNA alkylation.

Malvezzi S, Farnung L, Aloisi CMN, Angelov T, Cramer P, Sturla SJ.

Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):12172-12177. doi: 10.1073/pnas.1706592114. Epub 2017 Oct 30.

12.

Mechanism of Transcription Anti-termination in Human Mitochondria.

Hillen HS, Parshin AV, Agaronyan K, Morozov YI, Graber JJ, Chernev A, Schwinghammer K, Urlaub H, Anikin M, Cramer P, Temiakov D.

Cell. 2017 Nov 16;171(5):1082-1093.e13. doi: 10.1016/j.cell.2017.09.035. Epub 2017 Oct 12.

PMID:
29033127
13.

Nucleosome-Chd1 structure and implications for chromatin remodelling.

Farnung L, Vos SM, Wigge C, Cramer P.

Nature. 2017 Oct 26;550(7677):539-542. doi: 10.1038/nature24046. Epub 2017 Oct 11.

14.

CDK9-dependent RNA polymerase II pausing controls transcription initiation.

Gressel S, Schwalb B, Decker TM, Qin W, Leonhardt H, Eick D, Cramer P.

Elife. 2017 Oct 10;6. pii: e29736. doi: 10.7554/eLife.29736.

15.

Structure of a transcribing RNA polymerase II-DSIF complex reveals a multidentate DNA-RNA clamp.

Bernecky C, Plitzko JM, Cramer P.

Nat Struct Mol Biol. 2017 Oct;24(10):809-815. doi: 10.1038/nsmb.3465. Epub 2017 Sep 11.

PMID:
28892040
16.

Characterization of atrial fibrillation adverse events reported in ibrutinib randomized controlled registration trials.

Brown JR, Moslehi J, O'Brien S, Ghia P, Hillmen P, Cymbalista F, Shanafelt TD, Fraser G, Rule S, Kipps TJ, Coutre S, Dilhuydy MS, Cramer P, Tedeschi A, Jaeger U, Dreyling M, Byrd JC, Howes A, Todd M, Vermeulen J, James DF, Clow F, Styles L, Valentino R, Wildgust M, Mahler M, Burger JA.

Haematologica. 2017 Oct;102(10):1796-1805. doi: 10.3324/haematol.2017.171041. Epub 2017 Jul 27.

17.

Impact of gender on outcome after chemoimmunotherapy in patients with chronic lymphocytic leukemia: a meta-analysis by the German CLL study group.

Al-Sawaf O, Robrecht S, Bahlo J, Fink AM, Cramer P, von Tresckow J, Maurer C, Bergmann M, Seiler T, Lange E, Kneba M, Stilgenbauer S, Döhner H, Kiehl MG, Jäger U, Wendtner CM, Fischer K, Goede V, Hallek M, Eichhorst B, Hopfinger G.

Leukemia. 2017 Oct;31(10):2251-2253. doi: 10.1038/leu.2017.221. Epub 2017 Jul 12. No abstract available.

PMID:
28745332
18.

Childhood Precursors of the Narcissistic Personality.

Cramer P.

J Nerv Ment Dis. 2017 Sep;205(9):679-684. doi: 10.1097/NMD.0000000000000703.

PMID:
28632514
19.

Architecture of the RNA polymerase II-Paf1C-TFIIS transcription elongation complex.

Xu Y, Bernecky C, Lee CT, Maier KC, Schwalb B, Tegunov D, Plitzko JM, Urlaub H, Cramer P.

Nat Commun. 2017 Jun 6;8:15741. doi: 10.1038/ncomms15741.

20.

Bendamustine and its role in the treatment of unfit patients with chronic lymphocytic leukaemia: a perspective review.

Al-Sawaf O, Cramer P, Goede V, Hallek M, Pflug N.

Ther Adv Hematol. 2017 Jun;8(6):197-205. doi: 10.1177/2040620717699365. Epub 2017 Mar 30. Review.

21.

RNA-dependent chromatin association of transcription elongation factors and Pol II CTD kinases.

Battaglia S, Lidschreiber M, Baejen C, Torkler P, Vos SM, Cramer P.

Elife. 2017 May 24;6. pii: e25637. doi: 10.7554/eLife.25637.

22.

Structural Molecular Biology-A Personal Reflection on the Occasion of John Kendrew's 100th Birthday.

Cramer P.

J Mol Biol. 2017 Aug 18;429(17):2603-2610. doi: 10.1016/j.jmb.2017.05.007. Epub 2017 May 10.

PMID:
28501586
23.

Core Mediator structure at 3.4 Å extends model of transcription initiation complex.

Nozawa K, Schneider TR, Cramer P.

Nature. 2017 May 11;545(7653):248-251. doi: 10.1038/nature22328. Epub 2017 May 3.

