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International Practice Variation in Weaning Critically Ill Adults From Invasive Mechanical Ventilation.

Burns KEA, Raptis S MSc, Nisenbaum R PhD, Rizvi L, Jones A, Bakshi J, Tan W, Meret A, Cook DJ, Lellouche F, Epstein SK, Gattas D, Kapadia FN, Villar J, Brochard L, Lessard MR, Meade MO.

Ann Am Thorac Soc. 2018 Mar 6. doi: 10.1513/AnnalsATS.201705-410OC. [Epub ahead of print]


Learning Activity Predictors from Sensor Data: Algorithms, Evaluation, and Applications.

Minor B, Doppa JR, Cook DJ.

IEEE Trans Knowl Data Eng. 2017 Dec 1;29(12):2744-2757. doi: 10.1109/TKDE.2017.2750669. Epub 2017 Sep 11.


7 versus 14 days of antibiotic treatment for critically ill patients with bloodstream infection: a pilot randomized clinical trial.

Daneman N, Rishu AH, Pinto R, Aslanian P, Bagshaw SM, Carignan A, Charbonney E, Coburn B, Cook DJ, Detsky ME, Dodek P, Hall R, Kumar A, Lamontagne F, Lauzier F, Marshall JC, Martin CM, McIntyre L, Muscedere J, Reynolds S, Sligl W, Stelfox HT, Wilcox ME, Fowler RA; Canadian Critical Care Trials Group.

Trials. 2018 Feb 17;19(1):111. doi: 10.1186/s13063-018-2474-1.


Functionalized metal-organic framework nanocomposites for dispersive solid phase extraction and enantioselective capture of chiral drug intermediates.

Ma X, Zhou X, Yu A, Zhao W, Zhang W, Zhang S, Wei L, Cook DJ, Roy A.

J Chromatogr A. 2018 Feb 16;1537:1-9. doi: 10.1016/j.chroma.2017.12.067. Epub 2018 Jan 6.


Organ donation in the ICU: A document analysis of institutional policies, protocols, and order sets.

Oczkowski SJW, Centofanti JE, Durepos P, Arseneau E, Kelecevic J, Cook DJ, Meade MO.

Intensive Crit Care Nurs. 2018 Jan 10. pii: S0964-3397(17)30243-4. doi: 10.1016/j.iccn.2017.12.005. [Epub ahead of print]


Pooled analysis of higher versus lower blood pressure targets for vasopressor therapy septic and vasodilatory shock.

Lamontagne F, Day AG, Meade MO, Cook DJ, Guyatt GH, Hylands M, Radermacher P, Chrétien JM, Beaudoin N, Hébert P, D'Aragon F, Meziani F, Asfar P.

Intensive Care Med. 2018 Jan;44(1):12-21. doi: 10.1007/s00134-017-5016-5. Epub 2017 Dec 19. Review.


A novel perspective to calibrate temporal delays in cerebrovascular reactivity using hypercapnic and hyperoxic respiratory challenges.

Champagne AA, Bhogal AA, Coverdale NS, Mark CI, Cook DJ.

Neuroimage. 2017 Dec 4. pii: S1053-8119(17)30978-3. doi: 10.1016/j.neuroimage.2017.11.044. [Epub ahead of print]


Recovery after critical illness: putting the puzzle together-a consensus of 29.

Azoulay E, Vincent JL, Angus DC, Arabi YM, Brochard L, Brett SJ, Citerio G, Cook DJ, Curtis JR, Dos Santos CC, Ely EW, Hall J, Halpern SD, Hart N, Hopkins RO, Iwashyna TJ, Jaber S, Latronico N, Mehta S, Needham DM, Nelson J, Puntillo K, Quintel M, Rowan K, Rubenfeld G, Van den Berghe G, Van der Hoeven J, Wunsch H, Herridge M.

Crit Care. 2017 Dec 5;21(1):296. doi: 10.1186/s13054-017-1887-7. Review.


Complete Acid-Based Hydrolysis Assay for Carbohydrate Quantification in Seaweed: A Species-Specific Optimized Approach.

Kostas ET, Wilkinson SJ, White DA, Cook DJ.

Methods Mol Biol. 2017 Nov 14. doi: 10.1007/7651_2017_105. [Epub ahead of print]


Aspirin in Patients With Previous Percutaneous Coronary Intervention Undergoing Noncardiac Surgery.

