Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 302

1.

Evidence that the Plasmodium falciparum Protein Sortilin Potentially Acts as an Escorter for the Trafficking of the Rhoptry-Associated Membrane Antigen to the Rhoptries.

Hallée S, Boddey JA, Cowman AF, Richard D.

mSphere. 2018 Jan 3;3(1). pii: e00551-17. doi: 10.1128/mSphere.00551-17. eCollection 2018 Jan-Feb.

2.

Identification of highly-protective combinations of Plasmodium vivax recombinant proteins for vaccine development.

França CT, White MT, He WQ, Hostetler JB, Brewster J, Frato G, Malhotra I, Gruszczyk J, Huon C, Lin E, Kiniboro B, Yadava A, Siba P, Galinski MR, Healer J, Chitnis C, Cowman AF, Takashima E, Tsuboi T, Tham WH, Fairhurst RM, Rayner JC, King CL, Mueller I.

Elife. 2017 Sep 26;6. pii: e28673. doi: 10.7554/eLife.28673.

3.

The Molecular Basis of Erythrocyte Invasion by Malaria Parasites.

Cowman AF, Tonkin CJ, Tham WH, Duraisingh MT.

Cell Host Microbe. 2017 Aug 9;22(2):232-245. doi: 10.1016/j.chom.2017.07.003. Review.

PMID:
28799908
4.

Vaccines to Accelerate Malaria Elimination and Eventual Eradication.

Healer J, Cowman AF, Kaslow DC, Birkett AJ.

Cold Spring Harb Perspect Med. 2017 Sep 1;7(9). pii: a025627. doi: 10.1101/cshperspect.a025627. Review.

PMID:
28490535
5.

Recruitment of Human C1 Esterase Inhibitor Controls Complement Activation on Blood Stage Plasmodium falciparum Merozoites.

Kennedy AT, Wijeyewickrema LC, Huglo A, Lin C, Pike R, Cowman AF, Tham WH.

J Immunol. 2017 Jun 15;198(12):4728-4737. doi: 10.4049/jimmunol.1700067. Epub 2017 May 8.

PMID:
28484054
6.

Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis.

Wong W, Bai XC, Sleebs BE, Triglia T, Brown A, Thompson JK, Jackson KE, Hanssen E, Marapana DS, Fernandez IS, Ralph SA, Cowman AF, Scheres SHW, Baum J.

Nat Microbiol. 2017 Mar 13;2:17031. doi: 10.1038/nmicrobiol.2017.31.

7.

Plasmodium falciparum ligand binding to erythrocytes induce alterations in deformability essential for invasion.

Sisquella X, Nebl T, Thompson JK, Whitehead L, Malpede BM, Salinas ND, Rogers K, Tolia NH, Fleig A, O'Neill J, Tham WH, David Horgen F, Cowman AF.

Elife. 2017 Feb 22;6. pii: e21083. doi: 10.7554/eLife.21083.

8.

Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium falciparum protein CyRPA.

Chen L, Xu Y, Wong W, Thompson JK, Healer J, Goddard-Borger ED, Lawrence MC, Cowman AF.

Elife. 2017 Feb 14;6. pii: e21347. doi: 10.7554/eLife.21347.

9.

Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity.

Gilson PR, Tan C, Jarman KE, Lowes KN, Curtis JM, Nguyen W, Di Rago AE, Bullen HE, Prinz B, Duffy S, Baell JB, Hutton CA, Jousset Subroux H, Crabb BS, Avery VM, Cowman AF, Sleebs BE.

J Med Chem. 2017 Feb 9;60(3):1171-1188. doi: 10.1021/acs.jmedchem.6b01673. Epub 2017 Jan 26.

PMID:
28080063
10.

Malaria: Biology and Disease.

Cowman AF, Healer J, Marapana D, Marsh K.

Cell. 2016 Oct 20;167(3):610-624. doi: 10.1016/j.cell.2016.07.055. Review.

11.

Essential Role of the PfRh5/PfRipr/CyRPA Complex during Plasmodium falciparum Invasion of Erythrocytes.

Volz JC, Yap A, Sisquella X, Thompson JK, Lim NT, Whitehead LW, Chen L, Lampe M, Tham WH, Wilson D, Nebl T, Marapana D, Triglia T, Wong W, Rogers KL, Cowman AF.

Cell Host Microbe. 2016 Jul 13;20(1):60-71. doi: 10.1016/j.chom.2016.06.004. Epub 2016 Jun 30.

