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Evaluation of criteria for clinical control in a prospective, international, multicenter study of patients with COPD.

Miravitlles M, Sliwinski P, Rhee CK, Costello RW, Carter V, Tan J, Lapperre TS, Alcazar B, Gouder C, Esquinas C, García-Rivero JL, Kemppinen A, Tee A, Roman-Rodríguez M, Soler-Cataluña JJ, Price DB.

Respir Med. 2018 Mar;136:8-14. doi: 10.1016/j.rmed.2018.01.019. Epub 2018 Jan 31.


CDA as a predictive marker for life-threatening toxicities in patients with AML treated with cytarabine.

Fanciullino R, Farnault L, Donnette M, Imbs DC, Roche C, Venton G, Berda-Haddad Y, Ivanov V, Ciccolini J, Ouafik L, Lacarelle B, Costello R.

Blood Adv. 2018 Mar 13;2(5):462-469. doi: 10.1182/bloodadvances.2017014126.


Objective Assessment of Patient Inhaler User Technique Using an Audio-Based Classification Approach.

Taylor TE, Zigel Y, Egan C, Hughes F, Costello RW, Reilly RB.

Sci Rep. 2018 Feb 1;8(1):2164. doi: 10.1038/s41598-018-20523-w.


The Clinical Impact of Different Adherence Behaviours in Patients with Severe COPD.

Cushen B, Sulaiman I, Greene G, MacHale E, Mokoka M, Reilly RB, Bennett K, van Boven JF, Costello RW.

Am J Respir Crit Care Med. 2018 Jan 19. doi: 10.1164/rccm.201712-2469LE. [Epub ahead of print] No abstract available.


Estimation of inhalation flow profile using audio-based methods to assess inhaler medication adherence.

Taylor TE, Lacalle Muls H, Costello RW, Reilly RB.

PLoS One. 2018 Jan 18;13(1):e0191330. doi: 10.1371/journal.pone.0191330. eCollection 2018.


A randomised clinical trial of feedback on inhaler adherence and technique in patients with severe uncontrolled asthma.

Sulaiman I, Greene G, MacHale E, Seheult J, Mokoka M, D'Arcy S, Taylor T, Murphy DM, Hunt E, Lane SJ, Diette GB, FitzGerald JM, Boland F, Sartini Bhreathnach A, Cushen B, Reilly RB, Doyle F, Costello RW.

Eur Respir J. 2018 Jan 4;51(1). pii: 1701126. doi: 10.1183/13993003.01126-2017. Print 2018 Jan.


Bone disease in monoclonal gammopathy of undetermined significance: results from a screened population-based study.

Thorsteinsdottir S, Lund SH, Lindqvist EK, Thordardottir M, Sigurdsson G, Costello R, Burton D, Steingrimsdottir H, Gudnason V, Eiriksdottir G, Siggeirsdottir K, Harris TB, Landgren O, Kristinsson SY.

Blood Adv. 2017 Dec 21;1(27):2790-2798. doi: 10.1182/bloodadvances.2017010454. eCollection 2017 Dec 26.


Obesity and risk of monoclonal gammopathy of undetermined significance and progression to multiple myeloma: a population-based study.

Thordardottir M, Lindqvist EK, Lund SH, Costello R, Burton D, Korde N, Mailankody S, Eiriksdottir G, Launer LJ, Gudnason V, Harris TB, Landgren O, Kristinsson SY.

Blood Adv. 2017 Nov 1;1(24):2186-2192. doi: 10.1182/bloodadvances.2017007609. eCollection 2017 Nov 14.


Baseline mutational patterns and sustained MRD negativity in patients with high-risk smoldering myeloma.

Mailankody S, Kazandjian D, Korde N, Roschewski M, Manasanch E, Bhutani M, Tageja N, Kwok M, Zhang Y, Zingone A, Lamy L, Costello R, Morrison C, Hultcrantz M, Christofferson A, Washington M, Boateng M, Steinberg SM, Stetler-Stevenson M, Figg WD, Papaemmanuil E, Wilson WH, Keats JJ, Landgren O.