PMID:
28467824
24.

Conserved RNA polymerase II initiation complex structure.

Hantsche M, Cramer P.

Curr Opin Struct Biol. 2017 Dec;47:17-22. doi: 10.1016/j.sbi.2017.03.013. Epub 2017 Apr 22. Review.

PMID:
28437704
25.

Architecture of a transcribing-translating expressome.

Kohler R, Mooney RA, Mills DJ, Landick R, Cramer P.

Science. 2017 Apr 14;356(6334):194-197. doi: 10.1126/science.aal3059.

26.

The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA.

Wittmann S, Renner M, Watts BR, Adams O, Huseyin M, Baejen C, El Omari K, Kilchert C, Heo DH, Kecman T, Cramer P, Grimes JM, Vasiljeva L.

Nat Commun. 2017 Apr 3;8:14861. doi: 10.1038/ncomms14861.

27.

Spt5 Plays Vital Roles in the Control of Sense and Antisense Transcription Elongation.

Shetty A, Kallgren SP, Demel C, Maier KC, Spatt D, Alver BH, Cramer P, Park PJ, Winston F.

Mol Cell. 2017 Apr 6;66(1):77-88.e5. doi: 10.1016/j.molcel.2017.02.023. Epub 2017 Mar 30.

28.

Structural Basis of RNA Polymerase I Transcription Initiation.

Engel C, Gubbey T, Neyer S, Sainsbury S, Oberthuer C, Baejen C, Bernecky C, Cramer P.

Cell. 2017 Mar 23;169(1):120-131.e22. doi: 10.1016/j.cell.2017.03.003.

29.

Genome-wide Analysis of RNA Polymerase II Termination at Protein-Coding Genes.

Baejen C, Andreani J, Torkler P, Battaglia S, Schwalb B, Lidschreiber M, Maier KC, Boltendahl A, Rus P, Esslinger S, Söding J, Cramer P.

Mol Cell. 2017 Apr 6;66(1):38-49.e6. doi: 10.1016/j.molcel.2017.02.009. Epub 2017 Mar 16.

30.

Defense Mechanisms and Utilization in Cancer Patients Undergoing Radiation Therapy: A Pilot Study.

Porcerelli JH, Cramer P, Porcerelli DJ, Arterbery VE.

J Nerv Ment Dis. 2017 Jun;205(6):466-470. doi: 10.1097/NMD.0000000000000674.

PMID:
28291059
31.

TT-seq captures enhancer landscapes immediately after T-cell stimulation.

Michel M, Demel C, Zacher B, Schwalb B, Krebs S, Blum H, Gagneur J, Cramer P.

Mol Syst Biol. 2017 Mar 7;13(3):920. doi: 10.15252/msb.20167507.

32.

TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation.

Jinn S, Drolet RE, Cramer PE, Wong AH, Toolan DM, Gretzula CA, Voleti B, Vassileva G, Disa J, Tadin-Strapps M, Stone DJ.

Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2389-2394. doi: 10.1073/pnas.1616332114. Epub 2017 Feb 13.

33.

Gastrointestinal and Hepatic Complications of Immune Checkpoint Inhibitors.

Cramer P, Bresalier RS.

Curr Gastroenterol Rep. 2017 Jan;19(1):3. doi: 10.1007/s11894-017-0540-6. Review.

PMID:
28124291
34.

Accurate Promoter and Enhancer Identification in 127 ENCODE and Roadmap Epigenomics Cell Types and Tissues by GenoSTAN.

Zacher B, Michel M, Schwalb B, Cramer P, Tresch A, Gagneur J.

PLoS One. 2017 Jan 5;12(1):e0169249. doi: 10.1371/journal.pone.0169249. eCollection 2017.

35.

Structure of RNA polymerase I transcribing ribosomal DNA genes.

Neyer S, Kunz M, Geiss C, Hantsche M, Hodirnau VV, Seybert A, Engel C, Scheffer MP, Cramer P, Frangakis AS.

Nature. 2016 Nov 14. doi: 10.1038/nature20561. [Epub ahead of print]

PMID:
27842382
36.

Nucleosomal arrangement affects single-molecule transcription dynamics.

Fitz V, Shin J, Ehrlich C, Farnung L, Cramer P, Zaburdaev V, Grill SW.

Proc Natl Acad Sci U S A. 2016 Oct 24. pii: 201602764. [Epub ahead of print]

37.

Inference of gene regulation functions from dynamic transcriptome data.

Hillenbrand P, Maier KC, Cramer P, Gerland U.

Elife. 2016 Sep 21;5. pii: e12188. doi: 10.7554/eLife.12188.

38.

Current strategies to create tailored and risk-adapted therapies for CLL patients.

Cramer P, Eichhorst B, Reinhardt HC, Hallek M.