12.

Merozoite Antigens of Plasmodium falciparum Elicit Strain-Transcending Opsonizing Immunity.

Hill DL, Wilson DW, Sampaio NG, Eriksson EM, Ryg-Cornejo V, Harrison GLA, Uboldi AD, Robinson LJ, Beeson JG, Siba P, Cowman AF, Hansen DS, Mueller I, Schofield L.

Infect Immun. 2016 Jul 21;84(8):2175-2184. doi: 10.1128/IAI.00145-16. Print 2016 Aug.

13.

Exploration of the P3 region of PEXEL peptidomimetics leads to a potent inhibitor of the Plasmodium protease, plasmepsin V.

Gazdik M, Jarman KE, O'Neill MT, Hodder AN, Lowes KN, Jousset Sabroux H, Cowman AF, Boddey JA, Sleebs BE.

Bioorg Med Chem. 2016 May 1;24(9):1993-2010. doi: 10.1016/j.bmc.2016.03.027. Epub 2016 Mar 16.

PMID:
27021426
14.

Different Regions of Plasmodium falciparum Erythrocyte-Binding Antigen 175 Induce Antibody Responses to Infection of Varied Efficacy.

Chiu CY, White MT, Healer J, Thompson JK, Siba PM, Mueller I, Cowman AF, Hansen DS.

J Infect Dis. 2016 Jul 1;214(1):96-104. doi: 10.1093/infdis/jiw119. Epub 2016 Mar 28.

PMID:
27020092
15.

Export of malaria proteins requires co-translational processing of the PEXEL motif independent of phosphatidylinositol-3-phosphate binding.

Boddey JA, O'Neill MT, Lopaticki S, Carvalho TG, Hodder AN, Nebl T, Wawra S, van West P, Ebrahimzadeh Z, Richard D, Flemming S, Spielmann T, Przyborski J, Babon JJ, Cowman AF.

Nat Commun. 2016 Feb 1;7:10470. doi: 10.1038/ncomms10470.

16.

Multiple Plasmodium falciparum Merozoite Surface Protein 1 Complexes Mediate Merozoite Binding to Human Erythrocytes.

Lin CS, Uboldi AD, Epp C, Bujard H, Tsuboi T, Czabotar PE, Cowman AF.

J Biol Chem. 2016 Apr 1;291(14):7703-15. doi: 10.1074/jbc.M115.698282. Epub 2016 Jan 28.

17.

Recruitment of Factor H as a Novel Complement Evasion Strategy for Blood-Stage Plasmodium falciparum Infection.

Kennedy AT, Schmidt CQ, Thompson JK, Weiss GE, Taechalertpaisarn T, Gilson PR, Barlow PN, Crabb BS, Cowman AF, Tham WH.

J Immunol. 2016 Feb 1;196(3):1239-48. doi: 10.4049/jimmunol.1501581. Epub 2015 Dec 23.

18.

Plasmodium falciparum Adhesins Play an Essential Role in Signalling and Activation of Invasion into Human Erythrocytes.

Tham WH, Lim NT, Weiss GE, Lopaticki S, Ansell BR, Bird M, Lucet I, Dorin-Semblat D, Doerig C, Gilson PR, Crabb BS, Cowman AF.

PLoS Pathog. 2015 Dec 22;11(12):e1005343. doi: 10.1371/journal.ppat.1005343. eCollection 2015 Dec.

19.

Contrasting Patterns of Serologic and Functional Antibody Dynamics to Plasmodium falciparum Antigens in a Kenyan Birth Cohort.

Dent AE, Malhotra I, Wang X, Babineau D, Yeo KT, Anderson T, Kimmel RJ, Angov E, Lanar DE, Narum D, Dutta S, Richards J, Beeson JG, Crabb BS, Cowman AF, Horii T, Muchiri E, Mungai PL, King CL, Kazura JW.

Clin Vaccine Immunol. 2015 Dec 9;23(2):104-16. doi: 10.1128/CVI.00452-15. Print 2016 Feb.

20.

Localisation-based imaging of malarial antigens during erythrocyte entry reaffirms a role for AMA1 but not MTRAP in invasion.

Riglar DT, Whitehead L, Cowman AF, Rogers KL, Baum J.

J Cell Sci. 2016 Jan 1;129(1):228-42. doi: 10.1242/jcs.177741. Epub 2015 Nov 24.

21.