Graham MM, Sessler DI, Parlow JL, Biccard BM, Guyatt G, Leslie K, Chan MTV, Meyhoff CS, Xavier D, Sigamani A, Kumar PA, Mrkobrada M, Cook DJ, Tandon V, Alvarez-Garcia J, Villar JC, Painter TW, Landoni G, Fleischmann E, Lamy A, Whitlock R, Le Manach Y, Aphang-Lam M, Cata JP, Gao P, Terblanche NCS, Ramana PV, Jamieson KA, Bessissow A, Mendoza GR, Ramirez S, Diemunsch PA, Yusuf S, Devereaux PJ.

Ann Intern Med. 2018 Feb 20;168(4):237-244. doi: 10.7326/M17-2341. Epub 2018 Nov 14.


2009-2010 Influenza A(H1N1)-related critical illness among Aboriginal and non-Aboriginal Canadians.

Jung JJ, Pinto R, Zarychanski R, Cook DJ, Jouvet P, Marshall JC, Kumar A, Long J, Rodin R, Fowler RA; Canadian Critical Care Trials Group H1N1 Collaborative.

PLoS One. 2017 Oct 19;12(10):e0184013. doi: 10.1371/journal.pone.0184013. eCollection 2017.


Collegial Activity Learning between Heterogeneous Sensors.

Feuz KD, Cook DJ.

Knowl Inf Syst. 2017 Nov;53(2):337-364. doi: 10.1007/s10115-017-1043-3. Epub 2017 Mar 27.


Smart Secure Homes: A Survey of Smart Home Technologies that Sense, Assess, and Respond to Security Threats.

Dahmen J, Cook DJ, Wang X, Honglei W.

J Reliab Intell Environ. 2017 Aug;3(2):83-98. doi: 10.1007/s40860-017-0035-0. Epub 2017 Feb 15.


Canada-DONATE study protocol: a prospective national observational study of the medical management of deceased organ donors.

D'Aragon F, Dhanani S, Lamontagne F, Cook DJ, Burns K, Akhtar A, Chassé M, Frenette AJ, Keenan S, Lize JF, Kutsogiannis DJ, Kramer A, Hand LE, Arseneau E, Masse MH, Ribic C, Ball I, Baker A, Boyd G, Rochwerg B, Healey A, Hanna S, Guyatt GH, Meade MO; Canadian Critical Care Trials Group and the Canadian National Transplant Research Program.

BMJ Open. 2017 Sep 28;7(9):e018858. doi: 10.1136/bmjopen-2017-018858.


Management of Acute Respiratory Distress Syndrome and Refractory Hypoxemia. A Multicenter Observational Study.

Duan EH, Adhikari NKJ, D'Aragon F, Cook DJ, Mehta S, Alhazzani W, Goligher E, Charbonney E, Arabi YM, Karachi T, Turgeon AF, Hand L, Zhou Q, Austin P, Friedrich J, Lamontagne F, Lauzier F, Patel R, Muscedere J, Hall R, Aslanian P, Piraino T, Albert M, Bagshaw SM, Jacka M, Wood G, Henderson W, Dorscheid D, Ferguson ND, Meade MO; Canadian Critical Care Trials Group.

Ann Am Thorac Soc. 2017 Dec;14(12):1818-1826. doi: 10.1513/AnnalsATS.201612-1042OC.


Need for a Randomized Controlled Trial of Stress Ulcer Prophylaxis in Critically Ill Children: A Canadian Survey.

Duffett M, Choong K, Foster J, Gilfoyle E, Lacroix J, Cook DJ.

Can J Hosp Pharm. 2017 Jul-Aug;70(4):288-293. Epub 2017 Aug 31.


Erratum to: Pediatric intensive care stress ulcer prevention (PIC-UP): a protocol for a pilot randomized trial.

Duffett M, Choong K, Foster J, Gilfoyle E, Lacroix J, Pai N, Thabane L, Cook DJ; Canadian Critical Care Trials Group.

Pilot Feasibility Stud. 2017 Aug 18;3:33. doi: 10.1186/s40814-017-0173-4. eCollection 2017.


The authors reply.

Oczkowski SJW, Duan EH, Groen A, Warren D, Cook DJ.