Blood Adv. 2017 Sep 29;1(22):1911-1918. doi: 10.1182/bloodadvances.2017005934. eCollection 2017 Oct 10.


Reduction in exhaled nitric oxide tracks improved patient inhaler compliance in difficult asthma-a case study.

Hunt E, Flynn D, MacHale E, Costello RW, Murphy DM.

J Asthma. 2017 Dec 26:1-3. doi: 10.1080/02770903.2017.1414237. [Epub ahead of print]


Hospital Resource Utilisation by Patients with Community-Acquired Pneumonia.

McCarthy H, O'Donnell S, Costello RW, Humphreys H.

Ir Med J. 2017 Aug 12;110(7):613.


Prevalence of myeloma precursor state monoclonal gammopathy of undetermined significance in 12372 individuals 10-49 years old: a population-based study from the National Health and Nutrition Examination Survey.

Landgren O, Graubard BI, Kumar S, Kyle RA, Katzmann JA, Murata K, Costello R, Dispenzieri A, Caporaso N, Mailankody S, Korde N, Hultcrantz M, Therneau TM, Larson DR, Cerhan JR, Rajkumar SV.

Blood Cancer J. 2017 Oct 20;7(10):e618. doi: 10.1038/bcj.2017.97.


Outcomes for HIV-associated diffuse large B-cell lymphoma in the modern combined antiretroviral therapy era.

Besson C, Lancar R, Prevot S, Algarte-Genin M, Delobel P, Bonnet F, Meyohas MC, Partisani M, Oberic L, Gabarre J, Goujard C, Boue F, Coppo P, Costello R, Hendel-Chavez H, Mekerri N, Dos Santos G, Recher C, Delarue R, Casasnovas RO, Taoufik Y, Mounier N, Costagliola D; ANRS-CO16 LYMPHOVIR Cohort.

AIDS. 2017 Nov 28;31(18):2493-2501. doi: 10.1097/QAD.0000000000001652.


Advances in Audio-Based Systems to Monitor Patient Adherence and Inhaler Drug Delivery.

Taylor TE, Zigel Y, De Looze C, Sulaiman I, Costello RW, Reilly RB.

Chest. 2018 Mar;153(3):710-722. doi: 10.1016/j.chest.2017.08.1162. Epub 2017 Sep 5. Review.


Interpreting magnesium status to enhance clinical care: key indicators.

Costello RB, Nielsen F.

Curr Opin Clin Nutr Metab Care. 2017 Nov;20(6):504-511. doi: 10.1097/MCO.0000000000000410.


Host-related immunodeficiency in the development of multiple myeloma.

Dosani T, Mailankody S, Korde N, Manasanch E, Bhutani M, Tageja N, Roschewski M, Kwok M, Kazandjian D, Costello R, Burton D, Zhang Y, Liewehr D, Steinberg SM, Maric I, Landgren O.

Leuk Lymphoma. 2018 May;59(5):1127-1132. doi: 10.1080/10428194.2017.1361026. Epub 2017 Aug 9.


Physical activity patterns and clusters in 1001 patients with COPD.

Mesquita R, Spina G, Pitta F, Donaire-Gonzalez D, Deering BM, Patel MS, Mitchell KE, Alison J, van Gestel AJ, Zogg S, Gagnon P, Abascal-Bolado B, Vagaggini B, Garcia-Aymerich J, Jenkins SC, Romme EA, Kon SS, Albert PS, Waschki B, Shrikrishna D, Singh SJ, Hopkinson NS, Miedinger D, Benzo RP, Maltais F, Paggiaro P, McKeough ZJ, Polkey MI, Hill K, Man WD, Clarenbach CF, Hernandes NA, Savi D, Wootton S, Furlanetto KC, Cindy Ng LW, Vaes AW, Jenkins C, Eastwood PR, Jarreta D, Kirsten A, Brooks D, Hillman DR, Sant'Anna T, Meijer K, Dürr S, Rutten EP, Kohler M, Probst VS, Tal-Singer R, Gil EG, den Brinker AC, Leuppi JD, Calverley PM, Smeenk FW, Costello RW, Gramm M, Goldstein R, Groenen MT, Magnussen H, Wouters EF, ZuWallack RL, Amft O, Watz H, Spruit MA.

