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Items: 35

1.

FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex.

Künzel U, Grieve AG, Meng Y, Sieber B, Cowley SA, Freeman M.

Elife. 2018 Jun 13;7. pii: e35012. doi: 10.7554/eLife.35012. [Epub ahead of print]

2.

LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages.

Härtlova A, Herbst S, Peltier J, Rodgers A, Bilkei-Gorzo O, Fearns A, Dill BD, Lee H, Flynn R, Cowley SA, Davies P, Lewis PA, Ganley IG, Martinez J, Alessi DR, Reith AD, Trost M, Gutierrez MG.

EMBO J. 2018 Jun 15;37(12). pii: e98694. doi: 10.15252/embj.201798694. Epub 2018 May 22.

3.

Stem cell modeling of mitochondrial parkinsonism reveals key functions of OPA1.

Jonikas M, Madill M, Mathy A, Zekoll T, Zois CE, Wigfield S, Kurzawa-Akanbi M, Browne C, Sims D, Chinnery PF, Cowley SA, Tofaris GK.

Ann Neurol. 2018 Mar 31. doi: 10.1002/ana.25221. [Epub ahead of print]

PMID:
29604226
4.

A Simplified Method for Generating Purkinje Cells from Human-Induced Pluripotent Stem Cells.

Watson LM, Wong MMK, Vowles J, Cowley SA, Becker EBE.

Cerebellum. 2018 Feb 3. doi: 10.1007/s12311-017-0913-2. [Epub ahead of print]

PMID:
29397531
5.

Alpha-synuclein induces the unfolded protein response in Parkinson's disease SNCA triplication iPSC-derived neurons.

Heman-Ackah SM, Manzano R, Hoozemans JJM, Scheper W, Flynn R, Haerty W, Cowley SA, Bassett AR, Wood MJA.

Hum Mol Genet. 2017 Nov 15;26(22):4441-4450. doi: 10.1093/hmg/ddx331.

PMID:
28973645
6.

Excess α-synuclein compromises phagocytosis in iPSC-derived macrophages.

Haenseler W, Zambon F, Lee H, Vowles J, Rinaldi F, Duggal G, Houlden H, Gwinn K, Wray S, Luk KC, Wade-Martins R, James WS, Cowley SA.

Sci Rep. 2017 Aug 21;7(1):9003. doi: 10.1038/s41598-017-09362-3.

7.

MAPT Genetic Variation and Neuronal Maturity Alter Isoform Expression Affecting Axonal Transport in iPSC-Derived Dopamine Neurons.

Beevers JE, Lai MC, Collins E, Booth HDE, Zambon F, Parkkinen L, Vowles J, Cowley SA, Wade-Martins R, Caffrey TM.

Stem Cell Reports. 2017 Aug 8;9(2):587-599. doi: 10.1016/j.stemcr.2017.06.005. Epub 2017 Jul 6.

8.

A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response.

Haenseler W, Sansom SN, Buchrieser J, Newey SE, Moore CS, Nicholls FJ, Chintawar S, Schnell C, Antel JP, Allen ND, Cader MZ, Wade-Martins R, James WS, Cowley SA.

Stem Cell Reports. 2017 Jun 6;8(6):1727-1742. doi: 10.1016/j.stemcr.2017.05.017.

9.

LRRK2 in peripheral and central nervous system innate immunity: its link to Parkinson's disease.

Lee H, James WS, Cowley SA.

Biochem Soc Trans. 2017 Feb 8;45(1):131-139. doi: 10.1042/BST20160262. Review.

10.

Multiplex High-Throughput Targeted Proteomic Assay To Identify Induced Pluripotent Stem Cells.

Baud A, Wessely F, Mazzacuva F, McCormick J, Camuzeaux S, Heywood WE, Little D, Vowles J, Tuefferd M, Mosaku O, Lako M, Armstrong L, Webber C, Cader MZ, Peeters P, Gissen P, Cowley SA, Mills K.

Anal Chem. 2017 Feb 21;89(4):2440-2448. doi: 10.1021/acs.analchem.6b04368. Epub 2017 Feb 6.

PMID:
28192931
11.

