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The PAQosome, an R2TP-Based Chaperone for Quaternary Structure Formation.

Houry WA, Bertrand E, Coulombe B.

Trends Biochem Sci. 2018 Jan;43(1):4-9. doi: 10.1016/j.tibs.2017.11.001. Epub 2017 Dec 5.


Functional 5' UTR motif discovery with LESMoN: Local Enrichment of Sequence Motifs in biological Networks.

Lavallée-Adam M, Cloutier P, Coulombe B, Blanchette M.

Nucleic Acids Res. 2017 Oct 13;45(18):10415-10427. doi: 10.1093/nar/gkx751.


R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.

Cloutier P, Poitras C, Durand M, Hekmat O, Fiola-Masson É, Bouchard A, Faubert D, Chabot B, Coulombe B.

Nat Commun. 2017 May 31;8:15615. doi: 10.1038/ncomms15615.


Absence of neurological abnormalities in mice homozygous for the Polr3a G672E hypomyelinating leukodystrophy mutation.

Choquet K, Yang S, Moir RD, Forget D, Larivière R, Bouchard A, Poitras C, Sgarioto N, Dicaire MJ, Noohi F, Kennedy TE, Rochford J, Bernard G, Teichmann M, Coulombe B, Willis IM, Kleinman CL, Brais B.

Mol Brain. 2017 Apr 13;10(1):13. doi: 10.1186/s13041-017-0294-y.


Core Stability Exercise Versus General Exercise for Chronic Low Back Pain.

Coulombe BJ, Games KE, Neil ER, Eberman LE.

J Athl Train. 2017 Jan;52(1):71-72. doi: 10.4085/1062-6050-51.11.16. Epub 2016 Nov 16. Review.


Recessive mutations in POLR1C cause a leukodystrophy by impairing biogenesis of RNA polymerase III.

Thiffault I, Wolf NI, Forget D, Guerrero K, Tran LT, Choquet K, Lavallée-Adam M, Poitras C, Brais B, Yoon G, Sztriha L, Webster RI, Timmann D, van de Warrenburg BP, Seeger J, Zimmermann A, Máté A, Goizet C, Fung E, van der Knaap MS, Fribourg S, Vanderver A, Simons C, Taft RJ, Yates JR 3rd, Coulombe B, Bernard G.

Nat Commun. 2015 Jul 7;6:7623. doi: 10.1038/ncomms8623.


Introduction for the Special Issue of METHODS on Detection and quantification of proteins in clinical samples by mass spectrometry.

Coulombe B, Gauthier MS.

Methods. 2015 Jun 15;81:1-2. doi: 10.1016/j.ymeth.2015.05.015. No abstract available.


Abnormal expression of RNA polymerase II-associated proteins in muscle of patients with myofibrillar myopathies.

Guglielmi V, Marini M, Masson ÉF, Malatesta M, Forget D, Tomelleri G, Coulombe B, Vattemi G.

Histopathology. 2015 Dec;67(6):859-65. doi: 10.1111/his.12715. Epub 2015 May 25.


A semi-automated mass spectrometric immunoassay coupled to selected reaction monitoring (MSIA-SRM) reveals novel relationships between circulating PCSK9 and metabolic phenotypes in patient cohorts.

Gauthier MS, Pérusse JR, Awan Z, Bouchard A, Tessier S, Champagne J, Krastins B, Byram G, Chabot K, Garneau P, Rabasa-Lhoret R, Faubert D, Lopez MF, Seidah NG, Coulombe B.

Methods. 2015 Jun 15;81:66-73. doi: 10.1016/j.ymeth.2015.03.003. Epub 2015 Mar 11.


USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin.

Durcan TM, Tang MY, Pérusse JR, Dashti EA, Aguileta MA, McLelland GL, Gros P, Shaler TA, Faubert D, Coulombe B, Fon EA.

EMBO J. 2014 Nov 3;33(21):2473-91. doi: 10.15252/embj.201489729. Epub 2014 Sep 12.


Increased subcutaneous adipose tissue expression of genes involved in glycerolipid-fatty acid cycling in obese insulin-resistant versus -sensitive individuals.

Gauthier MS, Pérusse JR, Lavoie MÈ, Sladek R, Madiraju SR, Ruderman NB, Coulombe B, Prentki M, Rabasa-Lhoret R.