Chron Respir Dis. 2017 Aug;14(3):256-269. doi: 10.1177/1479972316687207. Epub 2017 Feb 24.


Effective deployment of technology-supported management of chronic respiratory conditions: a call for stakeholder engagement.

Costello RW, Dima AL, Ryan D, McIvor RA, Boycott K, Chisholm A, Price D, Blakey JD.

Pragmat Obs Res. 2017 Jul 5;8:119-128. doi: 10.2147/POR.S132316. eCollection 2017.


Disseminated Intravascular Coagulation (DIC).

Costello RA, Nehring SM.

StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2018 Jan-.
2017 Oct 10.


Vorinostat and Mithramycin A in combination therapy as an interesting strategy for the treatment of Sézary T lymphoma: a transcriptomic approach.

Ragheb R, Venton G, Chelbi R, Bonnet N, Le Treut T, Ivanov V, Mercier C, Poulin P, Beaufils N, Gabert J, Suchon P, Rihet P, Loriod B, Kahn-Perlès B, Costello RT.

Arch Dermatol Res. 2017 Oct;309(8):611-623. doi: 10.1007/s00403-017-1761-0. Epub 2017 Jul 10.


Colonisation of Irish patients with chronic obstructive pulmonary disease by Streptococcus pneumoniae and analysis of the pneumococcal vaccine coverage: a non-interventional, observational, prospective cohort study.

McCarthy H, Jackson M, Corcoran M, McElligott M, MacHale E, Sulaiman I, Cushen B, Costello RW, Humpreys H.

BMJ Open. 2017 Jul 9;7(7):e013944. doi: 10.1136/bmjopen-2016-013944.


In patients with severe uncontrolled asthma, does knowledge of adherence and inhaler technique using electronic monitoring improve clinical decision making? A protocol for a randomised controlled trial.

Mokoka MC, Lombard L, MacHale EM, Walsh J, Cushen B, Sulaiman I, Carthy DM, Boland F, Doyle F, Hunt E, Murphy DM, Faul J, Butler M, Hetherington K, Mark FitzGerald J, Boven JFV, Heaney LG, Reilly RB, Costello RW.

BMJ Open. 2017 Jun 15;7(6):e015367. doi: 10.1136/bmjopen-2016-015367.


Circulating Adiponectin Levels Differ Between Patients with Multiple Myeloma and its Precursor Disease.

Hofmann JN, Mailankody S, Korde N, Wang Y, Tageja N, Costello R, Zingone A, Hultcrantz M, Pollak MN, Purdue MP, Landgren O.

Obesity (Silver Spring). 2017 Aug;25(8):1317-1320. doi: 10.1002/oby.21894. Epub 2017 Jun 11.


Response to: Quantifying the hepatotoxic risk of alcohol consumption in patients with rheumatoid arthritis by Kremer and Weinblatt.

Humphreys JH, Costello R, Verstappen SM, Dixon WG.

Ann Rheum Dis. 2018 Jan;77(1):e5. doi: 10.1136/annrheumdis-2017-211670. Epub 2017 Jun 8. No abstract available.


ALDH1A3 is epigenetically regulated during melanocyte transformation and is a target for melanoma treatment.