Transcriptomic profiling of purified patient-derived dopamine neurons identifies convergent perturbations and therapeutics for Parkinson's disease.

Sandor C, Robertson P, Lang C, Heger A, Booth H, Vowles J, Witty L, Bowden R, Hu M, Cowley SA, Wade-Martins R, Webber C.

Hum Mol Genet. 2017 Feb 1;26(3):552-566. doi: 10.1093/hmg/ddw412.

12.

Variant U1 snRNAs are implicated in human pluripotent stem cell maintenance and neuromuscular disease.

Vazquez-Arango P, Vowles J, Browne C, Hartfield E, Fernandes HJ, Mandefro B, Sareen D, James W, Wade-Martins R, Cowley SA, Murphy S, O'Reilly D.

Nucleic Acids Res. 2016 Dec 15;44(22):10960-10973. Epub 2016 Aug 17.

13.

A novel real time imaging platform to quantify macrophage phagocytosis.

Kapellos TS, Taylor L, Lee H, Cowley SA, James WS, Iqbal AJ, Greaves DR.

Biochem Pharmacol. 2016 Sep 15;116:107-19. doi: 10.1016/j.bcp.2016.07.011. Epub 2016 Jul 27.

14.

C9orf72 Hexanucleotide Expansions Are Associated with Altered Endoplasmic Reticulum Calcium Homeostasis and Stress Granule Formation in Induced Pluripotent Stem Cell-Derived Neurons from Patients with Amyotrophic Lateral Sclerosis and Frontotemporal Dementia.

Dafinca R, Scaber J, Ababneh N, Lalic T, Weir G, Christian H, Vowles J, Douglas AG, Fletcher-Jones A, Browne C, Nakanishi M, Turner MR, Wade-Martins R, Cowley SA, Talbot K.

Stem Cells. 2016 Aug;34(8):2063-78. doi: 10.1002/stem.2388. Epub 2016 May 4.

15.

ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons.

Fernandes HJ, Hartfield EM, Christian HC, Emmanoulidou E, Zheng Y, Booth H, Bogetofte H, Lang C, Ryan BJ, Sardi SP, Badger J, Vowles J, Evetts S, Tofaris GK, Vekrellis K, Talbot K, Hu MT, James W, Cowley SA, Wade-Martins R.

Stem Cell Reports. 2016 Mar 8;6(3):342-56. doi: 10.1016/j.stemcr.2016.01.013. Epub 2016 Feb 18.

16.

The Current State of Naïve Human Pluripotency.

Dodsworth BT, Flynn R, Cowley SA.

Stem Cells. 2015 Nov;33(11):3181-6. doi: 10.1002/stem.2085. Epub 2015 Jul 14. Review.

17.

CRISPR-mediated genotypic and phenotypic correction of a chronic granulomatous disease mutation in human iPS cells.

Flynn R, Grundmann A, Renz P, Hänseler W, James WS, Cowley SA, Moore MD.

Exp Hematol. 2015 Oct;43(10):838-848.e3. doi: 10.1016/j.exphem.2015.06.002. Epub 2015 Jun 19.

18.

Physiological characterisation of human iPS-derived dopaminergic neurons.

Hartfield EM, Yamasaki-Mann M, Ribeiro Fernandes HJ, Vowles J, James WS, Cowley SA, Wade-Martins R.

PLoS One. 2014 Feb 21;9(2):e87388. doi: 10.1371/journal.pone.0087388. eCollection 2014.

19.

The productive entry pathway of HIV-1 in macrophages is dependent on endocytosis through lipid rafts containing CD4.

van Wilgenburg B, Moore MD, James WS, Cowley SA.

PLoS One. 2014 Jan 22;9(1):e86071. doi: 10.1371/journal.pone.0086071. eCollection 2014.

20.

Efficient, long term production of monocyte-derived macrophages from human pluripotent stem cells under partly-defined and fully-defined conditions.

van Wilgenburg B, Browne C, Vowles J, Cowley SA.

PLoS One. 2013 Aug 12;8(8):e71098. doi: 10.1371/journal.pone.0071098. eCollection 2013.

21.

Differentially expressed, variant U1 snRNAs regulate gene expression in human cells.