Best Pract Res Clin Haematol. 2016 Mar;29(1):111-121. doi: 10.1016/j.beha.2016.08.010. Epub 2016 Aug 12. Review.

PMID:
27742065
39.

The Structural Basis of Transcription: 10 Years After the Nobel Prize in Chemistry.

Hantsche M, Cramer P.

Angew Chem Int Ed Engl. 2016 Dec 23;55(52):15972-15981. doi: 10.1002/anie.201608066. Epub 2016 Nov 11. Review.

PMID:
27723202
40.

Minimal Residual Disease Assessment Improves Prediction of Outcome in Patients With Chronic Lymphocytic Leukemia (CLL) Who Achieve Partial Response: Comprehensive Analysis of Two Phase III Studies of the German CLL Study Group.

Kovacs G, Robrecht S, Fink AM, Bahlo J, Cramer P, von Tresckow J, Maurer C, Langerbeins P, Fingerle-Rowson G, Ritgen M, Kneba M, Döhner H, Stilgenbauer S, Klapper W, Wendtner CM, Fischer K, Hallek M, Eichhorst B, Böttcher S.

J Clin Oncol. 2016 Nov 1;34(31):3758-3765. doi: 10.1200/JCO.2016.67.1305.

PMID:
27573660
41.

Structure determination of transient transcription complexes.

Cramer P.

Biochem Soc Trans. 2016 Aug 15;44(4):1177-82. doi: 10.1042/BST20160079. Review.

PMID:
27528766
42.

Defense Mechanism Card Pull in TAT Stories.

Cramer P.

J Pers Assess. 2017 Jan-Feb;99(1):15-24. doi: 10.1080/00223891.2016.1207080. Epub 2016 Aug 2.

PMID:
27484927
43.

Efficacy of antineoplastic treatment is associated with the use of antibiotics that modulate intestinal microbiota.

Pflug N, Kluth S, Vehreschild JJ, Bahlo J, Tacke D, Biehl L, Eichhorst B, Fischer K, Cramer P, Fink AM, von Bergwelt-Baildon M, Stilgenbauer S, Hallek M, Cornely OA, Vehreschild MJ.

Oncoimmunology. 2016 Apr 22;5(6):e1150399. doi: 10.1080/2162402X.2016.1150399. eCollection 2016 Jun.

44.

RNA polymerase I-Rrn3 complex at 4.8 Å resolution.

Engel C, Plitzko J, Cramer P.

Nat Commun. 2016 Jul 15;7:12129. doi: 10.1038/ncomms12129.

45.

Low volume polyethylene glycol with ascorbic acid, sodium picosulfate-magnesium citrate, and clear liquid diet alone prior to small bowel capsule endoscopy.

Rayner-Hartley E, Alsahafi M, Cramer P, Chatur N, Donnellan F.

World J Gastrointest Endosc. 2016 Jun 10;8(11):433-8. doi: 10.4253/wjge.v8.i11.433.

46.

Architecture and RNA binding of the human negative elongation factor.

Vos SM, Pöllmann D, Caizzi L, Hofmann KB, Rombaut P, Zimniak T, Herzog F, Cramer P.

Elife. 2016 Jun 10;5. pii: e14981. doi: 10.7554/eLife.14981.

47.

TT-seq maps the human transient transcriptome.

Schwalb B, Michel M, Zacher B, Frühauf K, Demel C, Tresch A, Gagneur J, Cramer P.

Science. 2016 Jun 3;352(6290):1225-8. doi: 10.1126/science.aad9841.

48.

Transcription initiation complex structures elucidate DNA opening.

Plaschka C, Hantsche M, Dienemann C, Burzinski C, Plitzko J, Cramer P.

Nature. 2016 May 19;533(7603):353-8. doi: 10.1038/nature17990. Epub 2016 May 11.

PMID:
27193681
49.

Effect of first-line treatment on second primary malignancies and Richter's transformation in patients with CLL.

Maurer C, Langerbeins P, Bahlo J, Cramer P, Fink AM, Pflug N, Engelke A, von Tresckow J, Kovacs G, Stilgenbauer S, Wendtner CM, Müller L, Ritgen M, Seiler T, Fischer K, Hallek M, Eichhorst B.

Leukemia. 2016 Oct;30(10):2019-2025. doi: 10.1038/leu.2016.113. Epub 2016 May 2.

PMID:
27133817
50.

Dose-reduced fludarabine, cyclophosphamide and rituximab (FCR) in older patients with chronic lymphocytic leukemia: does one size fit all?

Cramer P, Langerbeins P, Fischer K, Eichhorst B, Hallek M, Goede V.

Leuk Lymphoma. 2016 May;57(5):987-90. doi: 10.3109/10428194.2016.1164858. No abstract available.

PMID:
27096890

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