Pérez-Alea M, McGrail K, Sánchez-Redondo S, Ferrer B, Fournet G, Cortés J, Muñoz E, Hernandez-Losa J, Tenbaum S, Martin G, Costello R, Ceylan I, Garcia-Patos V, Recio JA.

Oncogene. 2017 Oct 12;36(41):5695-5708. doi: 10.1038/onc.2017.160. Epub 2017 Jun 5.


The impact of change of renal replacement therapy modality on sleep quality in patients with end-stage renal disease: a systematic review and meta-analysis.

Kennedy C, Ryan SA, Kane T, Costello RW, Conlon PJ.

J Nephrol. 2018 Feb;31(1):61-70. doi: 10.1007/s40620-017-0409-7. Epub 2017 Jun 1. Review.


Is Nutrient Content and Other Label Information for Prescription Prenatal Supplements Different from Nonprescription Products?

Saldanha LG, Dwyer JT, Andrews KW, Brown LL, Costello RB, Ershow AG, Gusev PA, Hardy CJ, Pehrsson PR.

J Acad Nutr Diet. 2017 Sep;117(9):1429-1436. doi: 10.1016/j.jand.2017.04.002. Epub 2017 May 29.


First case of B ALL with KMT2A-MAML2 rearrangement: a case report.

Menu E, Beaufils N, Usseglio F, Balducci E, Lafage Pochitaloff M, Costello R, Gabert J.

BMC Cancer. 2017 May 23;17(1):363. doi: 10.1186/s12885-017-3368-4.


Patient perceptions of glucocorticoid side effects: a cross-sectional survey of users in an online health community.

Costello R, Patel R, Humphreys J, McBeth J, Dixon WG.

BMJ Open. 2017 Apr 3;7(4):e014603. doi: 10.1136/bmjopen-2016-014603.


Multivariate genetic architecture of the Anolis dewlap reveals both shared and sex-specific features of a sexually dimorphic ornament.

Cox RM, Costello RA, Camber BE, McGlothlin JW.

J Evol Biol. 2017 Jul;30(7):1262-1275. doi: 10.1111/jeb.13080. Epub 2017 Apr 29.


Targeting patients with asthma for omalizumab therapy: choosing the right patient to get the best value for money.

Al Said A, Cushen B, Costello RW.

Ther Adv Chronic Dis. 2017 Feb;8(2-3):31-45. doi: 10.1177/2040622317690494. Epub 2017 Feb 1. Review.


Quantifying the hepatotoxic risk of alcohol consumption in patients with rheumatoid arthritis taking methotrexate.

Humphreys JH, Warner A, Costello R, Lunt M, Verstappen SMM, Dixon WG.

Ann Rheum Dis. 2017 Sep;76(9):1509-1514. doi: 10.1136/annrheumdis-2016-210629. Epub 2017 Mar 23.


Omega-3 Polyunsaturated Fatty Acid (Fish Oil) Supplementation and the Prevention of Clinical Cardiovascular Disease: A Science Advisory From the American Heart Association.

Siscovick DS, Barringer TA, Fretts AM, Wu JH, Lichtenstein AH, Costello RB, Kris-Etherton PM, Jacobson TA, Engler MB, Alger HM, Appel LJ, Mozaffarian D; American Heart Association Nutrition Committee of the Council on Lifestyle and Cardiometabolic Health; Council on Epidemiology and Prevention; Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; and Council on Clinical Cardiology.

Circulation. 2017 Apr 11;135(15):e867-e884. doi: 10.1161/CIR.0000000000000482. Epub 2017 Mar 13. Review.


The Impact of Common Inhaler Errors on Drug Delivery: Investigating Critical Errors with a Dry Powder Inhaler.

Sulaiman I, Seheult J, Sadasivuni N, MacHale E, Killane I, Giannoutsos S, Cushen B, Mokoka MC, Bhreathnach AS, Boland F, Reilly RB, Costello RW.

J Aerosol Med Pulm Drug Deliv. 2017 Aug;30(4):247-255. doi: 10.1089/jamp.2016.1334. Epub 2017 Mar 9.