Characterization of Inhibitors and Monoclonal Antibodies That Modulate the Interaction between Plasmodium falciparum Adhesin PfRh4 with Its Erythrocyte Receptor Complement Receptor 1.

Lim NT, Harder MJ, Kennedy AT, Lin CS, Weir C, Cowman AF, Call MJ, Schmidt CQ, Tham WH.

J Biol Chem. 2015 Oct 16;290(42):25307-21. doi: 10.1074/jbc.M115.657171. Epub 2015 Aug 31.

22.

Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes.

Hodder AN, Sleebs BE, Czabotar PE, Gazdik M, Xu Y, O'Neill MT, Lopaticki S, Nebl T, Triglia T, Smith BJ, Lowes K, Boddey JA, Cowman AF.

Nat Struct Mol Biol. 2015 Aug;22(8):590-6. doi: 10.1038/nsmb.3061. Epub 2015 Jul 27.

PMID:
26214367
23.

Revealing the sequence and resulting cellular morphology of receptor-ligand interactions during Plasmodium falciparum invasion of erythrocytes.

Weiss GE, Gilson PR, Taechalertpaisarn T, Tham WH, de Jong NW, Harvey KL, Fowkes FJ, Barlow PN, Rayner JC, Wright GJ, Cowman AF, Crabb BS.

PLoS Pathog. 2015 Feb 27;11(2):e1004670. doi: 10.1371/journal.ppat.1004670. eCollection 2015 Feb.

24.

Antibodies to the Plasmodium falciparum Proteins MSPDBL1 and MSPDBL2 Opsonize Merozoites, Inhibit Parasite Growth, and Predict Protection From Clinical Malaria.

Chiu CY, Hodder AN, Lin CS, Hill DL, Li Wai Suen CS, Schofield L, Siba PM, Mueller I, Cowman AF, Hansen DS.

J Infect Dis. 2015 Aug 1;212(3):406-15. doi: 10.1093/infdis/jiv057. Epub 2015 Feb 2.

PMID:
25646353
25.

Crystal structure of PfRh5, an essential P. falciparum ligand for invasion of human erythrocytes.

Chen L, Xu Y, Healer J, Thompson JK, Smith BJ, Lawrence MC, Cowman AF.

Elife. 2014 Oct 8;3. doi: 10.7554/eLife.04187. No abstract available.

26.

Transition state mimetics of the Plasmodium export element are potent inhibitors of Plasmepsin V from P. falciparum and P. vivax.

Sleebs BE, Gazdik M, O'Neill MT, Rajasekaran P, Lopaticki S, Lackovic K, Lowes K, Smith BJ, Cowman AF, Boddey JA.

J Med Chem. 2014 Sep 25;57(18):7644-62. doi: 10.1021/jm500797g. Epub 2014 Sep 11.

PMID:
25167370
27.

Insights and controversies into the role of the key apicomplexan invasion ligand, Apical Membrane Antigen 1.

Harvey KL, Yap A, Gilson PR, Cowman AF, Crabb BS.

Int J Parasitol. 2014 Oct 15;44(12):853-7. doi: 10.1016/j.ijpara.2014.08.001. Epub 2014 Aug 23.

28.

Export of virulence proteins by malaria-infected erythrocytes involves remodeling of host actin cytoskeleton.

Rug M, Cyrklaff M, Mikkonen A, Lemgruber L, Kuelzer S, Sanchez CP, Thompson J, Hanssen E, O'Neill M, Langer C, Lanzer M, Frischknecht F, Maier AG, Cowman AF.

Blood. 2014 Nov 27;124(23):3459-68. doi: 10.1182/blood-2014-06-583054. Epub 2014 Aug 19.

29.

The merozoite surface protein 1 complex is a platform for binding to human erythrocytes by Plasmodium falciparum.

Lin CS, Uboldi AD, Marapana D, Czabotar PE, Epp C, Bujard H, Taylor NL, Perugini MA, Hodder AN, Cowman AF.

J Biol Chem. 2014 Sep 12;289(37):25655-69. doi: 10.1074/jbc.M114.586495. Epub 2014 Jul 29.

30.

Association of antibodies to Plasmodium falciparum reticulocyte binding protein homolog 5 with protection from clinical malaria.

Chiu CY, Healer J, Thompson JK, Chen L, Kaul A, Savergave L, Raghuwanshi A, Li Wai Suen CS, Siba PM, Schofield L, Mueller I, Cowman AF, Hansen DS.

