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A roadmap to advance dementia research in prevention, diagnosis, intervention, and care by 2025.

Pickett J, Bird C, Ballard C, Banerjee S, Brayne C, Cowan K, Clare L, Comas-Herrera A, Corner L, Daley S, Knapp M, Lafortune L, Livingston G, Manthorpe J, Marchant N, Moriarty J, Robinson L, van Lynden C, Windle G, Woods B, Gray K, Walton C.

Int J Geriatr Psychiatry. 2018 Feb 22. doi: 10.1002/gps.4868. [Epub ahead of print]


Corrigendum to 'Effects of RG7652, a Monoclonal Antibody Against PCSK9, on Low-Density Lipoprotein Cholesterol (LDL-C), LDL-C Subfractions, and Inflammatory Biomarkers in Patients at High Risk of or with Established Coronary Heart Disease (From the Phase 2 EQUATOR Study)' The American Journal of Cardiology 119 (2017) 1576-1583.

Baruch A, Mosesova S, Davis JD, Budha N, Vilimovskij A, Kahn R, Peng K, Cowan KJ, Harris LP, Gelzleichter T, Lehrer J, Davis JC Jr, Tingley WG.

Am J Cardiol. 2018 Feb 12. pii: S0002-9149(18)30115-2. doi: 10.1016/j.amjcard.2018.01.010. [Epub ahead of print] No abstract available.


White matter tauopathy: Transient functional loss and novel myelin remodeling.

Jackson J, Bianco G, Rosa AO, Cowan K, Bond P, Anichtchik O, Fern R.

Glia. 2018 Apr;66(4):813-827. doi: 10.1002/glia.23286. Epub 2018 Jan 8.


Accumulation of beta-synuclein in cortical neurons is associated with autophagy attenuation in the brains of dementia with Lewy body patients.

Evans T, Kok WL, Cowan K, Hefford M, Anichtchik O.

Brain Res. 2018 Feb 15;1681:1-13. doi: 10.1016/j.brainres.2017.12.026. Epub 2017 Dec 24.


Top 10 research priorities in head and neck cancer: Results of an Alberta priority setting partnership of patients, caregivers, family members, and clinicians.

Lechelt LA, Rieger JM, Cowan K, Debenham BJ, Krewski B, Nayar S, Regunathan A, Seikaly H, Singh AE, Laupacis A; Alberta Head and Neck Cancer Priority Setting Partnership Steering Committee.

Head Neck. 2018 Mar;40(3):544-554. doi: 10.1002/hed.24998. Epub 2017 Nov 17.


The kidney cancer research priority-setting partnership: Identifying the top 10 research priorities as defined by patients, caregivers, and expert clinicians.

Jones J, Bhatt J, Avery J, Laupacis A, Cowan K, Basappa N, Basiuk J, Canil C, Al-Asaaed S, Heng D, Wood L, Stacey D, Kollmannsberger C, Jewett MAS.

Can Urol Assoc J. 2017 Dec;11(12):379-387. doi: 10.5489/cuaj.4590. Epub 2017 Nov 1.


Top ten research priorities for type 2 diabetes: results from the Diabetes UK-James Lind Alliance Priority Setting Partnership.

Finer S, Robb P, Cowan K, Daly A, Robertson E, Farmer A.

Lancet Diabetes Endocrinol. 2017 Dec;5(12):935-936. doi: 10.1016/S2213-8587(17)30324-8. Epub 2017 Oct 30. No abstract available.


Fistula, Enterocutaneous.

Cowan KB, Cassaro S.

StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2017 Jun-.
2017 Oct 26.


Recommendations for Selection and Characterization of Protein Biomarker Assay Calibrator Material.

Cowan KJ, Amaravadi L, Cameron MJ, Fink D, Jani D, Kamat M, King L, Neely RJ, Ni Y, Rhyne P, Riffon R, Zhu Y.

AAPS J. 2017 Nov;19(6):1550-1563. doi: 10.1208/s12248-017-0146-9. Epub 2017 Oct 2.


Does funded research reflect the priorities of people living with type 1 diabetes? A secondary analysis of research questions.

