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Items: 1 to 50 of 76

1.

Reconstitution of T Cell Proliferation under Arginine Limitation: Activated Human T Cells Take Up Citrulline via L-Type Amino Acid Transporter 1 and Use It to Regenerate Arginine after Induction of Argininosuccinate Synthase Expression.

Werner A, Koschke M, Leuchtner N, Luckner-Minden C, Habermeier A, Rupp J, Heinrich C, Conradi R, Closs EI, Munder M.

Front Immunol. 2017 Jul 24;8:864. doi: 10.3389/fimmu.2017.00864. eCollection 2017.

2.

Uncoupling of Endothelial Nitric Oxide Synthase in Perivascular Adipose Tissue of Diet-Induced Obese Mice.

Xia N, Horke S, Habermeier A, Closs EI, Reifenberg G, Gericke A, Mikhed Y, Münzel T, Daiber A, Förstermann U, Li H.

Arterioscler Thromb Vasc Biol. 2016 Jan;36(1):78-85. doi: 10.1161/ATVBAHA.115.306263. Epub 2015 Nov 19.

3.

Dexamethasone, tetrahydrobiopterin and uncoupling of endothelial nitric oxide synthase.

Tobias S, Habermeier A, Siuda D, Reifenberg G, Xia N, Closs EI, Förstermann U, Li H.

J Geriatr Cardiol. 2015 Sep;12(5):528-39. doi: 10.11909/j.issn.1671-5411.2015.05.013.

4.

Induced arginine transport via cationic amino acid transporter-1 is necessary for human T-cell proliferation.

Werner A, Amann E, Schnitzius V, Habermeier A, Luckner-Minden C, Leuchtner N, Rupp J, Closs EI, Munder M.

Eur J Immunol. 2016 Jan;46(1):92-103. doi: 10.1002/eji.201546047. Epub 2015 Nov 2.

5.

Asymmetric dimethylarginine is transported by the mitochondrial carrier SLC25A2.

Porcelli V, Longo A, Palmieri L, Closs EI, Palmieri F.

Amino Acids. 2016 Feb;48(2):427-36. doi: 10.1007/s00726-015-2096-9. Epub 2015 Sep 24.

PMID:
26403849
6.

Hypomorphic variants of cationic amino acid transporter 3 in males with autism spectrum disorders.

Nava C, Rupp J, Boissel JP, Mignot C, Rastetter A, Amiet C, Jacquette A, Dupuits C, Bouteiller D, Keren B, Ruberg M, Faudet A, Doummar D, Philippe A, Périsse D, Laurent C, Lebrun N, Guillemot V, Chelly J, Cohen D, Héron D, Brice A, Closs EI, Depienne C.

Amino Acids. 2015 Dec;47(12):2647-58. doi: 10.1007/s00726-015-2057-3. Epub 2015 Jul 28.

7.

Putative role of cationic amino acid transporter-3 in murine liver metabolism.

Closs EI.

Hepatology. 2015 Oct;62(4):1326-7. doi: 10.1002/hep.27763. Epub 2015 Mar 25. No abstract available.

PMID:
25712160
8.

Metabolism via Arginase or Nitric Oxide Synthase: Two Competing Arginine Pathways in Macrophages.

Rath M, Müller I, Kropf P, Closs EI, Munder M.

Front Immunol. 2014 Oct 27;5:532. doi: 10.3389/fimmu.2014.00532. eCollection 2014. Review.

9.

System L amino acid transporter LAT1 accumulates O-(2-fluoroethyl)-L-tyrosine (FET).

Habermeier A, Graf J, Sandhöfer BF, Boissel JP, Roesch F, Closs EI.

Amino Acids. 2015 Feb;47(2):335-44. doi: 10.1007/s00726-014-1863-3. Epub 2014 Nov 11.

PMID:
25385314
10.

Granulocyte functions are independent of arginine availability.

Kapp K, Prüfer S, Michel CS, Habermeier A, Luckner-Minden C, Giese T, Bomalaski J, Langhans CD, Kropf P, Müller I, Closs EI, Radsak MP, Munder M.

J Leukoc Biol. 2014 Dec;96(6):1047-53. doi: 10.1189/jlb.3AB0214-082R. Epub 2014 Aug 7.

PMID:
25104794
11.

Differential cystine and dibasic amino acid handling after loss of function of the amino acid transporter b0,+AT (Slc7a9) in mice.