Front Microbiol. 2014 Jun 30;5:314. doi: 10.3389/fmicb.2014.00314. eCollection 2014.

31.

Inhibition of Plasmepsin V activity demonstrates its essential role in protein export, PfEMP1 display, and survival of malaria parasites.

Sleebs BE, Lopaticki S, Marapana DS, O'Neill MT, Rajasekaran P, Gazdik M, Günther S, Whitehead LW, Lowes KN, Barfod L, Hviid L, Shaw PJ, Hodder AN, Smith BJ, Cowman AF, Boddey JA.

PLoS Biol. 2014 Jul 1;12(7):e1001897. doi: 10.1371/journal.pbio.1001897. eCollection 2014 Jul.

32.

Conditional expression of apical membrane antigen 1 in Plasmodium falciparum shows it is required for erythrocyte invasion by merozoites.

Yap A, Azevedo MF, Gilson PR, Weiss GE, O'Neill MT, Wilson DW, Crabb BS, Cowman AF.

Cell Microbiol. 2014 May;16(5):642-56. doi: 10.1111/cmi.12287. Epub 2014 Mar 27.

33.

Plasmodium falciparum is dependent on de novo myo-inositol biosynthesis for assembly of GPI glycolipids and infectivity.

Macrae JI, Lopaticki S, Maier AG, Rupasinghe T, Nahid A, Cowman AF, McConville MJ.

Mol Microbiol. 2014 Feb;91(4):762-76. doi: 10.1111/mmi.12496. Epub 2014 Jan 16.

34.

Using mutagenesis and structural biology to map the binding site for the Plasmodium falciparum merozoite protein PfRh4 on the human immune adherence receptor.

Park HJ, Guariento M, Maciejewski M, Hauhart R, Tham WH, Cowman AF, Schmidt CQ, Mertens HD, Liszewski MK, Hourcade DE, Barlow PN, Atkinson JP.

J Biol Chem. 2014 Jan 3;289(1):450-63. doi: 10.1074/jbc.M113.520346. Epub 2013 Nov 8.

35.

Kinetic flux profiling elucidates two independent acetyl-CoA biosynthetic pathways in Plasmodium falciparum.

Cobbold SA, Vaughan AM, Lewis IA, Painter HJ, Camargo N, Perlman DH, Fishbaugher M, Healer J, Cowman AF, Kappe SH, Llinás M.

J Biol Chem. 2013 Dec 20;288(51):36338-50. doi: 10.1074/jbc.M113.503557. Epub 2013 Oct 25.

36.

Vaccination with conserved regions of erythrocyte-binding antigens induces neutralizing antibodies against multiple strains of Plasmodium falciparum.

Healer J, Thompson JK, Riglar DT, Wilson DW, Chiu YH, Miura K, Chen L, Hodder AN, Long CA, Hansen DS, Baum J, Cowman AF.

PLoS One. 2013 Sep 10;8(9):e72504. doi: 10.1371/journal.pone.0072504. eCollection 2013.

37.

Plasmodium nesting: remaking the erythrocyte from the inside out.

Boddey JA, Cowman AF.

Annu Rev Microbiol. 2013;67:243-69. doi: 10.1146/annurev-micro-092412-155730. Epub 2013 Jun 26. Review.

PMID:
23808341
38.

Identification and prioritization of merozoite antigens as targets of protective human immunity to Plasmodium falciparum malaria for vaccine and biomarker development.

Richards JS, Arumugam TU, Reiling L, Healer J, Hodder AN, Fowkes FJ, Cross N, Langer C, Takeo S, Uboldi AD, Thompson JK, Gilson PR, Coppel RL, Siba PM, King CL, Torii M, Chitnis CE, Narum DL, Mueller I, Crabb BS, Cowman AF, Tsuboi T, Beeson JG.

J Immunol. 2013 Jul 15;191(2):795-809. doi: 10.4049/jimmunol.1300778. Epub 2013 Jun 17.

39.

Erythrocyte-binding antigens of Plasmodium falciparum are targets of human inhibitory antibodies and function to evade naturally acquired immunity.

Persson KE, Fowkes FJ, McCallum FJ, Gicheru N, Reiling L, Richards JS, Wilson DW, Lopaticki S, Cowman AF, Marsh K, Beeson JG.

J Immunol. 2013 Jul 15;191(2):785-94. doi: 10.4049/jimmunol.1300444. Epub 2013 Jun 17.

40.

Cell-cell communication between malaria-infected red blood cells via exosome-like vesicles.