Crit Care Med. 2017 Sep;45(9):e990-e991. doi: 10.1097/CCM.0000000000002545. No abstract available.


Increased functional connectivity after stroke correlates with behavioral scores in non-human primate model.

Hernandez-Castillo CR, Nashed JY, Fernandez-Ruiz J, Wang J, Gallivan J, Cook DJ.

Sci Rep. 2017 Jul 27;7(1):6701. doi: 10.1038/s41598-017-07175-y.


Fluids in Sepsis and Septic Shock (FISSH): protocol for a pilot randomised controlled trial.

Rochwerg B, Millen T, Austin P, Zeller M, D'Aragon F, Jaeschke R, Masse MH, Mehta S, Lamontagne F, Meade M, Guyatt G, Cook DJ; Canadian Critical Care Trials Group.

BMJ Open. 2017 Jul 20;7(7):e017602. doi: 10.1136/bmjopen-2017-017602.


Protocol adherence for continuously titrated interventions in randomized trials: an overview of the current methodology and case study.

Lauzier F, Adhikari NK, Seely A, Koo KKY, Belley-Côté EP, Burns KEA, Cook DJ, D'Aragon F, Rochwerg B, Kho ME, Oczkowksi SJW, Duan EH, Meade MO, Day AG, Lamontagne F; for ACCADEMY (Academy of Critical Care – Development, Evaluation, and Methodology).

BMC Med Res Methodol. 2017 Jul 17;17(1):106. doi: 10.1186/s12874-017-0388-3.


Forecasting Occurrences of Activities.

Minor B, Cook DJ.

Pervasive Mob Comput. 2017 Jul;38(Pt 1):77-91. doi: 10.1016/j.pmcj.2016.09.010. Epub 2016 Sep 27.


Measuring Changes in Gait and Vehicle Transfer Ability During Inpatient Rehabilitation with Wearable Inertial Sensors.

Borisov V, Sprint G, Cook DJ, Weeks DL.

Proc IEEE Int Conf Pervasive Comput Commun Workshops. 2017 Mar;2017. doi: 10.1109/PERCOMW.2017.7917600. Epub 2017 May 4.


Genome-scale metabolic models applied to human health and disease.

Cook DJ, Nielsen J.

Wiley Interdiscip Rev Syst Biol Med. 2017 Nov;9(6). doi: 10.1002/wsbm.1393. Epub 2017 Jun 23. Review.


An environmental scan of quality indicators in critical care.

Valiani S, Rigal R, Stelfox HT, Muscedere J, Martin CM, Dodek P, Lamontagne F, Fowler R, Gheshmy A, Cook DJ, Forster AJ, Hébert PC.

CMAJ Open. 2017 Jun 21;5(2):E488-E495. doi: 10.9778/cmajo.20150139.


A Survey of Methods for Time Series Change Point Detection.

Aminikhanghahi S, Cook DJ.

Knowl Inf Syst. 2017 May;51(2):339-367. doi: 10.1007/s10115-016-0987-z. Epub 2016 Sep 8.


Pediatric intensive care stress ulcer prevention (PIC-UP): a protocol for a pilot randomized trial.

Duffett M, Choong K, Foster J, Gilfoyle E, Lacroix J, Pai N, Thabane L, Cook DJ; Canadian Critical Care Trials Group.

Pilot Feasibility Stud. 2017 May 19;3:26. doi: 10.1186/s40814-017-0142-y. eCollection 2017. Erratum in: Pilot Feasibility Stud. 2017 Aug 18;3:33.


Erratum to: Cardiac ischemia in patients with septic shock randomized to vasopressin or norepinephrine.

Mehta S, Granton J, Gordon AC, Cook DJ, Lapinsky S, Newton G, Bandayrel K, Little A, Siau C, Ayers D, Singer J, Lee TCK, Walley KR, Storms M, Cooper DJ, Holmes CL, Hebert P, Presneill J, Russell JA; Vasopressin and Septic Shock Trial (VASST) Investigators.

Crit Care. 2017 May 4;21(1):98. doi: 10.1186/s13054-017-1680-7. No abstract available.


Activity Learning as a Foundation for Security Monitoring in Smart Homes.

Dahmen J, Thomas BL, Cook DJ, Wang X.

Sensors (Basel). 2017 Mar 31;17(4). pii: E737. doi: 10.3390/s17040737.