Di Giacopo A, Rubio-Aliaga I, Cantone A, Artunc F, Rexhepaj R, Frey-Wagner I, Font-Llitjós M, Gehring N, Stange G, Jaenecke I, Mohebbi N, Closs EI, Palacín M, Nunes V, Daniel H, Lang F, Capasso G, Wagner CA.

Am J Physiol Renal Physiol. 2013 Dec 15;305(12):F1645-55. doi: 10.1152/ajprenal.00221.2013. Epub 2013 Oct 9.

12.

Identification of cysteine residues in human cationic amino acid transporter hCAT-2A that are targets for inhibition by N-ethylmaleimide.

Beyer SR, Mallmann RT, Jaenecke I, Habermeier A, Boissel JP, Closs EI.

J Biol Chem. 2013 Oct 18;288(42):30411-9. doi: 10.1074/jbc.M113.490698. Epub 2013 Sep 9.

13.

Decoding the substrate supply to human neuronal nitric oxide synthase.

Simon A, Karbach S, Habermeier A, Closs EI.

PLoS One. 2013 Jul 9;8(7):e67707. doi: 10.1371/journal.pone.0067707. Print 2013.

14.

A chimera carrying the functional domain of the orphan protein SLC7A14 in the backbone of SLC7A2 mediates trans-stimulated arginine transport.

Jaenecke I, Boissel JP, Lemke M, Rupp J, Gasnier B, Closs EI.

J Biol Chem. 2012 Aug 31;287(36):30853-60. doi: 10.1074/jbc.M112.350322. Epub 2012 Jul 11.

15.

Impairment of the extrusion transporter for asymmetric dimethyl-L-arginine: a novel mechanism underlying vasospastic angina.

Closs EI, Ostad MA, Simon A, Warnholtz A, Jabs A, Habermeier A, Daiber A, Förstermann U, Münzel T.

Biochem Biophys Res Commun. 2012 Jun 29;423(2):218-23. doi: 10.1016/j.bbrc.2012.05.044. Epub 2012 May 15.

PMID:
22609206
16.

Relative contribution of different l-arginine sources to the substrate supply of endothelial nitric oxide synthase.

Karbach S, Simon A, Slenzka A, Jaenecke I, Habermeier A, Martiné U, Förstermann U, Closs EI.

J Mol Cell Cardiol. 2011 Nov;51(5):855-61. doi: 10.1016/j.yjmcc.2011.07.024. Epub 2011 Aug 2.

PMID:
21839088
17.

Protein kinase C-dependent ubiquitination and clathrin-mediated endocytosis of the cationic amino acid transporter CAT-1.

Vina-Vilaseca A, Bender-Sigel J, Sorkina T, Closs EI, Sorkin A.

J Biol Chem. 2011 Mar 11;286(10):8697-706. doi: 10.1074/jbc.M110.186858. Epub 2011 Jan 5.

18.

Resveratrol reverses endothelial nitric-oxide synthase uncoupling in apolipoprotein E knockout mice.

Xia N, Daiber A, Habermeier A, Closs EI, Thum T, Spanier G, Lu Q, Oelze M, Torzewski M, Lackner KJ, Münzel T, Förstermann U, Li H.

J Pharmacol Exp Ther. 2010 Oct;335(1):149-54. doi: 10.1124/jpet.110.168724. Epub 2010 Jul 7.

19.

Polyamines Impair Immunity to Helicobacter pylori by Inhibiting L-Arginine Uptake Required for Nitric Oxide Production.

Chaturvedi R, Asim M, Hoge S, Lewis ND, Singh K, Barry DP, de Sablet T, Piazuelo MB, Sarvaria AR, Cheng Y, Closs EI, Casero RA Jr, Gobert AP, Wilson KT.

Gastroenterology. 2010 Nov;139(5):1686-98, 1698.e1-6. doi: 10.1053/j.gastro.2010.06.060. Epub 2010 Jul 1.

20.

Neuronal nitric oxide synthase modulates maturation of human dendritic cells.

Adler HS, Simon A, Graulich E, Habermeier A, Bacher N, Friebe A, Closs EI, Steinbrink K.

J Immunol. 2010 Jun 1;184(11):6025-34. doi: 10.4049/jimmunol.0901327. Epub 2010 Apr 26.

21.

Arginine transport in human erythroid cells: discrimination of CAT1 and 4F2hc/y+LAT2 roles.

Rotoli BM, Closs EI, Barilli A, Visigalli R, Simon A, Habermeier A, Bianchi N, Gambari R, Gazzola GC, Bussolati O, Dall'Asta V.