Regev-Rudzki N, Wilson DW, Carvalho TG, Sisquella X, Coleman BM, Rug M, Bursac D, Angrisano F, Gee M, Hill AF, Baum J, Cowman AF.

Cell. 2013 May 23;153(5):1120-33. doi: 10.1016/j.cell.2013.04.029. Epub 2013 May 15.

41.

Modulation of PF10_0355 (MSPDBL2) alters Plasmodium falciparum response to antimalarial drugs.

Van Tyne D, Uboldi AD, Healer J, Cowman AF, Wirth DF.

Antimicrob Agents Chemother. 2013 Jul;57(7):2937-41. doi: 10.1128/AAC.02574-12. Epub 2013 Apr 15.

42.

Electron tomography of Plasmodium falciparum merozoites reveals core cellular events that underpin erythrocyte invasion.

Hanssen E, Dekiwadia C, Riglar DT, Rug M, Lemgruber L, Cowman AF, Cyrklaff M, Kudryashev M, Frischknecht F, Baum J, Ralph SA.

Cell Microbiol. 2013 Sep;15(9):1457-72. doi: 10.1111/cmi.12132. Epub 2013 Mar 22.

PMID:
23461734
43.

Role of plasmepsin V in export of diverse protein families from the Plasmodium falciparum exportome.

Boddey JA, Carvalho TG, Hodder AN, Sargeant TJ, Sleebs BE, Marapana D, Lopaticki S, Nebl T, Cowman AF.

Traffic. 2013 May;14(5):532-50. doi: 10.1111/tra.12053. Epub 2013 Feb 27.

44.

Spatial association with PTEX complexes defines regions for effector export into Plasmodium falciparum-infected erythrocytes.

Riglar DT, Rogers KL, Hanssen E, Turnbull L, Bullen HE, Charnaud SC, Przyborski J, Gilson PR, Whitchurch CB, Crabb BS, Baum J, Cowman AF.

Nat Commun. 2013;4:1415. doi: 10.1038/ncomms2449.

45.

Efficient measurement of opsonising antibodies to Plasmodium falciparum merozoites.

Hill DL, Eriksson EM, Carmagnac AB, Wilson DW, Cowman AF, Hansen DS, Schofield L.

PLoS One. 2012;7(12):e51692. doi: 10.1371/journal.pone.0051692. Epub 2012 Dec 26.

46.

Defining the antigenic diversity of Plasmodium falciparum apical membrane antigen 1 and the requirements for a multi-allele vaccine against malaria.

Drew DR, Hodder AN, Wilson DW, Foley M, Mueller I, Siba PM, Dent AE, Cowman AF, Beeson JG.

PLoS One. 2012;7(12):e51023. doi: 10.1371/journal.pone.0051023. Epub 2012 Dec 5.

47.

Unveiling malaria's "cloak of invisibility": the role of PfSET10 in the genetic control of P. falciparum virulence.

Volz JC, Cowman AF.

Virulence. 2012 Aug 15;3(5):449-51. doi: 10.4161/viru.20994. Epub 2012 Aug 15. No abstract available.

48.

The Plasmodium falciparum erythrocyte invasion ligand Pfrh4 as a target of functional and protective human antibodies against malaria.

Reiling L, Richards JS, Fowkes FJ, Wilson DW, Chokejindachai W, Barry AE, Tham WH, Stubbs J, Langer C, Donelson J, Michon P, Tavul L, Crabb BS, Siba PM, Cowman AF, Mueller I, Beeson JG.

PLoS One. 2012;7(9):e45253. doi: 10.1371/journal.pone.0045253. Epub 2012 Sep 20.

49.

The cellular and molecular basis for malaria parasite invasion of the human red blood cell.

Cowman AF, Berry D, Baum J.

J Cell Biol. 2012 Sep 17;198(6):961-71. doi: 10.1083/jcb.201206112. Review.

50.

Targets of antibodies against Plasmodium falciparum-infected erythrocytes in malaria immunity.

Chan JA, Howell KB, Reiling L, Ataide R, Mackintosh CL, Fowkes FJ, Petter M, Chesson JM, Langer C, Warimwe GM, Duffy MF, Rogerson SJ, Bull PC, Cowman AF, Marsh K, Beeson JG.

J Clin Invest. 2012 Sep;122(9):3227-38. doi: 10.1172/JCI62182. Epub 2012 Aug 1.

Supplemental Content

Loading ...
Support Center