The INCATM (Inhaler Compliance AssessmentTM): A comparison with established measures of adherence.

Moran C, Doyle F, Sulaiman I, Bennett K, Greene G, Molloy GJ, Reilly RB, Costello RW, Mellon L.

Psychol Health. 2017 Oct;32(10):1266-1287. doi: 10.1080/08870446.2017.1290243. Epub 2017 Feb 28.


Changes in inhaler inhalation acoustic features during induced bronchoconstriction: a pilot study.

McCartan TA, Taylor TE, Sulaiman I, Costello RW, Reilly RB.

Conf Proc IEEE Eng Med Biol Soc. 2016 Aug;2016:3749-3752. doi: 10.1109/EMBC.2016.7591543.


Fitness to drive-How well do we know the rules? Survey of 19 ENT surgeons in Wales.

Yap D, Shakir A, Costello R, Browning S.

Clin Otolaryngol. 2017 Oct;42(5):1078-1081. doi: 10.1111/coa.12852. Epub 2017 Mar 7. No abstract available.


Perspective: The Case for an Evidence-Based Reference Interval for Serum Magnesium: The Time Has Come.

Costello RB, Elin RJ, Rosanoff A, Wallace TC, Guerrero-Romero F, Hruby A, Lutsey PL, Nielsen FH, Rodriguez-Moran M, Song Y, Van Horn LV.

Adv Nutr. 2016 Nov 15;7(6):977-993. doi: 10.3945/an.116.012765. Print 2016 Nov.


Analysis of nocturnal actigraphic sleep measures in patients with COPD and their association with daytime physical activity.

Spina G, Spruit MA, Alison J, Benzo RP, Calverley PMA, Clarenbach CF, Costello RW, Donaire-Gonzalez D, Dürr S, Garcia-Aymerich J, van Gestel AJR, Gramm M, Hernandes NA, Hill K, Hopkinson NS, Jarreta D, Kohler M, Kirsten AM, Leuppi JD, Magnussen H, Maltais F, Man WD, McKeough ZJ, Mesquita R, Miedinger D, Pitta F, Singh SJ, Smeenk FWJM, Tal-Singer R, Vagaggini B, Waschki B, Watz H, Wouters EFM, Zogg S, den Brinker AC.

Thorax. 2017 Aug;72(8):694-701. doi: 10.1136/thoraxjnl-2016-208900. Epub 2017 Jan 12.


The use of multiple respiratory inhalers requiring different inhalation techniques has an adverse effect on COPD outcomes.

Bosnic-Anticevich S, Chrystyn H, Costello RW, Dolovich MB, Fletcher MJ, Lavorini F, Rodríguez-Roisin R, Ryan D, Wan Yau Ming S, Price DB.

Int J Chron Obstruct Pulmon Dis. 2016 Dec 21;12:59-71. doi: 10.2147/COPD.S117196. eCollection 2017.


Acquired TET2 mutation in one patient with familial platelet disorder with predisposition to AML led to the development of pre-leukaemic clone resulting in T2-ALL and AML-M0.

Manchev VT, Bouzid H, Antony-Debré I, Leite B, Meurice G, Droin N, Prebet T, Costello RT, Vainchenker W, Plo I, Diop M, Macintyre E, Asnafi V, Favier R, Baccini V, Raslova H.

J Cell Mol Med. 2017 Jun;21(6):1237-1242. doi: 10.1111/jcmm.13051. Epub 2016 Dec 20.


Timing of glucocorticoid administration: a cross-sectional survey of glucocorticoid users in an online social network for health.

Costello R, Patel R, Humphreys J, McBeth J, Dixon WG.

Rheumatology (Oxford). 2017 Mar 1;56(3):494-495. doi: 10.1093/rheumatology/kew421. No abstract available.