J Clin Endocrinol Metab. 2014 Dec;99(12):E2518-28. doi: 10.1210/jc.2014-1662.


Methylation of the DNA/RNA-binding protein Kin17 by METTL22 affects its association with chromatin.

Cloutier P, Lavallée-Adam M, Faubert D, Blanchette M, Coulombe B.

J Proteomics. 2014 Apr 4;100:115-24. doi: 10.1016/j.jprot.2013.10.008. Epub 2013 Oct 16.


The CRAPome: a contaminant repository for affinity purification-mass spectrometry data.

Mellacheruvu D, Wright Z, Couzens AL, Lambert JP, St-Denis NA, Li T, Miteva YV, Hauri S, Sardiu ME, Low TY, Halim VA, Bagshaw RD, Hubner NC, Al-Hakim A, Bouchard A, Faubert D, Fermin D, Dunham WH, Goudreault M, Lin ZY, Badillo BG, Pawson T, Durocher D, Coulombe B, Aebersold R, Superti-Furga G, Colinge J, Heck AJ, Choi H, Gstaiger M, Mohammed S, Cristea IM, Bennett KL, Washburn MP, Raught B, Ewing RM, Gingras AC, Nesvizhskii AI.

Nat Methods. 2013 Aug;10(8):730-6. doi: 10.1038/nmeth.2557. Epub 2013 Jul 7.


Nuclear import of RNA polymerase II is coupled with nucleocytoplasmic shuttling of the RNA polymerase II-associated protein 2.

Forget D, Lacombe AA, Cloutier P, Lavallée-Adam M, Blanchette M, Coulombe B.

Nucleic Acids Res. 2013 Aug;41(14):6881-91. doi: 10.1093/nar/gkt455. Epub 2013 May 30.


Regulation of molecular chaperones through post-translational modifications: decrypting the chaperone code.

Cloutier P, Coulombe B.

Biochim Biophys Acta. 2013 May;1829(5):443-54. doi: 10.1016/j.bbagrm.2013.02.010. Epub 2013 Feb 28. Review.


A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity.

Cloutier P, Lavallée-Adam M, Faubert D, Blanchette M, Coulombe B.

PLoS Genet. 2013;9(1):e1003210. doi: 10.1371/journal.pgen.1003210. Epub 2013 Jan 17.


Rapid development of sensitive, high-throughput, quantitative and highly selective mass spectrometric targeted immunoassays for clinically important proteins in human plasma and serum.

Krastins B, Prakash A, Sarracino DA, Nedelkov D, Niederkofler EE, Kiernan UA, Nelson R, Vogelsang MS, Vadali G, Garces A, Sutton JN, Peterman S, Byram G, Darbouret B, Pérusse JR, Seidah NG, Coulombe B, Gobom J, Portelius E, Pannee J, Blennow K, Kulasingam V, Couchman L, Moniz C, Lopez MF.

Clin Biochem. 2013 Apr;46(6):399-410. doi: 10.1016/j.clinbiochem.2012.12.019. Epub 2013 Jan 8.


Discovery of cell compartment specific protein-protein interactions using affinity purification combined with tandem mass spectrometry.

Lavallée-Adam M, Rousseau J, Domecq C, Bouchard A, Forget D, Faubert D, Blanchette M, Coulombe B.

J Proteome Res. 2013 Jan 4;12(1):272-81. doi: 10.1021/pr300778b. Epub 2012 Dec 4.


Molecular dynamics and mutational analysis of the catalytic and translocation cycle of RNA polymerase.

Kireeva ML, Opron K, Seibold SA, Domecq C, Cukier RI, Coulombe B, Kashlev M, Burton ZF.

BMC Biophys. 2012 Jun 7;5:11. doi: 10.1186/2046-1682-5-11.


Interaction of RNA polymerase II fork loop 2 with downstream non-template DNA regulates transcription elongation.

Kireeva ML, Domecq C, Coulombe B, Burton ZF, Kashlev M.

J Biol Chem. 2011 Sep 2;286(35):30898-910. doi: 10.1074/jbc.M111.260844. Epub 2011 Jul 5.


The RPB2 flap loop of human RNA polymerase II is dispensable for transcription initiation and elongation.

Palangat M, Grass JA, Langelier MF, Coulombe B, Landick R.