The Use of Bowel Protocols in Critically Ill Adult Patients: A Systematic Review and Meta-Analysis.

Oczkowski SJW, Duan EH, Groen A, Warren D, Cook DJ.

Crit Care Med. 2017 Jul;45(7):e718-e726. doi: 10.1097/CCM.0000000000002315. Review.


High-Quality Randomized Controlled Trials in Pediatric Critical Care: A Survey of Barriers and Facilitators.

Duffett M, Choong K, Foster J, Meade M, Menon K, Parker M, Cook DJ; Canadian Critical Care Trials Group.

Pediatr Crit Care Med. 2017 May;18(5):405-413. doi: 10.1097/PCC.0000000000001144.


Toward personalized and context-aware prompting for smartphone-based intervention.

Fallahzadeh R, Aminikhanghahi S, Gibson AN, Cook DJ.

Conf Proc IEEE Eng Med Biol Soc. 2016 Aug;2016:6010-6013. doi: 10.1109/EMBC.2016.7592098.


Severity of Hypoxemia and Effect of High-Frequency Oscillatory Ventilation in Acute Respiratory Distress Syndrome.

Meade MO, Young D, Hanna S, Zhou Q, Bachman TE, Bollen C, Slutsky AS, Lamb SE, Adhikari NKJ, Mentzelopoulos SD, Cook DJ, Sud S, Brower RG, Thompson BT, Shah S, Stenzler A, Guyatt G, Ferguson ND.

Am J Respir Crit Care Med. 2017 Sep 15;196(6):727-733. doi: 10.1164/rccm.201609-1938OC.


Gender Parity in Critical Care Medicine.

Mehta S, Burns KEA, Machado FR, Fox-Robichaud AE, Cook DJ, Calfee CS, Ware LB, Burnham EL, Kissoon N, Marshall JC, Mancebo J, Finfer S, Hartog C, Reinhart K, Maitland K, Stapleton RD, Kwizera A, Amin P, Abroug F, Smith O, Laake JH, Shrestha GS, Herridge MS.

Am J Respir Crit Care Med. 2017 Aug 15;196(4):425-429. doi: 10.1164/rccm.201701-0076CP. Review.


Vasopressor Use for Severe Hypotension-A Multicentre Prospective Observational Study.

Lamontagne F, Cook DJ, Meade MO, Seely A, Day AG, Charbonney E, Serri K, Skrobik Y, Hebert P, St-Arnaud C, Quiroz-Martinez H, Mayette M, Heyland DK.

PLoS One. 2017 Jan 20;12(1):e0167840. doi: 10.1371/journal.pone.0167840. eCollection 2017.


TryCYCLE: A Prospective Study of the Safety and Feasibility of Early In-Bed Cycling in Mechanically Ventilated Patients.

Kho ME, Molloy AJ, Clarke FJ, Ajami D, McCaughan M, Obrovac K, Murphy C, Camposilvan L, Herridge MS, Koo KK, Rudkowski J, Seely AJ, Zanni JM, Mourtzakis M, Piraino T, Cook DJ; Canadian Critical Care Trials Group.

PLoS One. 2016 Dec 28;11(12):e0167561. doi: 10.1371/journal.pone.0167561. eCollection 2016.


Outcomes of elderly critically ill medical and surgical patients: a multicentre cohort study.

Ball IM, Bagshaw SM, Burns KE, Cook DJ, Day AG, Dodek PM, Kutsogiannis DJ, Mehta S, Muscedere JG, Turgeon AF, Stelfox HT, Wells GA, Stiell IG.

Can J Anaesth. 2017 Mar;64(3):260-269. doi: 10.1007/s12630-016-0798-4. Epub 2016 Dec 27.


An introduction to multiplicity issues in clinical trials: the what, why, when and how.

Li G, Taljaard M, Van den Heuvel ER, Levine MA, Cook DJ, Wells GA, Devereaux PJ, Thabane L.

Int J Epidemiol. 2017 Apr 1;46(2):746-755. doi: 10.1093/ije/dyw320.


Mashing with unmalted sorghum using a novel low temperature enzyme system: Impacts of sorghum grain composition and microstructure.

Holmes CP, Casey J, Cook DJ.

Food Chem. 2017 Apr 15;221:324-334. doi: 10.1016/j.foodchem.2016.10.083. Epub 2016 Oct 20.