Boddy K, Cowan K, Gibson A, Britten N.

BMJ Open. 2017 Sep 27;7(9):e016540. doi: 10.1136/bmjopen-2017-016540.


Dr. Rackley et al. reply.

Rackley SJ, Lewis CP, Takala CR, Qaadir A, Cowan KE.

J Am Acad Child Adolesc Psychiatry. 2017 Oct;56(10):894-895. doi: 10.1016/j.jaac.2017.07.788. No abstract available.


Preclinical pharmacokinetic characterization of an adipose tissue-targeting monoclonal antibody in obese and non-obese animals.

Rajan S, Mandikian D, Baruch A, Gelzleichter TR, Stevens D, Sonoda J, Cowan K, Boswell CA, Stefanich E.

MAbs. 2017 Nov/Dec;9(8):1379-1388. doi: 10.1080/19420862.2017.1373923. Epub 2017 Sep 12.


Performance evaluation of three platforms with ultrasensitive ligand-binding assay potential.

Cowan KJ, Geiger A, Hornauer H, Rourick R, Siguenza PY.

Bioanalysis. 2017 Jun;9(12):937-946. doi: 10.4155/bio-2017-0024. Epub 2017 Jun 19.


Jinn and Psychosis: Providing Culturally Informed Care to Muslim Adolescents and Families.

Lewis CP, Takala CR, Qaadir A, Cowan KE, Borreggine KL, Rackley SJ.

J Am Acad Child Adolesc Psychiatry. 2017 Jun;56(6):455-457. doi: 10.1016/j.jaac.2017.03.009. No abstract available.


Setting Research Priorities for Kidney Cancer.

Jones JM, Bhatt J, Avery J, Laupacis A, Cowan K, Basappa NS, Basiuk J, Canil C, Al-Asaaed S, Heng DYC, Wood L, Stacey D, Kollmannsberger C, Jewett MAS.

Eur Urol. 2017 Dec;72(6):861-864. doi: 10.1016/j.eururo.2017.04.011. Epub 2017 May 8.


Dexmedetomidine as an Adjunct to Treat Anticholinergic Toxidrome in Children.

Cowan K, Landman RA, Saini A.

Glob Pediatr Health. 2017 Apr 24;4:2333794X17704764. doi: 10.1177/2333794X17704764. eCollection 2017. No abstract available.


Restrictive ID Policies: Implications for Health Equity.

LeBrón AM, Lopez WD, Cowan K, Novak NL, Temrowski O, Ibarra-Frayre M, Delva J.

J Immigr Minor Health. 2017 Apr 8. doi: 10.1007/s10903-017-0579-3. [Epub ahead of print] No abstract available.


Effects of RG7652, a Monoclonal Antibody Against PCSK9, on LDL-C, LDL-C Subfractions, and Inflammatory Biomarkers in Patients at High Risk of or With Established Coronary Heart Disease (from the Phase 2 EQUATOR Study).

Baruch A, Mosesova S, Davis JD, Budha N, Vilimovskij A, Kahn R, Peng K, Cowan KJ, Harris LP, Gelzleichter T, Lehrer J, Davis JC Jr, Tingley WG.

Am J Cardiol. 2017 May 15;119(10):1576-1583. doi: 10.1016/j.amjcard.2017.02.020. Epub 2017 Mar 1. Erratum in: Am J Cardiol. 2018 Feb 12;:.


A phase 1 study to evaluate the safety and LDL cholesterol-lowering effects of RG7652, a fully human monoclonal antibody against proprotein convertase subtilisin/kexin type 9.

Baruch A, Luca D, Kahn RS, Cowan KJ, Leabman M, Budha NR, Chiu CPC, Wu Y, Kirchhofer D, Peterson A, Davis JC Jr, Tingley WG.

Clin Cardiol. 2017 Jul;40(7):503-511. doi: 10.1002/clc.22687. Epub 2017 Mar 22.


Novel Roles for Staufen1 in Embryonal and Alveolar Rhabdomyosarcoma via c-myc-dependent and -independent events.

Crawford Parks TE, Marcellus KA, Langill J, Ravel-Chapuis A, Michaud J, Cowan KN, Côté J, Jasmin BJ.