Pflugers Arch. 2009 Oct;458(6):1163-73. doi: 10.1007/s00424-009-0692-9. Epub 2009 Jun 28.

PMID:
19562367
22.

Paradoxical effect of L-arginine: acceleration of endothelial cell senescence.

Scalera F, Closs EI, Flick E, Martens-Lobenhoffer J, Boissel JP, Lendeckel U, Heimburg A, Bode-Böger SM.

Biochem Biophys Res Commun. 2009 Sep 4;386(4):650-5. doi: 10.1016/j.bbrc.2009.06.091. Epub 2009 Jun 21.

PMID:
19545540
23.

6-mercaptopurine and 9-(2-phosphonyl-methoxyethyl) adenine (PMEA) transport altered by two missense mutations in the drug transporter gene ABCC4.

Janke D, Mehralivand S, Strand D, Gödtel-Armbrust U, Habermeier A, Gradhand U, Fischer C, Toliat MR, Fritz P, Zanger UM, Schwab M, Fromm MF, Nürnberg P, Wojnowski L, Closs EI, Lang T.

Hum Mutat. 2008 May;29(5):659-69. doi: 10.1002/humu.20694.

PMID:
18300232
24.

Antiatherosclerotic effects of small-molecular-weight compounds enhancing endothelial nitric-oxide synthase (eNOS) expression and preventing eNOS uncoupling.

Wohlfart P, Xu H, Endlich A, Habermeier A, Closs EI, Hübschle T, Mang C, Strobel H, Suzuki T, Kleinert H, Förstermann U, Ruetten H, Li H.

J Pharmacol Exp Ther. 2008 May;325(2):370-9. doi: 10.1124/jpet.107.128009. Epub 2008 Feb 5.

25.

In human endothelial cells rapamycin causes mTORC2 inhibition and impairs cell viability and function.

Barilli A, Visigalli R, Sala R, Gazzola GC, Parolari A, Tremoli E, Bonomini S, Simon A, Closs EI, Dall'Asta V, Bussolati O.

Cardiovasc Res. 2008 Jun 1;78(3):563-71. doi: 10.1093/cvr/cvn024. Epub 2008 Feb 4.

PMID:
18250144
26.

Structure and function of cationic amino acid transporters (CATs).

Closs EI, Boissel JP, Habermeier A, Rotmann A.

J Membr Biol. 2006;213(2):67-77. Epub 2007 Apr 6. Review.

PMID:
17417706
27.

Rapamycin stimulates arginine influx through CAT2 transporters in human endothelial cells.

Visigalli R, Barilli A, Bussolati O, Sala R, Gazzola GC, Parolari A, Tremoli E, Simon A, Closs EI, Dall'Asta V.

Biochim Biophys Acta. 2007 Jun;1768(6):1479-87. Epub 2007 Feb 24.

28.

Stress-induced reversal of microRNA repression and mRNA P-body localization in human cells.

Bhattacharyya SN, Habermacher R, Martine U, Closs EI, Filipowicz W.

Cold Spring Harb Symp Quant Biol. 2006;71:513-21. Review.

PMID:
17381334
29.

Activation of classical protein kinase C decreases transport via systems y+ and y+L.

Rotmann A, Simon A, Martiné U, Habermeier A, Closs EI.

Am J Physiol Cell Physiol. 2007 Jun;292(6):C2259-68. Epub 2007 Feb 28.

30.

Transport of peptides, amino acids, and derivatives.

Closs EI, Leibach F.

Amino Acids. 2006 Sep;31(2):91. No abstract available.

PMID:
16906357
31.

Reversal of endothelial nitric oxide synthase uncoupling and up-regulation of endothelial nitric oxide synthase expression lowers blood pressure in hypertensive rats.

Li H, Witte K, August M, Brausch I, Gödtel-Armbrust U, Habermeier A, Closs EI, Oelze M, Münzel T, Förstermann U.

J Am Coll Cardiol. 2006 Jun 20;47(12):2536-44. Epub 2006 May 26.

32.

Relief of microRNA-mediated translational repression in human cells subjected to stress.

Bhattacharyya SN, Habermacher R, Martine U, Closs EI, Filipowicz W.

Cell. 2006 Jun 16;125(6):1111-24.

33.

Granulocyte-macrophage colony-stimulating factor increases L-arginine transport through the induction of CAT2 in bone marrow-derived macrophages.