Mol Cell Biol. 2011 Aug;31(16):3312-25. doi: 10.1128/MCB.05318-11. Epub 2011 Jun 13.


Transcription factor IIS cooperates with the E3 ligase UBR5 to ubiquitinate the CDK9 subunit of the positive transcription elongation factor B.

Cojocaru M, Bouchard A, Cloutier P, Cooper JJ, Varzavand K, Price DH, Coulombe B.

J Biol Chem. 2011 Feb 18;286(7):5012-22. doi: 10.1074/jbc.M110.176628. Epub 2010 Dec 2.


Modeling contaminants in AP-MS/MS experiments.

Lavallée-Adam M, Cloutier P, Coulombe B, Blanchette M.

J Proteome Res. 2011 Feb 4;10(2):886-95. doi: 10.1021/pr100795z. Epub 2010 Dec 31.


Mapping the disease protein interactome: toward a molecular medicine GPS to accelerate drug and biomarker discovery.

Coulombe B.

J Proteome Res. 2011 Jan 7;10(1):120-5. doi: 10.1021/pr100609a. Epub 2010 Nov 15.


The protein interaction network of the human transcription machinery reveals a role for the conserved GTPase RPAP4/GPN1 and microtubule assembly in nuclear import and biogenesis of RNA polymerase II.

Forget D, Lacombe AA, Cloutier P, Al-Khoury R, Bouchard A, Lavallée-Adam M, Faubert D, Jeronimo C, Blanchette M, Coulombe B.

Mol Cell Proteomics. 2010 Dec;9(12):2827-39. doi: 10.1074/mcp.M110.003616. Epub 2010 Sep 20.


Conformational coupling, bridge helix dynamics and active site dehydration in catalysis by RNA polymerase.

Seibold SA, Singh BN, Zhang C, Kireeva M, Domecq C, Bouchard A, Nazione AM, Feig M, Cukier RI, Coulombe B, Kashlev M, Hampsey M, Burton ZF.

Biochim Biophys Acta. 2010 Aug;1799(8):575-87. doi: 10.1016/j.bbagrm.2010.05.002. Epub 2010 May 15.


New insights into the biogenesis of nuclear RNA polymerases?

Cloutier P, Coulombe B.

Biochem Cell Biol. 2010 Apr;88(2):211-21. doi: 10.1139/o09-173. Review.


Detection of locally over-represented GO terms in protein-protein interaction networks.

Lavallée-Adam M, Coulombe B, Blanchette M.

J Comput Biol. 2010 Mar;17(3):443-57. doi: 10.1089/cmb.2009.0165.


Site-directed mutagenesis, purification and assay of Saccharomyces cerevisiae RNA polymerase II.

Domecq C, Kireeva M, Archambault J, Kashlev M, Coulombe B, Burton ZF.

Protein Expr Purif. 2010 Jan;69(1):83-90. doi: 10.1016/j.pep.2009.06.016. Epub 2009 Jun 28.


High-resolution mapping of the protein interaction network for the human transcription machinery and affinity purification of RNA polymerase II-associated complexes.

Cloutier P, Al-Khoury R, Lavallée-Adam M, Faubert D, Jiang H, Poitras C, Bouchard A, Forget D, Blanchette M, Coulombe B.

Methods. 2009 Aug;48(4):381-6. doi: 10.1016/j.ymeth.2009.05.005. Epub 2009 May 18.


Defining protein interactions that regulate disease progression.

Al-Khoury R, Coulombe B.

Expert Opin Ther Targets. 2009 Jan;13(1):13-7. doi: 10.1517/14728220802631876 .


Steps towards a repertoire of comprehensive maps of human protein interaction networks: the Human Proteotheque Initiative (HuPI).

Coulombe B, Blanchette M, Jeronimo C.

Biochem Cell Biol. 2008 Apr;86(2):149-56. doi: 10.1139/O08-006. Review.


LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated.

Krueger BJ, Jeronimo C, Roy BB, Bouchard A, Barrandon C, Byers SA, Searcey CE, Cooper JJ, Bensaude O, Cohen EA, Coulombe B, Price DH.

Nucleic Acids Res. 2008 Apr;36(7):2219-29. doi: 10.1093/nar/gkn061. Epub 2008 Feb 16.


Human papillomavirus E1 helicase interacts with the WD repeat protein p80 to promote maintenance of the viral genome in keratinocytes.