Enzymatic activities of circulating plasma proteasomes in newly diagnosed multiple myeloma patients treated with carfilzomib, lenalidomide and dexamethasone.

Manasanch EE, de Larrea CF, Zingone A, Steinberg SM, Kwok M, Tageja N, Bhutani M, Kazandjian D, Roschewski M, Wu P, Carter G, Zuchlinski D, Mulquin M, Lamping L, Costello R, Burton D, Gil LA, Figg WD, Maric I, Calvo KR, Yuan C, Stetler-Stevenson M, Korde N, Landgren O.

Leuk Lymphoma. 2017 Mar;58(3):639-645. doi: 10.1080/10428194.2016.1214953. Epub 2016 Aug 9.


Do Cinnamon Supplements Have a Role in Glycemic Control in Type 2 Diabetes? A Narrative Review.

Costello RB, Dwyer JT, Saldanha L, Bailey RL, Merkel J, Wambogo E.

J Acad Nutr Diet. 2016 Nov;116(11):1794-1802. doi: 10.1016/j.jand.2016.07.015. Epub 2016 Sep 8. Review.


Safety and performance benefits of arginine supplements for military personnel: a systematic review.

Brooks JR, Oketch-Rabah H, Low Dog T, Gorecki DK, Barrett ML, Cantilena L, Chung M, Costello RB, Dwyer J, Hardy ML, Jordan SA, Maughan RJ, Marles RJ, Osterberg RE, Rodda BE, Wolfe RR, Zuniga JM, Valerio LG Jr, Jones D, Deuster P, Giancaspro GI, Sarma ND.

Nutr Rev. 2016 Nov;74(11):708-721. Review.


A pilot study to monitor changes in spirometry and lung volume, following an exacerbation of Chronic Obstructive Pulmonary Disease (COPD), as part of a supported discharge program.

Cushen B, McCormack N, Hennigan K, Sulaiman I, Costello RW, Deering B.

Respir Med. 2016 Oct;119:55-62. doi: 10.1016/j.rmed.2016.08.019. Epub 2016 Aug 24.


Aldehyde dehydrogenases inhibition eradicates leukemia stem cells while sparing normal progenitors.

Venton G, Pérez-Alea M, Baier C, Fournet G, Quash G, Labiad Y, Martin G, Sanderson F, Poullin P, Suchon P, Farnault L, Nguyen C, Brunet C, Ceylan I, Costello RT.

Blood Cancer J. 2016 Sep 9;6(9):e469. doi: 10.1038/bcj.2016.78.


Irregular and Ineffective: A Quantitative Observational Study of the Time and Technique of Inhaler Use.

Sulaiman I, Seheult J, MacHale E, D'Arcy S, Boland F, McCrory K, Casey J, Bury G, Al-Alawi M, O'Dwyer S, Ryder SA, Reilly RB, Costello RW.

J Allergy Clin Immunol Pract. 2016 Sep-Oct;4(5):900-909.e2. doi: 10.1016/j.jaip.2016.07.009.


The Seven Stages of Man: The Role of Developmental Stage on Medication Adherence in Respiratory Diseases.

Costello RW, Foster JM, Grigg J, Eakin MN, Canonica W, Yunus F, Ryan D; Respiratory Effectiveness Group.

J Allergy Clin Immunol Pract. 2016 Sep-Oct;4(5):813-20. doi: 10.1016/j.jaip.2016.04.002. Review.


Qualitative investigation into a wearable system for chronic obstructive pulmonary disease: the stakeholders' perspective.

Kayyali R, Savickas V, Spruit MA, Kaimakamis E, Siva R, Costello RW, Chang J, Pierscionek B, Davies N, Vaes AW, Paradiso R, Philip N, Perantoni E, D'Arcy S, Raptopoulos A, Nabhani-Gebara S.

BMJ Open. 2016 Aug 31;6(8):e011657. doi: 10.1136/bmjopen-2016-011657.

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