Sci Rep. 2017 Feb 17;7:42342. doi: 10.1038/srep42342.


Elastase and matrix metalloproteinase activities are associated with pulmonary vascular disease in the nitrofen rat model of congenital diaphragmatic hernia.

Wild B, St-Pierre ME, Langlois S, Cowan KN.

J Pediatr Surg. 2017 May;52(5):693-701. doi: 10.1016/j.jpedsurg.2017.01.010. Epub 2017 Jan 27.


Single-base LOH can be used as Specific Marker to Classify BRCAx Familial Breast Cancer into More Homogenous Subtypes.

Downs B, Xiao F, Kim YC, Chen PX, Huang D, Fleissner EA, Cowan K, Wang SM.

Breast J. 2017 Jul;23(4):479-481. doi: 10.1111/tbj.12777. Epub 2017 Jan 24. No abstract available.


Impact of SPR biosensor assay configuration on antibody: Neonatal Fc receptor binding data.

Wang X, McKay P, Yee LT, Dutina G, Hass PE, Nijem I, Allison D, Cowan KJ, Lin K, Quarmby V, Yang J.

MAbs. 2017 Feb/Mar;9(2):319-332. doi: 10.1080/19420862.2016.1261774. Epub 2016 Dec 21.


Engaging Cell Death Pathways for the Treatment of Rhabdomyosarcoma.

Dobson CC, Langlois S, Grynspan D, Cowan KN, Holcik M.

Crit Rev Oncog. 2016;21(3-4):221-239. Review.


2016 White Paper on recent issues in bioanalysis: focus on biomarker assay validation (BAV): (Part 3 - LBA, biomarkers and immunogenicity).

Richards S, Amaravadi L, Pillutla R, Birnboeck H, Torri A, Cowan KJ, Papadimitriou A, Garofolo F, Satterwhite C, Piccoli S, Wu B, Krinos-Fiorotti C, Allinson J, Berisha F, Cocea L, Croft S, Fraser S, Galliccia F, Gorovits B, Gupta S, Gupta V, Haidar S, Hottenstein C, Ishii-Watabe A, Jani D, Kadavil J, Kamerud J, Kramer D, Litwin V, Lima Santos GM, Nelson R, Ni Y, Pedras-Vasconcelos J, Qiu Y, Rhyne P, Safavi A, Saito Y, Savoie N, Scheibner K, Schick E, Siguenza PY, Smeraglia J, Staack RF, Subramanyam M, Sumner G, Thway T, Uhlinger D, Ullmann M, Vitaliti A, Welink J, Whiting CC, Xue L, Zeng R.

Bioanalysis. 2016 Dec;8(23):2475-2496.


Fit-for-purpose biomarker immunoassay qualification and validation: three case studies.

Cowan K, Gao X, Parab V, Nguy T, Wu L, Arron JR, Townsend M, Wallin J, Cheu M, Morimoto A, Wakshull E.

Bioanalysis. 2016 Oct 7. [Epub ahead of print]


Regulation of Skeletal Muscle Myoblast Differentiation and Proliferation by Pannexins.

Langlois S, Cowan KN.

Adv Exp Med Biol. 2017;925:57-73. doi: 10.1007/5584_2016_53. Review.


Top 10 research priorities for eating disorders.

van Furth EF, van der Meer A, Cowan K.

Lancet Psychiatry. 2016 Aug;3(8):706-7. doi: 10.1016/S2215-0366(16)30147-X. No abstract available.


Implementing fit-for-purpose biomarker assay approaches: a bioanalytical perspective.

Cowan KJ.

Bioanalysis. 2016 Jun;8(12):1221-3. doi: 10.4155/bio-2016-0070. Epub 2016 May 6. No abstract available.


Preclinical pharmacokinetics, pharmacodynamics, tissue distribution, and tumor penetration of anti-PD-L1 monoclonal antibody, an immune checkpoint inhibitor.

Deng R, Bumbaca D, Pastuskovas CV, Boswell CA, West D, Cowan KJ, Chiu H, McBride J, Johnson C, Xin Y, Koeppen H, Leabman M, Iyer S.