Martín L, Comalada M, Marti L, Closs EI, MacLeod CL, Martín del Río R, Zorzano A, Modolell M, Celada A, Palacín M, Bertran J.

Am J Physiol Cell Physiol. 2006 May;290(5):C1364-72. Epub 2005 Dec 21.

34.

Activation of classical protein kinase C reduces the expression of human cationic amino acid transporter 3 (hCAT-3) in the plasma membrane.

Rotmann A, Vékony N, Gassner D, Niegisch G, Strand D, Martiné U, Closs EI.

Biochem J. 2006 Apr 1;395(1):117-23.

35.

Monovalent cation conductance in Xenopus laevis oocytes expressing hCAT-3.

Gilles W, Vulcu SD, Liewald JF, Habermeier A, Vékony N, Closs EI, Rupp J, Nawrath H.

Biochim Biophys Acta. 2005 Mar 1;1668(2):234-9. Epub 2005 Jan 21.

36.

Dexamethasone suppresses eNOS and CAT-1 and induces oxidative stress in mouse resistance arterioles.

Schäfer SC, Wallerath T, Closs EI, Schmidt C, Schwarz PM, Förstermann U, Lehr HA.

Am J Physiol Heart Circ Physiol. 2005 Jan;288(1):H436-44. Erratum in: Am J Physiol Heart Circ Physiol. 2005 Dec;289(6):H2752.

37.
38.

Plasma membrane transporters for arginine.

Closs EI, Simon A, Vékony N, Rotmann A.

J Nutr. 2004 Oct;134(10 Suppl):2752S-2759S; discussion 2765S-2767S. Review.

PMID:
15465780
39.

Regulation of intestinal phosphate cotransporter NaPi IIb by ubiquitin ligase Nedd4-2 and by serum- and glucocorticoid-dependent kinase 1.

Palmada M, Dieter M, Speil A, Böhmer C, Mack AF, Wagner HJ, Klingel K, Kandolf R, Murer H, Biber J, Closs EI, Lang F.

Am J Physiol Gastrointest Liver Physiol. 2004 Jul;287(1):G143-50. Epub 2004 Mar 25.

40.

CATs and HATs: the SLC7 family of amino acid transporters.

Verrey F, Closs EI, Wagner CA, Palacin M, Endou H, Kanai Y.

Pflugers Arch. 2004 Feb;447(5):532-42. Epub 2003 Jun 11. Review.

PMID:
14770310
41.
42.

Stimulation of endothelial nitric oxide synthase by proinsulin C-peptide.

Wallerath T, Kunt T, Forst T, Closs EI, Lehmann R, Flohr T, Gabriel M, Schäfer D, Göpfert A, Pfützner A, Beyer J, Förstermann U.

Nitric Oxide. 2003 Sep;9(2):95-102.

PMID:
14623175
43.

Role of neutral amino acid transport and protein breakdown for substrate supply of nitric oxide synthase in human endothelial cells.

Simon A, Plies L, Habermeier A, Martiné U, Reining M, Closs EI.

Circ Res. 2003 Oct 31;93(9):813-20. Epub 2003 Sep 25.

44.

Two amino acid residues determine the low substrate affinity of human cationic amino acid transporter-2A.

Habermeier A, Wolf S, Martiné U, Gräf P, Closs EI.

J Biol Chem. 2003 May 23;278(21):19492-9. Epub 2003 Mar 12.

45.

Expression of solute carrier 7A4 (SLC7A4) in the plasma membrane is not sufficient to mediate amino acid transport activity.

Wolf S, Janzen A, Vékony N, Martiné U, Strand D, Closs EI.

Biochem J. 2002 Jun 15;364(Pt 3):767-75.

46.

Expression, regulation and function of carrier proteins for cationic amino acids.

Closs EI.

Curr Opin Nephrol Hypertens. 2002 Jan;11(1):99-107. Review.

PMID:
11753094
47.

Human cationic amino acid transporter hCAT-3 is preferentially expressed in peripheral tissues.

Vékony N, Wolf S, Boissel JP, Gnauert K, Closs EI.

Biochemistry. 2001 Oct 16;40(41):12387-94.

PMID:
11591158
48.
49.
50.

Voltage dependence of L-arginine transport by hCAT-2A and hCAT-2B expressed in oocytes from Xenopus laevis.

Nawrath H, Wegener JW, Rupp J, Habermeier A, Closs EI.

Am J Physiol Cell Physiol. 2000 Nov;279(5):C1336-44.

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