O'Reilly D, Dienstbier M, Cowley SA, Vazquez P, Drozdz M, Taylor S, James WS, Murphy S.

Genome Res. 2013 Feb;23(2):281-91. doi: 10.1101/gr.142968.112. Epub 2012 Oct 15.

22.

Cellular reprogramming: a new approach to modelling Parkinson's disease.

Hartfield EM, Fernandes HJ, Vowles J, Cowley SA, Wade-Martins R.

Biochem Soc Trans. 2012 Oct;40(5):1152-7. Review.

PMID:
22988881
23.

Derivation and functional analysis of patient-specific induced pluripotent stem cells as an in vitro model of chronic granulomatous disease.

Jiang Y, Cowley SA, Siler U, Melguizo D, Tilgner K, Browne C, Dewilton A, Przyborski S, Saretzki G, James WS, Seger RA, Reichenbach J, Lako M, Armstrong L.

Stem Cells. 2012 Apr;30(4):599-611. doi: 10.1002/stem.1053.

24.

Transportin 3 promotes a nuclear maturation step required for efficient HIV-1 integration.

Zhou L, Sokolskaja E, Jolly C, James W, Cowley SA, Fassati A.

PLoS Pathog. 2011 Aug;7(8):e1002194. doi: 10.1371/journal.ppat.1002194. Epub 2011 Aug 25.

25.

Episomal transgene expression in pluripotent stem cells.

Lufino MM, Popplestone AR, Cowley SA, Edser PA, James WS, Wade-Martins R.

Methods Mol Biol. 2011;767:369-87. doi: 10.1007/978-1-61779-201-4_27.

PMID:
21822889
26.

Protein kinase C and NF-κB-dependent CD4 downregulation in macrophages induced by T cell-derived soluble factors: consequences for HIV-1 infection.

Raposo RA, Trudgian DC, Thomas B, van Wilgenburg B, Cowley SA, James W.

J Immunol. 2011 Jul 15;187(2):748-59. doi: 10.4049/jimmunol.1003678. Epub 2011 Jun 10.

27.

Derivation and characterisation of the human embryonic stem cell line, OxF1.

Brook FA, Cowley SA, Evans EP, Turner K, James WS, Mardon HJ.

In Vitro Cell Dev Biol Anim. 2010 Apr;46(3-4):173-7. doi: 10.1007/s11626-010-9283-5. Epub 2010 Mar 24.

PMID:
20333479
28.

The effects of terminal illness on patients and their carers.

Davis BD, Cowley SA, Ryland RK.

J Adv Nurs. 1996 Mar;23(3):512-20.

PMID:
8655826
29.

Effects of transforming growth factor beta on megakaryocytic cell fusion and endomitosis.

Cowley SA, Groopman JE, Avraham H.

Int J Cell Cloning. 1992 Jul;10(4):223-31.

PMID:
1645030
30.

The rapid assessment of nerve stumps.

Gschmeissner SE, Pereira JH, Cowley SA.

J Bone Joint Surg Br. 1991 Jul;73(4):688-9. No abstract available.

PMID:
2071663
31.

Major histocompatibility complex class II antigen expression in nerves in leprosy; an immunoelectronmicroscopical study.

Cowley SA, Gschmeissner SE, Negesse Y, Curtis J, Turk JL.

Int J Lepr Other Mycobact Dis. 1990 Sep;58(3):560-5.

PMID:
2401839
32.

Denatured muscle grafts for nerve repair. An experimental model of nerve damage in leprosy.

Pereira JH, Cowley SA, Gschmeissner SE, Bowden RE, Turk JL.

J Bone Joint Surg Br. 1990 Sep;72(5):874-80.

PMID:
2170419
34.

Nerve damage induced by mycobacterial granulomas in guinea pig sciatic nerves.

Cowley SA, Butter C, Verghese S, Curtis J, Turk JL.

Int J Lepr Other Mycobact Dis. 1988 Jun;56(2):283-90.

PMID:
2842415
35.

We may need the bed.

Cowley SA.

Nurs Times. 1978 Feb 9;74(6):248. No abstract available.

PMID:
643678

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