MAbs. 2016;8(3):593-603. doi: 10.1080/19420862.2015.1136043. Epub 2016 Feb 26.


Erratum to: Patients', clinicians' and the research communities' priorities for treatment research: there is an important mismatch.

Crowe S, Fenton M, Hall M, Cowan K, Chalmers I.

Res Involv Engagem. 2015 Dec 23;1:14. doi: 10.1186/s40900-015-0014-7. eCollection 2015.


Top ten research priorities for spinal cord injury: the methodology and results of a British priority setting partnership.

van Middendorp JJ, Allison HC, Ahuja S, Bracher D, Dyson C, Fairbank J, Gall A, Glover A, Gray L, Masri WE, Uttridge A, Cowan K.

Spinal Cord. 2016 May;54(5):341-6. doi: 10.1038/sc.2015.199. Epub 2015 Nov 10.


Dementia priority setting partnership with the James Lind Alliance: using patient and public involvement and the evidence base to inform the research agenda.

Kelly S, Lafortune L, Hart N, Cowan K, Fenton M, Brayne C; Dementia Priority Setting Partnership.

Age Ageing. 2015 Nov;44(6):985-93. doi: 10.1093/ageing/afv143.


Recommendations for Use and Fit-for-Purpose Validation of Biomarker Multiplex Ligand Binding Assays in Drug Development.

Jani D, Allinson J, Berisha F, Cowan KJ, Devanarayan V, Gleason C, Jeromin A, Keller S, Khan MU, Nowatzke B, Rhyne P, Stephen L.

AAPS J. 2016 Jan;18(1):1-14. doi: 10.1208/s12248-015-9820-y. Epub 2015 Sep 16. Review.


Breast Cancer Risk Reduction, Version 2.2015.

Bevers TB, Ward JH, Arun BK, Colditz GA, Cowan KH, Daly MB, Garber JE, Gemignani ML, Gradishar WJ, Jordan JA, Korde LA, Kounalakis N, Krontiras H, Kumar S, Kurian A, Laronga C, Layman RM, Loftus LS, Mahoney MC, Merajver SD, Meszoely IM, Mortimer J, Newman L, Pritchard E, Pruthi S, Seewaldt V, Specht MC, Visvanathan K, Wallace A, Bergman MA, Kumar R.

J Natl Compr Canc Netw. 2015 Jul;13(7):880-915.


Research priorities in mesothelioma: A James Lind Alliance Priority Setting Partnership.

Stephens RJ, Whiting C, Cowan K; James Lind Alliance Mesothelioma Priority Setting Partnership Steering Committee.

Lung Cancer. 2015 Aug;89(2):175-80. doi: 10.1016/j.lungcan.2015.05.021. Epub 2015 Jun 4.


Patients', clinicians' and the research communities' priorities for treatment research: there is an important mismatch.

Crowe S, Fenton M, Hall M, Cowan K, Chalmers I.

Res Involv Engagem. 2015 Jun 25;1:2. doi: 10.1186/s40900-015-0003-x. eCollection 2015. Erratum in: Res Involv Engagem. 2015 Dec 23;1:14.


Two PALB2 germline mutations found in both BRCA1+ and BRCAx familial breast cancer.

Downs B, Kim YC, Xiao F, Snyder C, Chen P, Fleissner EA, Becirovic D, Wen H, Sherman S, Cowan KH, Lynch HT, Wang SM.

Breast Cancer Res Treat. 2015 May;151(1):219-24. doi: 10.1007/s10549-015-3358-7. Epub 2015 Apr 2.


Exome analysis reveals differentially mutated gene signatures of stage, grade and subtype in breast cancers.

Li Y, Wang X, Vural S, Mishra NK, Cowan KH, Guda C.

PLoS One. 2015 Mar 24;10(3):e0119383. doi: 10.1371/journal.pone.0119383. eCollection 2015.


Awareness of Federal Regulatory Mechanisms Relevant to Community-Engaged Research: Survey of Health Disparities-Oriented NIH-Funded Investigators.