Airway Management Strategies for Brain-injured Patients Meeting Standard Criteria to Consider Extubation. A Prospective Cohort Study.

McCredie VA, Ferguson ND, Pinto RL, Adhikari NK, Fowler RA, Chapman MG, Burrell A, Baker AJ, Cook DJ, Meade MO, Scales DC; Canadian Critical Care Trials Group.

Ann Am Thorac Soc. 2017 Jan;14(1):85-93. doi: 10.1513/AnnalsATS.201608-620OC.


The monitoring of activity at home after total hip arthroplasty.

Toogood PA, Abdel MP, Spear JA, Cook SM, Cook DJ, Taunton MJ.

Bone Joint J. 2016 Nov;98-B(11):1450-1454.


Unsupervised detection and analysis of changes in everyday physical activity data.

Sprint G, Cook DJ, Schmitter-Edgecombe M.

J Biomed Inform. 2016 Oct;63:54-65. doi: 10.1016/j.jbi.2016.07.020. Epub 2016 Jul 25.


One-Class Classification-Based Real-Time Activity Error Detection in Smart Homes.

Das B, Cook DJ, Krishnan NC, Schmitter-Edgecombe M.

IEEE J Sel Top Signal Process. 2016 Aug;10(5):914-923. Epub 2016 Feb 29.


Early mobilization of critically ill adults: a survey of knowledge, perceptions and practices of Canadian physicians and physiotherapists.

Koo KK, Choong K, Cook DJ, Herridge M, Newman A, Lo V, Guyatt G, Priestap F, Campbell E, Burns KE, Lamontagne F, Meade MO; Canadian Critical Care Trials Group.

CMAJ Open. 2016 Aug 18;4(3):E448-E454. eCollection 2016 Jul-Sep.


Erratum to: Risk factors for mortality in patients admitted to intensive care units with pneumonia.

Li G, Cook DJ, Thabane L, Friedrich JO, Crozier TM, Muscedere J, Granton J, Mehta S, Reynolds SC, Lopes RD, Lauzier F, Freitag AP, Levine MA; PROTECT Investigators for the Canadian Critical Care Trials Group; Australian and New Zealand Intensive Care Society Clinical Trials Group.

Respir Res. 2016 Oct 7;17(1):128. No abstract available.


Forecasting behavior in smart homes based on sleep and wake patterns.

Williams JA, Cook DJ.

Technol Health Care. 2017;25(1):89-110. doi: 10.3233/THC-161255.


Warm Handoff Versus Fax Referral for Linking Hospitalized Smokers to Quitlines.

Richter KP, Faseru B, Shireman TI, Mussulman LM, Nazir N, Bush T, Scheuermann TS, Preacher KJ, Carlini BH, Magnusson B, Ellerbeck EF, Cramer C, Cook DJ, Martell MJ.

Am J Prev Med. 2016 Oct;51(4):587-96. doi: 10.1016/j.amepre.2016.04.006.


Assessment of Postresuscitation Volume Status by Bioimpedance Analysis in Patients with Sepsis in the Intensive Care Unit: A Pilot Observational Study.

Rochwerg B, Cheung JH, Ribic CM, Lalji F, Clarke FJ, Gantareddy S, Ranganath N, Walele A, McDonald E, Meade MO, Cook DJ, Wilkieson TT, Clase CM, Margetts PJ, Gangji AS.

Can Respir J. 2016;2016:8671742. doi: 10.1155/2016/8671742. Epub 2016 Aug 15.


Cytochromes P450: History, Classes, Catalytic Mechanism, and Industrial Application.

Cook DJ, Finnigan JD, Cook K, Black GW, Charnock SJ.

Adv Protein Chem Struct Biol. 2016;105:105-26. doi: 10.1016/bs.apcsb.2016.07.003. Epub 2016 Aug 9. Review.


A clinical prediction tool for hospital mortality in critically ill elderly patients.

Ball IM, Bagshaw SM, Burns KE, Cook DJ, Day AG, Dodek PM, Kutsogiannis DJ, Mehta S, Muscedere JG, Stelfox HT, Turgeon AF, Wells GA, Stiell IG.

J Crit Care. 2016 Oct;35:206-12. doi: 10.1016/j.jcrc.2016.05.026. Epub 2016 Jun 7.


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