Côté-Martin A, Moody C, Fradet-Turcotte A, D'Abramo CM, Lehoux M, Joubert S, Poirier GG, Coulombe B, Laimins LA, Archambault J.

J Virol. 2008 Feb;82(3):1271-83. Epub 2007 Nov 21.


Genomic location of the human RNA polymerase II general machinery: evidence for a role of TFIIF and Rpb7 at both early and late stages of transcription.

Cojocaru M, Jeronimo C, Forget D, Bouchard A, Bergeron D, Côte P, Poirier GG, Greenblatt J, Coulombe B.

Biochem J. 2008 Jan 1;409(1):139-47.


Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.

Jeronimo C, Forget D, Bouchard A, Li Q, Chua G, Poitras C, Thérien C, Bergeron D, Bourassa S, Greenblatt J, Chabot B, Poirier GG, Hughes TR, Blanchette M, Price DH, Coulombe B.

Mol Cell. 2007 Jul 20;27(2):262-74.


PReMod: a database of genome-wide mammalian cis-regulatory module predictions.

Ferretti V, Poitras C, Bergeron D, Coulombe B, Robert F, Blanchette M.

Nucleic Acids Res. 2007 Jan;35(Database issue):D122-6. Epub 2006 Dec 5.


Amino acid substitutions that specifically impair the transcriptional activity of papillomavirus E2 affect binding to the long isoform of Brd4.

Sénéchal H, Poirier GG, Coulombe B, Laimins LA, Archambault J.

Virology. 2007 Feb 5;358(1):10-7. Epub 2006 Oct 3.


Genome-wide computational prediction of transcriptional regulatory modules reveals new insights into human gene expression.

Blanchette M, Bataille AR, Chen X, Poitras C, Laganière J, Lefèbvre C, Deblois G, Giguère V, Ferretti V, Bergeron D, Coulombe B, Robert F.

Genome Res. 2006 May;16(5):656-68. Epub 2006 Apr 10.


Structural perspective on mutations affecting the function of multisubunit RNA polymerases.

Trinh V, Langelier MF, Archambault J, Coulombe B.

Microbiol Mol Biol Rev. 2006 Mar;70(1):12-36. Review.


Functional dissection of the catalytic mechanism of mammalian RNA polymerase II.

Coulombe B, Langelier MF.

Biochem Cell Biol. 2005 Aug;83(4):497-504. Review.


The highly conserved glutamic acid 791 of Rpb2 is involved in the binding of NTP and Mg(B) in the active center of human RNA polymerase II.

Langelier MF, Baali D, Trinh V, Greenblatt J, Archambault J, Coulombe B.

Nucleic Acids Res. 2005 May 10;33(8):2629-39. Print 2005.


RPAP1, a novel human RNA polymerase II-associated protein affinity purified with recombinant wild-type and mutated polymerase subunits.

Jeronimo C, Langelier MF, Zeghouf M, Cojocaru M, Bergeron D, Baali D, Forget D, Mnaimneh S, Davierwala AP, Pootoolal J, Chandy M, Canadien V, Beattie BK, Richards DP, Workman JL, Hughes TR, Greenblatt J, Coulombe B.

Mol Cell Biol. 2004 Aug;24(16):7043-58.


Interaction networks of the molecular machines that decode, replicate, and maintain the integrity of the human genome.

Coulombe B, Jeronimo C, Langelier MF, Cojocaru M, Bergeron D.

Mol Cell Proteomics. 2004 Sep;3(9):851-6. Epub 2004 Jun 22. Review.


Ordered conformational changes in damaged DNA induced by nucleotide excision repair factors.

Tapias A, Auriol J, Forget D, Enzlin JH, Schärer OD, Coin F, Coulombe B, Egly JM.

J Biol Chem. 2004 Apr 30;279(18):19074-83. Epub 2004 Feb 23.


Interactions of a DNA-bound transcriptional activator with the TBP-TFIIA-TFIIB-promoter quaternary complex.

Dion V, Coulombe B.

J Biol Chem. 2003 Mar 28;278(13):11495-501. Epub 2003 Jan 21.


[Focus on RNA polymerase II].

Langelier MF, Trinh V, Coulombe B.

Med Sci (Paris). 2002 Feb;18(2):210-216. Epub 2002 Feb 15. French. No abstract available.

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