Fullerton SM, Anderson EE, Cowan K, Malen RC, Brugge D.

J Empir Res Hum Res Ethics. 2015 Feb;10(1):13-21. doi: 10.1177/1556264614561964. Epub 2014 Dec 10.


Setting research priorities to improve the health of children and young people with neurodisability: a British Academy of Childhood Disability-James Lind Alliance Research Priority Setting Partnership.

Morris C, Simkiss D, Busk M, Morris M, Allard A, Denness J, Janssens A, Stimson A, Coghill J, Robinson K, Fenton M, Cowan K.

BMJ Open. 2015 Jan 28;5(1):e006233. doi: 10.1136/bmjopen-2014-006233.


Sparse modeling of spatial environmental variables associated with asthma.

Chang TS, Gangnon RE, David Page C, Buckingham WR, Tandias A, Cowan KJ, Tomasallo CD, Arndt BG, Hanrahan LP, Guilbert TW.

J Biomed Inform. 2015 Feb;53:320-9. doi: 10.1016/j.jbi.2014.12.005. Epub 2014 Dec 20.


Top ten research priorities for spinal cord injury.

van Middendorp JJ, Allison H, Cowan K; Spinal Cord Injury Priority Setting Partnership.

Lancet Neurol. 2014 Dec;13(12):1167. doi: 10.1016/S1474-4422(14)70253-4. Epub 2014 Nov 10. No abstract available.


Inhibition of RAC1 GTPase sensitizes pancreatic cancer cells to γ-irradiation.

Yan Y, Hein AL, Etekpo A, Burchett KM, Lin C, Enke CA, Batra SK, Cowan KH, Ouellette MM.

Oncotarget. 2014 Nov 15;5(21):10251-70.


Pannexin 1 and pannexin 3 channels regulate skeletal muscle myoblast proliferation and differentiation.

Langlois S, Xiang X, Young K, Cowan BJ, Penuela S, Cowan KN.

J Biol Chem. 2014 Oct 31;289(44):30717-31. doi: 10.1074/jbc.M114.572131. Epub 2014 Sep 19.


The Sight Loss and Vision Priority Setting Partnership (SLV-PSP): overview and results of the research prioritisation survey process.

Rowe F, Wormald R, Cable R, Acton M, Bonstein K, Bowen M, Bronze C, Bunce C, Conroy D, Cowan K, Evans K, Fenton M, Giles H, Gordon I, Halfhide L, Harper R, Lightstone A, Votruba M, Waterman H, Zekite A.

BMJ Open. 2014 Jul 23;4(7):e004905. doi: 10.1136/bmjopen-2014-004905.


Family-specific, novel, deleterious germline variants provide a rich resource to identify genetic predispositions for BRCAx familial breast cancer.

Wen H, Kim YC, Snyder C, Xiao F, Fleissner EA, Becirovic D, Luo J, Downs B, Sherman S, Cowan KH, Lynch HT, Wang SM.

BMC Cancer. 2014 Jun 26;14:470. doi: 10.1186/1471-2407-14-470.


A novel function of HER2/Neu in the activation of G2/M checkpoint in response to γ-irradiation.

Yan Y, Hein AL, Greer PM, Wang Z, Kolb RH, Batra SK, Cowan KH.

Oncogene. 2015 Apr 23;34(17):2215-26. doi: 10.1038/onc.2014.167. Epub 2014 Jun 9.


Genome instability in blood cells of a BRCA1+ breast cancer family.

Xiao F, Kim YC, Snyder C, Wen H, Chen PX, Luo J, Becirovic D, Downs B, Cowan KH, Lynch H, Wang SM.

BMC Cancer. 2014 May 19;14:342. doi: 10.1186/1471-2407-14-342.


IGF2BP1 controls cell death and drug resistance in rhabdomyosarcomas by regulating translation of cIAP1.

Faye MD, Beug ST, Graber TE, Earl N, Xiang X, Wild B, Langlois S, Michaud J, Cowan KN, Korneluk RG, Holcik M.

Oncogene. 2015 Mar 19;34(12):1532-41. doi: 10.1038/onc.2014.90. Epub 2014 Apr 7.


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